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1. Analysis of influenza vaccination coverage among the elderly living in Rome, based on a deprivation index, 2009-2013

Author

Vukovic, V., Lillini, R., Asta, F., Chini, F., and DE Waure, C.

Subjects
Deprivation, Elderly, Influenza vaccination, Vaccine coverage, Aged, Female, Humans, Influenza Vaccines, Influenza, Human, Male, Mortality, Registries, Rome, Poverty, Social Class, Vaccination Coverage, Vaccination Refusal, Influenza, Original Article, Human
Abstract

Summary Introduction Elderly people are more likely to develop influenza-related complications. However, despite the recommendations, the optimal vaccination coverage is not reached. The use of deprivation indexes can help to identify subgroups with lower vaccination uptake. We analyzed vaccination coverage among elderly subjects living in the city of Rome on the basis of their socioeconomic characteristics by using a local deprivation index. Methods We focused on the population aged ≥ 65 years living in the city of Rome from 2009 to 2013. Information on vaccination coverage was collected from general practitioners. A combination of multivariate techniques, including multiple linear regression, factor and cluster analysis, was used to construct a composite area-based Index of Socio-Economic and Health Deprivation (SEHDI). The index was calculated for each census tract on the basis of data from the 2001 Italian census. Results The majority of elderly subjects living in Rome belonged to the medium (40.4%) and medium-high (24%) deprivation groups; only 4.5% of the population was in the low-deprivation group. An inverse relationship was found between influenza vaccination coverage and the deprivation index: elderly subjects in the low-deprivation group displayed lower coverage (55.45%) than those in the high-deprivation group (57.59%). Specifically, vaccination coverage decreased with the increase of replacement index, employment rate and the percentage of: single and divorced individuals; university and high-school graduates; employees, entrepreneurs and freelancers, family assistants, students; foreigners and stateless persons residing in Italy; families consisting of one person. Conclusions Our results show an inverse relationship between deprivation and vaccination coverage and may help to identify subgroups that could benefit from targeted initiatives to increase vaccination coverage.

Published
2018

3. How to choose health technologies to be assessed by HTA? A review of criteria for priority setting

Author

HTA Working Group of the Italian Society of Hygiene, Preventive Medicine and Public Health (SItI), de Waure, C, Ricciardi, W, Favaretti, C, Rotundo, G, Di Nardo, F, Favale, M, and Specchia, Ml

Subjects
Europe, Internationality, Technology Assessment, Biomedical, Cost of Illness, Health Priorities, Cost-Benefit Analysis, Biomedical Technology, HTA, Priority setting, Humans, Social Change, Settore MED/42 - IGIENE GENERALE E APPLICATA, Resource Allocation
Abstract

Health Technology Assessment (HTA) plays a key role in the policy and decision-making process. Nevertheless, it is time- and resource-consuming, and therefore requires proper resource allocation. Priority setting, as a best way to organize effective and explicit resource allocation systems, may be applied even in this field.The aim of this study was to provide an overview of criteria used for priority setting in HTA at European level.A systematic review of the scientific literature was performed through PubMed alongside consultation of the websites of the European HTA Agencies belonging to the INAHTA. The search was limited to papers written in English and provided with the full text. Documents were considered eligible if providing criteria for priority setting in HTA.Seven scientific articles were retrieved from PubMed and 14 European HTA Agencies released prioritization criteria were analysed. The most relevant criteria were: frequency/burden of disease, economic impact and costs, potential benefits, impact on ethical, social, cultural and/or legal aspects.This work is meant to contribute to supranational discussion on priority setting at European level and shows that, despite the available evidence, work still needs to be done toward harmonization and sharing of the criteria to adopt.

Published
2015

4. Metodologia epidemiologica

Author

Damiani G, Federico B, Pavia M, Villari P, de Waure C., ANGELILLO, Italo Francesco, Ricciardi W, Angelillo I.F. et al., Damiani, G, Federico, B, Angelillo, Italo Francesco, Pavia, M, Villari, P, and de Waure, C.

Published
2013

5. Balancing donor and recipient risk factors in liver transplantation: the value of D-MELD with particular reference to HCV recipients

Author

Avolio, A, Cillo, U, Salizzoni, M, DE CARLIS, LUCIANO GREGORIO, Colledan, M, Gerunda, G, Mazzaferro, V, Tisone, G, Romagnoli, R, Caccamo, L, Rossi, M, Vitale, A, Cucchetti, A, Lupo, L, Gruttadauria, S, Nicolotti, N, Burra, P, Gasbarrini, A, Agnes, S, Lirosi, M, Miele, L, Pompili, M, Siciliano, M, Perilli, V, Gaspari, R, Castagneto, M, Lupo, F, Tandoi, F, De Carlis, L, Mangoni, I, Belli, L, Pinna, A, Cescon, M, Gridelli, B, Li Petri, S, Volpes, R, Pinelli, D, Fagiuoli, S, Montalti, R, Regalia, E, Rossi, G, Antonelli, B, Berloco, P, Lai, Q, Risaliti, A, Nicolini, D, Valente, U, Gelli, M, Morelli, N, Zamboni, F, Tondolo, V, Ettorre, G, Vennarecci, G, Bresadola, F, Baccarani, U, Toniutto, P, Manzia, T, Anselmo, A, Angelico, M, Calise, F, Scuderi, V, Romano, M, Rendina, M, Barone, M, Cuomo, O, Perrella, A, Santaniello, W, Donataccio, M, Dalle Ore, G, De Ville De Goyet, J, Monti, L, De Waure, C., Avolio A.W., Cillo U., Salizzoni M., De Carlis L., Colledan M., Gerunda G.E., Mazzaferro V., Tisone G., Romagnoli R., Caccamo L., Rossi M., Vitale A., Cucchetti A., Lupo L., Gruttadauria S., Nicolotti N., Burra P., Gasbarrini A., Agnes S., Lirosi M.C., Miele L., Pompili M., Siciliano M., Perilli V., Gaspari R., Castagneto M., Tandoi F., Mangoni I., Belli L., Pinna A.D., Cescon M., Gridelli B., Li Petri S., Volpes R., Pinelli D., Fagiuoli S., Montalti R., Regalia E., Rossi G., Antonelli B., Berloco P., Lai Q., Risaliti A., Nicolini D., Valente U., Gelli M., Morelli N., Zamboni F., Tondolo V., Brotzu G., Ettorre G.M., Vennarecci G., Bresadola F., Baccarani U., Toniutto P.L., Manzia T., Anselmo A., Angelico M., Calise F., Scuderi V., Romano M., Rendina M., Barone M., Cuomo O., Perrella A., Santaniello W., Donataccio M., Dalle Ore G., de Ville de J., Monti L., Avolio, A W, Cillo, U, Salizzoni, M, De Carlis, L, Colledan, M, Gerunda, G E, Mazzaferro, Mariapia, Tisone, G, Romagnoli, R, Caccamo, L, Rossi, M, Vitale, A, Cucchetti, A, Lupo, L, Gruttadauria, S, Nicolotti, N, Burra, P, Gasbarrini, A, Agnes, S, Montalti, Roberto, Avolio, A, DE CARLIS, L, Gerunda, G, Mazzaferro, V, Lirosi, M, Miele, L, Pompili, M, Siciliano, M, Perilli, V, Gaspari, R, Castagneto, M, Lupo, F, Tandoi, F, Mangoni, I, Belli, L, Pinna, A, Cescon, M, Gridelli, B, Li Petri, S, Volpes, R, Pinelli, D, Fagiuoli, S, Montalti, R, Regalia, E, Rossi, G, Antonelli, B, Berloco, P, Lai, Q, Risaliti, A, Nicolini, D, Valente, U, Gelli, M, Morelli, N, Zamboni, F, Tondolo, V, Ettorre, G, Vennarecci, G, Bresadola, F, Baccarani, U, Toniutto, P, Manzia, T, Anselmo, A, Angelico, M, Calise, F, Scuderi, V, Romano, M, Rendina, M, Barone, M, Cuomo, O, Perrella, A, Santaniello, W, Donataccio, M, Dalle Ore, G, De Ville De Goyet, J, Monti, L, and De Waure, C

Subjects
Graft Rejection, Male, medicine.medical_treatment, Settore MED/18 - CHIRURGIA GENERALE, Hepacivirus, Liver transplantation, Gastroenterology, Liver disease, Postoperative Complications, Retrospective Studie, UNSUSTAINABLE MATCH, Models, Risk Factors, Immunology and Allergy, Health Status Indicators, Age Factor, PROGNOSTIC INDICES, Pharmacology (medical), Health Status Indicator, D-MELD, Liver Transplantation, liver transplantation, Hazard ratio, Graft Survival, donor-recipient match, outcome, prognosis, risk factors, Age Factors, Trapianto epatico, Hepatitis C, Hepatitis B, Statistical, Middle Aged, Prognosis, Tissue Donors, Survival Rate, Italy, HCV, Female, Human, Adult, medicine.medical_specialty, Prognosi, Donor Selection, End Stage Liver Disease, Young Adult, Internal medicine, medicine, Humans, fattori di rischio, Aged, Retrospective Studies, Transplantation, Hepaciviru, Models, Statistical, business.industry, Donor selection, Risk Factor, Settore MED/09 - MEDICINA INTERNA, Odds ratio, medicine.disease, Settore MED/18, Surgery, body regions, Postoperative Complication, business
Abstract

Donor-recipient match is a matter of debate in liver transplantation. D-MELD (donor age × recipient biochemical model for end-stage liver disease [MELD]) and other factors were analyzed on a national Italian database recording 5946 liver transplants. Primary endpoint was to determine factors predictive of 3-year patient survival. D-MELD cutoff predictive of 5-year patient survival 1628). At 3 years, the odds ratio (OR) for death was 2.03 (95% confidence interval [CI], 1.44-2.85) in D-MELD class C versus B. The OR was 0.40 (95% CI, 0.24-0.66) in class A versus class B. Other predictors were hepatitis C virus (HCV; OR = 1.42; 95% CI, 1.11-1.81), hepatitis B virus (HBV; OR = 0.69; 95% CI, 0.51-0.93), retransplant (OR = 1.82; 95% CI, 1.16-2.87) and low-volume center (OR = 1.48; 95% CI, 1.11-1.99). Cox regressions up to 90 months confirmed results. The hazard ratio was 1.97 (95% CI, 1.59-2.43) for D-MELD class C versus class B and 0.42 (95% CI, 0.29-0.60) for D-MELD class A versus class B. Recipient age, HCV, HBV and retransplant were also significant. The 5yrsPS

Published
2011

6. Use of HBcAb Positive Liver Grafts. Medium Term Results According to Donor-Recipient Risk Factors

Author

Avolio, A., Agnes, S., Salizzoni, M., Pinna, A., Gridelli, B., De Carlis, L., Colledan, M., Gerunda, G., Valente, U., Rossi, G., Ettorre, G., Risaliti, A., Mazzaferro, V., Bresadola, F., Rossi, Massimo, Tisone, G., Zamboni, F., Lupo, L., Cuomo, O., Calise, F., Lirosi, M., Vitale, A., Nicolotti, N., Romagnoli, R., Cucchetti, A., Gruttadauria, S., Mangoni, I., Pinelli, D., Montalti, R., Gelli, M., Caccamo, L., Vennarecci, G., Nicolini, D., Regalia, E., Baccarani, U., Lai, Q., Manzia, T., Tondolo, E., Rendina, M., Perrella, A., Scudieri, E., Antonelli, B., de Waure, C., De Feo, T., Burra, P., Gasbarrini, A., Cillo, U., Avolio, A, Agnes, S, Salizzoni, M, Pinna, A, Gridelli, B, De Carlis, L, Colledan, M, Gerunda, G, Valente, U, Rossi, G, Ettorre, G, Risaliti, A, Mazzaferro, V, Bresadola, F, Rossi, M, Tisone, G, Zamboni, F, Lupo, L, Cuomo, O, Calise, F, Lirosi, M, Vitale, A, Nicolotti, N, Romagnoli, R, Cucchetti, A, Gruttadauria, S, Mangoni, I, Pinelli, D, Montalti, R, Gelli, M, Caccamo, L, Vennarecci, G, Nicolini, D, Regalia, E, Baccarani, U, Lai, Q, Manzia, T, Tondolo, E, Rendina, M, Perrella, A, Scudieri, E, Antonelli, B, de Waure, C, De Feo, T, Burra, P, Gasbarrini, A, and Cillo, U

Subjects
liver transplantation, HBcAb positive donor
Published
2011

8. Use of HBCAB positive liver organs. Medium term results: according to the Donor –Recipient risk factors

Author

Avolio, A. W., Agnes, S., Salizzoni, M., Pinna, A. D., Gridelli, B., De Carlis, L., Colledan, M., Gerunda, G. E., Valente, U., Rossi, G., Ettorre, G. M., Risaliti, A., Mazzaferro, V., Bresadola, F., Rossi, M., Tisone, G., Zamboni, F., Lupo, L., Cuomo, O., Calise, F., Donataccio, M., Nicolotti, N., Vitale, A., Romagnoli, R., Lupo, F., Cucchetti, A., Gruttadauria, Salvatore Giovanni, Mangoni, I., Pinelli, D., Montalti, R., Gelli, M., Caccamo, L., Vennarecci, G., Nicolini, D., Regalia, E., Baccarani, U., Lai, Q., Manzia, T., Tondolo, E., Rendina, M., Barone, M., Perrella, A., Romano, M., de Waure, C., Burra, P., Gasbarrini, A., and Cillo, U.

Published
2011

9. Balancing Donor and Recipient Risk Factors in Liver Transplantation: The Value of D-MELD in Particluar Reference to a HCV Recipients

Author

Avolio, Aw, Cillo, U, Salizzoni, M, De Carlis, L, Colledan, M, Gerunda, Ge, Mazzaferro, V, Tisone, G, Romagnoli, R, Caccamo, L, Rossi, M, Vitale, A, Cucchetti, A, Lupo, L, Gruttadauria, S, Nicolotti, N, Burra, P, Gasbarrini, A, Agnes, S, Lirosi, Mc, Miele, L, Pompili, M, Siciliano, M, Perilli, V, Gaspari, R, Castagneto, M, Tandoi, F, Mangoni, I, Belli, L, Pinna, Ad, Cescon, M, Gridelli, B, Li Petri, S, Volpes, R, Fagiuoli, S, Montalti, R, Regalia, E, Antonelli, B, Berloco, P, Lai, Q, Risaliti, A, Nicolini, D, Valente, U, Gelli, M, Morelli, N, Zamboni, F, Tondolo, V, Ettorre, Gm, Vennarecci, G, Bresadola, F, Baccarani, U, Toniutto, Pl, Manzia, T, Anselmo, A, Angelico, M, Calise, F, Scuderi, V, Romano, M, Rendina, M, Barone, M, Cuomo, O, Perrella, A, Santaniello, W, Donataccio, M, Dalle Ore, G, De Ville De Goyet, J, Monti, L, and De Waure, C.

Published
2011

10. WWW.D-MELD.COM THE PROGNOSTIC CALCULATOR TO BALANCE DONOR AND RECIPIENT LIVER TRANSPLANT FACTORS USING D-MELD AND COVARIATES

Author

Avolio, A. W., Agnes, S., Lirosi, M. C., Salizzoni, M., Pinna, A. D., Gridelli, B., De Carlis, L., Colledan, M., Gerunda, G. E., Valente, U., Rossi, G., Ettorre, G. M., Risaliti, A., Mazzaferro, V., Bresadola, F., Rossi, M., Tisone, G., Zamboni, F., Lupo, L., Cuomo, O., Calise, F., Donataccio, M., Nicolotti, N., Vitale, A., Romagnoli, R, Lupo, F., Cucchetti, A., Gruttadauria, S., Mangoni, I., Pinelli, D., Montalti, R, Gelli, M., Caccamo, L., Vennarecci, G., Nicolini, D., Regalia, E., Baccarani, U., Lai, Q., Manzia, T., Tondolo, E., Rendina, M., Perrella, A., Scuderi, E., Antonelli, B., de Waure, C., De Feo, T., Burra, P., Gasbarrini, A., and Cillo, U.

Published
2011

11. Optimization of donor recipient match and identification of the futile match cutoff a national italian study on liver transplantation

Author

Avolio, A. W., Agnes, S., Lirosi, M. C., Salizzoni, M., Pinna, A. D., Gridelli, B., De Carlis, L., Colledan, M., Gerunda, G. E., Valente, U., Rossi, G., Ettorre, G. M., Risaliti, A., Mazzaferro, V., Bresadola, F., Rossi, M., Tisone, G., Zamboni, F., Lupo, L., Cuomo, O., Calise, F., Donataccio, M., Nicolotti, N., Vitale, A., Romagnoli, R., Lupo, F., Cucchetti, A., Gruttadauria, Salvatore Giovanni, Mangoni, I., Pinelli, D., Montalti, R., Gelli, M., Caccamo, L., Vennarecci, G., Nicolini, D., Regalia, E., Baccarani, U., Lai, Q., Manzia, T., Tondolo, E., Rendina, M., Barone, M., Perrella, A., Romano, M., de Waure, C., Burra, P., and Gasbarrini, A.

Published
2011

12. [The Italian legislation on Health Impact Assessment: the current national and regional regulatory framework]

Author

Bert, F, Ceruti, M, Colombo, A, Lovato, E, Bruno, S, Costa, G, Liguori, G, Manzoli, L, Siliquini, R, de WAURE, C., Specchia, M. L., Ricciardi, W., Versino, E., Scaletti, A., Capunzo, M., Boccia, G., Cavallo, P., Geraci, S., Nante, N., Lupoli, A., Marcarelli, M., DE VITO, Elisabetta, and Del Cimmuto, A.

Subjects
Italy, Humans, Public Health, Environment
Abstract

The scientific literature on HIA is particularly rich in Anglo-Saxon countries (United Kingdom, Canada, New Zealand), in Sweden and in the Netherlands, while in Italy there are not many scientific studies published on this theme. The study conducted showed that in Italy no laws relating to HIA have been enacted yet and that all laws enacted so far considered only EIA. Actually, legislation on environmental impact is in continuous expansion, even if at present, some regions have not yet passed a specified EIA-dealing law. In Italy the protection of health is promoted almost exclusively at a strictly medical level; decisions with strong social and environmental impact are not normally designed with particular regard to health issues. To increase in our country the interest for HIA, it would seem appropriate to discuss the usefulness of introducing health impact assessment in national and regional legislation. A possible law may indeed sensitize non-health decision makers to HIA, bringing Italy among the most innovative countries.

Published
2010

13. Il D-MELD espressione del match donatore-ricevente. Analisi retrospettiva multicentrica italiana relativa al periodo 2002-2009

Author

Avolio, A., Agnes, S., Cillo, U., Vitale, A., Lirosi, M. C., Salizzoni, M., Romagnoli, R., Lupo, L., Pinna, A., Cucchetti, A., Pinelli, D., Colledan, M., Gerunda, G., Montalti, R., Gridelli, B., Gruttadauria, Salvatore Giovanni, De Carlis, L., Mangoni, I., Valente, U., Gelli, M., Mazzaferro, V., Regalia, E., Ettorre, G., Vennarecci, G., Lai, Q., Rossi, M., Tisone, G., Sforza, D., Nicolini, D., Risaliti, A., Cuomo, O., Perrella, A., Tondolo, V., Zamboni, F., Rossi, G., Caccamo, L., Rendina, M., Bresadola, F., Baccarani, U., Donataccio, M., Dalle, O., Romano, M., Calise, F., Nicolotti, N., and de Waure, C.

Published
2010

14. Il graft HBcAb+ nella esperienza trapiantologica italiana (2002-2009). Analisi retrospettiva in rela-zione all’effetto centro ed all’epoca di effettuazione del trapianto

Author

Avolio, A., Cillo, U., Salizzoni, M., Pinna, A., Colledan, M., Gerunda, G., Gridelli, B., De, C., Valente, U., Mazzaferro, V., Ettorre, G., Rossi, M., Tisone, G., Risaliti, A., Cuomo, O., Zamboni, F., Rossi, G., Lupo, L., Bresadola, F., Donataccio, M., Calise, F., Nicolotti, N., Nure, E., Vitale, A., Romagnoli, R., Cucchetti, A., Pinelli, D., Montalti, R., Gruttadauria, Salvatore Giovanni, Mangoni, I., Gelli, M., Regalia, E., Vennarecci, G., Lai, Q., Sforza, D., Nicolini, D., Perrella, A., Tondolo, V., Caccamo, L., Rendina, M., Baccarani, U., Dalle Ore, G., Romano, M., de Waure, C., and Agnes, S.

Published
2010

24. Attitudes towards compulsory vaccination in Italy: Results from the NAVIDAD multicentre study

Author

A. Miduri, F Quattrocolo, Francesca Pennino, F. Di Donna, E Olivero, Azzurra Massimi, Maria Rosaria Gualano, C de Waure, Fabrizio Stracci, Ilaria Loperto, P Di Giovanni, Nicola Nante, Antonio Giuliani, Marina Marranzano, Emilia Prospero, LG Sisti, C. Signorelli, Giuseppe Michele Masanotti, Silvana Castaldi, G Voglino, M. Golfera, Roberta Siliquini, Raffaele Squeri, Fabrizio Bert, P Rossello, M P Fantini, M. M. D'Errico, P. Greco, A. Stefanati, Annalisa Rosso, C Genovese, Davide Gori, G Di Martino, E. Buttinelli, G. Zappalà, Gualano, M. R., Bert, F., Voglino, G., Buttinelli, E., D'Errico, M. M., De Waure, C., Di Giovanni, P., Fantini, M. P., Giuliani, A. R., Marranzano, M., Masanotti, G., Massimi, A., Nante, N., Pennino, F., Squeri, R., Stefanati, A., Signorelli, C., Siliquini, R., Castaldi, S., Di Donna, F., Di Martino, G., Genovese, C., Golfera, M., Gori, D., Greco, P., Loperto, I., Miduri, A., Olivero, E., Prospero, E., Quattrocolo, F., Rossello, P., Rosso, A., Sisti, L. G., Stracci, F., Zappalà, G., Gualano, Mr, Bert, F, Voglino, G, Buttinelli, E, D'Errico, Mm, De Waure, C, Di Giovanni, P, Fantini, Mp, Giuliani, Ar, Marranzano, M, Masanotti, G, Massimi, A, Nante, N, Pennino, F, Squeri, R, Stefanati, A, Signorelli, C, Siliquini, R, Gualano, M R, D'Errico, M M, Fantini, M P, and Giuliani, A R

Subjects
Health Knowledge, Attitudes, Practice, Multivariate analysis, Cross-sectional study, Immunology and Microbiology (all), Attitudes, Italy, Mandatory vaccination, Multicentre survey, Pregnancy, Vaccine hesitancy, Molecular Medicine, Veterinary (all), Public Health, Environmental and Occupational Health, Infectious Diseases, Mandatory Programs, Socioeconomic Factor, Heterogeneous-Nuclear Ribonucleoproteins, Health personnel, 0302 clinical medicine, Medicine, 030212 general & internal medicine, Multivariate Analysi, Practice, Immunization Program, Health Knowledge, Mandatory Program, Vaccination, Adolescent, Adult, Cross-Sectional Studies, Female, Health Personnel, Humans, Multivariate Analysis, Pregnant Women, Socioeconomic Factors, Immunization Programs, Public Health, Human, medicine.medical_specialty, Socio-culturale, 03 medical and health sciences, 030225 pediatrics, Socioeconomic status, Cross-Sectional Studie, Mandatory vaccination, Vaccine hesitancy, Pregnancy, Multicentre survey, Italy, General Veterinary, General Immunology and Microbiology, Health professionals, business.industry, Environmental and Occupational Health, Attitude, Family medicine, Heterogeneous-Nuclear Ribonucleoprotein, Healthcare service, business
Abstract

Background: Vaccine hesitancy is a considerable issue in European countries and leads to low coverage rates. After a long debate, Italy has made vaccination mandatory for admission to its schools.Methods: In the NAVIDAD study (a cross-sectional multicentre study), a 63-item questionnaire was administered to 1820 pregnant women from 15 Italian cities. The questionnaire assessed the interviewee's opinion on mandatory vaccines, as well as their socioeconomic status, sources of information about vaccines, confidence in the Italian National Healthcare Service (NHS), and intention to vaccinate their newborn.Results: Information sources play a key role in determining the opinion on restoration of mandatory vaccines; in particular, women who obtained information from anti-vaccination movements are less likely to accept the vaccines (OR: 0.35, 95% CI: 0.21-0.58, p < 0.001). Women who had confidence in healthcare professional information agreed more on mandatory vaccination than did the other women (OR: 2.66, 95% CI: 1.62-4.36, p < 0.001); those who perceived that healthcare professionals have economic interest in child immunization and who declared that healthcare providers inform only on vaccinations benefits not on risks were less likely to agree on compulsory vaccination (OR: 0.66, CI 95%: 0.46-0.96, p = 0.03; OR: 0.66, CI 95%: 0.46-0.95, p = 0.03, respectively).Conclusion: Information sources and confidence towards health professionals are the main determinants of acceptance of mandatory vaccine restoration. To increase the acceptability of the restoration and reduce vaccine hesitancy, these aspects need to be strengthened.

Published
2018

25. The management of multiple sclerosis by reference centers in south of Italy: a 2011 survey on health demands and needs in Campania region

Author

Daniele Spitaleri, Emilio Lombardi, Walter Di Iorio, Roberta Lanzillo, Mario Alberto Battaglia, Anna Pia Spadera, F. Romano, Giuseppe Orefice, Antonio Gallo, Pasquale Vivo, Francesco Di Nardo, Darko Nedovic, Vincenzo Busillo, Giorgia Teresa Maniscalco, Chiara De Waure, Walter Mazzucco, Walter Ricciardi, Leonardo Sinisi, Maria Petracca, de Waure, Chiara, Di Nardo, Francesco, Mazzucco, Walter, Nedovic, Darko, Battaglia, Mario Alberto, Busillo, Vincenzo, Di Iorio, Walter, Gallo, Antonio, Lanzillo, Roberta, Lombardi, Emilio, Maniscalco, Giorgia Teresa, Orefice, Giuseppe, Petracca, Maria, Romano, Felice, Sinisi, Leonardo, Spadera, Anna Pia, Spitaleri, Daniele, Vivo, Pasquale, Ricciardi, Walter, de Waure, C, Di Nardo, F, Mazzucco, W, Nedovic, D, Battaglia, Ma, Busillo, V, Di Iorio, W, Lanzillo, R, Lombardi, E, Maniscalco, Gt, Orefice, G, Petracca, M, Romano, F, Sinisi, L, Spadera, Ap, Spitaleri, D, Vivo, P, and Ricciardi, W.

Subjects
Adult, Male, medicine.medical_specialty, Pediatrics, Multiple Sclerosis, Cross-sectional study, Neurological examination, Dermatology, Disease management, Health services needs and demand, Multiple sclerosis, Cross-Sectional Studies, Female, Humans, Italy, Surveys and Questionnaires, Needs Assessment, 2708, Neurology (clinical), Psychiatry and Mental Health, 03 medical and health sciences, 0302 clinical medicine, medicine, Multiple sclerosi, 030212 general & internal medicine, Disease management (health), Glatiramer acetate, Settore MED/42 - IGIENE GENERALE E APPLICATA, Neuroradiology, Expanded Disability Status Scale, medicine.diagnostic_test, business.industry, General Medicine, Management of multiple sclerosis, medicine.disease, Psychiatry and Mental health, Physical therapy, business, 030217 neurology & neurosurgery, medicine.drug
Abstract

This cross-sectional study has investigated the diagnostic and therapeutic management of patients suffering from multiple sclerosis (MS) in the Campania Region (Italy). A survey involving all the reference centers for MS in Campania Region was conducted from March to August 2011. Centers responded to a web-administered questionnaire on management and clinical characteristics of MS patients. In the study period, 3263 patients (mean age 37 years, 66 % females) accessed the centers. Patients received a first diagnosis of MS in 161 cases (4.9 %). About 37 % of the subjects without a previous diagnosis came to the centers on their own initiative. All patients underwent a complete neurological examination and expanded disability status scale. The other most common investigations were magnetic resonance imaging (44.0 %) and evoked potentials (22.1 %). The number of treated patients was 2797 (87.1 %). The most used drugs were interferon β and glatiramer acetate. The time between diagnosis and initiation of therapy exceeded 6 months in 32 % of cases. Second-line drugs were under-used: 16 % of patients who might benefit from them show high clinical and radiological disease activity despite treatment with immunomodulant drugs. The MS care management of the surveyed centers showed consistent margins for improvement in 2011. Even though these data do not represent the current situation, they can be used to monitor improvements in MS care.

Published
2015

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