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1. KEY MESSAGES FOR A FRAILTY PREVENTION AND MANAGEMENT POLICY IN EUROPE FROM THE ADVANTAGE JOINT ACTION CONSORTIUM

Author

Manas L, Garcia-Sanchez I, Hendry A, Bernabei R, Roller-Wirnsberger R, Gabrovec B, Liew A, Carriazo A, Redon J, Galluzzo L, Vina J, Antoniadou E, Targowski T, di Furia L, Lattanzio F, Bozdog E, Telo M, and ADVANTAGE Joint Action Partners

Abstract

In the 2015 Ageing Report, the European Commission (EC) and the Economic Policy Committee stated that coping with the challenge posed by an ageing population will require determined policy action in Europe, particularly in reforming pension, health care and long-term care systems. The concern for this situation motivated the EC, the Parliament and many of the Member States (MS) to co-fund, in the 2015 call of the Third European Health Programme of the European Union 2014-2020, the first Joint Action (JA) on the prevention of frailty. ADVANTAGE JA brings together 33 partners from 22 MSs for 3 years. It aims to build a common understanding on frailty to be used in the MSs by policy makers and other stakeholders involved in the management, both at individual and population level, of older people who are frail or at risk for developing frailty throughout the European Union (EU). It is a formidable challenge but also a great opportunity for concerted action resulting in fostering effective and successful policies in frailty prevention and management in the participating MS. The Consortium has 2 years of hard work ahead to contribute to the needed change for frailty related disability free Europe. The first practical step towards this aim was the preparation of a document: the State of the Art on Frailty Report to support an overview of evidence of what works and what does not work on frailty prevention and management. Subsequently, this will be reflected in the advice that the JA will give to policy makers at MS level. Overall, these messages intend to be an instrument of added value to advocate for policy driven decisions on frailty prevention and management in the JA participating MSs and subsequently towards a frailty related disability free older population in Europe. The aim of this paper is to describe ADVANTAGE JA general structure, approach and recommendations towards a European health and social policy which will support frailty prevention in the participating MS.

Published
2018

2. Incidence of traumatic spinal cord injury in Italy during 2013-2014: a population-based study

Author

Ferro, S., Cecconi, L., Bonavita, J., Pagliacci, M. C., Biggeri, A., Franceschini, M., Bellentani, M., Cavina, A., De Iure, F., Gordini, G., Redaelli, T., Actis, M. V., Del Popolo, G., Bertagnoni, G., Avesani, R., Falabella, V., Stillittano, M., Petrozzino, S., Cisari, C., Salvini, M., Tosi, R., Borghi, C. M., Bava, A., Pistarini, C., Molinero, G., Signorelli, A., Sandri, S., Simeoni, F., Brambilla, M., Banchero, M. A., Olivero, A., Zanaboni, G., Leucci, M., Lain, L., Saia, M., Zampa, A., Del Fabro, P., Saccavini, M., Fanzutto, A., Massone, A., Gaddoni, D., Olivi, S., Musumeci, G., Pederzini, R., Bazo, H. C., Nicolotti, D., Nora, M., Brianti, R., Iaccarino, C., Volpi, A., Lombardi, A., Cavazza, S., Casoni, F., Piperno, R., Teodorani, G., Naldi, A., Vergoni, G., Maietti, E., Botti, A., Pagoto, G., Moresi, M., Postiglione, M., Bini, C., Tagliaferri, M., Recchioni, M. A., Pelaia, P., Di Furia, L., Maschke, R., Caruso, L., Speziali, L., Zenzeri, M., Fiore, P., Marvulli, R., Nardulli, R., Lanzillotti, C., Ruccia, M., Onesta, M. P., Di Gregorio, T., Franchina, F., Furnari, M. G., Pilati, C., Merafina, M., Crescia, F., Fletzer, D., Scivoletto, G., and Di Lallo, N.

Subjects
Adult, Male, 030506 rehabilitation, medicine.medical_specialty, Pediatrics, Adolescent, Population, 03 medical and health sciences, Young Adult, 0302 clinical medicine, statistica medica, Sex Factors, Epidemiology, medicine, Humans, Prospective Studies, Prospective cohort study, education, Tetraplegia, Spinal cord injury, Spinal Cord Injuries, Aged, Aged, 80 and over, education.field_of_study, business.industry, Incidence (epidemiology), Incidence, Age Factors, General Medicine, Middle Aged, medicine.disease, Neurology, Italy, Etiology, Physical therapy, Female, Neurology (clinical), 0305 other medical science, Paraplegia, business, 030217 neurology & neurosurgery
Abstract

Observational prospective population-based incidence study. The main objective of this study was to assess the incidence of traumatic spinal cord injuries (TSCIs) and incidence rates, in order to provide estimates by age, gender, characteristics and cause. This study was conducted at acute-care spinal cord injury (SCI) hospitals and SCI centers from 11 Italian regions, between 1 October 2013 and 30 September 2014. Data of all consecutive patients with acute TSCI who met the inclusion criteria were obtained through case reporting by clinicians. The data were collected into a web database. Incidence rates and incidence rate ratios were calculated and stratified by age, gender, cause, level and completeness. From 50% of the entire population of Italy, 445 new cases of TSCI were included. The crude incidence rate of TSCI was 14.7 cases per million per year (95% CI: 13.4–16.4); the overall male to female ratio was 4:1 and the mean age was 54. Complete information was available in 85% of the sample and revealed tetraplegia in 58% and incomplete lesion in 67% of cases. The leading cause of TSCI was falls (40.9%) followed by road traffic accidents (33.5%). The leading cause was falls for patients over 55 and road traffic accidents for patients under 55. The changing trend of TSCI epidemiology concerns the increase in the average age of TSCI people and the increase of both cervical and incomplete lesions. The etiology shows the primacy of falls over road traffic accidents and suggests the need for a change in prevention policies.

Published
2017

3. The Italian Dementia National Plan. Commentary

Author

Di Fiandra, T, Canevelli, M, Di Pucchio, A, Vanacore, N, Italian Dementia National Plan, W. G, Corti, Mc, Chiodini, M, Trequattrini, A, Lombardi, A, Gilli, M, Trambusti, B, Vassalle, A, Giordano, M, Pomo, V, Scarcali, G, Vitale, R, Lagalla, G, Di Furia, L, Petrali, R, Bersani, M, Mancardi, GIOVANNI LUIGI, Zammitti, P, Scalmana, S, Agnoletto, A, Carafelli, A, Fabrizio, R, Fabbo, A, Greco, A, Bruni, A, Desideri, G, Angeli, G, Spadin, P, Salvini Porro, G, Possenti, M, Bartorelli, L, Ruocco, G, Guerra, R, Malara, P, and Pisanti, P.

Subjects
Aged, 80 and over, dementia, alzheimer’s disease, national plan, public health, national strategies, Health Policy, Social Support, Caregivers, Italy, Quality of Life, Humans, Dementia, Aged
Abstract

The Italian Dementia National Plan was formulated in October 2014 by the Italian Ministry of Health in close cooperation with the regions, the National Institute of Health and the three major national associations of patients and carers. The main purpose of this strategy was to provide directive indications for promoting and improving interventions in the dementia field, not limiting to specialist and therapeutic actions, but particularly focusing on the support of patients and families throughout the pathways of care. Four main objectives are indicated: 1) promote health- and social-care interventions and policies; 2) create/strengthen the integrated network of services for dementia based on an integrated approach; 3) implement strategies for promoting appropriateness and quality of care; and 4) improve the quality of life of persons with dementia and their families by supporting empowerment and stigma reduction. These objectives and the pertaining actions are described in the present paper.

Published
2016

4. Socioeconomic Predictors of the Employment of Migrant Care Workers by Italian Families Assisting Older Alzheimer's Disease Patients: Evidence From the Up-Tech Study

Author

Barbabella, F., Chiatti, C., Rimland, J. M., Melchiorre, M. G., Lamura, G., Lattanzio, F., Baldassarri, D., Bitti, L., Carosi, A., Sabbatini, M., Paolasini, E., Fiori, T., Fronzi, C., Giacchetta, S., Giacomini, V., Giovagnoli, L., Lattanzi, G., Manca, A. M., Pigini, V., Pignotti, M., Proietti, M. C., Quarticelli, A., Rovedi, M., Tasso, L., Valeri, V., Antonioli, A., Barabucci, M., Bassani, M., Bollettini, P., Bruttapasta, M. C., Buccolini, C., Carangella, R., Carboni, F., Ceccolini, D., D'Incecco, P., Di Felice, M., Dini, L., Gioia, G., Di Prima, G., Giusepponi, G., Lanciotti, C., Loffreda, A., Luciani, O., Mariani, L., Mastrorilli, F., Moroni, R., Piatkowska, I., Rucoli, R., Scoccia, G., Teodori, N., Tonelli, T., Angeloni, R., Bratti, R. A., Bonafede, G., Lorenzetti, S., Paci, C., Picciotti, G., Pezzola, D., Rea, V., Scialè, V., Signorino, M., Sorvillo, F., Tomassini, P. F., Ciccola, A., Cionfrini, L., Alessandrini, D., De Santis, A., Formica, B., Tacchi, G., Tortorelli, S., Regional, M., Marchegiani, G., Pozzari, G., Santarelli, G., Bartolucci, D., Caraffa, G., Cavallo, Filippo, Di Furia, L., Lacetera, A., Maffei, C. M., Manzoli, L., Postacchini, D., Bonfigli, A. R., Bonfranceschi, F., Bustacchini, S., Capasso, M., Cassetta, L., Civerchia, P., Demma, F., Di Rosa, M., Furneri, G., Giuli, C., Marcellini, M., Marinelli, P., Melchiorre, G., Moraca, M. E., Principi, A., Rocchetti, C., Spazzafumo, L., Vincitorio, D., Bartulewicz, K., Olivetti, P., and Rossi, L.

Subjects
Gerontology, Migrant care worker, Male, Financing, Government, very elderly, aged, Alzheimer disease, caregiver, economics, educational status, employment, female, financial management, home care, human, Italy, long term care, male, middle aged, migration, socioeconomics, standards, statistics and numerical data, supply and distribution, very elderly, Aged, Aged, 80 and over, Alzheimer Disease, Caregivers, Educational Status, Employment, Female, Financing, Personal, Home Care Services, Humans, Long-Term Care, Middle Aged, Socioeconomic Factors, Transients and Migrants, Alzheimer's disease, Care allowance, Family caregiver, Socioeconomic factors, Up-Tech, Disease, 0302 clinical medicine, 050602 political science & public administration, 80 and over, 030212 general & internal medicine, Family caregivers, 05 social sciences, 0506 political science, Clinical Psychology, Government, population characteristics, Financing, geographic locations, Social Psychology, Social class, Financial management, 03 medical and health sciences, medicine, Personal, Socioeconomic status, Aged, business.industry, medicine.disease, Long-term care, Care workers, Geriatrics and Gerontology, business
Abstract

The availability of family caregivers of older people is decreasing in Italy as the number of migrant care workers (MCWs) hired by families increases. There is little evidence on the influence of socioeconomic factors in the employment of MCWs.We analyzed baseline data from 438 older people with moderate Alzheimer's disease (AD), and their family caregivers enrolled in the Up-Tech trial. We used bivariate analysis and multilevel regressions to investigate the association between independent variables-education, social class, and the availability of a care allowance-and three outcomes-employment of a MCW, hours of care provided by the primary family caregiver, and by the family network (primary and other family caregivers).The availability of a care allowance and the educational level were independently associated with employing MCWs. A significant interaction between education and care allowance was found, suggesting that more educated families are more likely to spend the care allowance to hire a MCW.Socioeconomic inequalities negatively influenced access both to private care and to care allowance, leading disadvantaged families to directly provide more assistance to AD patients. Care allowance entitlement needs to be reformed in Italy and in countries with similar long-term care and migration systems.

Published
2014

5. A phase II study with teniposide (VM26) in patients with progressed or relapsed small cell lung cancer (SCLC)

Author

Guidi F, Di Furia L, E. T. Menichetti, A. Gramazio, Diego Tummarello, and R. Cellerino

Subjects
0301 basic medicine, Oncology, Adult, Male, medicine.medical_specialty, Lung Neoplasms, medicine.medical_treatment, 030106 microbiology, Phases of clinical research, 03 medical and health sciences, 0302 clinical medicine, Stable Disease, Internal medicine, medicine, Humans, Pharmacology (medical), Carcinoma, Small Cell, Aged, Podophyllotoxin, Retrospective Studies, Teniposide, Pharmacology, Response rate (survey), Chemotherapy, business.industry, Retrospective cohort study, Middle Aged, medicine.disease, Infectious Diseases, 030220 oncology & carcinogenesis, Drug Evaluation, Female, business, Progressive disease, medicine.drug
Abstract

Sixteen patients with advanced small cell lung cancer who relapsed or progressed under first-line therapy, were treated with second-line chemotherapy consisting of: teniposide, 60 mg/m2, i.v. days 1-5, every 3 weeks until further progression. The response rate was: 3 minor responses, 6 stable disease, 5 progressive disease, 1 early death and 1 not evaluable. After the introduction of teniposide, median survival was 4.5 (range 1-11) months, compared to the median survival (2 months, range 1-11) observed in 40 contemporary patients of our series, who relapsed or progressed and subsequently received no treatment. The assessment of the difference was significant: chi-square = 4.05, P less than 0.05. In addition a particular comparison was performed with 15/40 patients who matched according to the major predictive parameters of disease. These patients experienced 2 months (range 1-7) of median survival which was significantly shorter than that of the teniposide treated group (chi-square = 4.48, P less than 0.05). On these bases, teniposide appeared to be effective, but the small size of the study suggests caution in evaluating the results.

Published
1989

6. Screening for colorectal cancer in Italy: 2011-2012 survey

Author

Zorzi, M., Da Re, F., Mantellini, P., Naldoni, C., Bianchi, P. S., Senore, C., Turrin, A., Visioli, C. B., Zappa, M., Crotta, S., Polizzi, S., Sartori, M., Alibrandi, M. P., Germinetti, F., Bestagini, P., Orione, L., Miroglio, T., Faragli, G., Cereda, D., Coppola, L., Zerbi, L., Gramegna, M., Tessandri, L., Imbrogno, P., Rocca, G., Pesenti, B., Schivardi, M., Crisetig, M., Grassi, E., Speziani, F., Gola, G., Gotti, S., Dal Soldà, M., Boldori, L., Moretti, G., Ilardo, A., Belloni, A., Rossetti, E., Marazza, G., Anghinoni, E., Silvestri, A., Tidone, E., Frammartino, B., Leonardo, N., Deandrea, S., Ceresa, P., Beghi, G., Lucchini, R., Acerbi, L., Lo Buono, F., Cavalieri D Oro, L., Magenes, G., Camana, L., Cioccarelli, A. M., Fanetti, A. C., Cecconami, L., Bardelli, R., Violini, M., Sambo, F., Domenighini, S., Pieracci, G., Pertile, R., Piffer, S., Fedato, C., Franzo, A., Fabro, J., Gobbato, M., Zanier, L., Bonelli, L., Orlando, M., Vaccari, D., Franxo, A., Scotto, M., Valle, I., Ferrari Bravo, M., Sticchi, C., Maddalo, F., Pensa, F., Sassoli Bianchi, P., Landi, P., Borciani, E., Fornari, F., Gatti, G., Zurlini, C., Zatelli, M., Maradini, F., Paterlini, L., Cinzia Campari, Sassatelli, R., Corradini, R., Goldoni, C., Pasquini, A., Manfredi, M., Baldazzi, P., Nannini, R., Caprara, L., Carpanelli, M. C., Zoli, G., Matarese, V., Triossi, O., Serafini, M., Vitali, B., Falcini, F., Colamartini, A., Giuliani, O., Vattiato, R., Palazzi, M., Imolesi, C., Pazzi, P., Canuti, D., Casale, C., Giovanardi, M., Monticelli, G., Nicolai, C., Vivani, P., Giorgi, D., Finucci, G., Rapanà, M., Epifani, C., Abdelghani, L., Allegrini, G., Maffei, C., Turillazzi, R., Mirri, F., Ceccatelli, P., Rosati, R., Piacentini, P., Falini, P., Amico, P., Ciabattoni, C., Giaimo, M., Prandini, S., Vinti, G., Di Marco, A., Malaspina, M., Corvetti, R., Di Furia, L., Barca, A., Baiocchi, D., Quadrino, F., Di Giacomo, M., Lattanzio, F. M., Minna, M., Di Credico, A., Pizzuti, R., Sigillito, A., Montesi, M. P., Landro, T., Giorno, A., Santino, M., Magrì, G., Ferrara, G., and Masala, R.

7. Screening for colorectal cancer in Italy: 2011-2012 survey

Author

Zorzi, M., Da Re, F., Mantellini, P., Naldoni, C., Bianchi, P. S., Senore, C., Turrin, A., Visioli, C. B., Zappa, M., Crotta, S., Polizzi, S., Sartori, M., Alibrandi, M. P., Germinetti, F., Bestagini, P., Orione, L., Miroglio, T., Faragli, G., danilo Cereda, Coppola, L., Zerbi, L., Gramegna, M., Tessandri, L., Imbrogno, P., Rocca, G., Pesenti, B., Schivardi, M., Crisetig, M., Grassi, E., Speziani, F., Gola, G., Gotti, S., Dal Soldà, M., Boldori, L., Moretti, G., Ilardo, A., Belloni, A., Rossetti, E., Marazza, G., Anghinoni, E., Silvestri, A., Tidone, E., Frammartino, B., Leonardo, N., Deandrea, S., Ceresa, P., Beghi, G., Lucchini, R., Acerbi, L., Lo Buono, F., Cavalieri D Oro, L., Magenes, G., Camana, L., Cioccarelli, A. M., Fanetti, A. C., Cecconami, L., Bardelli, R., Violini, M., Sambo, F., Domenighini, S., Pieracci, G., Pertile, R., Piffer, S., Fedato, C., Franzo, A., Fabro, J., Gobbato, M., Zanier, L., Bonelli, L., Orlando, M., Vaccari, D., Franxo, A., Scotto, M., Valle, I., Ferrari Bravo, M., Sticchi, C., Maddalo, F., Pensa, F., Sassoli Bianchi, P., Landi, P., Borciani, E., Fornari, F., Gatti, G., Zurlini, C., Zatelli, M., Maradini, F., Paterlini, L., Campari, C., Sassatelli, R., Corradini, R., Goldoni, C., Pasquini, A., Manfredi, M., Baldazzi, P., Nannini, R., Caprara, L., Carpanelli, M. C., Zoli, G., Matarese, V., Triossi, O., Serafini, M., Vitali, B., Falcini, F., Colamartini, A., Giuliani, O., Vattiato, R., Palazzi, M., Imolesi, C., Pazzi, P., Canuti, D., Casale, C., Giovanardi, M., Monticelli, G., Nicolai, C., Vivani, P., Giorgi, D., Finucci, G., Rapanà, M., Epifani, C., Abdelghani, L., Allegrini, G., Maffei, C., Turillazzi, R., Mirri, F., Ceccatelli, P., Rosati, R., Piacentini, P., Falini, P., Amico, P., Ciabattoni, C., Giaimo, M., Prandini, S., Vinti, G., Di Marco, A., Malaspina, M., Corvetti, R., Di Furia, L., Barca, A., Baiocchi, D., Quadrino, F., Di Giacomo, M., Lattanzio, F. M., Minna, M., Di Credico, A., Pizzuti, R., Sigillito, A., Montesi, M. P., Landro, T., Giorno, A., Santino, M., Magrì, G., Ferrara, G., and Masala, R.

8. Novel psychoactive substances (NPS) – knowledge and experiences of drug users from Hungary, Poland, the UK and the USA,Új pszichoaktív szerek (ÚPSz) – magyarországi, lengyel, egyesült királyságbeli és amerikai drog-használók tudása és tapasztalatai

Author

Pisarska, A., Deluca, P., Demetrovics, Z., Moskalewicz, J., Corazza, O., Assi, S., Davey, Z., Simonato, P., Corkery, J. M., Stair, J. L., Fergus, S., Pezzolesi, C., Pasinetti, M., Drummond, C., Blaszko, U., Mervo, B., Di Furia, L., Farre, M., Flesland, L., Shapiro, H., Siemann, H., Skutle, A., Marta Torrens, Marsa-Sambola, F., Kreeft, P., Scherbaum, N., and Schifano, F.

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