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3 results on '"for Cohort Studies of Memory in an International Consortium"'

1. Dose-response relationship between late-life physical activity and incident dementia: A pooled analysis of 10 cohort studies of memory in an international consortium

Author

Wu, Wanqing, Ding, Ding, Zhao, Qianhua, Xiao, Zhenxu, Luo, Jianfeng, Ganguli, Mary, Hughes, Tiffany F, Jacobsen, Erin, Haan, Mary N, van Dang, Kristine, Lima-Costa, Maria Fernanda, Blay, Sergio Luis, de Castro-Costa, Erico, Ng, Tze Pin, Gwee, Xinyi, Gao, Qi, Gureje, Oye, Ojagbemi, Akin, Bello, Toyin, Shahar, Suzana, Ludin, Arimi Fitri Mat, Rivan, Nurul Fatin Malek, Scarmeas, Nikolaos, Anastasiou, Costas A, Yannakoulia, Mary, Brodaty, Henry, Crawford, John D, Lipton, Richard B, Derby, Carol A, Katz, Mindy J, Lipnicki, Darren M, Sachdev, Perminder S, and for Cohort Studies of Memory in an International Consortium (COSMIC)

Subjects
dose-response, Aging, Prevention, Rehabilitation, Clinical Sciences, Neurosciences, physical activity, cohort, population-based, Brain Disorders, Cohort Studies, for Cohort Studies of Memory in an International Consortium, Risk Factors, Clinical Research, Geriatrics, Neurological, Acquired Cognitive Impairment, Humans, Dementia, pooled analysis, Proportional Hazards Models, Aged, dementia
Abstract

IntroductionThough consistent evidence suggests that physical activity may delay dementia onset, the duration and amount of activity required remains unclear.MethodsWe harmonized longitudinal data of 11,988 participants from 10 cohorts in eight countries to examine the dose-response relationship between late-life physical activity and incident dementia among older adults.ResultsUsing no physical activity as a reference, dementia risk decreased with duration of physical activity up to 3.1 to 6.0hours/week (hazard ratio [HR] 0.88, 95% confidence interval [CI] 0.67 to 1.15 for 0.1 to 3.0hours/week; HR 0.68, 95% CI 0.52 to 0.89 for 3.1 to 6.0hours/week), but plateaued with higher duration. For the amount of physical activity, a similar pattern of dose-response curve was observed, with an inflection point of 9.1 to 18.0 metabolic equivalent value (MET)-hours/week (HR 0.92, 95% CI 0.70 to 1.22 for 0.1 to 9.0 MET-hours/week; HR 0.70, 95% CI 0.53 to 0.93 for 9.1 to 18.0 MET-hours/week).DiscussionThis cross-national analysis suggests that performing 3.1 to 6.0hours of physical activity and expending 9.1 to 18.0/MET-hours of energy per week may reduce dementia risk.

Published
2023

2. A cross-national study of depression in preclinical dementia: A COSMIC collaboration study

Author

Carles, Sophie, Carrière, Isabelle, Reppermund, Simone, Davin, Annalisa, Guaita, Antonio, Vaccaro, Roberta, Ganguli, Mary, Jacobsen, Erin P, Beer, Joanne C, Riedel-Heller, Steffi G, Roehr, Susanne, Pabst, Alexander, Haan, Mary N, Brodaty, Henry, Kochan, Nicole A, Trollor, Julian N, Kim, Ki Woong, Han, Ji Won, Suh, Seung Wan, Lobo, Antonio, la Camara, Concepción De, Lobo, Elena, Lipnicki, Darren M, Sachdev, Perminder S, Ancelin, Marie-Laure, Ritchie, Karen, and for Cohort Studies of Memory in an International Consortium (COSMIC)

Subjects
Male, Aging, Depression, Incidence, Clinical Sciences, Neurosciences, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Prodromal Symptoms, Neurodegenerative, Alzheimer's Disease, Brain Disorders, Cohort Studies, for Cohort Studies of Memory in an International Consortium, Mental Health, Geriatrics, Neurological, 80 and over, Acquired Cognitive Impairment, Humans, Dementia, Female, Longitudinal Studies, Aged
Abstract

IntroductionDepression commonly accompanies Alzheimer's disease, but the nature of this association remains uncertain.MethodsLongitudinal data from the COSMIC consortium were harmonized for eight population-based cohorts from four continents. Incident dementia was diagnosed in 646 participants, with a median follow-up time of 5.6 years to diagnosis. The association between years to dementia diagnosis and successive depressive states was assessed using a mixed effect logistic regression model. A generic inverse variance method was used to group study results, construct forest plots, and generate heterogeneity statistics.ResultsA common trajectory was observed showing an increase in the incidence of depression as the time to dementia diagnosis decreased despite cross-national variability in depression rates.DiscussionThe results support the hypothesis that depression occurring in the preclinical phases of dementia is more likely to be attributable to dementia-related brain changes than environment or reverse causality.

Published
2020

3. Education and the moderating roles of age, sex, ethnicity and apolipoprotein epsilon 4 on the risk of cognitive impairment

Author

Makkar, S.R., Lipnicki, D.M., Crawford, J.D., Kochan, N.A., Castro-Costa, E., Lima-Costa, M.F., Diniz, B.S., Brayne, C., Stephan, B., Matthews, F., Llibre-Rodriguez, J.J., Llibre-Guerra, J.J., Valhuerdi-Cepero, A.J., Lipton, R.B., Katz, M.J., Zammit, A., Ritchie, K., Carles, S., Carriere, I., Scarmeas, N., Yannakoulia, M., Kosmidis, M., Lam, L., Fung, A., Chan, W.C., Guaita, A., Vaccaro, R., Davin, A., Kim, K.W., Han, J.W., Suh, S.W., Riedel-Heller, S.G., Roehr, S., Pabst, A., Ganguli, M., Hughes, T.F., Jacobsen, E.P., Anstey, K.J., Cherbuin, N., Haan, M.N., Aiello, A.E., Dang, K., Kumagai, S., Narazaki, K., Chen, S., Ng, T.P., Gao, Q., Nyunt, M.S.Z., Meguro, K., Yamaguchi, S., Ishii, H., Lobo, A., Lobo Escolar, E., De la Cámara, C., Brodaty, H., Trollor, J.N., Leung, Y., Lo, J.W., Sachdev, P., for, Cohort, Studies, of, Memory, in, an, International, Consortium, (COSMIC), University of New South Wales [Sydney] (UNSW), Fiocruz Minas - René Rachou Research Center / Instituto René Rachou [Belo Horizonte, Brésil], Fundação Oswaldo Cruz (FIOCRUZ), Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), University of Toronto, University of Cambridge [UK] (CAM), Newcastle University [Newcastle], University of Havana (Universidad de la Habana) (UH), University of California [San Francisco] (UCSF), University of California, Universidad de Matanzas, Albert Einstein College of Medicine [New York], Neuropsychiatrie : recherche épidémiologique et clinique (PSNREC), Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), University of Edinburgh, Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Hôpital de la Colombière, Columbia University [New York], National and Kapodistrian University of Athens (NKUA), Harokopio University of Athens, Aristotle University of Thessaloniki, The Chinese University of Hong Kong [Hong Kong], The Hong Kong Polytechnic University [Hong Kong] (POLYU), The University of Hong Kong (HKU), Golgi Cenci Foundation, Seoul National University College of Natural Sciences, Seoul National University Bundang Hospital (SNUBH), Universität Leipzig [Leipzig], University of Pittsburgh School of Medicine, Pennsylvania Commonwealth System of Higher Education (PCSHE), Youngstown State University (YSU), Australian National University (ANU), University of North Carolina [Chapel Hill] (UNC), University of North Carolina System (UNC), Kyushu University [Fukuoka], Fukuoka Institute of Technology (FIT), National Center for Global Health and Medicine [Japan] (NCGM), National University of Singapore (NUS), Tohoku University [Sendai], and University of Zaragoza - Universidad de Zaragoza [Zaragoza]

Subjects
Apolipoprotein E, Male, Aging, Health (social science), Apolipoprotein B, [SDV]Life Sciences [q-bio], Apolipoprotein E4, Ethnic group, Cognitive decline, MESH: Cognitive Dysfunction, 0302 clinical medicine, MESH: Aged, 80 and over, MESH: Risk Factors, Risk Factors, 80 and over, Ethnicity, Medicine, 030212 general & internal medicine, Longitudinal Studies, MESH: Apolipoprotein E4, Cognitive impairment, MESH: Longitudinal Studies, Aged, 80 and over, MESH: Aged, biology, Hazard ratio, Educational Status, MESH: Ethnic Groups, Female, Sex, Clinical Sciences, Article, Education, 03 medical and health sciences, Age, Clinical Research, Acquired Cognitive Impairment, Humans, Cognitive Dysfunction, Aged, MESH: Humans, 030214 geriatrics, business.industry, Prevention, Neurosciences, Educational attainment, MESH: Male, Brain Disorders, Quality Education, Ageing, for Cohort Studies of Memory in an International Consortium, Geriatrics, biology.protein, Dementia, Geriatrics and Gerontology, business, MESH: Educational Status, Gerontology, MESH: Female, Demography
Abstract

International audience; Background: We examined how the relationship between education and latelife cognitive impairment (defined as a Mini Mental State Examination score below 24) is influenced by age, sex, ethnicity, and Apolipoprotein E epsilon 4 (APOE*4).Methods: Participants were 30,785 dementia-free individuals aged 55-103 years, from 18 longitudinal cohort studies, with an average follow-up ranging between 2 and 10 years. Pooled hazard ratios were obtained from multilevel parametric survival analyses predicting cognitive impairment (CI) from education and its interactions with baseline age, sex, APOE*4 and ethnicity. In separate models, education was treated as continuous (years) and categorical, with participants assigned to one of four education completion levels: Incomplete Elementary; Elementary; Middle; and High School.Results: Compared to Elementary, Middle (HR = 0.645, P = 0.004) and High School (HR = 0.472, P < 0.001) education were related to reduced CI risk. The decreased risk of CI associated with Middle education weakened with older baseline age (HR = 1.029, P = 0.056) and was stronger in women than men (HR = 1.309, P = 0.001). The association between High School and lowered CI risk, however, was not moderated by sex or baseline age, but was stronger in Asians than Whites (HR = 1.047, P = 0.044), and significant among Asian (HR = 0.34, P < 0.001) and Black (HR = 0.382, P = 0.016), but not White, APOE*4 carriers.Conclusion: High School completion may reduce risk of CI associated with advancing age and APOE*4. The observed ethnoregional differences in this effect are potentially due to variations in social, economic, and political outcomes associated with educational attainment, in combination with neurobiological and genetic differences, and warrant further study.

Published
2020
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