1. Unfaithful association of FCGR2B genetic polymorphisms with susceptibility to SLE
- Author
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Elisabetta Bolli, Valerio Napolioni, Antonio Concetti, Alessandra Barucca, and Franco M. Venanzi
- Subjects
China ,Genotype ,IgG ,Population ,Immunology ,Molecular Sequence Data ,Single-nucleotide polymorphism ,FCGR2B ,Biology ,Polymorphism, Single Nucleotide ,DNA sequencing ,Gene Frequency ,Receptors ,Genetics ,Immunology and Allergy ,Humans ,Lupus Erythematosus, Systemic ,Family ,Genetic Predisposition to Disease ,Polymorphism ,skin and connective tissue diseases ,Genotyping ,epidemiology/genetics ,Lupus Erythematosus ,Base Sequence ,Medical screening ,Systemic ,Receptors, IgG ,Single Nucleotide ,Genetics, Population ,Base Sequence, China ,epidemiology, Family, Gene Frequency, Genetic Predisposition to Disease ,genetics, Genetics ,Population, Genotype, Humans, Lupus Erythematosus ,epidemiology/genetics, Molecular Sequence Data, Polymorphism ,Single Nucleotide, Receptors ,genetics ,Proofreading ,epidemiology ,Human genome - Abstract
Correcting errors and proofreading are crucial in a post-genomic era, when DNA sequences are already part of an effective medical screening and treatments. SNPs genotyping of complex human genes can lead to questionable associations if not properly handled. Here, we report about a spurious (reitered) association between FCGR2B genetic polymorphisms and systemic lupus erythematosus.
- Published
- 2008