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Complete animal models investigating the pathogenesis and treatment of polycystic ovarian syndrome (PCOS) are not completely established. Although dehydroepiandrosterone (DHEA)-induced pre-pubertal rat model for PCOS has been widely used, the model exhibits weaknesses such as decreased ovary weight. Here, we report an innovative DHEA-induced PCOS model that addresses limitations of the pre-pubertal model. The 21-day-old (pre-pubertal) and 42-day-old (post-pubertal) female rats were subcutaneously injected with DHEA (60 mg/kg body weight) daily for up to 20–30 days. The post-pubertal model showed a steady increase in ovary weight and the number of ovarian cysts as well as uterine weight and thickness, which may be key features of PCOS, compared with the pre-pubertal model. Therefore, a post-pubertal PCOS model induced by DHEA may be an improved model to investigate the etiology of PCOS and development of therapeutic interventions.

This is the final version of the following article: "Dynamic Analysis of the Viscoelastic Pipeline Conveying Fluid with an Improved Variable Fractional Order Model Based on Shifted Legendre Polynomials", which has been published in final form at https://www.mdpi.com/2504-3110/3/4/52; International audience; Viscoelastic pipeline conveying fluid is analyzed with an improved variable fractional order model for researching its dynamic properties accurately in this study. After introducing the improved model, an involuted variable fractional order, which is an unknown piecewise nonlinear function for analytical solution, an equation is established as the governing equation for the dynamic displacement of the viscoelastic pipeline. In order to solve this class of equations, a numerical method based on shifted Legendre polynomials is presented for the first time. The method is effective and accurate after the numerical example verifying. Numerical results show that how dynamic properties are influenced by internal fluid velocity, force excitation, and variable fractional order through the proposed method. More importantly, the numerical method has shown great potentials for dynamic problems with the high precision model.

Published diffuse X-ray scattering from the high-T c superconductor HgBa2CuO4+δ has been re-examined with a view to developing a model that more satisfactorily accounts for the observed patterns. It is proposed that it is correlated shifts of the Ba atoms along the length of the defect chains that are the primary source of the observed diffuse scattering lines and that the variations of intensity within these lines originate from lateral shifts of both Hg and Ba atoms away from the defects., Published diffuse X-ray scattering from the high-T c superconductor HgBa2CuO4+δ has been reexamined with a view to developing a model that more satisfactorily accounts for the observed patterns. The present work agrees with the previous conclusion that the doping oxygen atoms form long and isolated interstitial chains that run in both tetragonal directions. However, a distinctly different model is proposed for the accompanying displacement patterns of the atoms surrounding these linear defects. In this new model it is proposed that it is the correlated shifts of the Ba atoms along the length of the defect chains that are the primary source of the observed scattering, and that the variations of intensity in the generated diffuse streaks of scattering originate from lateral shifts of both Hg and Ba atoms away from defects. The new model yields diffraction patterns that are in much more convincing agreement with the observations than the original model.

In this paper, an improved theoretical interfacial stress analysis is presented for simply supported concrete beam bonded with a FRP plate. The adherend shear deformations have been included in the present theoretical analyses by assuming a linear shear stress through the thickness of the adherends, while all existing solutions neglect this effect. Remarkable effect of shear deformations of adherends has been noted in the results. Indeed, the resulting interfacial stresses concentrations are considerably smaller than those obtained by other models which neglect adherent shear deformations. It is shown that both the normal and shear stresses at the interface are influenced by the material and geometry parameters of the composite beam. This research is helpful for the understanding on mechanical behavior of the interface and design of the FRP–RC hybrid structures.

The excursion set theory, where density perturbations evolve stochastically with the smoothing scale, provides a method for computing the dark matter halo mass function. The computation of the mass function is mapped into the so-called first-passage time problem in the presence of a moving barrier. The excursion set theory is also a powerful formalism to study other properties of dark matter halos such as halo bias, accretion rate, formation time, merging rate and the formation history of halos. This is achieved by computing conditional probabilities with non-trivial initial conditions, and the conditional two-barrier first-crossing rate. In this paper we use the path integral formulation of the excursion set theory to calculate analytically these conditional probabilities in the presence of a generic moving barrier, including the one describing the ellipsoidal collapse, and for both Gaussian and non-Gaussian initial conditions. While most of our analysis associated with Gaussian initial conditions assumes Markovianity (top-hat in momentum space smoothing, rather than generic filters), the non-Markovianity of the random walks induced by non-Gaussianity is consistently accounted for. We compute, for a generic barrier, the first two scale-independent halo bias parameters, the conditional mass function and the halo formation time probability, including the effects of non-Gaussianities. We also provide the expression for the two-constant-barrier first-crossing rate when non-Markovian effects are induced by a top-hat filter function in real space., 20 pages, 5 figures. Typos in Appendix B corrected and other minor corrections. Version to appear in MNRAS