1. CARD9 Signaling in Intestinal Immune Homeostasis and Oncogenesis
- Author
-
Lara Hartjes and Jürgen Ruland
- Subjects
lcsh:Immunologic diseases. Allergy ,0301 basic medicine ,Colorectal cancer ,Carcinogenesis ,Mini Review ,Immunology ,gut microbiome ,Biology ,Gut flora ,medicine.disease_cause ,Inflammatory bowel disease ,digestive system ,Polymorphism, Single Nucleotide ,03 medical and health sciences ,Mice ,0302 clinical medicine ,Immune system ,inflammatory bowel disease ,intestinal inflammation ,medicine ,Immunology and Allergy ,Animals ,Homeostasis ,Humans ,Immune homeostasis ,Intestinal Mucosa ,intestinal carcinogenesis ,Innate immune system ,Regeneration (biology) ,intestinal immune homeostasis ,medicine.disease ,biology.organism_classification ,Inflammatory Bowel Diseases ,3. Good health ,Gastrointestinal Microbiome ,ddc ,CARD Signaling Adaptor Proteins ,030104 developmental biology ,lcsh:RC581-607 ,Colorectal Neoplasms ,CARD9 ,030215 immunology - Abstract
Intestinal homeostasis requires a balanced interaction between the host innate immune system and the gut microbiota. A dysregulation of this interdependency can result in inflammatory bowel diseases (IBDs), and this dysregulation is a key pathogenic factor during the development of colorectal cancer. CARD9 is a central signalling molecule in the innate immune system, which is essential for host defence against infection. Moreover, polymorphisms in CARD9 are key risk factors for IBD development, indicating that CARD9 signalling is critical for intestinal immune homeostasis. This review summarizes recent insights into the regulation of CARD9 signalling, its pathophysiological role during IBD development via effects on the microbiota and epithelial regeneration and the pro- and antitumour immune functions of CARD9 during intestinal carcinogenesis.
- Published
- 2018