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Your search keyword '"methylchloroisothiazolinone/methylisothiazolinone"' showing total 2 results
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2 results on '"methylchloroisothiazolinone/methylisothiazolinone"'

1. Contact dermatitis associated with preservatives: Retrospective analysis of North American Contact Dermatitis Group data, 1994 through 2016

Author

Atwater, Amber Reck, Petty, Amy J, Liu, Beiyu, Green, Cynthia L, Silverberg, Jonathan I, DeKoven, Joel G, Belsito, Donald V, Reeder, Margo J, Sasseville, Denis, Taylor, James S, Maibach, Howard I, Zirwas, Matthew J, Marks, James G, Zug, Kathryn A, Fowler, Joseph F, Pratt, Melanie D, DeLeo, Vincent A, and Warshaw, Erin M

Subjects
Male, Canada, Allergic Contact, Immediate, paraben, Clinical Sciences, Dermatitis, Hand Dermatoses, contact dermatitis, methylchloroisothiazolinone/methylisothiazolinone, formaldehyde releaser, iodopropynyl butylcarbamate, Age Distribution, preservative, Hypersensitivity, Humans, Sex Distribution, NACDG, Retrospective Studies, phenoxyethanol, Dermatology & Venereal Diseases, preservative allergy, methylisothiazolinone, Patch Tests, Middle Aged, Occupational, United States, Cross-Sectional Studies, Organ Specificity, Pharmaceutical, Linear Models, formaldehyde, methyldibromo glutaronitrile/phenoxyethanol, Female, allergic contact dermatitis, Preservatives, patch test, benzyl alcohol
Abstract

BackgroundPreservativesare often necessary components of commercial products. Large-scale North American studies on preservative allergy are limited.ObjectiveTo evaluate demographics, positive patch test reactions (PPTRs), clinical relevance, and trends for preservatives tested by the North American Contact Dermatitis Group.MethodsWe conducted a retrospective cross-sectional analysis of North American Contact Dermatitis Group patch testing results of preservatives from 1994 through 2016.ResultsA total of 50,799 patients were tested; 11,338 (22.3%) had a PPTR to at least 1 preservative. The most frequent reactions were to methylisothiazolinone 0.2% aqueous (aq) (12.2%), formaldehyde 2% aq (7.8%), formaldehyde 1% aq (7.8%), quaternium-15 2% petrolatum (pet) (7.7%), and methyldibromo glutaronitrile/phenoxyethanol 2% pet (5.1%). Paraben mix 12% pet (1%), iodopropynyl butylcarbamate 0.1% pet (0.4%), benzyl alcohol 1% pet (0.3%), and phenoxyethanol 1% pet (0.2%) had the lowest PPTRs. Linear regression analysis of preservatives tested showed that only methylchloroisothiazolinone/methylisothiazolinone 0.01% aq (parameter estimate, 0.42; 95% CI, 0.17-0.66; P&nbsp

Published
2021

2. Patch test results of the European baseline series among patients with occupational contact dermatitis across Europe - analyses of the European Surveillance System on Contact Allergy network, 2002-2010

Author

Maria, Pesonen, Riitta, Jolanki, Francesca, Larese Filon, Mark, Wilkinson, Beata, Kręcisz, Marta, Kieć-Świerczyńska, Andrea, Bauer, Vera, Mahler, Swen M, John, Axel, Schnuch, Wolfgang, Uter, Anthony D, Ormerod, Pesonen, Maria, Jolanki, Riitta, LARESE FILON, Francesca, Wilkinson, Mark, Krecisz, Beata, Kieć Świerczyńska, Marta, Bauer, Andrea, Mahler, Vera, John, Swen M., Schnuch, Axel, and Uter, Wolfgang

Subjects
Chromium, Adult, Male, Allergic Contact, Adolescent, Contact allergy, Dermatitis, occupational dermatitis, methylchloroisothiazolinone/methylisothiazolinone, p-phenylenediamine, Young Adult, epoxy resins, Risk Factors, Formaldehyde, Methylchloroisothiazolinone/methylisothiazolinone, Immunology and Allergy, Humans, Epoxy resin, chromium, clinical epidemiology, cobalt, contact allergy, formaldehyde, methyldibromo glutaronitrile, p -phenylenediamine, patch testing, thiurams, Aged, Allergens, Dermatitis, Allergic Contact, Dermatitis, Occupational, Europe, Female, Middle Aged, Occupations, Patch Tests, 2708, Medicine (all), Occupational dermatiti, Patch testing, Thiuram, Clinical epidemiology, Cobalt, Methyldibromo glutaronitrile, Occupational, Epoxy resins, Occupational dermatitis, Thiurams
Abstract

BACKGROUND: Occupational contact dermatitis is one of the most common occupational diseases in Europe. In order to develop effective preventive measures, detailed and up-to-date data on the incidence, main causes and professions at risk of occupational contact dermatitis are needed. OBJECTIVES: To describe the pattern of patch test reactivity to allergens in the European baseline series of patients with occupational contact dermatitis in different occupations. METHODS: We analysed data collected by the European Surveillance System on Contact Allergy (ESSCA) network from 2002 to 2010, from 11 European countries. RESULTS: Allergens in the European baseline series associated with an at least doubled risk of occupational contact dermatitis include: thiuram rubber chemical accelerators, epoxy resin, and the antimicrobials methylchloroisothiazolinone/methylisothiazolinone, methyldibromo glutaronitrile, and formaldehyde. The highest risk of occupational contact dermatitis was found in occupations classified as 'other personal services workers', which includes hairdressers, nursing and other healthcare professionals, precision workers in metal and related materials, and blacksmiths, tool-makers and related trades workers. CONCLUSIONS: In the planning and implementation of measures aimed at preventing occupational contact dermatitis, the focus should be on the identified high-risk occupational groups and the most common occupational allergies.

Published
2014

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