1. Molecular alterations in pancreatic tumors
- Author
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Annalisa Pession, Lidia Merlo, Antonio De Leo, Dario de Biase, Enrico Franceschi, Giorgia Acquaviva, Michele Masetti, Monica Di Battista, Sirio Fiorino, Viviana Sanza, Alba A. Brandes, Giovanni Tallini, Elio Jovine, Michela Visani, Thais Maloberti, Visani M., Acquaviva G., de Leo A., Sanza V., Merlo L., Maloberti T., Brandes A.A., Franceschi E., Di Battista M., Masetti M., Jovine E., Fiorino S., Pession A., Tallini G., and de Biase D.
- Subjects
Molecular alteration ,DNA damage ,Review ,Molecular marker ,Biology ,Pancreatic ductal adenocarcinomas ,medicine.disease_cause ,law.invention ,Pancreatic ductal adenocarcinoma ,03 medical and health sciences ,Pancreatic tumor ,0302 clinical medicine ,law ,Genome maintenance ,medicine ,Humans ,Molecular alterations ,Pancreatic carcinoma ,Pancreatic lesion ,Endoscopic Ultrasound-Guided Fine Needle Aspiration ,Gene ,Oncogene ,Mutation ,Pancreatic tumors ,Intraductal papillary mucinous neoplasm ,Gastroenterology ,Molecular markers ,Oncogenes ,General Medicine ,medicine.disease ,Pancreatic Neoplasms ,030220 oncology & carcinogenesis ,Cancer research ,Suppressor ,030211 gastroenterology & hepatology ,Mutations ,Human ,Carcinoma, Pancreatic Ductal - Abstract
Genetic alterations in pancreatic tumors can usually be classified in: (1) Mutational activation of oncogenes; (2) Inactivation of tumor suppressor genes; and (3) Inactivation of genome maintenance genes controlling the repair of DNA damage. Endoscopic ultrasound-guided fine-needle aspiration has improved pre-operative diagnosis, but the management of patients with a pancreatic lesion is still challenging. Molecular testing could help mainly in solving these “inconclusive” specimens. The introduction of multi-gene analysis approaches, such as next-generation sequencing, has provided a lot of useful information on the molecular characterization of pancreatic tumors. Different types of pancreatic tumors (e.g., pancreatic ductal adenocarcinomas, intraductal papillary mucinous neoplasms, solid pseudopapillary tumors) are characterized by specific molecular alterations. The aim of this review is to summarize the main molecular alterations found in pancreatic tumors.
- Published
- 2021
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