1. Infectious complications after transrectal MRI-targeted and systematic prostate biopsy
- Author
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Inari Kalalahti, Kaisa Huotari, Andrew. M. Erickson, Anssi Petas, Hanna Vasarainen, Antti Rannikko, HUS Abdominal Center, Urologian yksikkö, Research Program in Systems Oncology, Faculty of Medicine, Hyvinkää Hospital Area, HUS Inflammation Center, Infektiosairauksien yksikkö, Department of Medicine, University of Helsinki, Department of Surgery, and Clinicum
- Subjects
Image-Guided Biopsy ,Male ,Biopsy ,Urology ,Prostate ,Prostatic Neoplasms ,Targeted ,3126 Surgery, anesthesiology, intensive care, radiology ,Magnetic Resonance Imaging ,PREVENTION ,Prostate biopsy ,3121 General medicine, internal medicine and other clinical medicine ,Humans ,Transrectal ,Infection ,Complication ,Ultrasonography, Interventional ,Retrospective Studies ,Perineal - Abstract
Purpose To compare infectious complications after transrectal systematic prostate biopsy (SB) and magnetic resonance imaging (MRI)-targeted biopsy (TB) in a large retrospective cohort to assess whether one technique is superior to the other regarding infectious complications. Methods A total of 4497 patients underwent 5288 biopsies, 2875 (54%) SB and 2413 (46%) MRI-TB only. On average, 12 SB cores and 3.7 MRI-TB cores were taken per biopsy session during the study period. Infection-related complications within 30 days were compared. The primary endpoint was a positive urine culture. Secondary endpoints were positive blood cultures, urine tests with elevated leukocytes ≥ 100 E6/L and elevated C-reactive protein (CRP) ≥ 100 mg/L. Chi-square test was used to compare the cohorts. Results Positive urine cultures were found in 77 (2.7%) after SB and in 42 (1.7%) after MRI-TB (p = 0.022). In total, 46 (0.9%) blood culture positive infections were found, 23 (0.9%) occurred after SB and 23 (1.0%) after MRI-TB, (p = 0.848). Urine tests with elevated leukocytes ≥ 100 E6/L were found in 111 (3.9%) after SB and in 61 (2.5%) after MRI-TB (p = 0.006). Elevated CRP ≥ 100 mg/L was found in 122 (4.2%) after SB and in 72 (3.0%) after MRI-TB (p = 0.015). Blood cultures were drawn more often after SB than after MRI-TB, but the difference was not statistically significant. However, urine cultures and CRP were taken more often after SB than MRI-TB. Conclusion Blood culture positive infections were equally rare after SB and MRI-TB. However, all other infectious complications were more common after SB than MRI-TB.
- Published
- 2022
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