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11 results on '"van Lonkhuijzen L"'

1. THE IMPACT OF MICROMETASTASES IN CERVICAL CANCER PATIENTS - A RETROSPECTIVE STUDY OF THE SCCAN (SURVEILLANCE IN CERVICAL CANCER) PROJECT

Author

Dostalek, L., Borcinova, M., Benesova, K., Klat, J., Falconer, H., Kim, S. H., Van Lonkhuijzen, L. R., Lopez, A., Isla Ortiz, D., Landoni, F., Kostun, J., Dos Reis, R., Odetto, D., Zapardiel, I., Jarkovsky, J., Javukova, V., Salehi, S., Abu-Rustum, N. R., Graf, P., Cibula, D., Obstetrics and Gynaecology, and CCA - Cancer Treatment and Quality of Life

Published
2021

3. SENTIX - SENTINEL LYMPH NODES IN PATIENTS WITH CERVICAL CANCER: SLN DETECTION AND THE FALSE NEGATIVE RATE OF SLN FROZEN SECTION (CEEGOG-CX01; ENGOT-CX2; NCT02494063)

Author

Kocian, R., Koehler, C., Klat, J., Germanova, A., Plaikner, A., Bajsova, S., Marnitz, S., Ostojich, M., Zapardiel, I., Gil-Ibanez, B., Sehnal, B., Petiz, A., Pilka, R., Martin-Martinez, A., Presl, J., Buda, A., van Lonkhuijzen, L., Minar, L., Barahona, M., Wydra, D., Blecharz, P., Dundr, P., Dusek, L., Cibula, D., Gynecologic, Cent Eastern European, Gynaecological, Belgium Luxembourg, Obstetrics and Gynaecology, and CCA - Cancer Treatment and Quality of Life

Published
2019

4. BETTER QUALITY OF LIFE IN BRCA MUTATION CARRIERS AFTER SALPINGECTOMY WITH DELAYED OOPHORECTOMY COMPARED TO SALPINGO-OOPHORECTOMY; FIRST RESULTS OF THE DUTCH TUBA STUDY

Author

Steenbeek, M. P., Harmsen, M. G., Hoogerbrugge, N., Arts-de Jong, M., Maas, A. H. E. M., Prins, J. B., Bulten, J., Teerenstra, S., Piek, J. M. J., van Doorn, H. C., van Beurden, M., Mourits, M. J. E., Zweemer, R. P., Gaarenstroom, K. N., Slangen, B. F. M., Vos, M. C., van Lonkhuijzen, L. R. C. W., van Mello, N. M., Apperloo, M. J., Coppus, S. F. P. J., Massuger, L. F. A. G., Hermens, R. P. M. G., de Hullu, J. A., Obstetrics and Gynaecology, and CCA - Cancer Treatment and Quality of Life

Published
2019

5. THE CLINICAL POTENTIAL OF FOXL2 C.402C > G MUTATION DETECTION IN CIRCULATING TUMOUR DNA OF PATIENTS WITH GRANULOSA CELL TUMOURS

Author

Groeneweg, J. W., Roze, J. F., Monroe, G. M., Paijens, S. T., Nijman, H. W., van Meurs, H. S., van Lonkhuijzen, L. R. C. W., Piek, J. M. J., Lok, C. A. R., Jonges, G. N., Zweemer, R. P., Obstetrics and Gynaecology, CCA - Cancer Treatment and Quality of Life, ACS - Atherosclerosis & ischemic syndromes, ACS - Microcirculation, Cardiology, Targeted Gynaecologic Oncology (TARGON), and Translational Immunology Groningen (TRIGR)

Published
2019

6. GENERATION OF ORGANOIDS FROM OVARIAN ADULT GRANULOSA CELL TUMOURS FOR INDIVIDUALIZED DRUG SCREENING

Author

Monroe, G., Roze, J., Stelloo, E., Stangl, C., Sereno, F., Groeneweg, J., Paijens, S., Nijman, H., van Meurs, H., van Lonkhuijzen, L., Piek, J., Lok, C., Jonges, G., Witteveen, P., Zweemer, R., Obstetrics and Gynaecology, CCA - Cancer Treatment and Quality of Life, ACS - Atherosclerosis & ischemic syndromes, ACS - Microcirculation, Cardiology, and Radiology and Nuclear Medicine

Published
2019

11. Stratification of lymph node metastases as macrometastases, micrometastases, or isolated tumor cells has no clinical implication in patients with cervical cancer: Subgroup analysis of the SCCAN project

Author

Dostálek, Lukáš, Benešová, Klára, Klát, Jaroslav, Kim, Sarah H., Falconer, Henrik, Kostun, Jan, dos Reis, Ricardo, Zapardiel, Ignacio, Landoni, Fabio, Ortiz, David Isla, van Lonkhuijzen, Luc R. C. W., Lopez, Aldo, Odetto, Diego, Borčinová, Martina, Jarkovsky, Jiri, Salehi, Sahar, Němejcová, Kristýna, Bajsová, Sylva, Park, Kay J., Javůrková, Veronika, Abu-Rustum, Nadeem R., Dundr, Pavel, Cibula, David, Dostalek, L, Benesova, K, Klat, J, Kim, S, Falconer, H, Kostun, J, dos Reis, R, Zapardiel, I, Landoni, F, Ortiz, D, van Lonkhuijzen, L, Lopez, A, Odetto, D, Borcinova, M, Jarkovsky, J, Salehi, S, Nemejcova, K, Bajsova, S, Park, K, Javurkova, V, Abu-Rustum, N, Dundr, P, Cibula, D, Obstetrics and Gynaecology, and CCA - Cancer Treatment and Quality of Life

Subjects
History, Low volume metastasis, Macrometastasi, Polymers and Plastics, Prognosi, Disease-free survival, Isolated tumor cells, Macrometastasis, Obstetrics and Gynecology, Isolated tumor cell, Classification, Prognosis, Industrial and Manufacturing Engineering, Low volume metastasi, Micrometastasis, Micrometastasi, Oncology, Cervical cancer, Histopathological ultrastaging, Business and International Management, Sentinel lymph node
Abstract

Background: In cervical cancer, presence of lymph-node macrometastases (MAC) is a major prognostic factor and an indication for adjuvant treatment. However, since clinical impact of micrometastases (MIC) and isolated tumor-cells (ITC) remains controversial, we sought to identify a cut-off value for the metastasis size not associated with negative prognosis. Methods: We analyzed data from 967 cervical cancer patients (T1a1L1-T2b) registered in the SCCAN (Surveillance in Cervical CANcer) database, who underwent primary surgical treatment, including sentinel lymph-node (SLN) biopsy with pathological ultrastaging. The size of SLN metastasis was considered a continuous variable and multiple testing was performed for cut-off values of 0.01-1.0 mm. Disease-free survival (DFS) was compared between N0 and subgroups of N1 patients defined by cut-off ranges. Results: LN metastases were found in 172 (18%) patients, classified as MAC, MIC, and ITC in 79, 54, and 39 patients, respectively. DFS was shorter in patients with MAC (HR 2.20, P = 0.003) and MIC (HR 2.87, P < 0.001), while not differing between MAC/MIC (P = 0.484). DFS in the ITC subgroup was neither different from N0 (P = 0.127) nor from MIC/MAC subgroups (P = 0.449). Cut-off analysis revealed significantly shorter DFS compared to N0 in all subgroups with metastases ≥0.4 mm (HR 2.311, P = 0.04). The significance of metastases

Published
2023
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