1. Identification and characteristics of imipenem-resistant Acinetobacter baumannii in surgical wards in a Chinese university hospital.
- Author
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Wang, Dalin, Ma, Linlin, Wu, Zhenyu, Li, Mingcheng, Li, Xiaohan, Zhang, Wei, and Chen, Kun
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DRUG resistance in bacteria ,ACINETOBACTER baumannii ,IMIPENEM ,ANTI-infective agents ,UNIVERSITY hospitals ,HOSPITALS ,NOSOCOMIAL infections - Abstract
The aim of this study was to investigate the prevalence and characteristics of imipenem-resistant Acinetobacter baumanni isolated from surgical wards in a university hospital, China. A total of 143 non-duplicate A. baumannii were isolated from 517 inpatients in surgery intensive care units (ICUs), burn wards, and general surgery wards. Of these, 102 isolates of A. baumannii (71.3%) were resistant to imipenem. Among imipenem-resistant isolates, all isolates were resistant to almost all antimicrobial agents except polymyxin E, all isolates were positive for bla
OXA-23 and bla OXA-51 in addition to IS Aba1, 52 (51%) were positive for blaOXA-58 , 8 (7.8%) contained blaVIM-2 , which co-harbored with blaOXA-58 . Molecular typing revealed the presence of three clones among imipenem-resistant isolates. This study confirmed that A. baumannii strains harboring OXA or VIM type β-lactamases are widely distributed throughout the surgery wards. The data demonstrate that there was a high prevalence of imipenem-resistant A. baumannii infection in the region. [ABSTRACT FROM AUTHOR]- Published
- 2015
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