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Start Over Author "Collins, R." Publication Type Academic Journals Publication Type Book Reviews
4,150 results on '"Collins, R."'

1. Apprenticeship Reforms in West Africa: An Outcome-Process Evaluation of a Pilot Dual Training Model-Based Apprenticeship Reform Scheme in Ghana

Author

Collins R. Nunyonameh, Elizabeth Obinnim, and Eric Kodzo Adzivor

Abstract

Context: Faced with deep challenges with access to formal education, many West African countries are increasingly taking steps to reform their informal apprenticeship systems to make them a quality skills development alternative for their teeming youth. A review of the literature shows that although different countries in the region are deploying different reform strategies, what is emerging as a dominant reform model is the "dual training model" (DTM), a collaborative arrangement in which the task of training apprentices is shared between informal trainers (master craftspersons, under their respective trade associations) and formal vocational training institutions (FVTIs). This paper presents an outcome-process evaluation of a DTM-based apprenticeship reform programme piloted in Ghana. Methods: Designed as a case study, the paper adopts an interpretivist approach, relying on diverse sources of data, both secondary and primary. Secondary data includes journal articles, attendance registers of participants, memorandums of understanding, relevant media reports, websites, and official reports by all relevant actors. The primary data originated from in-depth interviews with fourteen (14) key informants, as well as from overt and covert observations of respondents. Results: At the outcome level, the paper shows that the programme has largely failed in transferring new skills or in changing dominant poor practices among trainees, foundational objectives of the programme. At the process level, the paper revealed deep flaws in implementation; these are discussed in detail in an attempt to clarify the programme outcomes. Conclusion: The paper concludes that although the dual training model remains a potentially viable reform model in informal apprenticeships, its success ultimately depends on the quality of implementation, which in turn depends on the strength and quality of inter-stakeholder collaboration in programme design and implementation.

Published
2024

8. Purification-based quantum error mitigation of pair-correlated electron simulations

Author

O’Brien, T. E., Anselmetti, G., Gkritsis, F., Elfving, V. E., Polla, S., Huggins, W. J., Oumarou, O., Kechedzhi, K., Abanin, D., Acharya, R., Aleiner, I., Allen, R., Andersen, T. I., Anderson, K., Ansmann, M., Arute, F., Arya, K., Asfaw, A., Atalaya, J., Bardin, J. C., Bengtsson, A., Bortoli, G., Bourassa, A., Bovaird, J., Brill, L., Broughton, M., Buckley, B., Buell, D. A., Burger, T., Burkett, B., Bushnell, N., Campero, J., Chen, Z., Chiaro, B., Chik, D., Cogan, J., Collins, R., Conner, P., Courtney, W., Crook, A. L., Curtin, B., Debroy, D. M., Demura, S., Drozdov, I., Dunsworth, A., Erickson, C., Faoro, L., Farhi, E., Fatemi, R., Ferreira, V. S., Flores Burgos, L., Forati, E., Fowler, A. G., Foxen, B., Giang, W., Gidney, C., Gilboa, D., Giustina, M., Gosula, R., Grajales Dau, A., Gross, J. A., Habegger, S., Hamilton, M. C., Hansen, M., Harrigan, M. P., Harrington, S. D., Heu, P., Hoffmann, M. R., Hong, S., Huang, T., Huff, A., Ioffe, L. B., Isakov, S. V., Iveland, J., Jeffrey, E., Jiang, Z., Jones, C., Juhas, P., Kafri, D., Khattar, T., Khezri, M., Kieferová, M., Kim, S., Klimov, P. V., Klots, A. R., Korotkov, A. N., Kostritsa, F., Kreikebaum, J. M., Landhuis, D., Laptev, P., Lau, K.-M., Laws, L., Lee, J., Lee, K., Lester, B. J., Lill, A. T., Liu, W., Livingston, W. P., Locharla, A., Malone, F. D., Mandrà, S., Martin, O., Martin, S., McClean, J. R., McCourt, T., McEwen, M., Mi, X., Mieszala, A., Miao, K. C., Mohseni, M., Montazeri, S., Morvan, A., Movassagh, R., Mruczkiewicz, W., Naaman, O., Neeley, M., Neill, C., Nersisyan, A., Newman, M., Ng, J. H., Nguyen, A., Nguyen, M., Niu, M. Y., Omonije, S., Opremcak, A., Petukhov, A., Potter, R., Pryadko, L. P., Quintana, C., Rocque, C., Roushan, P., Saei, N., Sank, D., Sankaragomathi, K., Satzinger, K. J., Schurkus, H. F., Schuster, C., Shearn, M. J., Shorter, A., Shutty, N., Shvarts, V., Skruzny, J., Smith, W. C., Somma, R. D., Sterling, G., Strain, D., Szalay, M., Thor, D., Torres, A., Vidal, G., Villalonga, B., Vollgraff Heidweiller, C., White, T., Woo, B. W. K., Xing, C., Yao, Z. J., Yeh, P., Yoo, J., Young, G., Zalcman, A., Zhang, Y., Zhu, N., Zobrist, N., Bacon, D., Boixo, S., Chen, Y., Hilton, J., Kelly, J., Lucero, E., Megrant, A., Neven, H., Smelyanskiy, V., Gogolin, C., Babbush, R., and Rubin, N. C.

Published
2023
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9. Formation of robust bound states of interacting microwave photons

Author

Morvan, A, Andersen, TI, Mi, X, Neill, C, Petukhov, A, Kechedzhi, K, Abanin, DA, Michailidis, A, Acharya, R, Arute, F, Arya, K, Asfaw, A, Atalaya, J, Bardin, JC, Basso, J, Bengtsson, A, Bortoli, G, Bourassa, A, Bovaird, J, Brill, L, Broughton, M, Buckley, BB, Buell, DA, Burger, T, Burkett, B, Bushnell, N, Chen, Z, Chiaro, B, Collins, R, Conner, P, Courtney, W, Crook, AL, Curtin, B, Debroy, DM, Del Toro Barba, A, Demura, S, Dunsworth, A, Eppens, D, Erickson, C, Faoro, L, Farhi, E, Fatemi, R, Flores Burgos, L, Forati, E, Fowler, AG, Foxen, B, Giang, W, Gidney, C, Gilboa, D, Giustina, M, Grajales Dau, A, Gross, JA, Habegger, S, Hamilton, MC, Harrigan, MP, Harrington, SD, Hoffmann, M, Hong, S, Huang, T, Huff, A, Huggins, WJ, Isakov, SV, Iveland, J, Jeffrey, E, Jiang, Z, Jones, C, Juhas, P, Kafri, D, Khattar, T, Khezri, M, Kieferová, M, Kim, S, Kitaev, AY, Klimov, PV, Klots, AR, Korotkov, AN, Kostritsa, F, Kreikebaum, JM, Landhuis, D, Laptev, P, Lau, K-M, Laws, L, Lee, J, Lee, KW, Lester, BJ, Lill, AT, Liu, W, Locharla, A, Malone, F, Martin, O, McClean, JR, McEwen, M, Meurer Costa, B, Miao, KC, Mohseni, M, Montazeri, S, Mount, E, Mruczkiewicz, W, Naaman, O, and Neeley, M

Subjects
Quantum Physics, Physical Sciences, Photons, Microwaves, Electrons, Fees and Charges, Reproduction, General Science & Technology
Abstract

Systems of correlated particles appear in many fields of modern science and represent some of the most intractable computational problems in nature. The computational challenge in these systems arises when interactions become comparable to other energy scales, which makes the state of each particle depend on all other particles1. The lack of general solutions for the three-body problem and acceptable theory for strongly correlated electrons shows that our understanding of correlated systems fades when the particle number or the interaction strength increases. One of the hallmarks of interacting systems is the formation of multiparticle bound states2-9. Here we develop a high-fidelity parameterizable fSim gate and implement the periodic quantum circuit of the spin-½ XXZ model in a ring of 24 superconducting qubits. We study the propagation of these excitations and observe their bound nature for up to five photons. We devise a phase-sensitive method for constructing the few-body spectrum of the bound states and extract their pseudo-charge by introducing a synthetic flux. By introducing interactions between the ring and additional qubits, we observe an unexpected resilience of the bound states to integrability breaking. This finding goes against the idea that bound states in non-integrable systems are unstable when their energies overlap with the continuum spectrum. Our work provides experimental evidence for bound states of interacting photons and discovers their stability beyond the integrability limit.

Published
2022

10. ASCEND-Eye: Effects of Aspirin on Diabetic Retinopathy

Author

Sammons, Emily, Bowman, Louise, Stevens, William, Buck, Georgina, Hammami, Imen, Parish, Sarah, Armitage, Jane, Collins, R., Armitage, J., Bowman, L., Parish, S., Peto, R., Barton, J., Simpson, D., Adler, A., Aung, T., Baigent, C., Bodansky, H.J., Farmer, A., Haynes, R., McPherson, R., Mafham, M., Neil, H.A.W., Samani, N., Sleight, P., Weissberg, P., Sandercock, P., Gerstein, H., Gray, R., Hennekens, C., Fletcher, L., Murphy, K., Hurley, S., Lee, R., Pickworth, S., Willett, M., Wincott, M., Sammons, E., Lay, M., Buck, G., Murawska, A., Stevens, W., Wallendszus, K., Young, A., Hammami, I., Melham, K., Brown, G., Latham-Mollart, J., Brewer, A., Scanlon, P., Patel, P., Olson, M., Kay, J., Banerjee, S., Evans, L., Davies, A., Griffiths, M., Clayton, H., Kirby, P., Pennington, M., Clarke, D., Anslow, J., Hallam, A., Witts, J., Egan, S., Wharton, A., Sachdev, A., Derbyshire, A., Williamson, E., Hepplestone, K., Mithra, S., Oliver, S., Wiatrak-Olszewska, P., Gazis, T., Alvey, K., Wu, E., Cook, H., Gregory, N., Parkinson, P., Anderson, J., Bolter, L., Maharajan, P., McFee, R., Allsop, L., Sowter, D., Hodgson, D., Thow, J., Featonby, J., Furnival, R., Lipinski, H., Benjamin, H., McAfee, T., Payne, E., Still, L., Sammons, Emily L., Bowman, Louise J., and Stevens, William M.

Published
2024
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13. ASCEND-Eye: Effects of Omega-3 Fatty Acids on Diabetic Retinopathy

Author

Sammons, Emily, Bowman, Louise, Stevens, William, Buck, Georgina, Hammami, Imen, Parish, Sarah, Armitage, Jane, Collins, R., Armitage, J., Barton, J., Simpson, D., Adler, A., Aung, T., Baigent, C., Bodansky, H.J., Farmer, A., Haynes, R., McPherson, R., Mafham, M., Neil, H.A.W., Samani, N., Sleight, P., Weissberg, P., Sandercock, P., Gerstein, H., Gray, R., Hennekens, C., Fletcher, L., Murphy, K., Hurley, S., Lee, R., Pickworth, S., Willett, M., Wincott, M., Lay, M., Buck, G., Murawska, A., Stevens, W., Wallendszus, K., Young, A., Hammami, I., Brown, G., Latham-Mollart, J., Brewer, A., Scanlon, P., Patel, P., Olson, M., Kay, J., Banerjee, S., Evans, L., Davies, A., Griffiths, M., Clayton, H., Kirby, P., Pennington, M., Clarke, D., Anslow, J., Hallam, A., Witts, J., Egan, S., Wharton, A., Sachdev, A., Derbyshire, A., Williamson, E., Hepplestone, K., Mithra, S., Oliver, S., Wiatrak-Olszewska, P., Gazis, T., Alvey, K., Wu, E., Cook, H., Gregory, N., Parkinson, P., Anderson, J., Bolter, L., Maharajan, P., McFee, R., Allsop, L., Sowter, D., Hodgson, D., Thow, J., Featonby, J., Furnival, R., Lipinski, H., Benjamin, H., McAfee, T., Payne, E., Still, L., Sammons, Emily L., Bowman, Louise J., and Stevens, William M.

Published
2024
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15. Research methods anxiety, attitude, self-efficacy and academic effort: A social cognitive theory perspective

Author

Christopher Mensah, Edem M. Azila-Gbettor, Collins R. Nunyonameh, Melody E. Appietu, and Sedem N. Amedome

Subjects
Research anxiety, attitude, self-efficacy, usefulness, efforts, university students, Psychology, BF1-990, Neurophysiology and neuropsychology, QP351-495
Abstract

AbstractThe integration and mandatory study of research method courses by university students is a global phenomenon. However, students demonstrate apprehension and disinterest in research methods courses. Consequently, this study investigated the interplay among research methods anxiety, positive disposition toward research, perception of usefulness, self-efficacy, and academic effort in research. Paper-and-pencil questionnaires were used to collect data from a convenience sample of 636 technical university students in Ghana. Based on partial least squares structural equation modeling results, research anxiety reduces students’ self-beliefs (β = −0.172; t = 2.729; p = .000) and negatively affects perception of research usefulness (β = −0.172; t = 2.729; p = .000). A positive disposition towards research enhances students’ academic efforts in research (β = 0.919; t = 3.308; p = 0.001). Furthermore, self-efficacy drives students’ efforts (β = −0.172; t = 2.729; p = .000), enhances positive disposition toward research (β = 0.191; t = 3.308; p = .001) and perception of research usefulness among students (β = 0.224; t = 3.064; p = .002). Students’ perception of research usefulness mediates the relationship between anxiety and effort in research (β = −0.075; t = 3.653; p = .000), positive research disposition and effort (β = −0.056; t = 2.519; p = .012) as well as research self-efficacy and effort in studies (β = 0.083; t = 3.02; p = .003).

Published
2023
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20. Removing leakage-induced correlated errors in superconducting quantum error correction

Author

McEwen, M, Kafri, D, Chen, Z, Atalaya, J, Satzinger, KJ, Quintana, C, Klimov, PV, Sank, D, Gidney, C, Fowler, AG, Arute, F, Arya, K, Buckley, B, Burkett, B, Bushnell, N, Chiaro, B, Collins, R, Demura, S, Dunsworth, A, Erickson, C, Foxen, B, Giustina, M, Huang, T, Hong, S, Jeffrey, E, Kim, S, Kechedzhi, K, Kostritsa, F, Laptev, P, Megrant, A, Mi, X, Mutus, J, Naaman, O, Neeley, M, Neill, C, Niu, M, Paler, A, Redd, N, Roushan, P, White, TC, Yao, J, Yeh, P, Zalcman, A, Chen, Yu, Smelyanskiy, VN, Martinis, John M, Neven, H, Kelly, J, Korotkov, AN, Petukhov, AG, and Barends, R

Subjects
Quantum Physics, Engineering, Electronics, Sensors and Digital Hardware, Physical Sciences, Atomic, Molecular and Optical Physics, quant-ph
Abstract

Quantum computing can become scalable through error correction, but logical error rates only decrease with system size when physical errors are sufficiently uncorrelated. During computation, unused high energy levels of the qubits can become excited, creating leakage states that are long-lived and mobile. Particularly for superconducting transmon qubits, this leakage opens a path to errors that are correlated in space and time. Here, we report a reset protocol that returns a qubit to the ground state from all relevant higher level states. We test its performance with the bit-flip stabilizer code, a simplified version of the surface code for quantum error correction. We investigate the accumulation and dynamics of leakage during error correction. Using this protocol, we find lower rates of logical errors and an improved scaling and stability of error suppression with increasing qubit number. This demonstration provides a key step on the path towards scalable quantum computing.

Published
2021

25. Blood pressure-lowering treatment for prevention of major cardiovascular diseases in people with and without type 2 diabetes: an individual participant-level data meta-analysis

Author

Agodoa, L, Algra, A, Asselbergs, F W, Beckett, N, Berge, E, Black, H, Brouwers, F P J, Brown, M, Bulpitt, C J, Byington, B, Cutler, J, Devereaux, R B, Dwyer, J, Estacio, R, Fagard, R, Fox, K, Fukui, T, Imai, Y, Ishii, M, Julius, S, Kanno, Y, Kjeldsen, S E, Kostis, J, Kuramoto, K, Lanke, J, Lewis, E, Lewis, J, Lievre, M, Lindholm, L H, Lueders, S, MacMahon, S, Mancia, G, Matsuzaki, M, Mehlum, M H, Nissen, S, Ogawa, H, Ogihara, T, Ohkubo, T, Palmer, C, Patel, A, Pfeffer, M, Poulter, N R, Rakugi, H, Reboldi, G, Reid, C, Remuzzi, G, Ruggenenti, P, Saruta, T, Schrader, J, Schrier, R, Sever, P, Sleight, P, Staessen, J A, Suzuki, H, Thijs, L, Ueshima, K, Umemoto, S, van Gilst, W H, Verdecchia, P, Wachtell, K, Whelton, P, Wing, L, Yui, Y, Yusuf, S, Zanchetti, A, Zhang, Z Y, Anderson, C, Baigent, C, Brenner, BM, Collins, R, de Zeeuw, D, Lubsen, J, Malacco, E, Neal, B, Perkovic, V, Pitt, B, Rodgers, A, Rothwell, P, Salimi-Khorshidi, G, Sundström, J, Turnbull, F, Viberti, G, Wang, J, Nazarzadeh, Milad, Bidel, Zeinab, Canoy, Dexter, Copland, Emma, Bennett, Derrick A, Dehghan, Abbas, Davey Smith, George, Holman, Rury R, Woodward, Mark, Gupta, Ajay, Adler, Amanda I, Wamil, Malgorzata, Sattar, Naveed, Cushman, William C, McManus, Richard J, Teo, Koon, Davis, Barry R, Chalmers, John, Pepine, Carl J, and Rahimi, Kazem

Published
2022
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28. Apprenticeship Reforms in West Africa: An Outcome-Process Evaluation of a Pilot Dual Training Model-Based Apprenticeship Reform Scheme in Ghana.

Author

Nunyonameh, Collins R., Obinnim, Elizabeth, and Adzivor, Eric Kodzo

Subjects
APPRENTICESHIP programs, RIGHT to education, VOCATIONAL education, EDUCATIONAL outcomes
Abstract

Context: Faced with deep challenges with access to formal education, many West African countries are increasingly taking steps to reform their informal apprenticeship systems to make them a quality skills development alternative for their teeming youth. A review of the literature shows that although different countries in the region are deploying different reform strategies, what is emerging as a dominant reform model is the "dual training model" (DTM), a collaborative arrangement in which the task of training apprentices is shared between informal trainers (master craftspersons, under their respective trade associations) and formal vocational training institutions (FVTIs). This paper presents an outcome-process evaluation of a DTM-based apprenticeship reform programme piloted in Ghana. Methods: Designed as a case study, the paper adopts an interpretivist approach, relying on diverse sources of data, both secondary and primary. Secondary data includes journal articles, attendance registers of participants, memorandums of understanding, relevant media reports, websites, and official reports by all relevant actors. The primary data originated from in-depth interviews with fourteen (14) key informants, as well as from overt and covert observations of respondents. Results: At the outcome level, the paper shows that the programme has largely failed in transferring new skills or in changing dominant poor practices among trainees, foundational objectives of the programme. At the process level, the paper revealed deep flaws in implementation; these are discussed in detail in an attempt to clarify the programme outcomes. Conclusion: The paper concludes that although the dual training model remains a potentially viable reform model in informal apprenticeships, its success ultimately depends on the quality of implementation, which in turn depends on the strength and quality of interstakeholder collaboration in programme design and implementation. [ABSTRACT FROM AUTHOR]

Published
2024
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33. Accurately computing the electronic properties of a quantum ring

Author

Neill, C., McCourt, T., Mi, X., Jiang, Z., Niu, M. Y., Mruczkiewicz, W., Aleiner, I., Arute, F., Arya, K., Atalaya, J., Babbush, R., Bardin, J. C., Barends, R., Bengtsson, A., Bourassa, A., Broughton, M., Buckley, B. B., Buell, D. A., Burkett, B., Bushnell, N., Campero, J., Chen, Z., Chiaro, B., Collins, R., Courtney, W., Demura, S., Derk, A. R., Dunsworth, A., Eppens, D., Erickson, C., Farhi, E., Fowler, A. G., Foxen, B., Gidney, C., Giustina, M., Gross, J. A., Harrigan, M. P., Harrington, S. D., Hilton, J., Ho, A., Hong, S., Huang, T., Huggins, W. J., Isakov, S. V., Jacob-Mitos, M., Jeffrey, E., Jones, C., Kafri, D., Kechedzhi, K., Kelly, J., Kim, S., Klimov, P. V., Korotkov, A. N., Kostritsa, F., Landhuis, D., Laptev, P., Lucero, E., Martin, O., McClean, J. R., McEwen, M., Megrant, A., Miao, K. C., Mohseni, M., Mutus, J., Naaman, O., Neeley, M., Newman, M., O’Brien, T. E., Opremcak, A., Ostby, E., Pató, B., Petukhov, A., Quintana, C., Redd, N., Rubin, N. C., Sank, D., Satzinger, K. J., Shvarts, V., Strain, D., Szalay, M., Trevithick, M. D., Villalonga, B., White, T. C., Yao, Z., Yeh, P., Zalcman, A., Neven, H., Boixo, S., Ioffe, L. B., Roushan, P., Chen, Y., and Smelyanskiy, V.

Published
2021
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35. Antihypertensive treatment and risk of cancer: an individual participant data meta-analysis

Author

Adler, A, Agodoa, L, Algra, A, Asselbergs, F W, Beckett, N, Berge, E, Black, H, Brouwers, F P J, Brown, M, Bulpitt, C J, Byington, B, Chalmers, J, Cushman, W C, Cutler, J, Davis, B R, Devereaux, R B, Dwyer, J, Estacio, R, Fagard, R, Fox, K, Fukui, T, Gupta, A K, Holman, R R, Imai, Y, Ishii, M, Julius, S, Kanno, Y, Kjeldsen, S E, Kostis, J, Kuramoto, K, Lanke, J, Lewis, E, Lewis, J, Lievre, M, Lindholm, L H, Lueders, S, MacMahon, S, Mancia, G, Matsuzaki, M, Mehlum, M H, Nissen, S, Ogawa, H, Ogihara, T, Ohkubo, T, Palmer, C, Patel, A, Pepine, C J, Pfeffer, M, Poulter, N R, Rakugi, H, Reboldi, G, Reid, C, Remuzzi, G, Ruggenenti, P, Saruta, T, Schrader, J, Schrier, R, Sever, P, Sleight, P, Staessen, J A, Suzuki, H, Thijs, L, Ueshima, K, Umemoto, S, van Gilst, W H, Verdecchia, P, Wachtell, K, Whelton, P, Wing, L, Woodward, M, Yui, Y, Yusuf, S, Zanchetti, A, Zhang, Z Y, Anderson, C, Baigent, C, Brenner, BM, Collins, R, de Zeeuw, D, Lubsen, J, Malacco, E, Neal, B, Perkovic, V, Pitt, B, Rodgers, A, Rothwell, P, Salimi-Khorshidi, G, Sundström, J, Turnbull, F, Viberti, G, Wang, J, Copland, Emma, Canoy, Dexter, Nazarzadeh, Milad, Bidel, Zeinab, Ramakrishnan, Rema, Woodward, Mark, Chalmers, John, Teo, Koon K, Pepine, Carl J, Davis, Barry R, Kjeldsen, Sverre, Sundström, Johan, and Rahimi, Kazem

Published
2021
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36. Efficacy and Safety of Epratuzumab in Moderately to Severely Active Systemic Lupus Erythematosus: Results From Two Phase III Randomized, Double‐Blind, Placebo‐Controlled Trials

Author

Clowse, Megan EB, Wallace, Daniel J, Furie, Richard A, Petri, Michelle A, Pike, Marilyn C, Leszczyński, Piotr, Neuwelt, C Michael, Hobbs, Kathryn, Keiserman, Mauro, Duca, Liliana, Kalunian, Kenneth C, Galateanu, Catrinel, Bongardt, Sabine, Stach, Christian, Beaudot, Carolyn, Kilgallen, Brian, Gordon, Caroline, Batalov, A, Bojinca, M, Djerassi, R, Duca, L, Horak, P, Kolarov, Z, Milasiene, R, Monova, D, Otsa, K, Pileckyte, M, Popova, T, Radulescu, F, Rashkov, R, Rednic, S, Repin, M, Stoilov, R, Tegzova, D, Vezikova, N, Vitek, P, Zainea, C, East, Far, Baek, H, Chen, Y, Chiu, Y, Cho, C, Chou, C, Choe, J, Huang, C, Kang, Y, Kang, S, Lai, N, Lee, S, Park, W, Shim, S, Suh, C, Yoo, W, Armengol, H Avila, Zapata, F Avila, Santiago, M Barreto, Cavalcanti, F, Chahade, W, Costallat, L, Keiserman, M, Alcala, J Orozco, Remus, C Ramos, Roimicher, L, Abu‐Shakra, M, Agarwal, V, Agmon‐Levin, N, Kadel, J, Levy, Y, Mevorach, D, Paran, D, Reitblat, T, Rosner, I, Shobha, V, Sthoeger, Z, Zisman, D, Ayesu, K, Berney, S, Box, J, Busch, H, Buyon, J, Carter, J, Chi, J, Clowse, M, Collins, R, Dao, K, Diab, I, Dikranian, A, El‐Shahawy, M, Gaylis, N, Grossman, J, Halpert, E, Huff, J, Jarjour, W, Kao, A, Katz, R, Kennedy, A, Khan, M, Kivitz, A, Kohen, M, and Lawrence‐Ford, T

Subjects
Autoimmune Disease, Clinical Trials and Supportive Activities, Clinical Research, Lupus, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Inflammatory and immune system, Adult, Antibodies, Monoclonal, Humanized, Double-Blind Method, Female, Humans, Lupus Erythematosus, Systemic, Male, Severity of Illness Index, Treatment Outcome, EMBODY Investigator Group, Clinical Sciences, Immunology, Public Health and Health Services, Arthritis & Rheumatology
Abstract

ObjectiveEpratuzumab, a monoclonal antibody that targets CD22, modulates B cell signaling without substantial reductions in the number of B cells. The aim of this study was to report the results of 2 phase III multicenter randomized, double-blind, placebo-controlled trials, the EMBODY 1 and EMBODY 2 trials, assessing the efficacy and safety of epratuzumab in patients with moderately to severely active systemic lupus erythematosus (SLE).MethodsPatients met ≥4 of the American College of Rheumatology revised classification criteria for SLE, were positive for antinuclear antibodies and/or anti-double-stranded DNA antibodies, had an SLE Disease Activity Index 2000 (SLEDAI-2K) score of ≥6 (increased disease activity), had British Isles Lupus Assessment Group 2004 index (BILAG-2004) scores of grade A (severe disease activity) in ≥1 body system or grade B (moderate disease activity) in ≥2 body systems (in the mucocutaneous, musculoskeletal, or cardiorespiratory domains), and were receiving standard therapy, including mandatory treatment with corticosteroids (5-60 mg/day). BILAG-2004 grade A scores in the renal and central nervous system domains were excluded. Patients were randomized 1:1:1 to receive either placebo, epratuzumab 600 mg every week, or epratuzumab 1,200 mg every other week, with infusions delivered for the first 4 weeks of each 12-week dosing cycle, for 4 cycles. Patients across all 3 treatment groups also continued with their standard therapy. The primary end point was the response rate at week 48 according to the BILAG-based Combined Lupus Assessment (BICLA) definition, requiring improvement in the BILAG-2004 score, no worsening in the BILAG-2004 score, SLEDAI-2K score, or physician's global assessment of disease activity, and no disallowed changes in concomitant medications. Patients who discontinued the study medication were classified as nonresponders.ResultsIn the EMBODY 1 and EMBODY 2 trials of epratuzumab, 793 patients and 791 patients, respectively, were randomized, 786 (99.1%) and 788 (99.6%), respectively, received study medication, and 528 (66.6%) and 533 (67.4%), respectively, completed the study. There was no statistically significant difference in the primary end point between the groups, with the week 48 BICLA response rates being similar between the epratuzumab groups and the placebo group (response rates ranging from 33.5% to 39.8%). No new safety signals were identified.ConclusionIn patients with moderate or severely active SLE, treatment with epratuzumab + standard therapy did not result in improvements in response rates over that observed in the placebo + standard therapy group.

Published
2017

43. An End-to-End System for Content-Based Video Retrieval Using Behavior, Actions, and Appearance with Interactive Query Refinement

Author

Hoogs, A, Perera, AGA, Collins, R, Basharat, A, Fieldhouse, K, Atkins, C, Sherrill, L, Boeckel, B, Blue, R, Woehlke, M, Greco, C, Sun, Z, Swears, E, Cuntoor, N, Luck, J, Drew, B, Hanson, D, Rowley, D, Kopaz, J, Rude, T, Keefe, D, Srivastava, A, Khanwalkar, S, Kumar, A, Chen, CC, Aggarwal, JK, Davis, L, Yacoob, Y, Jain, A, Liu, D, Chang, S-F, Song, B, Rov-Chowdhurv, A, Sullivan, K, Tesi, J, Chandrasekaran, S, Maniunath, BS, Wang, X, Ji, Q, Reddy, K, Liu, J, Shah, M, Chang, K, Chen, T, and Desai, M

Subjects
Information and Computing Sciences, Computer Vision and Multimedia Computation
Published
2015

45. Safety and efficacy of inactivated varicella zoster virus vaccine in immunocompromised patients with malignancies: a two-arm, randomised, double-blind, phase 3 trial

Author

Cerana, S, Dictar, MO, Bonvehi, P, Tregnaghi, JP, Fein, L, Ashley, D, Singh, M, Hayes, T, Playford, G, Morrissey, O, Thaler, J, Kuehr, T, Greil, R, Pecherstorfer, M, Duck, L, Van Eygen, K, Aoun, M, De Prijck, B, Franke, FA, Barrios, CHE, Mendes, AVA, Serrano, SV, Garcia, RF, Moore, F, Camargo, JFC, Pires, LA, Alves, RS, Radinov, A, Oreshkov, K, Minchev, V, Hubenova, AI, Koynova, T, Ivanov, I, Rabotilova, B, Petrov, PA, Chilingirov, P, Karanikolov, S, Raynov, J, Grimard, D, McNeil, S, Kumar, D, Larratt, LM, Weiss, K, Delage, R, Diaz-Mitoma, FJ, Cano, PO, Couture, F, Carvajal, P, Yepes, A, Torres Ulloa, R, Fardella, P, Caglevic, C, Rojas, C, Orellana, E, Gonzalez, P, Acevedo, A, Galvez, KM, Gonzalez, ME, Franco, S, Restrepo, JG, Rojas, CA, Bonilla, C, Florez, LE, Ospina, AV, Manneh, R, Zorica, R, Vrdoljak, DV, Samarzija, M, Petruzelka, L, Vydra, J, Mayer, J, Cibula, D, Prausova, J, Paulson, G, Ontaneda, M, Palk, K, Vahlberg, A, Rooneem, R, Galtier, F, Postil, D, Lucht, F, Laine, F, Launay, O, Laurichesse, H, Duval, X, Cornely, OA, Camerer, B, Panse, J, Zaiss, M, Derigs, H-G, Menzel, H, Verbeek, M, Georgoulias, V, Mavroudis, D, Anagnostopoulos, A, Terpos, E, Cortes, D, Umanzor, J, Bejarano, S, Galeano, RW, Wong, RSM, Hui, P, Pedrazzoli, P, Ruggeri, L, Aversa, F, Bosi, A, Gentile, G, Rambaldi, A, Contu, A, Marei, L, Abbadi, A, Hayajneh, W, Kattan, J, Farhat, F, Chahine, G, Rutkauskiene, J, Marfil Rivera, LJ, Lopez Chuken, YA, Franco Villarreal, H, Lopez Hernandez, J, Blacklock, H, Lopez, RI, Alvarez, R, Gomez, AM, Quintana, TS, Moreno Larrea, MDC, Zorrilla, SJ, Alarcon, E, Samanez, FCA, Caguioa, PB, Tiangco, BJ, Mora, EM, Betancourt-Garcia, RD, Hallman-Navarro, D, Feliciano-Lopez, LJ, Velez-Cortes, HA, Cabanillas, F, Ganea, DE, Ciuleanu, TE, Ghizdavescu, DG, Miron, L, Cebotaru, CL, Cainap, CI, Anghel, R, Dvorkin, MV, Gladkov, OA, Fadeeva, NV, Kuzmin, AA, Lipatov, ON, Zbarskaya, II, Akhmetzyanov, FS, Litvinov, IV, Afanasyev, BV, Cherenkova, M, Lioznov, D, Lisukov, IA, Smirnova, YA, Kolomietz, S, Halawani, H, Goh, YT, Drgona, L, Chudej, J, Matejkova, M, Reckova, M, Rapoport, BL, Szpak, WM, Malan, DR, Jonas, N, Jung, CW, Lee, DG, Yoon, SS, Lopez Jimenez, J, Duran Martinez, I, Rodriguez Moreno, JF, Solano Vercet, C, de la Camara, R, Batlle Massana, M, Yeh, S-P, Chen, C-Y, Chou, H-H, Tsai, C-M, Chiu, C-H, Siritanaratkul, N, Norasetthada, L, Sriuranpong, V, Seetalarom, K, Akan, H, Dane, F, Ozcan, MA, Ozsan, GH, Kalayoglu Besisik, SF, Cagatay, A, Yalcin, S, Peniket, A, Mullan, SR, Dakhil, KM, Sivarajan, K, Suh, JJ-G, Sehgal, A, Marquez, F, Gomez, EG, Mullane, MR, Skinner, WL, Behrens, RJ, Trevarthe, DR, Mazurczak, MA, Lambiase, EA, Vidal, CA, Anac, SY, Rodrigues, GA, Baltz, B, Boccia, R, Wertheim, MS, Holladay, CS, Zenk, D, Fusselman, W, Wade III, JL, Jaslowsk, AJ, Keegan, J, Robinson, MO, Go, RS, Farnen, J, Amin, B, Jurgens, D, Risi, GF, Jr, Beatty, PG, Naqvi, T, Parshad, S, Hansen, VL, Ahmed, M, Steen, PD, Badarinath, S, Dekker, A, Scouros, MA, Young, DE, Graydon Harker, W, Kendall, SD, Citron, ML, Chedid, S, Posada, JG, Jr, Gupta, MK, Rafiyath, S, Buechler-Price, J, Sreenivasappa, S, Chay, CH, Burke, JM, Young, SE, Mahmood, A, Kugler, JW, Gerstner, G, Fuloria, J, Belman, ND, Geller, R, Nieva, J, Whittenberger, BP, Wong, BMY, Cescon, TP, Abesada-Terk, G, Jr, Guarino, MJ, Zweibach, A, Ibrahim, EN, Takahashi, G, Garrison, MA, Mowat, RB, Choi, BS, Oliff, IA, Singh, J, Guter, KA, Ayrons, K, Rowland, KM, Noga, SJ, Rao, SB, Columbie, A, Nualart, MT, Cecchi, GR, Campos, LT, Mohebtash, M, Flores, MR, Rothstein-Rubin, R, O'Connor, BM, Soori, G, Knapp, M, Miranda, FG, Goodgame, BW, Kassem, M, Belani, R, Sharma, S, Ortiz, T, Sonneborn, HL, Markowitz, AB, Wilbur, D, Meiri, E, Koo, VS, Jhangiani, HS, Wong, L, Sanani, S, Lawrence, SJ, Jones, CM, Murray, C, Papageorgiou, C, Gurtler, JS, Ascensao, JL, Venigalla, ML, D'Andrea, M, De Las Casas, C, Haile, DJ, Qazi, FU, Santander, JL, Thomas, MR, Rao, VP, Craig, M, Garg, RJ, Robles, R, Lyons, RM, Stegemoller, RK, Goel, S, Garg, S, Lowry, P, Lynch, C, Lash, B, Repka, T, Baker, J, Goueli, BS, Campbell, TC, Van Echo, DA, Lee, YJ, Reyes, EA, Senecal, FM, Donnelly, G, Byeff, P, Weiss, R, Reid, T, Roeland, E, Goel, A, Prow, DM, Brandt, DS, Kaplan, HG, Payne, JE, Boeckh, MG, Rosen, PJ, Mena, RR, Khan, R, Betts, RF, Sharp, SA, Morrison, VA, Fitz-Patrick, D, Congdon, J, Erickson, N, Abbasi, R, Henderson, S, Mehdi, A, Wos, EJ, Rehmus, E, Beltzer, L, Tamayo, RA, Mahmood, T, Reboli, AC, Moore, A, Brown, JM, Cruz, J, Quick, DP, Potz, JL, Kotz, KW, Hutchins, M, Chowhan, NM, Devabhaktuni, YD, Braly, P, Berenguer, RA, Shambaugh, SC, O'Rourke, TJ, Conkright, WA, Winkler, CF, Addo, FEK, Duic, JP, High, KP, Kutner, ME, Collins, R, Carrizosa, DR, Perry, DJ, Kailath, E, Rosen, N, Sotolongo, R, Shoham, S, Chen, T, Mullane, Kathleen M, Morrison, Vicki A, Camacho, Luis H, Arvin, Ann, McNeil, Shelly A, Durrand, Jessie, Campbell, Bernadette, Su, Shu-Chih, Chan, Ivan S F, Parrino, Janie, Kaplan, Susan S, Popmihajlov, Zoran, and Annunziato, Paula W

Published
2019
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46. Serious Adverse Effects of Extended-release Niacin/Laropiprant: Results From the Heart Protection Study 2–Treatment of HDL to Reduce the Incidence of Vascular Events (HPS2-THRIVE) Trial

Author

Haynes, Richard, Valdes-Marquez, Elsa, Hopewell, Jemma C., Chen, Fang, Li, Jing, Parish, Sarah, Landray, Martin J., Armitage, Jane, Collins, R., Armitage, J., Baigent, C., Chen, Z., Landray, M.J., Chen, Y., Jiang, L., Pedersen, T., Bowman, L., Haynes, R., Rahimi, K., Tobert, J., Sleight, P., Simpson, D., Parish, S., Baxter, A., Lay, M., Bray, C., Wincott, E., van Leijenhorst, G., Mitchel, Y., and Kuznetsova, O.

Published
2019
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48. Adverse Pregnancy and Neonatal Outcomes Among Marshallese Women Living in the United States

Author

Nembhard, Wendy N., Ayers, Britni L., Collins, R. Thomas, Shan, Xiaoyi, Rabie, Nader Z., Chang, Di, and Robbins, James M.

Subjects
Marshallese -- Emigration and immigration -- Family, Pregnancy, Complications of -- Demographic aspects -- Risk factors, Health care industry
Abstract

Objective Despite heterogeneity among Pacific Islanders, most studies aggregate them regardless of origin. Thus, limited information is available about perinatal outcomes among various subgroups of Pacific Islanders in the United States, including immigrants from the Republic of the Marshall Islands. We sought to evaluate perinatal outcomes among Marshallese women. Methods We conducted a cross-sectional study of women with at least one singleton live birth between 1997 and 2013 in two Arkansas counties using birth certificate data from the Arkansas Department of Health. Unadjusted and adjusted prevalence ratios (PR) and 95% confidence intervals (CI) were calculated from modified Poisson regression models. Results Of the 91,662 singleton births in both counties during the study period, 2488 were to Marshallese women. In adjusted analyses, Marshallese women had higher prevalence of 'other medical risk factors' (PR = 1.47; 95% CI 1.30, 1.65) than NH White women. Marshallese women had higher rates of precipitous labor and fetal distress during labor compared to NH White women (PR = 2.65; 95% CI 2.22, 3.17 and 1.89; 95% CI 1.62, 2.21, respectively). Marshallese were also more likely to have tocolysis (PR = 1.43; 95% CI 1.16, 1.76), forceps (PR = 1.68; 95% CI 1.16, 2.43) or vacuum (PR = 1.89; 95% CI 1.60, 2.22) used in delivery and cesarean section (PR = 1.13; 95% CI 1.01, 1.27). Marshallese infants had higher rates of anemia (PR = 3.10; 95% CI 2.01, 4.77), birth injury (PR = 2.13; 95% CI 1.50, 3.03), assisted ventilation < 30 min (PR = 2.11; 95% CI 1.64, 2.71), preterm birth (PR = 1.67; 95% CI 1.50, 1.83), and small-for-gestational age (PR = 1.25; 95% CI 1.12, 1.39) than NH White infants. Conclusions Marshallese women and infants had higher rates of adverse perinatal outcomes compared to their NH White counterparts. Additional studies are needed to determine if perinatal outcomes among the Marshallese differed from other Pacific Islander subgroups., Author(s): Wendy N. Nembhard [sup.1] [sup.2] , Britni L. Ayers [sup.3] , R. Thomas Collins [sup.6] , Xiaoyi Shan [sup.2] [sup.4] , Nader Z. Rabie [sup.7] , Di Chang [sup.5] [...]

Published
2019
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49. Methods for biogeochemical studies of sea ice: The state of the art, caveats, and recommendations

Author

Miller, Lisa A, Fripiat, Francois, Else, Brent GT, Bowman, Jeff S, Brown, Kristina A, Collins, R Eric, Ewert, Marcela, Fransson, Agneta, Gosselin, Michel, Lannuzel, Delphine, Meiners, Klaus M, Michel, Christine, Nishioka, Jun, Nomura, Daiki, Papadimitriou, Stathys, Russell, Lynn M, Sørensen, Lise Lotte, Thomas, David N, Tison, Jean-Louis, van Leeuwe, Maria A, Vancoppenolle, Martin, Wolff, Eric W, and Zhou, Jiayun

Subjects
Life Below Water
Abstract

Over the past two decades, with recognition that the ocean's sea-ice cover is neither insensitive to climate change nor a barrier to light and matter, research in sea-ice biogeochemistry has accelerated significantly, bringing together a multi-disciplinary community from a variety of fields. This disciplinary diversity has contributed a wide range of methodological techniques and approaches to sea-ice studies, complicating comparisons of the results and the development of conceptual and numerical models to describe the important biogeochemical processes occurring in sea ice. Almost all chemical elements, compounds, and biogeochemical processes relevant to Earth system science are measured in sea ice, with published methods available for determiningbiomass, pigments, net community production, primary production, bacterial activity, macronutrients, numerous natural and anthropogenic organic compounds, trace elements, reactive and inert gases, sulfur species, the carbon dioxide system parameters, stable isotopes, and water-ice-Atmosphere fluxes of gases, liquids, and solids. For most of these measurements, multiple sampling and processing techniques are available, but to date there has been little intercomparison or intercalibration between methods. In addition, researchers collect different types of ancillary data and document their samples differently, further confounding comparisons between studies. These problems are compounded by the heterogeneity of sea ice, in which even adjacent cores can have dramatically different biogeochemical compositions. We recommend that, in future investigations, researchers design their programs based on nested sampling patterns, collect a core suite of ancillary measurements, and employ a standard approach for sample identification and documentation. In addition, intercalibration exercises are most critically needed for measurements of biomass, primary production, nutrients, dissolved and particulate organic matter (including exopolymers), the CO2 system, air-ice gas fluxes, and aerosol production. We also encourage the development of in situ probes robust enough for long-Term deployment in sea ice, particularly for biological parameters, the CO2 system, and other gases.

Published
2015

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