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This paper explores how research advisory groups can be a vehicle for youth activism. It draws on our experiences with young activists, aged 15–26 years, in India and Brazil, who were advisors on a research project focused on youth livelihoods in cities. These young people played a vital role in supporting youth researchers, identifying research themes and developing engagement and advocacy strategies. Through this paper, we explore how the Youth Expert Group advisory model evolved differently in each location and examine how these were shaped by the context, the 'adult' research team and the youth activists themselves. A critically reflexive response in intergenerational partnership is essential to support youth activists in research activities. [ABSTRACT FROM AUTHOR]

In a context of rapid technological innovation and expensive new products, the paper calls for the generation of real-world data to inform decision-making and an international discussion on the affordability of new medicines, particularly for low- and middle-income countries. Without these, the challenges of health judicialization will continue to grow. [ABSTRACT FROM AUTHOR]

Leishmaniasis is a public health concern, especially in Brazil and India. The drugs available for therapy are old, cause toxicity and have reports of resistance. Therefore, this paper aimed to carry out initial structure-activity relationships (applying molecular docking and dynamic simulations) of arylindole scaffolds against the pteridine reductase (PTR1), which is essential target for the survival of the parasite. Thus, we used a series of 43 arylindole derivatives as a privileged skeleton, which have been evaluated previously for different biological actions. Compound 7 stood out among its analogues presenting the best results of average number of interactions with binding site (2.00) and catalytic triad (1.00). Additionally, the same compound presented the best binding free energy (−32.33 kcal/mol) in dynamic simulations. Furthermore, with computational studies, it was possible to comprehend and discuss the influences of the substituent sizes, positions of substitutions in the aromatic ring and electronic influences. Therefore, this study can be a starting point for the structural improvements needed to obtain a good leishmanicidal drug. [ABSTRACT FROM AUTHOR]

Inequality refers to the extent to which income is evenly distributed across a population (IMF, 2022). The World Inequality Report (WIR, 2022) reveals the latest trends in global income inequality. It shows that the richest 10% of the global population currently earns 52% of global income, while the poorest half of the population takes 8.5% of it. In emerging market economies, indications are that income inequality is rising; sometimes accompanied by accelerating economic growth. Reports reveal that Brazil's six richest individuals command the same wealth associated with the poorest 50% of the population, or about 100 million people. The World Inequality Report (2021) reveals India as a poor and unequal country, with the bottom half of the population earning only 13% of the nation's income, while the top 10% controls 57% by 2021. In South Africa, the IMF (2020) acknowledges that the nation's inequality has remained at high levels, perhaps the highest in the world. This is characterized by a highly skewed income distribution pattern, with the top 20% of the population controlling 68% of national income. These developments hold grave implications for emerging markets, particularly their ability to meet the 2030 Sustainable Development Goals. The main objective of this paper is to explore income inequality in emerging market economies, with a multi-country study of Brazil, India and South Africa. The methodological approach to the study involves both qualitative and quantitative analytical techniques. It relies on secondary data in publications from various sources, complemented by interviews of stakeholders in the study areas. Findings reveal the income inequality is undermining economic growth and development in emerging markets, fueling conflicts and triggering migration in some countries. The paper presents recommendations, underpinned by progressive taxation, social safety nets, gender equality, development of social services, and leveraging economic and financial incentives for labour-intensive industries. [ABSTRACT FROM AUTHOR]

Tobacco use is associated with an annual global economic cost of two trillion dollars and mortality of half of its regular users. Tobacco leaf cultivation is the starting point of the tobacco cycle. Tobacco farming employs millions of small-scale tobacco farmers around the globe, most of whom are out growers who rely on the tobacco industry. This paper aims to map the regions of greatest tobacco production globally (i.e., the US, Brazil, China, Indonesia, India, and Zambia) and tobacco use rates in these locations. Smoking rates were higher in those areas, except for India, where important population subgroups reported an upward trend for tobacco smoking. In general, there was a relationship between tobacco farming and tobacco smoking. Tobacco farming may lead to a higher risk of tobacco use and lower adherence to tobacco control policies. Therefore, promoting viable alternative livelihoods for tobacco farmers must have dual benefits. Additionally, specific health prevention policies might be necessary for those populations reporting higher tobacco use and lower perception of tobacco-related health risks. [ABSTRACT FROM AUTHOR]

Tropical wetlands are amongst the most biodiverse ecosystems on Earth and have immense socioecological value. However, tropical wetlands are considered exploitable resources and continue to be drained and converted to other "productive" uses. It is therefore urgent to identify and understand the interactions between various drivers of change triggering degradation of such wetlands. In the present study, we systematically reviewed and analyzed the existing literature on wetlands in two tropical countries namely India and Brazil with special reference to inland wetlands, and proposed a conceptual model illustrating the intricate linkages of such wetlands with different drivers of change. We also developed the Nature Futures' Framework to depict the diverse values of inland wetlands contributing to human wellbeing in the two tropical countries. Findings revealed similar drivers of change triggering the degradation of Indian and Brazilian wetlands. These include changes in climate & land use, population growth, poor land governance due to weak policies, besides other anthropogenic activities such as deforestation, and overexploitation of wetland resources. Among these, land-use change such as agriculture intensification and infrastructure development were the major direct drivers; whereas, institutional and governance factors such as the absence of concrete policy measures were the major indirect drivers threatening the inland wetlands in India and Brazil. Results also revealed some contrasting drivers of change such as illegal human settlements, and land grabbing by the brick industry for Indian wetlands; while, gold mining and intensification of bovine systems for Brazilian wetlands. Our paper also provides an insight into the status of wetland conservation in India and Brazil. We recommend the promotion of community-based conservation practices while adopting sustainable livelihood strategies by the local people for the conservation and wise use of inland wetlands in India and Brazil. The arguments raised in the paper have the potential to assist the stakeholders and/or decision-makers towards implementing sustainable management strategies for inland wetlands in the two countries, and tropical wetlands in general. [ABSTRACT FROM AUTHOR]

This paper examines the consequences of the hugely successful expansion of South-South Cooperation since the new millennium. For all the achievements, variations and change over the 1950s-late 1990s, 'SSC 1.0' was characterised by relative neglect within the 'international' development community, and by many orthodox and critical scholars. In the chronological schema of the paper, 'SSC 2.0' refers to the period of remarkable expansion from the early 2000s to the present. The emergence of 'SSC 3.0', I suggest, is currently revealed by a discernible set of shifts driven in large part by the expansionary successes of SSC 2.0, as well as other turns in the global political economy. Three contemporary trends are identified: cooperation narratives that are increasingly 'muscular', nationalistic and pragmatic; difficulties sustaining claims to 'non-interference' in partner countries; and the further erosion of ideational and operational distinctiveness. [ABSTRACT FROM AUTHOR]

Objectives: We aim to describe the history of iodine testing of the cervix and identify areas where further work is required.Study Design: We conducted a search of PubMed and Google Scholar. Full article texts were reviewed. Reference lists were screened for additional articles and books. 37 basic articles in journals including ones written in German and three basic articles in books were identified.Results: Glycogen staining of the ectocervical squamous epithelium with iodine goes back to Paul Ehrlich (1854-1915). Walter Schiller (1887-1960) examined nearly 200 different dyes and found that vital staining of the cervical squamous epithelium was best achieved with Lugol's iodine solution, which was indicated by Jean Guillaume Lugol (1786-1851) for disinfection of the vagina. In 1928 W. Lahm observed that the glycogen content of a squamous epithelium cell decreases as anaplasia increases. From the outset, H. Hinselmann included the iodine test in the minimum requirements for colposcopy. In 1946 H. J. Wespi first mentioned the finding of an "uncharacteristic iodine negative area." The first international colposcopic terminology from Graz in 1975 lists the "iodine light area" among the different colposcopy findings. The IFCPC nomenclatures from Rome 1990, Barcelona 2002, and Rio de Janeiro 2011 have evaluated the iodine test and classified their findings differently. A breakthrough to effective cervical cancer screening in resource-limited settings in Africa, India, and Latin America was achieved with R. Sankaranarayanan's publication on naked-eye visual inspection of the cervix after application of Lugol's iodine.Conclusions: This paper is a step toward a better understanding of what we think and do today with iodine testing and what problems and upcoming tasks will arise in future. [ABSTRACT FROM AUTHOR]

Purpose: The purpose of this paper is to report on recent performance measurement and impact evaluation progress made in Brazil, India, Indonesia, Moldova, Turkey and Vietnam as part of the last phase of the Global Libraries Initiative. Design/methodology/approach: The country reports are presented as a series of case studies, in some cases supplementing those reported earlier in this journal. Findings: Recent country-specific survey findings are reported and some conclusions are offered. Research limitations/implications: This paper demonstrates how the adoption of a common approach to library service evaluation across several countries can strengthen research practice at country level beyond the Global Libraries Initiative itself. Practical implications: This paper shares Global Libraries IPA learning at country level with people in other countries who may be contemplating public library evaluation at regional, national or local levels or who are interested in performance measurement and impact evaluation. Social implications: The paper shows how focusing on the impact of public library services on users can enhance the understanding of community requirements and inform the development of more effective services to library users and communities. Originality/value: These case studies reflect concentrated impact evaluation and performance measurement work at country level across a range of countries over more than 18 years. [ABSTRACT FROM AUTHOR]

Productivity of coffee plantations is threatened by both climate change and decreasing revenues of coffee growers. Using shade trees might protect against temperature variability, erosion and excessive radiation but there may be trade-offs in productivity and quality. While impacts of shade trees on arabica (Coffea arabica) have been reviewed, a global synthesis on robusta (Coffea canephora) coffee is lacking. We assessed how shade affects robusta growth and productivity, and what are the interactions and trade-offs. We conducted a systematic literature search in Web of Science and CAB Abstracts on 16 December 2019. Thirty papers fulfilled our inclusion criteria of being experimental studies on the impact of overstory trees with approximately half being from Brazil or India. Shade improved robusta tree growth and yield with some contrasting effects on physicochemical and biochemical properties. Shade (> 30%) was associated with reduced beverage quality. Significant interactions between shade and location, rainfall level and robusta clone were found. Among the clones tested, 06V, C153, LB1, GG229 and JM2 showed a higher productivity and growth (from + 17 to + 280%) under moderate shade (41–65%). This is the first meta-analysis of the effects of shade on robusta coffee. By synthesizing data from different studies, we highlight for the first time that the effect of shade on robusta coffee depends on tree age. Shade had positive impacts on older robusta trees (mean of 16 years), while the impact of shade on younger trees was either insignificant or negative. We highlight the importance of both clone type and tree ages. Research gaps included a lack of knowledge on the effects of shade with respect to coffee and shade tree age as well as interactive effects. More in-depth studies are needed to understand the mechanisms of how shade trees affect robusta coffee. [ABSTRACT FROM AUTHOR]

Civil society engagement around health care and population health improvement is an important driver towards Health for All. Research can improve the effectiveness of health activism by examining the resources, structures and strategies of civil society engagement. However, research to support such engagement faces epistemological and methodological challenges which call for specific research strategies. A four year multi-country study was undertaken by the People's Health Movement, a global network working for health for all. The research took place in six countries (Brazil, Colombia, DR Congo, India, Italy, South Africa) and globally, and was directed to understanding five domains of civil society engagement: movement building; campaigning and advocacy; capacity building; knowledge generation, access and use; and engaging with governance. The research plan and methods of data collection and analysis were tailored to address the objective of improving activist practice, while negotiating research challenges identified during the design phase. Results include insights into the practice of civil society engagement in relation to the five domains of activist practice, as well as experience gained in managing six methodological challenges which we describe as: making meaning, aligning research and action, managing power relations, valuing experiential knowledges, chaos and contingency, challenging preconceptions. Researching activism can produce useful insights into practice as well as support continuous improvement in the effectiveness of such activism. However, there are significant methodological challenges that can be addressed through appropriate strategies. More research, building on the approach described in this paper, can contribute to more effective civil society activism for health. [ABSTRACT FROM AUTHOR]

Abstract Integrated assessment models are extensively used in the analysis of climate change mitigation and are informing national decision makers as well as contribute to international scientific assessments. This paper conducts a comprehensive review of techno-economic assumptions in the electricity sector among fifteen different global and national integrated assessment models. Particular focus is given to six major economies in the world: Brazil, China, the EU, India, Japan and the US. The comparison reveals that techno-economic characteristics are quite different across integrated assessment models, both for the base year and future years. It is, however, important to recognize that techno-economic assessments from the literature exhibit an equally large range of parameters as the integrated assessment models reviewed. Beyond numerical differences, the representation of technologies also differs among models, which needs to be taken into account when comparing numerical parameters. While desirable, it seems difficult to fully harmonize techno-economic parameters across a broader range of models due to structural differences in the representation of technology. Therefore, making techno-economic parameters available in the future, together with of the technology representation as well as the exact definitions of the parameters should become the standard approach as it allows an open discussion of appropriate assumptions. Highlights • Comparison of technology representation and techno-economic parameters of 15 IAMs. • Structural differences in representing technology in IAMs are identified. • Methods of projecting techno-economic parameters differ across IAMs. • Strict harmonization of techno-economic parameters across models is difficult. • Recommendation to publish techno-economic parameters and technology representation. [ABSTRACT FROM AUTHOR]

The HIV epidemic has had a widespread impact on global scientific and cultural discourses related to gender, sexuality, and identity. ‘Male sex workers’ have been identified as a ‘key population’ in the global HIV epidemic; however, there are methodological and conceptual challenges for defining inclusion and exclusion of transgender women within this group. To assess these potential implications, this study employs self-critique and reflection to grapple with the empiric and conceptual implications of shifting understandings of sexuality and gender within the externally re-created etic category of ‘MSM’ and ‘transgender women’ in epidemiologic HIV research. We conducted a sensitivity analysis of our previously published meta-analysis which aimed to identify the scope of peer-reviewed articles assessing HIV prevalence among male sex workers globally between 2004 and 2013. The inclusion of four studies previously excluded due to non-differentiation of cisgender male from transgender women participants (studies from Spain, Thailand, India, and Brazil: 421 total participants) increased the overall estimate of global HIV prevalence among ‘men’ who engage in sex work from 10.5% (95% CI 9.4–11.5%) to 10.8% (95% CI 9.8–11.8%). The combination of social science critique with empiric epidemiologic analysis represents a first step in defining and operationalising ‘reflexive epidemiology’. Grounded in the context of sex work and HIV prevention, this paper highlights the multiplicity of genders and sexualities across a range of social and cultural settings, limitations of existing categories (i.e. ‘MSM’, ‘transgender’), and their global implications for epidemiologic estimates of HIV prevalence. [ABSTRACT FROM AUTHOR]

• A new implementation of the FP method for storage systems leads to a more accurate objective function evaluation especially in nonlinear cases and to a vectorized unconstrained optimization problem solved many times faster. • FP results as compared to stochastic dynamic programming and novel two-stage stochastic programming results show its overall superiority. • A multi-reservoir application of the FP model is developed with corrective simulations to estimate moments of spillway flows and all other covariance terms. The Fletcher-Ponnambalam (FP) method is an explicit stochastic optimization method for design and operations management of real-world storage systems including surface water reservoir and groundwater management problems. The FP method faces no curse of dimensionality and no need for scenario generation. The paper introduces a novel implementation for the FP method, named FP-2022 here for clarity, by removing the need for nonlinear constraints and by decreasing the number of decision variables to just one third of its original value, significantly reducing solving time (∼27 times faster than the original formulation). Additionally, new expressions derived for the first and second moments of both reservoir release deficit and surplus variables and the already-derived expression for the second moments of reservoir storages are incorporated into the FP-2022 formulation enabling the method to reach an improved optimality for a nonlinear objective function. The enhanced procedure is applied to solving a reservoir operation optimization problem for a major dam in Brazil. The result comparisons made with other methods along with a thorough analysis of release operation policies prove the optimality of this highly numerically efficient and convenient-to-use FP-2022 method. Finally, a multi-reservoir application of the model is also tested with corrective simulations for improved estimates of some additional variables of interest. A specific constraint-handling approach regarding reservoir release lower and upper bounds is also presented. Satisfactory results are obtained for solving the Parambikulam-Aliyar reservoir system, a real world five-reservoir operation optimization problem from India. [ABSTRACT FROM AUTHOR]

This paper compares and contrasts the spread and impact of COVID-19 in the three countries most heavily impacted by the pandemic: the United States (US), India and Brazil. All three of these countries have a federal structure, in which the individual states have largely determined the response to the pandemic. Thus, we perform an extensive analysis of the individual states of these three countries to determine patterns of similarity within each. First, we analyse structural similarity and anomalies in the trajectories of cases and deaths as multivariate time series. Next, we study the lengths of the different waves of the virus outbreaks across the three countries and their states. Finally, we investigate suitable time offsets between cases and deaths as a function of the distinct outbreak waves. In all these analyses, we consistently reveal more characteristically distinct behaviour between US and Indian states, while Brazilian states exhibit less structure in their wave behaviour and changing progression between cases and deaths. • We compare and contrast the natural history of COVID-19 in the US, India and Brazil. • Case, death and mortality rate trajectories are analysed on a state-by-state basis. • We quantify heterogeneity and identify anomalous states therein within each country. • Wave behaviours are explored and clustered across the three countries states. • New mathematical methods quantify the lag in the progression from cases and deaths. [ABSTRACT FROM AUTHOR]

Current article assesses emerging trends in global trade in the case of Brazil-India-China (BIC) Alliance. Although the globalized world is still recovering from the global 2008 crisis, it may be perceived that Brazil, India and China showed considerable growth during the crisis, continuing with the trend even after the crisis period. So that the growth observed in these three countries could be demonstrated, current paper is divided into three sections. The first section will deal with the emerging trends in global trade. Section two will examine emerging trends in Brazil, India, and China's foreign trade. The third section will examine the characteristics of the concept of 'new regionalism' and the role of WTO in accelerating the rate of growth in world trade for the coming years. Revised bibliography and descriptive statistics will be the methodology employed. [ABSTRACT FROM AUTHOR]

This paper presents international co-inventor networks as both a predictor variable of countries' ability to produce and disseminate internationally green inventions, and an alternative mechanism to support development of relevant programmes and policies in that regard. It includes cases from three developing countries with limited resources for clean technology development, Brazil, India and South Africa, which have shown successes owing to the potentials of co-inventor networks. It contributes the extent literature on this topic, which predominantly emphasizes firms' responses to conventional governments' interventions (subsidies, market price, standards, and interagency cooperation) to achieve cleaner production plans and particularly the Targets 17.6; 17.7 and 17.8 of the sustainable development goals. Broadly, such targets aim at enhancing countries' technological capabilities through partnership. The paper finds various correlations between co-inventor networks and growth of patents in solar energy, air pollution management and biofuels in the sample countries. Correlations are linear in India, followed by Brazil owing to the larger sizes of co-inventor networks but nonlinear in South Africa, which has smaller networks. The paper argues that co-inventor networks accelerate transnational exchanges of core human capital, and are fitting predictors of production and flows of green inventions. They are worth adopting in national and transnational industrial and innovation cluster policies globally to support sustainable production plans. [ABSTRACT FROM AUTHOR]

The research into bioactive natural products originating from medicinal plants, fungi and other organisms has a long history, accumulating abundant and diverse publications. However no quantitative literature analysis has been conducted so far. Here we analyze the bibliometric data of ethnopharmacology literature and relate the semantic content to the publication and citation data so that the major research themes, contributors, and journals of different time periods could be identified and evaluated. Web of Science (WoS) was searched to identify relevant publications. The Analyze function of WoS and bibliometric software (VOSviewer) were utilized to perform the analyses. Until the end of November 2018, 59,576 publications -linked to 'ethnopharmacology' indexed by WoS, published since 1958 in more than 5600 journals, and contributed by over 20,600 institutions located in more than 200 countries/regions, were identified. The papers were published under four dominating WoS categories, namely pharmacology/pharmacy (34.4%), plant sciences (28.6%), medicinal chemistry (25.3%), and integrative complementary medicine (20.6%). India (14.6%) and China (13.2%) were dominating the publication space. The United States and Brazil also had more than 8.0% contribution each. The rest of the top ten countries/regions were mainly from Asia. There were around ten-fold more original articles (84.6%) than reviews (8.4%). Ethnopharmacological research has a consistent focus on food and plant sciences, (bio)chemistry, complementary medicine and pharmacology, with a more limited scientific acceptance in the socio-cultural sciences. Dynamic global contributions have been shifting from developed countries to economically and scientifically emerging countries in Asia, South America and the Middle East. Research on recording medicinal plant species used by traditional medicine continues, but the evaluation of specific properties or treatment effects of extracts and compounds has increased enormously. Moreover increasing attention is paid to some widely distributed natural products, such as curcumin, quercetin, and rutin. Image 1 [ABSTRACT FROM AUTHOR]