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BACKGROUND: Abnormal lung volumes representing air trapping identify the subset of smokers with preserved spirometry who develop spirometric chronic obstructive pulmonary disease (COPD) and adverse outcomes. However, how lung volumes evolve in early COPD as airflow obstruction develops remains unclear. METHODS: To establish how lung volumes change with the development of spirometric COPD, we examined lung volumes from the pulmonary function data (seated posture) available in the U.S. Department of Veterans Affairs electronic health records (n=71,356) and lung volumes measured by computed tomography (supine posture) available from the COPD Genetic Epidemiology (COPDGene®) study (n=7969) and the SubPopulations and InterMediate Outcome Measures In COPD Study (SPIROMICS) (n=2552) cohorts, and studied their cross-sectional distributions and longitudinal changes across the airflow obstruction spectrum. Patients with preserved ratio-impaired spirometry (PRISm) were excluded from this analysis. RESULTS: Lung volumes from all 3 cohorts showed similar patterns of distributions and longitudinal changes with worsening airflow obstruction. The distributions for total lung capacity (TLC), vital capacity (VC), and inspiratory capacity (IC) and their patterns of change were nonlinear and included different phases. When stratified by airflow obstruction using Global initiative for chronic Obstructive Lung Disease (GOLD) stages, patients with GOLD 1 (mild) COPD had larger lung volumes (TLC, VC, IC) compared to patients with GOLD 0 (smokers with preserved spirometry) or GOLD 2 (moderate) disease. In longitudinal follow-up of baseline GOLD 0 patients who progressed to spirometric COPD, those with an initially higher TLC and VC developed mild obstruction (GOLD 1) while those with an initially lower TLC and VC developed moderate obstruction (GOLD 2). CONCLUSIONS: In COPD, TLC, and VC have biphasic distributions, change in nonlinear fashions as obstruction worsens, and could differentiate those GOLD 0 patients at risk for more rapid spirometric disease progression.

Rationale: United States veterans represent an important population to study sarcoidosis. Their unique history of environmental exposures, wide geographic distribution, and long-term enrollment in a single integrated healthcare system provides an unparalleled opportunity to understand the incidence, prevalence, and risk factors for sarcoidosis. Objectives: To determine the epidemiology, patient characteristics, geographic distribution, and associated risk factors of sarcoidosis among U.S. veterans. Methods: We used data from the Veterans Health Administration (VHA) electronic health record system between 2003 and 2019 to evaluate the annual incidence, prevalence, and geographic distribution of sarcoidosis (defined using the International Classification of Diseases codes). We used multivariate logistic regression to examine patient characteristics associated with sarcoidosis incidence. Results: Among more than 13 million veterans who received care through or paid for by the VHA, 23,747 (0.20%) incident diagnoses of sarcoidosis were identified. Compared with selected VHA control subjects using propensity score matching, veterans with sarcoidosis were more likely to be female (13.5% vs. 9.0%), of Black race (52.2% vs. 17.0%), and ever-tobacco users (74.2% vs. 64.5%). There was an increase in the annual incidence of sarcoidosis between 2004 and 2019 (from 38 to 52 cases/100,000 person-years) and the annual prevalence between 2003 and 2019 (from 79 to 141 cases/100,000 persons). In a multivariate logistic regression model, Black race (odds ratio [OR], 4.49; 95% confidence interval [CI], 4.33-4.65), female sex (OR, 1.64; 95% CI, 1.56-1.73), living in the Northeast compared with the western region (OR, 1.57; 95% CI, 1.48-1.67), history of tobacco use (OR, 1.36; 95% CI, 1.31-1.41), and serving in the Army, Air Force, or multiple branches compared with the Navy (OR, 1.08; 95% CI, 1.03-1.13; OR, 1.10; 95% CI, 1.04-1.17; OR, 1.27; 95% CI, 1.16-1.39, respectively) were significantly associated with incident sarcoidosis (P

In this paper, we collect the basic information data of online rumors and highly topical public opinions. In the research of the propagation model of online public opinion rumors, we use the improved SCIR model to analyze the characteristics of online rumor propagation under the suspicion mechanism at different propagation stages, based on considering the flow of rumor propagation. We analyze the stability of the evolution of rumor propagation by using the time-delay differential equation under the punishment mechanism. In this paper, the evolution of heterogeneous views with different acceptance and exchange thresholds is studied, using the standard Deffuant model and the improved model under the influence of the media, to analyze the evolution process and characteristics of rumor opinions. Based on the above results, it is found that improving the recovery rate is better than reducing the deception rate, and increasing the eviction rate is better than improving the detection rate. When the time lag τ < 110, it indicates that the spread of rumors tends to be asymptotic and stable, and the punishment mechanism can reduce the propagation time and the maximum proportion of deceived people. The proportion of deceived people increases with the decrease in the exchange threshold, and the range of opinion clusters increases with the decline in acceptance. [ABSTRACT FROM AUTHOR]

The natural wind velocities in tunnels under different natural conditions are distinct, and the longitudinal ventilation velocity significantly impacts the evacuation environment. This paper examines the evacuation conditions and strategies under varying wind velocities in bifurcated tunnels. Using Fire Dynamics Simulator (FDS) and Pathfinder software, the fire development and evacuation of three distinct longitudinal positions in a bifurcated tunnel are simulated. The simulation results demonstrate that the evacuation conditions for disparate fire sources at varying wind velocities are markedly disparate. In consideration of the construction cost and the maximization of evacuation capacity, the width of the evacuation doors at the three locations should be set to 2 m, 1.5 m, and 1.5 m, respectively. Furthermore, an analysis of the safety of individual personnel through Fractional Effective Dose (FED) revealed that directing evacuees towards the upstream of the fire after the fire is detected can significantly reduce individual personnel injuries while ensuring the overall success of the evacuation. [ABSTRACT FROM AUTHOR]

This integrated, multiplatform PanCancer Atlas study co-mapped and identified distinguishing molecular features of squamous cell carcinomas (SCCs) from five sites associated with smoking and/or human papillomavirus (HPV). SCCs harbor 3q, 5p, and other recurrent chromosomal copy-number alterations (CNAs), DNA mutations, and/or aberrant methylation of genes and microRNAs, which are correlated with the expression of multi-gene programs linked to squamous cell stemness, epithelial-to-mesenchymal differentiation, growth, genomic integrity, oxidative damage, death, and inflammation. Low-CNA SCCs tended to be HPV(+) and display hypermethylation with repression of TET1 demethylase and FANCF, previously linked to predisposition to SCC, or harbor mutations affecting CASP8, RAS-MAPK pathways, chromatin modifiers, and immunoregulatory molecules. We uncovered hypomethylation of the alternative promoter that drives expression of the ΔNp63 oncogene and embedded miR944. Co-expression of immune checkpoint, T-regulatory, and Myeloid suppressor cells signatures may explain reduced efficacy of immune therapy. These findings support possibilities for molecular classification and therapeutic approaches.

The wet flue gas desulfurization (WFGD) system is widely used in coal-fired power plants worldwide. Improving its efficiency is very important for economical running. In this study, SO2 removal by the spray scrubber by adding a new sieve tray was studied and compared to that by the traditional spray scrubber without a sieve tray (the WFGD system). The effects of gas flow rate, liquid flow rate, inlet SO2 concentration, and pH value on both types of scrubbers were evaluated. Pore diameter and porosity of the sieve tray in the sieve-tray spray scrubber were determined, and its enhanced efficiency under different experimental conditions was calculated. The results showed that the enhanced efficiency increased with the increasing liquid flow rate, gas flow rate under the same liquid/gas ratio (L/G), and pH value. Compared to the spray scrubber without a sieve tray, the sieve-tray spray scrubber had significantly higher efficiency. The enhanced efficiencies were mostly between 20% and 60% in the experimental range.