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Background: Although the COVID-19 outbreak occurred in December 2019, when cases of the unknown disease were made public, for the next 2020, an ongoing pandemic was the cause of one of the biggest public health crises. The purpose of this article is to review current and approved pharmacological treatments and highlight the potential ototoxic side-effects. Methods: Review of the available literature in the scientific databases: PubMed, ResearchGate, Scopus, and ScienceDirect. Results: Treatment with new therapeutic unit often begins with its use outside the primary indication the so-called off-label. Adverse events may be permanent or disappear over time. Ototoxicity and audiological side effects can directly cause hearing damage or vestibulocochlear disturbances, as well as be an indirect effect. Conclusions: The most frequently adverse reactions reported in clinical trials after pharmacotherapy of COVID-19 in the area of audiology and otorhinolaryngology were: dizziness, blurry vision with dizziness, nasopharyngitis, dysgeusia, tinnitus. As far as vaccines are considered, dizziness as an ototoxic effect may occur only in hypersensitive people as apart of anaphylactic shock and as adverse re action with uncommon frequency. In 2021 there were no report about new, different adverse reaction in the field of audiology and otorhinolaryngology. The presented methods of audiological tests allow for very quick determination of drug ototoxicity and can be used in the diagnosis of patients. [ABSTRACT FROM AUTHOR]