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This paper is a preliminary study that aims to analyze the Covid-19 pandemic in the Amazonian border between Brazil and Colombia, more specifically in the twin cities of Tabatinga and Leticia. To this end, it seeks to identify the main decrees issued by the public authorities, both municipal, state and national, and verify their impact on the circulation of people and air traffic and the results in the number of those infected and killed by this disease. The results show that Tabatinga and Letícia show considerable growth in the number of infected by Covid-19. It is concluded that the integration of these spaces with other regional centers made possible by the air and river transport network ended up contributing to the entry of the new Coronavirus, confirming the insertion of these cities in the globalization process. [ABSTRACT FROM AUTHOR]