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Objective To discuss the nursing strategy of dynamic navigation technology in the treatment of edentulous implantation with immediate restoration. Methods Totally 42 patients with edentulous jaws treated in First Clinical Division, Peking University School and Hospital of Stomatology from January 2019 to May 2023 were analyzed retrospectively. All the patients were treated with implant-supported immediate restoration of edentulous jaws under dynamic navigation. Nursing care experience was analyzed. Results Through preoperative design and dynamic navigation-assisted surgery, all the patients achieved successful immediate restoration with accurate location of implants and no complication. All the implant were placed at the correct position and achieved good initial stability. Immediate fixation and repair were completed, with a complication rate of 1. 59% at 6 months after surgery. Conclusion Dynamic navigation-assisted edentulous implantation requires nursing staff to get a good knowledge of related theories, appliance installment and software operation. Effective nursing plays important role in the treatment of dynamic navigation-assisted edentulous implantation. (回顾性分析基于以即刻修复为目标的动态导航下无牙颌种植手术的护理配合要点。方法 收集2019年1月—2023年5月收治的在动态导航系统引导下完成无牙颌种植手术伴即刻固定修复的42例患者的临床资料, 分析动态导航技术的应用情况及护理配合特点。结果 42例患者经过术前设计、术中导航均实现精确的种植体植入, 种植体就位率达100%, 并获得良好的初期稳定性, 完成即刻固定修复, 术后6个月并发症发生率为1. 59%。结论 动态导航辅助下的无牙颌种植手术需要护理人员熟练掌握动态导航理论知识、导航器械的安装使用及软件操作等相关技能, 做好充足的术前准备以及默契的术中护理配合, 以确保手术顺利完成。)

Our study evaluates the effects of sacubitril/valsartan (SAC/VAL) in the rabbit model of doxorubicin-induced heart failure. Twenty rabbits (5 per group) were administered with doxorubicin (DOX, 1.5 mg kg−1, i.v.) to induce heart failure. Specific biomarkers such as BNP, CnT, CRP and ROMs were determined. The cardiac enzymatic anti-oxidant systems were recorded with their electrographic profiles. HR, SBP, DBP and MAP were restored at 5 or 10 mg kg−1 (p.o.) of SAC/VAL compared to DOX, followed by reduced levels of creatinine and BNP (p < 0.001). Significant improvements (p < 0.05) compared to DOX were also noticed in CAT, SOD and LPO with the same doses of SAC/VAL. Specific biomarkers such as BNP, CnT, CRP and ROMs descended significantly (p < 0.001) with treatment when compared to their baseline values. Our findings implied that SAC/VAL treatment reduced the inflammation and oxidative stress to improve the cardiac function.

This paper proposes a modeling and analysis method for a Caputo–Fabrizio (C-F) definition-based fractional-order Boost converter with fractional-order inductive loads. The proposed method analyzes the system characteristics of a fractional-order circuit with three state variables. Firstly, this paper constructs a large signal model of a fractional-order Boost converter by taking advantage of the state space averaging method, providing accurate analytical solutions for the quiescent operating point and the ripple parameters of the circuit with three state variables. Secondly, this paper constructs a small signal model of the C-F definition-based fractional-order Boost converter by small signal linearization, providing the transfer function of the fractional-order system with three state variables. Finally, this paper conducts circuit-oriented simulation experiments where the steady-state parameters and the transfer function of the circuit are obtained, and then the effect of the order of capacitor, induced inductor, and load inductor on the quiescent operating point and ripple parameters is analyzed. The experimental results show that the simulation results are consistent with those obtained by the proposed mathematical model and that the three fractional orders in the fractional model with three state variables have a significant impact on the DC component and steady-state characteristics of the fractional-order Boost converter. In conclusion, the proposed mathematical model can more comprehensively analyze the system characteristics of the C-F definition-based fractional-order Boost converter with fractional-order inductive loads, benefiting the circuit design of Boost converters. [ABSTRACT FROM AUTHOR]

The rumen is divided into multiple rumen sacs based on anatomical structure, and each has its unique physiological environment. Tarim wapiti preserved roughage tolerance after domestication, and adaptation to the desertified environment led to the development of a unique rumen shape and intraruminal environment. In this work, six Tarim wapiti were chosen and tested for fermentation parameters, microbes, and histomorphology in four rumen areas (Dorsal sac, DS; Ventral sac, VS; Caudodorsal blind sac, CDBS; Caudoventral blind sac, CVBS). Tarim wapiti's rumen blind sac had better developed rumen histomorphology, the ventral sac was richer in VFAs, and the dominant bacteria varied most notably in the phylum Firmicutes, which was enriched in the caudoventral blind sac. The ventral sac biomarkers focused on carbohydrate fermentation-associated bacteria, the dorsal sac focused on N recycling, and the caudoventral blind sac identified the only phylum-level bacterium, Firmicutes; we were surprised to find a probiotic bacterium, Bacillus clausii, identified as a biomarker in the ventral sac. This research provides a better understanding of rumen fermentation parameters, microorganisms, and histomorphology in the Tarim wapiti rumen within a unique ecological habitat, laying the groundwork for future regulation targeting the rumen microbiota and subsequent animal production improvement. [ABSTRACT FROM AUTHOR]

The stepped shaft of ball screw was breakaway after loading test of transmission mechanism. To solve this problem,analysis and calculations were carried out from higher hardness,material defect,machining process and experimental loading. The results show that electro discharge machining（ EDM） causes tensile stress and microcosmic cracks on the surface microstructure. Meanwhile,thread corrosion of stepped shaft reduces the loaded area. As a result,torsional fracture of the stepped shaft happened. According to the result,improvement measures including process criterion of EDM control,grinding and polishing are proposed.

To investigate the tolerability and safety of two sublingual tree pollen extracts approved in 2018, a non-interventional study (NIS) was performed. This NIS was an 8-month observational study conducted at 84 sites throughout Germany. Study participants received either a sublingual liquid allergen extract of birch pollen (SBPE) or a liquid allergen extract consisting of a mixture of birch, hazel, and alder tree pollen (STPE). Data from 432 patients were analyzed for the occurrence of adverse events and patient compliance. At least one local reaction occurred in 69 (22.2%) patients, whereas systemic reactions were only observed in 27 (6.3%) patients. STPE-treated patients developed systemic reactions more frequently than SBPE-treated patients (SBPE: 9 (4.3%) vs. STPE: 18 (8.0%)). Only one patient developed a systemic grade III reaction. Severe systemic grade IV reactions were not observed. A total of 348 (98.6%) of the patients who completed all visits were satisfied or very satisfied with the sublingual immunotherapy (SLIT), and 322 (71%) patients completed all visits. Both investigated products were well tolerated by the patients and demonstrated a good safety profile. AEs were observed less frequently than in the preceding clinical phase III trial, and no new safety concerns were identified. [ABSTRACT FROM AUTHOR]

Bacterial endophthalmitis (BE) is an acute eye infection and potentially irreversible blinding ocular disease. The empirical intravitreous injection of antibiotic is the primary treatment once diagnosed as BE. However, the overuse of antibiotic contributes to the drug resistance of pathogens and the retinal toxicity of antibiotic limits its application in clinic. Herein, a cationic aggregation‐induced emission luminogens named with triphenylamine thiophen pyridinium (TTPy) is reported for photodynamic treatment of BE. TTPy can selectively discriminate and kill bacteria efficiently over normal ocular cells. More importantly, TTPy shows excellent antibacterial ability in BE rat models infected by Staphylococcus aureus. Meanwhile, the bacterial killing behavior triggered by TTPy induces innate immune response at an early stage of infection, limiting subsequent robust inflammation and protecting retina from bacterial toxins and inflammation‐induced bystander damage. In addition, TTPy performs better antibacterial ability than commercially used Rose Bengal, suggesting its excellent capability of vision salvage in acute BE. This study exhibits an efficient photodynamic antibacterial treatment to BE, which induces an early intraocular immune response and saves useful vision, endowing TTPy a promising potential for clinical application of ocular infections. [ABSTRACT FROM AUTHOR]

Age-related macular degeneration (AMD) is a multifactor disease, which is primarily characterized by retinal pigment epithelium (RPE) cell loss. Since the retina is the most metabolically active tissue, RPE cells are exposed to consistent oxidative environment. So, oxidation-induced RPE cell death has long been considered a contributor to the onset of AMD. Here, we applied a retinal degeneration (RD) rat model induced by blue light-emitting diode (LED) and a cell model constructed by H2O2 stimulus to mimic the prooxidant environment of the retina. We detected that the expression of miR-27a was upregulated and the expression of FOXO1 was downregulated in both models. So, we furtherly investigated the role of miR-27a-FOXO1 axis in RPE in protesting against oxidants. Lentivirus-mediated RNA was injected intravitreally into rats to modulate the miR-27a-FOXO1 axis. Retinal function and histopathological changes were evaluated by electroretinography (ERG) analysis and hematoxylin and eosin (H&E) staining, respectively. Massive photoreceptor and RPE cell death were examined by terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL). The damage to the retina was aggravated in the FOXO1 gene-knockdown and miR-27a-overexpression groups after exposure to LED but was alleviated in the FOXO1 gene-overexpression or miR-27a-knockdown groups. Dual luciferase assay was used to detect the binding site of miR-27a and FOXO1. Upregulated miR-27a inhibited the expression of FOXO1 by directly binding to the FOXO1 mRNA 3 ′ UTR and decreased the autophagy activity of ARPE-19 cells, resulting in the accumulation of reactive oxygen species (ROS) and decrease of cell viability. The results suggest that miR-27a is a negative regulator of FOXO1. Also, our data emphasize the prominent role of miR-27a/FOXO1 axis in modulating ROS accumulation and cell death in RPE cell model under oxidative stress and influencing the retinal function in the LED-induced RD rat model. [ABSTRACT FROM AUTHOR]

Purpose. The purpose of this meta-analysis was to assess the percent reduction in the intraocular pressure (IOP) after argon laser peripheral iridoplasty (ALPI) and systemic medical therapy in patients with acute primary angle closure (APAC). Methods. We searched a number of electronic databases, including MEDLINE, EMBASE, PubMed, and Cochrane Library. We searched the electronic databases from the inception of the databases to August 2018. The primary outcomes included the IOP reduction (IOPR), percent reduction in IOP (IOPR%) from baseline to the endpoint and peripheral anterior synechiae (PAS). The secondary outcomes included the cup-to-disc ratio (CDR), mean endothelial count, and percent of patients requiring topical glaucoma medication. Summary weighted mean difference (WMD), odds ratio (OR), and 95% confidence intervals (CIs) were calculated. Results. Four eligible studies including 183 eyes (92 in the ALPI group and 91 in the medical therapy group) were identified. When comparing ALPI to medical therapy, the WMDs of the IOPR% were 30.03 (95% CI: 21.33 to 38.72, p<0.00001) at 15 minutes, 27.39 (95% CI: 18.89 to 35.89, p<0.00001) at 30 minutes, 18.15 (95% CI: 10.63 to 25.68, p<0.00001) at 1 hour, and 12.91 (95% CI: 4.50 to 21.32, p=0.003) at 2 hours. There was no statistically significant difference between the two groups at 24 hours and at more than 6 months after therapy. Meanwhile, no significant difference was observed in the degree of PAS, CDR, mean endothelial count, and percent of patients requiring topical glaucoma medication after treatment between the two groups. Conclusions. Both ALPI and systemic medications were effective with regard to decreasing the IOP. ALPI was more effective in lowering the IOP within the first two hours. Therefore, ALPI may be a better choice for rapidly lowering the IOP in patients with APAC within a short period. [ABSTRACT FROM AUTHOR]

Background: Nasopharynx carcinoma (NPC) is the most common malignant tumor of the nasopharynx. Many studies have shown some factors related with the prognosis of NPC patients. Our study aims to evaluate the differences of prognosis between initial and second primary NPC., Material and Methods: The Surveillance, Epidemiology, and End Results (SEER) program was used to perform the population-based analysis in NPC patients who were newly diagnosed between 2004 and 2015. Kaplan-Meier and Cox regressions were used to evaluate the effects of primary site on the overall survival (OS), as well as the cancer-specific survival (CSS)., Results: Our study included 5,012 NPC patients: 4,474 initial primary NPC patients and 5,38 s primary NPC patients. Significant differences were observed in sex, age at diagnosis, race, median household income, histological type, American Joint Committee on Cancer (AJCC) stage, N-stage, radiation treatment and chemotherapy between patients with initial and second NPC ( P  < 0.05). Moreover, the patients with second NPC had longer survival months. In addition, radiation and chemotherapy were recommended both in first and second primary NPC patients., Conclusion: Worse prognosis was observed in patients with second primary NPC compared with those with primary NPC in all subgroups of AJCC stage and age at diagnosis., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (© 2022 Shen, Cai, Li, Yu, Ren and Yu.)

Our study evaluates the effects of sacubitril/valsartan (SAC/VAL) in the rabbit model of doxorubicin-induced heart failure. Twenty rabbits (5 per group) were administered with doxorubicin (DOX, 1.5 mg kg -1 , i.v. ) to induce heart failure. Specific biomarkers such as BNP, CnT, CRP and ROMs were determined. The cardiac enzymatic anti-oxidant systems were recorded with their electrographic profiles. HR, SBP, DBP and MAP were restored at 5 or 10 mg kg -1 ( p.o .) of SAC/VAL compared to DOX, followed by reduced levels of creatinine and BNP ( p < 0.001). Significant improvements ( p < 0.05) compared to DOX were also noticed in CAT, SOD and LPO with the same doses of SAC/VAL. Specific biomarkers such as BNP, CnT, CRP and ROMs descended significantly ( p < 0.001) with treatment when compared to their baseline values. Our findings implied that SAC/VAL treatment reduced the inflammation and oxidative stress to improve the cardiac function., (© 2021 Chun Yu et al., published by Sciendo.)

The microstructural evolution and underlying mechanism of a new high strength, high toughness near β titanium alloy, β20C, during hot deformation, and heat treatment were studied qualitatively and quantitatively. It was found that dynamic recovery occurs mainly in β phase, while α phase undergoes both a dynamic recovery and continuous incomplete dynamic recrystallization with a fraction of high-angle grain boundaries (≥15°) of 21.1% under hot-rolling. Subsequently, α phase undergoes static recrystallization with an increasing fraction of high-angle grain boundaries (21.1%→60.7%) under annealing, while the grains are equiaxed with refined grain sizes of 1.63 µm observed from the rolling direction (RD) and 1.66 µm observed from the transverse direction (TD). Moreover, the average aspect ratio of the lamellar α phase was 2.44 observed from the RD and 3.12 observed from the TD after hot rolling, but decreased to 2.20 observed from the RD, and 2.53 observed from the TD after annealing. Furthermore, the strict Burgers' relationship between α and β phases changed after hot-rolling and remains the distortion, even after the static recrystallization process of α phase during annealing., Competing Interests: The authors declare no conflict of interest.