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Both vitamin K antagonists (VKAs) and novel oral anticoagulants (NOACs) are effective for stroke prevention in nonvalvular atrial fibrillation (NVAF) patients. This study evaluated the utilization of VKA and NOACs in NVAF patients before and after catheter ablation in China. Prescription data were retrospectively collected between January 1, 2016, and December 31, 2016, including indication of use, dose, renal function, and risk assessment (CHA2DS2-VASc score and HAS-BLED score) in Zhongshan Hospital of Fudan University. Trends and factors associated with anticoagulants use before and after ablation were evaluated. A total of 475 patients with NVAF who received ablation were included in the analysis. Of all, 53.26% of them received antithrombotic therapy preablation. Warfarin was prescribed in 35.26%, with NOACs in 11.37%. Four hundred seventy-three patients received antithrombotic therapy (99.58%) postablation, 236 patients with NOACs (49.68%). CHA2DS2-VASc score, HAS-BLED score, hypertension, diabetes mellitus, and alcohol were independently associated with anticoagulant utilization before catheter ablation. The higher CHA2DS2-VASc score was associated with less frequent prescription of NOACs postablation. The preablation anticoagulation use was still inadequate in China, and CHA2DS2-VASc score was a significant factor influencing the preablation anticoagulant utilization. The utilization rate of NOACs increased significantly postablation, especially for dabigatran, which implied that more physicians prefer to prescribe NOACs for NVAF patients after ablation in our country and may be attributed to the aspects such as ease of NOAC use but also possibly the greater safety and efficacy. Furthermore, the physicians may reluctant to use NOACs for high stroke risk atrial fibrillation patients after catheter ablation. [ABSTRACT FROM AUTHOR]

Background: In China mainland, most Mycoplasma pneumoniae related studies are carried out in Beijing and Shanghai, while rare studies are performed in the other regions. In this study, we analyzed the molecular biology characteristics and antimicrobial susceptibility of clinical isolates of M. pneumoniae from 5 regions between January 2017 and December 2018. Methods: Genotyping was performed to 154 M. pneumoniae isolates from 5 cities using PCR and multiple-locus variable-number tandem repeat analysis (MLVA) method. Antimicrobial susceptibility test was performed to all the isolates against 4 antibiotics. Sequencing was performed to the amplification products of the 23S rRNA drug resistant gene. Results: Genotype I was detected in 118 M. pneumoniae isolates (76.6%), and genotype II was identified in 36 isolates (23.4%). The majority (92.2%) of the MLVA genotypes were 4–5–7-2 and 3–5–6-2, which represented the genotype I and II, respectively. The total macrolide (ML) resistance rate was 79.7%. The minimum inhibitory concentration (MIC) of the erythromycin was in a range of 128- > 256 μg/ml, while that for the azithromycin was 2-32 μg/ml. There were mutations in the 23S rRNA in each ML resistance isolate. Jilin city showed the highest prevalence of genotype I (100%) and ML resistance rate (100%), while Jinan showed the lowest prevalence of genotype I (45.5%) and ML resistance rate (54.5%). Conclusions: A large variance was identified in the M. pneumoniae genotype and ML resistance among the 5 cities. The proportion of M. pneumoniae with a genotype II genotype (3–5–6-2) showed an increased trend. [ABSTRACT FROM AUTHOR]

Using energy conservation measures (ECMs) for building retrofit can significantly reduce building operational carbon emissions (BOCEs) and contribute to Chinese carbon neutrality by 2060. This paper involves 11 feasible ECMs for commercial buildings in hot-summer and cold-winter zone, China, and proposes a quick assessment approach to BOCEs reduction. Prototypical models are simulated for ECMs using EnergyPlus and the emission intensity is corrected by the building shape factor and window-to-wall ratio. Based on pre-simulated results, effects on reducing emissions of individual measures and packages of them are studied to develop regression models in SPSS. The results show that decreasing the U-factor of external walls, lighting power density (LPD), or shading coefficient can reduce BOCEs linearly. BOCEs are most sensitive to LPD and using daylighting control can reduce emissions by 5–15%. In addition, increasing the boilers' efficiency reduces emissions linearly, while performance improvement of chillers or heat pumps reduces emissions logarithmically. Furthermore, utilizing variable speed pumps, heat recovery ventilation, and air-side economizers can reduce emissions by 3.8%, 6.6%, and 15.2%, respectively. Finally, significant interactions exist among measures of enhancing glazing U-factor, adding external shading, using energy-saving lamps, and improving cooling/heating system efficiencies. The developed regression models are validated in a retrofit case in Shanghai. Through assessment, the case can reduce BOCEs by 15.9 kgCO 2 /m2, with a reduction rate of 20.8%. Compared with recorded data, the relative error of assessing emission reduction is −13.0% and that of assessing reduction rate is 0.5%, which are acceptable in the decision-making stage of retrofit strategies. [ABSTRACT FROM AUTHOR]