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This study focuses on online supervisory written feedback on PhD supervisees' performance, given explicitly through online communication, particularly during the first wave of COVID-19. This unusual situation has brought many different effects on students' academic lives. This scenario has influenced both students' and teachers' mutual communication. A directed qualitative content analysis (DQCA) approach was adapted from previous research and modified for the present context. The current study planned to bring forth the supervisee and supervisors' perception of the communication and feedback process, considering that online feedback and communication has been a new experience for most students. According to the findings, teachers/supervisors give feedback on students' production, whereas teacher-student communication also seemed crucial for the performance improvising of learners. The result brought forth a wide range of social, educational, and surprisingly psychological issues both supervisees and supervisors faced during online communication during COVID-19.

This study investigates the validity of syntactic priming as a measure of implicit language aptitude. Syntactic priming refers to the tendency to reproduce a linguistic structure due to a previous exposure to the structure. The validity of the construct was verified by collating evidence for divergent validity--whether it is dissociable from explicit aptitude; convergent validity--whether it is correlated with other measures of implicit aptitude; and predictive validity--whether it is predictive of learning attainment. One hundred sixty-six university EFL learners completed three tests of implicit aptitude: syntactic priming, sequence learning, and LLAMA_D; three tests of explicit aptitude: LLAMA_B, _E, and _F; and three tests of L2 proficiency: untimed grammaticality judgment, metalinguistic knowledge, and elicited imitation. The results showed that syntactic priming was dissociable from explicit aptitude, but it failed to converge with the other measures of implicit aptitude, and it also failed to predict L2 proficiency. The results also showed that priming was negatively correlated with sequence learning and that sequence learning was a negative predictor of learners' metalinguistic knowledge. On the other hand, the construct validity of explicit aptitude was strong. The results suggest the multidimensionality of implicit aptitude and the need for more research into the construct validity of syntactic priming as a cognitive ability for implicit learning.

Capmatinib is a potent selective mesenchymal-epithelial transition inhibitor approved in 2020 for the treatment of metastatic non-small cell lung cancer. As real-world evidence is very limited, this study evaluated capmatinib-induced adverse events through data mining of the FDA Adverse Event Reporting System database. Four disproportionality analysis methods were employed to quantify the signals of capmatinib-related adverse events. The difference in capmatinib-associated adverse event signals was further investigated with respect to sex, age, weight, dose, onset time, continent, and concomitant drug. A total of 1518 reports and 4278 adverse events induced by capmatinib were identified. New significant adverse event signals emerged, such as dysphagia, dehydration, deafness, vocal cord paralysis, muscle disorder, and oesophageal stenosis. Notably, higher risk of alanine aminotransferase and aspartate aminotransferase increases were observed in females, especially when capmatinib was combined with immune checkpoint inhibitors. Compared with Europeans and Asians, Americans were more likely to experience peripheral swelling, especially in people > 65 years of age. Renal impairment and increased blood creatinine were more likely to occur with single doses above 400 mg and in Asians. This study improves the understanding of safety profile of capmatinib. [ABSTRACT FROM AUTHOR]

Pitolisant, a novel histamine H3‐receptor antagonist, holds significant promise for treating narcolepsy. However, a petition, which highlighted that pitolisant was associated with deaths during clinical trials, has propelled it into the spotlight of widespread societal attention on April 3, 2023. Till now, the clinical safety of pitolisant remains a heatedly debated topic. This study aimed to offer a comprehensive assessment of the safety profile of pitolisant in real‐world clinical settings. Adverse event reports where pitolisant was the primary suspect drug were extracted from the FDA Adverse Event Reporting System database. The clinical characteristics and concomitant drugs of the pitolisant‐associated adverse events were analyzed. The potential adverse event signals of pitolisant were explored using four disproportionality analysis methods. Furthermore, the difference in pitolisant‐associated adverse event signals was investigated concerning sex, age, weight, and dose. A total of 526 reports and 1695 adverse events with pitolisant as the primary suspected drug were identified. The most significant adverse event signals were generally mild and of short duration. The concomitant drugs of pitolisant were highly intricate, mainly included drugs for treating narcolepsy as well as antidepressants. Seven new significant adverse event signals emerged. The safety profile of pitolisant exhibited no significant differences across age and dose groups, although slight variations were observed in relation to sex and weight. The findings from reports of death and life‐threatening outcomes underscore the importance of enhanced monitoring for cardiac and respiratory adverse reactions when utilizing pitolisant. This study provided a broader understanding of the safety profile of pitolisant. [ABSTRACT FROM AUTHOR]

This study investigates the validity of syntactic priming as a measure of implicit language aptitude. Syntactic priming refers to the tendency to reproduce a linguistic structure due to a previous exposure to the structure. The validity of the construct was verified by collating evidence for divergent validity—whether it is dissociable from explicit aptitude; convergent validity—whether it is correlated with other measures of implicit aptitude; and predictive validity—whether it is predictive of learning attainment. One hundred sixty-six university EFL learners completed three tests of implicit aptitude: syntactic priming, sequence learning, and LLAMA_D; three tests of explicit aptitude: LLAMA_B, _E, and _F; and three tests of L2 proficiency: untimed grammaticality judgment, metalinguistic knowledge, and elicited imitation. The results showed that syntactic priming was dissociable from explicit aptitude, but it failed to converge with the other measures of implicit aptitude, and it also failed to predict L2 proficiency. The results also showed that priming was negatively correlated with sequence learning and that sequence learning was a negative predictor of learners' metalinguistic knowledge. On the other hand, the construct validity of explicit aptitude was strong. The results suggest the multidimensionality of implicit aptitude and the need for more research into the construct validity of syntactic priming as a cognitive ability for implicit learning. [ABSTRACT FROM AUTHOR]

Background: Cefuroxime has played a crucial role in the prevention and treatment of bacterial infections. However, the differences in adverse events across formulations and routes remain unclear., Objectives: This study aimed to investigate the post-marketing safety of cefuroxime, particularly concerning formulations and routes., Design: A retrospective pharmacovigilance study of cefuroxime was conducted using the data from Food and Drug Administration Adverse Event Reporting System database., Methods: The clinical characteristics and concomitant drugs reported with cefuroxime were investigated. Adverse event signals of cefuroxime were identified based on four disproportionality algorithms. The signal differences of cefuroxime across formulations and routes were further examined., Results: A total of 1810 adverse event reports associated with cefuroxime were identified, and 181 cefuroxime-associated signals were detected. Compared with tablets, injections were more likely to cause preferred terms 'blood pressure decreased' and 'anaphylactic shock'. In addition, system organ class 'eye disorders' significantly increased when cefuroxime was administered intraocularly, underscoring the importance of exercising caution regarding ocular toxicity., Conclusion: The adverse events associated with cefuroxime were significantly different across formulations and routes, which deserve special attention in clinical use., (© The Author(s), 2024.)

Psychologically complicated by nature, anxiety refers to feelings of worry, fear, or apprehension. Several research studies have been devoted to exploring anxiety's effects on language skills, including writing. Since foreign language anxiety directly influences a learner's motivation and determination to learn that language, it is imperative to study the findings and reasons behind these anxious feelings. One-third of foreign language learners have been experiencing at least a moderate level of anxiety. Researchers have attempted to investigate the causes of anxiety among foreign language pre-service teachers. The present study objectifies two goals to determine the extent of writing anxiety, followed by reasons and references to the role of gender. Seventy-two pre-service teachers of the English language training department from the University of Education, Multan, Pakistan, were selected for the study using convenience sampling. Second language writing anxiety inventory (SLWAI) and second language writing anxiety reasons inventory (SLWARI) were used to collect data, and semi-structured interviews were taken with students. The findings presented no difference in anxiety levels between genders, whereas cognitive anxiety type was distinctive in results. Most of the participants experienced high and medium levels of anxiety., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2023 Rasool, Qian and Aslam.)