1. Orexin receptors in GtoPdb v.2021.3
- Author
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Coleman, Paul, de Lecea, Luis, Gotter, Anthony, Hagan, Jim, Hoyer, Daniel, Kilduff, Thomas, Kukkonen, Jyrki P, Porter, Rod, Renger, John, Siegel, Jerome M, Sutcliffe, Gregor, Upton, Neil, and Winrow, Christopher J
- Subjects
Pharmacology and Pharmaceutical Sciences ,Biomedical and Clinical Sciences - Abstract
Orexin receptors (nomenclature as agreed by theNC-IUPHARSubcommittee on Orexin receptors [42]) are activated by the endogenous polypeptides orexin-A and orexin-B (also known as hypocretin-1 and -2; 33 and 28 aa) derived from a common precursor, preproorexin or orexin precursor, by proteolytic cleavage and some typical peptide modifications [109]. Currently the only orexin receptor ligands in clinical use are suvorexant and lemborexant, which are used as hypnotics. Orexin receptor crystal structures have been solved [134, 133, 54, 117, 46].
- Published
- 2021