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The study on the mechanical properties of soil-structure interface is the basis to solve the problem of soil-structure interaction, which involves many aspects of practical engineering. By modifying the conventional unsaturated direct shear apparatus and using the modified unsaturated direct shear apparatus, the shear tests of unsaturated sand-structure interface were carried out, and the effects of the matrix suction, the structural interface type and the net normal stress on the shear strength of the interface were studied. The experimental results show that the influence of matrix suction on the interface cohesion of unsaturated sand-structure interface is great, while that on the interface friction angle is small. With the increase of matrix suction, the shear strength of unsaturated sand-concrete interface increases first and then decreases, indicating a peak effect. The shear strength of unsaturated sand-steel interface was less affected by matrix suction. Under the condition of constant matrix suction, the shear strength of sand-steel interface increases nonlinearly with the increase of net normal stress. The influence of net normal stress on the friction angle (δb) corresponding to matrix suction is little. Finally, a shear strength formula of unsaturated sand-concrete interface was established based on peak effect. [ABSTRACT FROM AUTHOR]

Objective To investigate the effect of five-element music therapy combined with loxoprofen sodium on perioperative pain in patients with humeral shaft fracture. Methods Totally 90 cases of humeral shaft fracture patients were randomly divided into three groups, control group A (30 cases) and control group B (30 cases) and treatment group (30 cases). Control group A received oral administration of loxoprofen sodium, control group B received five-element music therapy, and treatment group received combined intervention of loxoprofen sodium oral administration and five-element music therapy. The Visual Analogue Scale(VAS) was adopted as the evaluation criteria to assess perioperative pain 2 days before surgery, 2 days and 7 days after the surgery. The Athens Insomnia Scale (AIS) was used to evaluate the sleep quality of patients 2 days before surgery, 2 days and 7 days after the surgery. Results The treatment group was found with a better improvement in VAS and AIS compared with that in the control group A and control group B, respectively (P

Partial discharge (PD) is the primary factor causing insulation degradation in transformers. However, the collected signals of partial discharge are often contaminated with significant noise. This makes it difficult to extract the PD signal and hinders subsequent signal analysis and processing. This paper proposes a denoising method for transformer partial discharge based on the Whale VMD algorithm combined with adaptive filtering and wavelet thresholding (WVNW). First, the WOA is used to optimize the important parameters of the VMD. The selected mode components from the VMD decomposition are then subjected to preliminary denoising based on the kurtosis criterion. The reconstructed signal is further denoised using the Adaptive Filter (NLMS) algorithm to remove narrowband interference noise. Finally, the residual white noise is eliminated using the Wavelet Thresholding algorithm. In simulation experiments and practical measurements, the proposed method is compared quantitatively with previous methods, VMD-WT, and EMD-WT, based on metrics such as SNR, RMSE, NCC, and NRR. The results indicate that the WVNW method effectively suppresses noise interference and restores the original PD signal waveform with high waveform similarity while preserving a significant amount of local discharge signal features. [ABSTRACT FROM AUTHOR]

This paper presents a well-controlled laboratory experimental study to evaluate wave attenuation by artifi- cial emergent plants (Phragmites australis) under different wave conditions and plant stem densities. Results showed substantial wave damping under investigated regular and irregular wave conditions and also the different rates of wave height and within canopy wave-induced flows as they travelled through the vegetated field under all tested conditions. The wave height decreased by 6%–25% at the insertion of the vegetation field and towards the downstream at a mean of 0.2 cm and 0.32 cm for regular and irregular waves respectively. The significant wave height along the vegetation field ranged from 0.89–1.76 cm and 0.8–1.28 cm with time mean height of 1.38 cm and 1.11 cm respectively for regu- lar and irregular waves. This patterns as affected by plant density and also location from the leading edge of vegetation is investigated in the study. The wave energy attenuated by plant induced friction was predicted in terms of energy dissipation factor (fe) by Nielsen's (1992) empirical model. Shear stress as a driving force of particle resuspension and the implication of the wave attenuation on near shore protection from erosion and sedimentation was discussed. The results and findings in this study will advance our understanding of wave attenuation by an emergent vegetation of Phragmites australis, in water system engineering like near shore and bank protection and restoration projects and also be employed for management purposes to reduce resuspension and erosion in shallow lakes. [ABSTRACT FROM PUBLISHER]

Nitric oxide (NO) is an important gas messenger molecule with a wide range of biological functions. High concentration of NO exerts promising antitumor effects and is regarded as one of the hot spots in cancer research, that have limitations in their direct application due to its gaseous state, short half-life (seconds) and high reactivity. Lysyl oxidase (LOX) is a copper-dependent amine oxidase that is responsible for the covalent bonding between collagen and elastin and promotes tumor cell invasion and metastasis. The overexpression of LOX in triple-negative breast cancer (TNBC) makes it an attractive target for TNBC therapy. Herein, novel NO donor prodrug molecules were designed and synthesized based on the naturally derived piperlongumine (PL) skeleton, which can be selectively activated by LOX to release high concentrations of NO and PL derivatives, both of them play a synergistic role in TNBC therapy. Among them, the compound TM-1 selectively released NO in highly invasive TNBC cells (MDA-MB-231), and TM-1 was also confirmed as a potential TNBC cell line inhibitor with an inhibitory concentration of 2.274 μM. Molecular docking results showed that TM-1 had a strong and selective binding affinity with LOX protein., Competing Interests: Declaration of competing interest The authors declare no conflict of interest., (Copyright © 2024 Elsevier B.V. All rights reserved.)

BACKGROUND The anatomy of the coracoid process and coracoclavicular (CC) ligament have been described and the correlation between them has been assessed based on 3-dimensional computed tomography (CT) reconstruction and magnetic resonance imaging (MRI), which provide a guide for coracoclavicular ligament reconstruction. MATERIAL AND METHODS Data were collected from 300 patients who underwent both CT and MRI of the shoulder joint from January 2017 to January 2019 at the Jiang'an Hospital of Traditional Chinese Medicine. The coracoid process was observed and classified and parameters of the CC ligament were measured according to different corneal types. All of the statistics were collected and classified by 2 radiologists, and average values were determined.Measurements of segments were taken as follows: ab - In the coronal plane, the length of the CC ligament from the central point of the CC ligament at the clavicular attachment to the CC ligament at the center of the CC attachment); ac - The distance from the center point of the CC ligament at the supraclavicular attachment to the acromioclavicular joint; de - In the sagittal plane, the length of the CC ligament from the center of the clavicular attachment to the coracoid attachment point; fg - The maximum diameter of the CC ligament at the anterior and posterior margins of the clavicle attachment; hi - The largest diameter of the CC ligament at the anterior and posterior edge of the coracoid process attachment; dj - The distance of the coracoclavicular ligament from the center point of the coracoid process attachment to the coracoid process tip; kl - The distance in the supraclavicular plane from the coracoclavicular ligament to the subcoracoid process. RESULTS The analysis showed that there are 5 types of coracoid process: gourd (31%), short rod (20%), long rod (22.3%), wedge (10.3%), and water drop (6.3%). There were statistically significant differences between the lengths of the ac and hi segments in the among the wedge and gourd-type and the short rod and water drop-type coracoid processes. There were statistically significant differences between the lengths of the ab, de, and fg segments in the short rod, gourd, and long rod-type coracoid processes. There were statistically significant differences between the lengths of the ac, fg, hi, dj, and kl segments in the water drop, gourd, and long rod-type coracoid processes. CONCLUSIONS The present study indicated that measurement of the CC ligament and the different shapes of the coracoid process provide an anatomical basis for the diagnosis and treatment of shoulder diseases and the data can be used to improve the safety of CC ligament reconstruction.