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Numerical studies have been performed to analyze the fluid flow and heat transfer characteristics of nine microchannel heat sinks (MCHS) with different shapes and different arrangements of the ribs and cavities on the sidewalls, using three common shapes (square, triangle, and circular) of ribs or cavities as the basic structure in this work. The boundary conditions, governing equations, friction factor (ƒ), Nusselt number (Nu), and performance evaluation criteria (ξ) were considered to determine which design was the best in terms of the heat transfer, the pressure drop, and the overall performance. It was observed that no matter how the circular ribs or cavities were arranged, its heat sink performance was better than the other two shapes for Reynolds number of 200–1000. Therefore, circular ribs or cavities can be considered as the best structure to improve the performance of MCHS. In addition, the heat sink performance of the microchannel heat sink with symmetrical circular ribs (MCHS-SCR) was improved by 31.2 % compared with the conventional microchannel heat sink at Re = 667. This was because in addition to the formation of transverse vortices in the channel, four symmetrical and reverse longitudinal vortices are formed to improve the mixing efficiency of the central fluid (low temperature) and the near-wall fluid (high temperature). Then, as the Reynolds number increases, the heat sink performance of MCHS-SCR dropped sharply. The heat sink performance of microchannel heat sinks with staggered ribs and cavities (MCHS-SCRC, MCHS-STRC, and MCHS-SSRC) exceeded that of MCHS-SCR. This indicated that the microchannel heat sink with staggered ribs and cavities was more suitable for high Reynolds number (Re > 800). [ABSTRACT FROM AUTHOR]