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Your search keyword '"Galluzzi, Lorenzo"' showing total 2 results
2 results on '"Galluzzi, Lorenzo"'

1. Calreticulin surface presentation can promote quality control of hematopoietic stem cells.

Author

Galluzzi, Lorenzo and Kroemer, Guido

Subjects
*HEMATOPOIETIC stem cells, *CALRETICULIN, *QUALITY control, *MYELOID cells, *STEM cells
Abstract

Endoplasmic reticulum stress can stimulate calreticulin (CALR) presentation on the cell surface, promoting the phagocytic uptake of stressed cells by myeloid cells. Recent findings from Wattrus et al. demonstrate that zebrafish and mouse embryonic macrophages engulf CALR-exposing nascent hematopoietic stem cells to ensure the selective survival of stem cells apt for adult hematopoiesis. [ABSTRACT FROM AUTHOR]

Published
2022
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2. Calreticulin exposure orchestrates innate immunosurveillance.

Author

Guilbaud, Emma, Kroemer, Guido, and Galluzzi, Lorenzo

Subjects
*CALRETICULIN, *MYELOID cells, *CELL communication
Abstract

Calreticulin (CALR) exposure on the cell surface is known to deliver robust pro-phagocytic signals to myeloid cells. In Nature , Sen Santara et al. demonstrate that surface-exposed CALR also operates as an endogenous activator of natural killer (NK) cells. Collectively, these findings suggest that CALR exposure orchestrates multiple facets of innate immunosurveillance. [ABSTRACT FROM AUTHOR]

Published
2023
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