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Your search keyword '"Galluzzi, Lorenzo"' showing total 2 results

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2 results on '"Galluzzi, Lorenzo"'

1. Using epigenetic modifiers to target cancer stem cell immunoevasion.

Author

Galassi, Claudia, Vitale, Ilio, and Galluzzi, Lorenzo

Subjects
*CANCER stem cells, *EPIGENETICS, *STEM cells, *IMMUNE checkpoint inhibitors
Abstract

Two recent reports in Nature highlight a novel mechanism of immunoevasion that relies on the SET domain bifurcated histone lysine methyltransferase 1 (SETDB1)-dependent epigenetic suppression of endogenous retroelements in melanoma cells. Because SETDB1 is highly expressed by the stem cell compartment, these findings delineate an innovative strategy for restoring cancer stem cell immunosurveillance. [ABSTRACT FROM AUTHOR]

Published
2021
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2. Using epigenetic modifiers to target cancer stem cell immunoevasion.

Author

Galassi, Claudia, Vitale, Ilio, and Galluzzi, Lorenzo

Subjects
*CANCER stem cells, *EPIGENETICS, *STEM cells, *IMMUNE checkpoint inhibitors, *MELANOMA
Abstract

Two recent reports in Nature highlight a novel mechanism of immunoevasion that relies on the SET domain bifurcated histone lysine methyltransferase 1 (SETDB1)-dependent epigenetic suppression of endogenous retroelements in melanoma cells. Because SETDB1 is highly expressed by the stem cell compartment, these findings delineate an innovative strategy for restoring cancer stem cell immunosurveillance. [ABSTRACT FROM AUTHOR]

Published
2021
Full Text
View/download PDF

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