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Since the beginning of the COVID-19 pandemic, many works have been published proposing solutions to the problems that arose in this scenario. In this vein, one of the topics that attracted the most attention is the development of computer-based strategies to detect COVID-19 from thoracic medical imaging, such as chest X-ray (CXR) and computerized tomography scan (CT scan). By searching for works already published on this theme, we can easily find thousands of them. This is partly explained by the fact that the most severe worldwide pandemic emerged amid the technological advances recently achieved, and also considering the technical facilities to deal with the large amount of data produced in this context. Even though several of these works describe important advances, we cannot overlook the fact that others only use well-known methods and techniques without a more relevant and critical contribution. Hence, differentiating the works with the most relevant contributions is not a trivial task. The number of citations obtained by a paper is probably the most straightforward and intuitive way to verify its impact on the research community. Aiming to help researchers in this scenario, we present a review of the top-100 most cited papers in this field of investigation according to the Google Scholar search engine. We evaluate the distribution of the top-100 papers taking into account some important aspects, such as the type of medical imaging explored, learning settings, segmentation strategy, explainable artificial intelligence (XAI), and finally, the dataset and code availability. [ABSTRACT FROM AUTHOR]

This paper provides a comprehensive summary of evidence to explore and position the role of serology testing in the context of coronavirus disease 19 (COVID-19) immunization and policy response in the Asia-Pacific (APAC) region. The document builds on a review of academic literature and existing policies followed by a process of discussion, validation, and feedback by a group of six experts. Six countries and territories—Australia, Hong Kong, India, Indonesia, Thailand, and Taiwan—were sampled to highlight the differing contexts and scenarios in the region. The review includes an overview of (1) the impact of the COVID-19 pandemic, including the emergence of Variants of Concern (VOCs), especially Omicron, (2) the introduction of immunization, (3) the available testing options and potential use of serology testing, (4) the landscape of guidelines and recommendations for their use, and (5) the barriers and challenges to implementing serology testing as a tool to support COVID-19 immunization. Based on the findings, the co-authors propose a set of recommendations to resolve knowledge gaps, to include the use of serology testing as part of the policy response, and to ensure adequate means of implementation. This paper's target audience includes members of the academic community, medical societies, health providers and practitioners, and decision-makers. [ABSTRACT FROM AUTHOR]

Subclinical Myocardial Dysfunction in Patients with Persistent Dyspnea One Year after COVID-19 - Why Should Screening for Cardiovascular Diseases Be Performed? The presence of persistent dyspnea was observed in one-third of the recovered COVID-19 patients, in line with the current data on the long-term evolution of COVID-19 [[3]]. A total of 66 COVID-19 patients without a previous history of cardiorespiratory diseases were evaluated at 12 months for potential subclinical cardiac dysfunction following the acute infection [[2]]. [Extracted from the article]

The aim of this paper is to understand the long-COVID impact on cultural heritage organisations, and future research needed. COVID-19 was disruptive to cultural heritage socioeconomic activities across the world during 2020 and 2021. Whilst government intervention and changes from physical to digital engagement generally prevailed, the long-COVID impact on cultural heritage organisations, their people and users, buildings, and collections remains unknown. The extent, also, to which financing, curating, visiting, and volunteering patterns have changed is uncertain. Following the pandemic closures and associated support, cultural heritage organisations are facing continuing economic, social, political, environmental, technological, and organisational culture pressures. This research examines the existing academic literature, sector publications, annual reports and associated visitor information to understand whether cultural heritage organisations have long-COVID, whether they can survive another pandemic, and what further research is needed to be better prepared. Four case studies from the UK look at the visitor and financial impacts of COVID-19 on the British Library, the London Transport Museum, The Theatre Royal Drury Lane, and Kensington Palace. This paper contributes to heritage research by providing a deeper understanding of the impact that COVID-19 had on heritage, and how to proactively plan for similar future disruptions. The impact themes show that change did not result in a new normal but in the need for a new space, consisting of blended space (physical and digital), mixed space (indoors and outdoors), and community of practice space (isolated or cross-sector networking space). The literature highlights the significance of the sector coming together during the pandemic to share knowledge and provide support through its networks. It also highlights how important it is for such unity not to be lost but to be harnessed to support ongoing organisational sustainability and better preparedness for future crises. Finally, future research suggestions are proposed grouped into social, digital, financial, and operational research themes. [ABSTRACT FROM AUTHOR]

However, the GCW and GWI values of the two groups, both with and without dyspnea, do not deviate from the normal reference values, which are based on the NORRE study [[2]] and that were underpinned by the authors. The study reports the following echocardiographic differences: Compared to asymptomatic patients, patients with dyspnea presented lower LV constructive work (GCW): 2183.7 ± 487.9 vs. 2483.1 ± 422.4, I p i = 0.024; and a lower global work index (GWI): 1960.0 ± 396.2 vs. 2221.1 ± 407.9, I p i = 0.030. This study compares 23 patients with self-reported dyspnea and 43 without 1 year after hospital admission for COVID-19. [Extracted from the article]

The COVID-19 epidemic has required countries to implement different containment strategies to limit its spread, like strict or weakened national lockdown rules and the application of age-stratified vaccine prioritization strategies. These interventions have in turn modified the age-dependent patterns of social contacts. In our recent paper, starting from the available age-structured real data at the national level, we identified, for the Italian case, specific virulence parameters for a two-age-structured COVID-19 epidemic compartmental model (under 60, and 60 years and over) in six different diseases transmission scenarios under concurrently adopted feedback interventions. An interpretation of how each external scenario modifies the age-dependent patterns of social contacts and the spread of COVID-19 disease has been accordingly provided. In this paper, which can be viewed as a sequel to the previous one, we mainly apply the same general methodology therein (involving the same dynamic model) to new data covering the three subsequent additional scenarios: (i) a mitigated coordinated intermittent regional action in conjunction with the II vaccination phase; (ii) a super-attenuated coordinated intermittent regional action in conjunction with the II vaccination phase; and (iii) a last step towards normality in conjunction with the start of the III vaccination phase. As a new contribution, we show how meaningful updated information can be drawn out, once the identification of virulence parameters, characterizing the two age groups within the latest three different phases, is successfully carried out. Nevertheless, differently from our previous paper, the global optimization procedure is carried out here with the number of susceptible individuals in each scenario being left free to change, to account for reinfection and immunity due to vaccination. Not only do the slightly different estimates we obtain for the previous scenarios not impact any of the previous considerations (and thus illustrate the robustness of the procedure), but also, and mainly, the new results provide a meaningful picture of the evolution of social behaviors, along with the goodness of strategic interventions. [ABSTRACT FROM AUTHOR]

As the proliferation of new variations of COVID-19 (Coronavirus Disease 2019) continues to increase, it is evident that the COVID-19 pandemic is not over. Indeed, we are living in a world of interrelating and overlapping pandemics—a syndemic. A syndemic accelerates the polarization of access to health care, financial support, and education opportunities in marginalized communities, and the polarization breeds social injustice, violence, and ignorance. What, then, is the Gospel the Church proclaims for those who have experienced the pandemic and are now facing a syndemic? As part of a liturgical response, this paper proposes preaching as a praxis of the ecclesiological Gospel. The ecclesiological Gospel is a term I suggest to highlight the contextual, sacramental, and communal aspects of the Gospel. Highlighting God's holistic work for salvation represented in baptism and the eucharist, the ecclesiological Gospel yearns to form a church that baptizes people in diversity, that severs evil interconnections, and that welcomes people to the table of hospitality that forms a new covenantal relationship. This paper examines the concept of a syndemic and its significance for preaching in marginalized communities. It contrasts a holistic Gospel perspective with a narrow view, proposes preaching as praxis of the ecclesiological Gospel, and illustrates its application within a particular context in responding to syndemic conditions. I hope this work offers a chance to reorient the meaning of the Gospel and the identity of the Church for people living in fear, grief, and hopelessness, while encouraging them with the unwavering hope revealed in Christ's suffering, death, and resurrection. [ABSTRACT FROM AUTHOR]

The essay outlines a four-phase triage process made by a fictive Talmudic rabbi working on an equally fictive hospital COVID-19 ward. The rabbi bases his decision on four different Talmudic texts, proceeding one by one, with each text building on the preceding one, until he is ready to allocate his scarce medical resources to one of the patients, thus being forced to deny them to others. Along the way, the paper will examine how this Talmudic reasoning can also be applied to the patient, or even a potential patient, clarifying the demands of the individual's ethical responsibility to avoid triage situations in the first place through social distancing and even more so through getting vaccinated. The paper argues that the rabbi has a number of Talmudic tools at hand that make his decision easier, not because he strictly follows Jewish law, but because of the rich experience standing behind Jewish legal traditions, making a universally valid ethical justification of difficult decisions possible. The essay proposes that including such theological material in triage guidelines would help make those decisions more acceptable in the long run, especially for societies in which religious traditions still play a certain role in the cultural consciousness. [ABSTRACT FROM AUTHOR]

Before the COVID-19 pandemic, ventilation in buildings was not always given its due importance. The World Health Organization has highlighted the important role of air exchange with the outdoors in improving the air quality in buildings; buildings should, therefore, be equipped with mechanical ventilation or adequate air conditioning systems. This paper aims to investigate different retrofit solutions for air conditioning, evaluating them in terms of energy consumption and cost and the impact of increased outdoor air exchange rates on countering the propagation of COVID-19; the latter is the main novelty of the paper. As a case study, we take an existing office building located in Central Italy that was previously not equipped with a mechanical ventilation system (a system with primary air was introduced during the study). The energy analysis was conducted using dynamic simulation software after validation through energy bills; energy and economic analyses were conducted considering different external-air exchange rates. An optimal number of outdoor air changes was found to mitigate the risk of COVID-19 infection, a finding in line with the international literature. The increase in air changes with outdoor air leads to a rise in energy consumption and costs. These values were evaluated for different air conditioning systems and operational schedules. These drawbacks can be made less significant by combining interventions in the system with energy-efficiency measures applied to the building envelope. [ABSTRACT FROM AUTHOR]

Arterial hypertension is one of the most common and significant cardiovascular risk factors. There are many well-known and identified risk factors for its development. In recent times, there has been growing concern about the potential impact of COVID-19 on the cardiovascular system and its relation to arterial hypertension. Various theories have been developed that suggest a connection between COVID-19 and elevated blood pressure. However, the precise link between SARS-CoV-2 infection and the long-term risk of developing hypertension remains insufficiently explored. Therefore, the primary objective of our study was to investigate the influence of COVID-19 infection on blood pressure elevation and the subsequent risk of developing arterial hypertension over an extended period. To accomplish this, we conducted a thorough search review of relevant papers in the PubMed and SCOPUS databases up to 3 September 2023. Our analysis encompassed a total of 30 eligible articles. Out of the 30 papers we reviewed, 19 of them provided substantial evidence showing a heightened risk of developing arterial hypertension following COVID-19 infection. Eight of the studies showed that blood pressure values increased after the infection, while three of the qualified studies did not report any notable impact of COVID-19 on blood pressure levels. The precise mechanism behind the development of hypertension after COVID-19 remains unclear, but it is suggested that endothelial injury and dysfunction of the renin–angiotensin–aldosterone system may be contributory. Additionally, changes in blood pressure following COVID-19 infection could be linked to lifestyle alterations that often occur alongside the illness. Our findings emphasize the pressing requirement for thorough research into the relationship between COVID-19 and hypertension. These insights are essential for the development of effective prevention and management approaches for individuals who have experienced COVID-19 infection. [ABSTRACT FROM AUTHOR]

In this paper, we examine the epidemiological model B-SIR, focusing on the dynamic law that governs the transmission rate B. We define this dynamic law by the differential equation B ′ / B = F ⊕ − F ⊖ , where F ⊖ represents a reaction factor reflecting the stress proportional to the active group's percentage variation. Conversely, F ⊕ is a factor proportional to the deviation of B from its intrinsic value. We introduce the notion of contagion impulse f and explore its role within the model. Specifically, for the case where F ⊕ = 0 , we derive an autonomous differential system linking the effective reproductive number with f and subsequently analyze its dynamics. This analysis provides new insights into the model's behavior and its implications for understanding disease transmission. [ABSTRACT FROM AUTHOR]

This paper reports a rapid and sensitive sensor for the detection and quantification of the COVID-19 N-protein (N-PROT) via an electrochemical mechanism. Single-frequency electrochemical impedance spectroscopy was used as a transduction method for real-time measurement of the N-PROT in an immunosensor system based on gold-conjugate-modified carbon screen-printed electrodes (Cov-Ag-SPE). The system presents high selectivity attained through an optimal stimulation signal composed of a 0.0 V DC potential and 10 mV RMS−1 AC signal at 100 Hz over 300 s. The Cov-Ag-SPE showed a log response toward N-PROT detection at concentrations from 1.0 ng mL−1 to 10.0 μg mL−1, with a 0.977 correlation coefficient for the phase (θ) variation. An ML-based approach could be created using some aspects observed from the positive and negative samples; hence, it was possible to classify 252 samples, reaching 83.0, 96.2 and 91.3% sensitivity, specificity, and accuracy, respectively, with confidence intervals (CI) ranging from 73.0 to 100.0%. Because impedance spectroscopy measurements can be performed with low-cost portable instruments, the immunosensor proposed here can be applied in point-of-care diagnostics for mass testing, even in places with limited resources, as an alternative to the common diagnostics methods. [ABSTRACT FROM AUTHOR]

Many ailments can be diagnosed while they are asymptomatic, meaning that the patient has no signs or symptoms of a progressing disease. If caught in their initial stage of formation, these disorders can be effectively treated, leading to successful outcomes; curative therapies can halt illnesses from advancing, thus improving the quality of life and long-term survival of the patient. Still, cutting-edge upgrades in precision technologies are necessary for early, reliable, affordable, and rapid disease detection, but also vital for the well-being of people and the future of global public health. The emerging role and utility of non-invasive and repeatable diagnostic test approaches for the detection of health conditions have been exemplified by liquid biopsies based on genomic biomarkers. As such, biological fluids permit any measurable molecular indicator or signature (e.g., proteins) to provide valuable information on an individual's wellness and/or disease. Among the bodily secretions used for non-invasive diagnostics is sputum, a complex viscous gel-like biopolymeric network that has gained growing recognition as a rich source of biomarkers of airway infections and pulmonary diseases, and serves as a determinant to reveal other illnesses. As per the World Health Organization, the burden of respiratory conditions is exacerbated by factors ranging from considerable subjection to air pollution and occupational contaminants to tobacco smoking and second-hand smoke, in addition to poor socio-economic status. Due to the likely increase in these determinants, respiratory tract ailments are on the rise, affecting the health of many individuals, in addition to putting stress on healthcare facilities and services worldwide. The aim of this study was to perform a narrative review of sputum constituents with an emphasis on proteins and glycoproteins assessed as possible biomarkers of lung and other organ diseases. A search was conducted using mucus, sputum proteomics, sputum biomarkers, and point-of-care testing as keywords employing Google, PubMed (MEDLINE), and Web of Science, selecting the most referenced and related papers of the last decade. We, therefore, highlight the need to use expectorated or induced sputum specimens as a routine sample source for testing valuable protein biomarkers to diagnose these chronic disorders, predict inflammation and disease progression, as well as monitor the effectiveness of treatments. Further, we discuss the urgent need for fast and reliable point-of-care methods to detect and quantify crucial protein biomarkers in sputum specimens, and the limitations faced when dealing with their complex matrices. [ABSTRACT FROM AUTHOR]

The COVID-19 pandemic has placed enormous pressure on healthcare systems. In the first line of the "war" against the virus, hospitals tried to maintain their general operations, while supplementing their services with COVID-19 patient care. To tackle the new difficulties, hospitals had to develop strategic response plans, and were in need of finding the most effective management structure for their institution. The focus of this paper is the aforementioned management structures. After overviewing the international literature, we identified three different approaches and we named them the Horizontal, Vertical, and Intermedier Approach. The separation is based on the following features: decision making, information distribution, command forwarding, intra-hospital communication channels, hierarchy, and control. After summarizing the international experiences, we introduce a Hungarian centrum hospital's approach, as the institution was assigned to fulfil COVID-19 centrum hospital duties in the middle of the first wave. The North-Buda Szent János Central hospital was in need of restructuring their management structure, and the leadership decided to transform it into a hierarchical, vertical structure, operating with centralized decision making and personal control. This control–command system idea came from the hospital's Internist Head Coordinator Physician, who is the first author of our article, and had serious military medicine experiences (in Afghanistan). [ABSTRACT FROM AUTHOR]

By integrating energy-efficient AIoT-based biosensor networks, healthcare systems can now predict COVID-19 outbreaks with unprecedented accuracy and speed, revolutionizing early detection and intervention strategies. Therefore, this paper explores the rapid growth of electronic technology in today's environment, driven by the proliferation of advanced devices capable of monitoring and controlling various healthcare systems. However, these devices' limited resources necessitate optimizing their utilization. To tackle this concern, we propose an enhanced Artificial Intelligence of Things (AIoT) system that utilizes the networking capabilities of IoT biosensors to forecast potential COVID-19 outbreaks. The system aims to efficiently collect data from deployed sensor nodes, enabling accurate predictions of possible disease outbreaks. By collecting and pre-processing diverse parameters from IoT nodes, such as body temperature (measured non-invasively using the open-source thermal camera TermoDeep), population density, age (captured via smartwatches), and blood glucose (collected via the CGM system), we enable the AI system to make accurate predictions. The model's efficacy was evaluated through performance metrics like the confusion matrix, F1 score, precision, and recall, demonstrating the optimal potential of the IoT-based wireless sensor network for predicting COVID-19 outbreaks in healthcare systems. [ABSTRACT FROM AUTHOR]

Introduction: This paper explores the potential influence of a single nucleotide variant in the ANK-2 gene on COVID-19 myocarditis-related ventricular tachycardia. Case Description: A 53-year-old female with a history of Crohn's disease and asthma developed COVID-19. Shortly after infection, she experienced symptoms of chest pressure, palpitations, and shortness of breath, leading to the eventual diagnosis of myocarditis complicated by recurrent ventricular tachycardia. Treatment with mechanistically driven anti-arrhythmic therapy and beta-blockers suppressed this highly symptomatic ventricular tachycardia. Genetic testing to further risk stratify and influence long term care identified a single nucleotide variant in the ANK-2 gene, which is known to be associated with arrhythmic risk. Discussion: This case study highlights the use of rationally selected anti-arrhythmic therapy, mexiletine, in the management of ventricular tachycardia associated with COVID-19 myocarditis and the presence of a single nucleotide variant in ANK-2, raising the possibility of its contribution to VT susceptibility and severity. Our patient demonstrated significant improvement with administered therapeutics, including the resolution of myocarditis and ventricular tachycardia. The normalization of the QT interval during the resolution phase further supports the potential influence of the genetic variant in ANK-2 on potassium channel activity. [ABSTRACT FROM AUTHOR]

This document is a comment on a review paper titled "Could Selenium Supplementation Prevent COVID-19? A Comprehensive Review of Available Studies." The authors of the comment are experienced selenium researchers who take issue with the assessments made in the review. They argue that the review is not comprehensive and fails to include important studies that support the association between selenium and COVID-19 outcomes. The authors also address specific criticisms made by the reviewers regarding their own work and highlight the importance of further research into the role of selenium in COVID-19. [Extracted from the article]

Air conditioning systems can play a positive or negative role in the spread of COVID-19 infection. The importance of sufficient outdoor air changes in buildings was highlighted by the World Health Organization, therefore these should be guaranteed by mechanical ventilation systems or adequate air conditioning systems. The proposed case study concerns the optimal number of outdoor air changes to limit COVID-19 contagion for a school building in Central Italy. The Wells–Riley model is used to assess the risk of airborne infection, while energy consumption is calculated by a dynamic energy simulation software. The scope of the paper offers an innovative method to define the optimal ventilation strategy for the building's HVAC system design to reduce the risk of infection with limited increases in energy consumption and greenhouse gas emissions. Results show that the desirable approach is the one in which the same low value of contagion risk is set in all rooms. This new approach results in significant energy savings, compared to the most common ones (setting the same high outdoor air rates for all rooms) to counteract the risk of infection. Finally, the zero-emission building target is verified by introducing a suitable photovoltaic system to offset pollutant emissions. [ABSTRACT FROM AUTHOR]

The coronavirus disease 2019 (COVID-19) pandemic disrupted public health and economies worldwide. In this paper, we investigate an optimal control problem to simultaneously minimize the epidemic size and control costs associated with intervention strategies based on official data. Considering people with undetected infections, we establish a control system of COVID-19 with time-varying parameters. To estimate these parameters, a parameter identification scheme is adopted and a mixed algorithm is constructed. Moreover, we present an optimal control problem with two objectives that involve the newly increased number of infected individuals and the control costs. A numerical scheme is conducted, simulating the epidemic data pertaining to Shanghai during the period of 2022, caused by the Omicron variant. Coefficient combinations of the objectives are obtained, and the optimal control measures for different infection peaks are indicated. The numerical results suggest that the identification variables obtained by using the constructed mixed algorithm to solve the parameter identification problem are feasible. Optimal control measures for different epidemic peaks can serve as references for decision-makers. [ABSTRACT FROM AUTHOR]

In this paper, an SEAI epidemic model with asymptomatic infection is studied under the background of mass transmission of COVID-19. First, we use the next-generation matrix method to obtain the basic reproductive number R 0 and calculate the equilibrium point. Secondly, when R 0 < 1 , the local asymptotic stability of the disease-free equilibrium is proved by Hurwitz criterion, and the global asymptotic stability of the disease-free equilibrium is proved by constructing the Lyapunov function. When R 0 > 1 , the system has a unique endemic equilibrium point and is locally asymptotically stable, and it is also proved that the system is uniformly persistent. Then, the application of optimal control theory is carried out, and the expression of the optimal control solution is obtained. Finally, in order to verify the correctness of the theory, the stability of the equilibrium point is numerically simulated and the sensitivity of the parameters of R 0 is analyzed. We also simulated the comparison of the number of asymptomatic infected people and symptomatic infected people before and after adopting the optimal control strategy. This shows that the infection of asymptomatic people cannot be underestimated in the spread of COVID-19 virus, and an isolation strategy should be adopted to control the spread speed of the disease. [ABSTRACT FROM AUTHOR]

Coronavirus disease-19 (COVID-19) has disproportionately affected certain demographics in England, exacerbating existing health disparities. Effective therapeutics are a critical line of defence against COVID-19, particularly for patients at elevated risk for severe disease. Surveillance systems were established to monitor the usage of COVID-19 therapeutics in hospital and community settings and to inform stewardship. Three antiviral therapies—nirmatrelvir plus ritonavir (Paxlovid®), remdesivir (Veklury®), and molnupiravir (Lagevrio®)—and two neutralising monoclonal antibody therapies (nMAbs)—sotrovimab (Xevudy®) and casirivimab with imdevimab (Ronapreve®)—were in use in England between July 2020 and April 2023. This paper aims to illuminate trends in the utilisation of COVID-19 therapeutics treatment in both hospital and community settings, stratified by the Index of Multiple Deprivation (IMD) in England. Chapter 3 of the English Surveillance Programme for Antimicrobial Utilisation and Resistance (ESPAUR) Report 2022 to 2023 also discusses the epidemiological surveillance of these five directly acting antiviral COVID-19 therapeutics' use in England between 2022 and 2023. [ABSTRACT FROM AUTHOR]

Due to immunosuppression, transplant recipients are at higher risk of infections with SARS-CoV-2 and worse clinical outcomes than immunocompetent hosts. Furthermore, lung transplant patients represent a special group among solid organ recipients, since pneumonia is the main manifestation of COVID-19. However, data on the course of disease and the changes in morbidity and mortality during the course of the pandemic are limited. In our pulmonary rehabilitation clinic, we treat patients shortly after lung transplant as well as long-term transplant patients. Over the last almost 4 years of pandemic, we witnessed several COVID-19 infections in lung transplant patients in our clinic as well as patients who acquired an infection beforehand. In this paper, we aim at retrospectively describing a series of recent COVID-19 cases in our clinic, looking at the clinical course of disease and outcomes in lung transplant patients. [ABSTRACT FROM AUTHOR]

The COVID-19 pandemic has resulted in millions of fatalities worldwide. The case of pediatric cancer patients stands out since, despite being considered a population at risk, few studies have been carried out concerning symptom detection or the description of the mechanisms capable of modifying the course of the COVID-19 disease, such as the interaction and response between the virus and the treatment given to cancer patients. By synthesizing existing studies, this paper aims to expose the treatment challenges for pediatric patients with COVID-19 in an oncology context. Additionally, this updated review includes studies that utilized the antiviral agents Remdesivir and PaxlovidTM in pediatric cancer patients. There is no specific treatment designed exclusively for pediatric cancer patients dealing with COVID-19, and it is advisable to avoid self-medication to prevent potential side effects. Managing COVID-19 in pediatric cancer patients is indeed a substantial challenge. New strategies, such as chemotherapy application rooms, have been implemented for children with cancer who were positive for COVID-19 but asymptomatic since the risk of disease progression is greater than the risk of complications from SARS-CoV-2. [ABSTRACT FROM AUTHOR]

Several research papers have attempted to describe the dynamics of COVID-19 based on systems of differential equations. These systems have taken into account quarantined or isolated cases, vaccinations, control measures, and demographic parameters, presenting propositions regarding theoretical results that often investigate the asymptotic behavior of the system. In this paper, we discuss issues that concern the theoretical results proposed in the paper "An Extended SEIR Model with Vaccination for Forecasting the COVID-19 Pandemic in Saudi Arabia Using an Ensemble Kalman Filter". We propose detailed explanations regarding the resolution of these issues. Additionally, this paper focuses on extending the local stability analysis of the disease-free equilibrium, as presented in the aforementioned paper, while emphasizing the derivation of theorems that validate the global stability of both epidemic equilibria. Emphasis is placed on the basic reproduction number R 0 , which determines the asymptotic behavior of the system. This index represents the expected number of secondary infections that are generated from an already infected case in a population where almost all individuals are susceptible. The derived propositions can inform health authorities about the long-term behavior of the phenomenon, potentially leading to more precise and efficient public measures. Finally, it is worth noting that the examined paper still presents an interesting epidemiological scheme, and the utilization of the Kalman filtering approach remains one of the state-of-the-art methods for modeling epidemic phenomena. [ABSTRACT FROM AUTHOR]

The global impact of the COVID-19 pandemic has been profound, placing significant challenges upon healthcare systems and the world economy. The pervasive presence of illness, uncertainty, and fear has markedly diminished overall life satisfaction. Consequently, sentiment analysis has gained substantial traction among scholars seeking to unravel the emotional and attitudinal dimensions of this crisis. This research endeavors to provide a bibliometric perspective, shedding light on the principal contributors to this emerging field. It seeks to spotlight the academic institutions associated with this research domain, along with identifying the most influential publications in terms of both paper volume and h-index metrics. To this end, we have meticulously curated a dataset comprising 646 papers sourced from the ISI Web of Science database, all centering on the theme of sentiment analysis during the COVID-19 pandemic. Our findings underscore a burgeoning interest exhibited by the academic community in this particular domain, evident in an astonishing annual growth rate of 153.49%. Furthermore, our analysis elucidates key keywords and collaborative networks within the authorship, offering valuable insights into the global proliferation of this thematic pursuit. In addition to this, our analysis encompasses an n-gram investigation across keywords, abstracts, titles, and keyword plus, complemented by an examination of the most frequently cited works. The results gleaned from these endeavors offer crucial perspectives, contribute to the identification of pertinent issues, and provide guidance for informed decision-making. [ABSTRACT FROM AUTHOR]

The COVID-19 pandemic affected nearly all strata of life, including scientific activities. Implementation of nationwide lockdowns, closures of universities, and other measures significantly limiting social mobility precluded field and laboratory research from being pursued at a pre-pandemic pace. On the other hand, working from home could translate into higher productivity of researchers in terms of publication output, ultimately affecting the journals' metrics. This effect has been well evidenced in the biomedical field, but whether it also occurred in aquatic sciences has not been explored. Therefore, this study aimed to analyze and compare various metrics of journals classified in the Scopus evaluations in 2019 (encompassing 2016–2019, the pre-pandemic period) and 2022 (covering 2019–2022, the pandemic period) within three subjects: aquatic science, oceanography, and water science and technology. In general, the number of journals classified into the considered categories increased in 2022 by 12%, and the majority (78%) experienced an increase in the CiteScore metric. The total published articles and received citations also significantly increased in 2022 by 17.5% and 63.5%, respectively, and were even higher in the case of open access journals—69% and 145%, respectively. The overall share of cited articles in the considered period was higher by 5% than in the 2019 Scopus evaluation and by 7% in the case of open access periodicals. However, source normalized impact per paper (SNIP) and the SCImago journal rank (SJR) values decreased by 7% and 8%, respectively. The highest share of citations was generated by Water Research, Water, and the Journal of Hydrology, and the highest number of articles was published by Water, Frontiers in Marine Science, and Desalination and Water Treatment. Only five of the COVID-19-related papers published in journals with the highest CiteScore and total number of citations received more than 200 citations, but their contribution to citations received by the journals was not high. In summary, the present study's findings indicate the high potential of the field dedicated to water sciences to adapt in a period challenged by an infectious disease pandemic. However, they do not exclude the adverse effect that this period could have on the activities of individual scientists and research teams. [ABSTRACT FROM AUTHOR]

This paper charts the journey from classroom-based training delivery to hybrid and virtual learning opportunities used to overcome the challenges imposed by public health restrictions introduced in response to the COVID-19 pandemic. The public health measures introduced in March 2020 had a significant effect on the ability of the Children First Information and Advice Service (CFIAS), in Tusla, Ireland's Child and Family Agency, to deliver services. One of the key tools used by the CFIAS to support understanding of responsibilities, and best practice, in child safeguarding by professionals, and within organisations, has been the provision of direct training and information sessions. The introduction of public health restrictions necessitated a complete rethink by the CFIAS on how child safeguarding training and information are delivered. The paper presents an outline of the background and context of child safeguarding in Ireland, followed by a description of some of the challenges experienced by the CFIAS in response to the pandemic public health restrictions. It includes discussion on strategies and solutions considered to overcome these challenges. There is further discussion on the tools and methods eventually used, followed by a reflection on lessons learned by the CFIAS in areas including training delivery and methodology, eLearning, and information provision. The paper provides an analysis of limited qualitative and quantitative data, as well as a reflection on the lived experience of the CFIAS team members responding to the challenges posed during this time period, rather than a preplanned research study on pedagogical approaches in adult learning. [ABSTRACT FROM AUTHOR]

Measuring the colorimetric signals produced by the biospecific accumulation of colorimetric probes and recording the results is a key feature for next-generation paper-based rapid tests. Manual processing of these tests is time-consuming and prone to a loss of accuracy when interpreting faint and patchy signals. Proprietary, closed-source readers and software companies offering automated smartphone-based assay readings have both been criticized for interoperability issues. Here, we introduce a minimal reader prototype composed of open-source hardware and open-source software that has the benefits of automatic assay quantification while avoiding the interoperability issues associated with closed-source readers. An image-processing algorithm was developed to automate the selection of an optimal region of interest and measure the average pixel intensity. When used to quantify signals produced by lateral flow immunoassays for detecting antibodies against SARS-CoV-2, results obtained with the proposed algorithm were comparable to those obtained with a manual method but with the advantage of improving the precision and accuracy when quantifying small spots or faint and patchy signals. [ABSTRACT FROM AUTHOR]

Losing a child is a traumatic event, disrupting life's natural cycle, profoundly affecting the family system, and causing enduring grief. Perinatal death, including ectopic pregnancies, miscarriages, stillbirths, and neonatal deaths, exacerbates this distress. Additionally, the COVID-19 pandemic has challenged healthcare systems and supporting services available to individuals in need. Thus, this research explores experiences of parents facing perinatal loss in 2020–2021, further focusing on the pandemic's impact. Using a mixed-methods design with self-reports and qualitative interviews, this paper presents results from the quantitative protocol, involving an update and follow-up of a previous study. It compares measurements across scales: COVID-19: The Impact of Event Scale-Revised; The Prolonged Grief-13; The Parental Assessment of Paternal/Maternal Affectivity; The Dyadic Adjustment Scale (short version); The Daily Spiritual Experiences Scale; and The Inventory of Complicated Spiritual Grief. In the baseline measurement, 45 parents participated (37 mothers and 8 fathers), with 20 (13 mothers and 7 fathers) contributing to the follow-up and 9 engaging in interviews. Baseline results showed higher scores for mothers compared to fathers, with effect sizes ranging from small to medium (ranging from −0.02 to 0.29), though statistical significance was limited due to the small sample size. Multiple regression analysis for distress measures at baseline identified two significant predictors: maternal/paternal affectivity and gestational week. Additionally, positive support from healthcare professionals emerged as a mitigating factor, particularly in relation to Avoidance. A significant reduction in stress measures and parental affectivity was observed at the 6-month follow-up. Qualitative analysis revealed three themes: Shifts in Self-Perception and Post-Loss Growth; Conflicted Relationship with One's Body; and Negative Impact of COVID-19 vs. Unexpectedly Positive Aspects. In conclusion, the findings emphasize the significance of psychological and psychosocial interventions based on meaning-making processes, along with the importance of spiritual care and empowerment for those navigating perinatal loss. [ABSTRACT FROM AUTHOR]

COVID-19 is a lung disease caused by a coronavirus family virus. Due to its extraordinary prevalence and associated death rates, it has spread quickly to every country in the world. Thus, achieving peaks and outlines and curing different types of relapses is extremely important. Given the worldwide prevalence of coronavirus and the participation of physicians in all countries, information has been gathered regarding the properties of the virus, its diverse types, and the means of analyzing it. Numerous approaches have been used to identify this evolving virus. It is generally considered the most accurate and acceptable method of examining the patient's lungs and chest through a CT scan. As part of the feature extraction process, a method known as fractional Fourier transform (FrFT) has been applied as one of the time-frequency domain transformations. The proposed method was applied to a database consisting of 2481 CT images. Following the transformation of all images into equal sizes and the removal of non-lung areas, multiple combination windows are used to reduce the number of features extracted from the images. In this paper, the results obtained for KNN and SVM classification have been obtained with accuracy values of 99.84% and 99.90%, respectively. [ABSTRACT FROM AUTHOR]

The purpose of this research is to examine whether Buddhist ethics can improve the health and well-being of Buddhist practitioners during pandemics like COVID-19. It is hypothesized that diseases are part of suffering, and Buddhist teachings aim to eliminate the suffering of all beings. Buddhism also offers ethical codes of conduct for its practitioners to improve their health and well-being. So, the Buddha's teaching or Buddhist ethics, when practiced seriously, should be able to improve one's health, physically and mentally, enhancing the well-being of all Buddhist practitioners during the spread of all pandemics including COVID-19. The present study found that Buddhist ethical practices like the chanting of Buddhist suttas and the development of mindfulness, concentration/meditation, and insight (vipassanā) can improve both physical and mental health, which are important for dealing with any pandemic, tremendously. If the cores of Buddhist ethics (morality, meditation, and wisdom) are perfectly practiced, not only will one live with good physical and mental health but one also will be able to eliminate all the mental defilements that are the root causes of all illnesses and thus enter nibbāna, the state of mind that is beyond all sources of suffering including pandemics/epidemics. More specifically, this paper highlights a set of Buddhist practices, called four bhāvanās (types of development), that can be used to improve health and well-being during any pandemic. [ABSTRACT FROM AUTHOR]

The process of SARS-CoV-2 infection, responsible for the COVID-19 pandemic, is carried out through different steps, with the interaction between ACE2 and Spike protein (S) being crucial. Besides of that, the acidic environment of endosomes seems to play a relevant role in the virus uptake into cells and its intracellular replication. Patients affected by two rare genetic tubulopathies, Gitelman's and Bartter's Syndromes, and a rare genetic metabolic disease, Fabry Disease, have shown intrinsic protection from SARS-CoV-2 infection and COVID-19 on account of specific intrinsic features that interfere with the virus uptake into cells and its intracellular replication, which will be reported and discussed in this paper, providing interesting insights for present and future research. [ABSTRACT FROM AUTHOR]

Extracorporeal membrane oxygenation (ECMO) is a cardiac or pulmonary function support system that is used in cases of refractory organ failure in addition to conventional treatment. Currently, Level I evidence is not yet available, which reflects improved outcomes with ECMO in pregnant women, the use in pregnancy should be indicated in selected cases and only in specialized centers. We searched articles in the most important scientific databases from 2009 until 31 December 2023 consulting also the site ClinicalTrials.com to find out about studies that have been recently conducted or are currently ongoing. We matched the combination of the following keywords: "ECMO and pregnancy", "H1N1 and pregnancy", "COVID-19 and pregnancy", "ARDS and pregnancy", "ECMO and pregnancy AND (cardiac arrest)". We selected the following number of articles for each keyword combination: "ECMO and pregnancy" (665 articles); "ECMO and influenza H1N1" (384 articles); "pregnancy and influenza H1N1" (1006 articles); "pregnancy and ARDS" (2930 articles); "ECMO and pregnancy and ARDS and influenza H1N1" (24 articles); and "[ECMO and pregnancy AND (cardiac arrest)]" (74 articles). After careful inspection, only 43 papers fitted our scope. There are two types of ECMO: venous-venous (VV-ECMO) and venous-arterial (VA-ECMO). The first-one is necessary to cope with severe hypoxia: oxygen-depleted blood is taken from the venous circulation, oxygenated, and carbon dioxide removed from the extracorporeal circuit and returned to the same venous system. The VA-ECMO is a type of mechanical assistance to the circulatory system that allows to put the failing organ at rest by ensuring adequate oxygenation and systemic de-oxygenation, avoiding multi-organ failure. The main indications for ECMO support in pregnant women are cardiogenic shock, acute respiratory distress syndrome (ARDS), pulmonary embolism, and eclampsia. There are also fetal indications for ECMO, and they are fetal distress, hypoxic-ischemic encephalopathy (HIE), and twin-to-twin transfusion syndrome (TTTS). Until now, based on the outcomes of the numerous clinical studies conducted, ECMO has been shown to be a successful therapeutic strategy in cases where medical treatment has been unsuccessful. In well-selected pregnant patients, it appears to be safe and associated with a low risk of maternal and fetal complications. The aim of this review is to report the main properties of ECMO (VV and VA) and the indications for its use in pregnant women. [ABSTRACT FROM AUTHOR]

This review aims to explore the role of professional diagnostic rapid testing of acute respiratory infections (ARIs), especially COVID-19 and influenza, ensuring proper disease management and treatment in Europe, and particularly in Czech Republic, Poland, and Romania. The paper was constructed based on a review of scientific evidence and national and international policies and recommendations, as well as a process of validation by four experts. The development of new testing technologies, treatment options, and increased awareness of the negative multidimensional impact of ARI profiles transformed differential diagnosis into a tangible and desirable reality. This review covers the following topics: (1) the multidimensional impact of ARIs, (2) ARI rapid diagnostic testing platforms and their value, (3) the policy landscape, (4) challenges and barriers to implementation, and (5) a set of recommendations illustrating a path forward. The findings indicate that rapid diagnostic testing, including at the point of care (POC), can have a positive impact on case management, antimicrobial and antibiotic stewardship, epidemiological surveillance, and decision making. Integrating this strategy will require the commitment of governments and the international and academic communities, especially as we identified room for improvement in the access and expansion of POC rapid testing in the focus countries and the inclusion of rapid testing in relevant policies. [ABSTRACT FROM AUTHOR]

Current advancements in the technology of the Internet of Things (IoT) have led to the proliferation of various applications in the healthcare sector that use IoT. Recently, it has been shown that voice signal data of the respiratory system (i.e., breathing, coughing, and speech) can be processed through machine learning techniques to detect different diseases of this system such as COVID-19, considered an ongoing global pandemic. Therefore, this paper presents a new IoT framework for the identification of COVID-19 based on breathing voice samples. Using IoT devices, voice samples were captured and transmitted to the cloud, where they were analyzed and processed using machine learning techniques such as the naïve Bayes (NB) algorithm. In addition, the performance of the NB algorithm was assessed based on accuracy, sensitivity, specificity, precision, F-Measure, and G-Mean. The experimental findings showed that the proposed NB algorithm achieved 82.97% accuracy, 75.86% sensitivity, 94.44% specificity, 95.65% precision, 84.61% F-Measure, and 84.64% G-Mean. [ABSTRACT FROM AUTHOR]

First described in December 2019 in Wuhan (China), COVID-19 disease rapidly spread worldwide, constituting the biggest pandemic in the last 100 years. Even if SARS-CoV-2, the agent responsible for COVID-19, is mainly associated with pulmonary injury, evidence is growing that this virus can affect many organs, including the heart and vascular endothelial cells, and cause haemostasis, CNS, and kidney and gastrointestinal tract abnormalities that can impact in the disease course and prognosis. In fact, COVID-19 may affect almost all the organs. Hence, SARS-CoV-2 is essentially a systemic infection that can present a large number of clinical manifestations, and it is variable in distribution and severity, which means it is potentially life-threatening. The goal of this comprehensive review paper in the series is to give an overview of non-pulmonary involvement in COVID-19, with a special focus on underlying pathophysiological mechanisms and clinical presentation. [ABSTRACT FROM AUTHOR]

In this paper, we analyse the genome sequence of COVID-19 on a information point of view, and we compare that with past and present genomes. We use the powerful tool of joint complexity in order to quantify the similarities measured between the various potential parent genomes. The tool has a computing complexity of several orders of magnitude below the classic Smith–Waterman algorithm and would allow it to be used on a larger scale. [ABSTRACT FROM AUTHOR]

This paper examines the relationships between the consumption of 'bad' or 'good' digital economic news and attitudes toward immigrant and ethnic minorities during the crisis that developed during the COVID-19 pandemic. The study considered attitudes toward two minority groups in Israel: immigrant citizens from English-speaking countries, and Israeli Palestinian citizens, an ethnic minority. The data were collected through an online survey of 866 respondents, who were members of the majority population group. The study found that, during the global crisis, exposure to bad digital news was associated with more positive attitudes toward both disadvantaged and non-disadvantaged minority groups. Moreover, in times of global crisis, people focused mostly on local rather than global digital news. In contrast to the idea of Intergroup Threat Theory, the study revealed that feelings of economic threat during the global crisis engendered higher cohesion between different population groups, and more positive attitudes toward minorities. In times of crisis, bad news for the economy brings good news for social solidarity—people tend to rally around the flag; this phenomenon even occurs between groups engaged in years-long, protracted conflict. [ABSTRACT FROM AUTHOR]

Background: COVID-19 caused a pandemic, due to its ease of transmission and high number of infections. The evolution of the pandemic and its consequences for the mortality and morbidity of populations, especially the elderly, generated several scientific studies and many research projects. Among them, we have the Predictive Models of COVID-19 Outcomes for Higher Risk Patients Towards a Precision Medicine (PREMO) research project. For such a project with many data records, it is necessary to provide a smooth graphical analysis to extract value from it. Methods: In this paper, we present the development of a full-stack Web application for the PREMO project, consisting of a dashboard providing statistical analysis, data visualization, data import, and data export. The main aspects of the application are described, as well as the diverse types of graphical representations and the possibility to use filters to extract relevant information for clinical practice. Results: The application, accessible through a browser, provides an interactive visualization of data from patients admitted to the intensive care unit (ICU), throughout the six waves of COVID-19 in two hospitals in Lisbon, Portugal. The analysis can be isolated per wave or can be seen in an aggregated view, allowing clinicians to create many views of the data and to study the behavior and consequences of different waves. For instance, the experimental results show clearly the effect of vaccination as well as the changes on the most relevant clinical parameters on each wave. Conclusions: The dashboard allows clinicians to analyze many variables of each of the six waves as well as aggregated data for all the waves. The application allows the user to extract information and scientific knowledge about COVID-19's evolution, yielding insights for this pandemic and for future pandemics. [ABSTRACT FROM AUTHOR]

COVID-19 is a contagious disease that poses a serious risk to public health worldwide. To reduce its spread, people need to adopt preventive behaviours such as wearing masks, maintaining physical distance, and isolating themselves if they are infected. However, the effectiveness of these measures may depend on various factors that differ across countries. This paper investigates how some factors, namely outsiders' effect, life expectancy, population density, smoker percentage, and temperature, influence the transmission and death rate of COVID-19 in ninety-five top-affected countries. We collect and analyse the data of COVID-19 cases and deaths using statistical tests. We also use fuzzy logic to model the chances of COVID-19 based on the results of the statistical tests. Unlike the conventional uniform weighting of the rule base in fuzzy logic, we propose a novel method to calculate the weights of the rule base according to the significance of the factors. This study aims to provide a comprehensive and comparative analysis of the factors of COVID-19 transmission and death rates among different countries. [ABSTRACT FROM AUTHOR]

Background: Personal emotions and affects have been identified and studied in the context of pandemics, as well as coping strategies centered on emotional regulation or the balance between positive and negative emotions. Objectives: The objectives of this paper are to identify an emotion and affect structure in our sample and analyze the relationship of these dimensions with resilient coping in the context of the COVID-19 pandemic. Method: This study employed a cross-sectional design that involved a non-probabilistic sample with 598 participants over the age of 18, with 51.1% being female, and an average age of 40.73 years. First, the emotional structure was identified through principal component analysis (PCA). Secondly, a linear regression analysis was performed to investigate emotional dimensions as predictors of coping. Results: A valid and reliable emotional structure with four dimensions was identified. The regression model revealed that coping is positively associated with the active and positive dimension and negatively correlated with the negative and moral dimensions. Conclusions: Emotional dimensions are predictors of coping, with moral and negative dimensions having a negative effect, while active and positive dimensions have a positive effect. When designing interventions for coping strategies, multiple dimensions of emotions and affective states in people who are in vulnerable situations must be considered. [ABSTRACT FROM AUTHOR]

COVID-19 analysis from medical imaging is an important task that has been intensively studied in the last years due to the spread of the COVID-19 pandemic. In fact, medical imaging has often been used as a complementary or main tool to recognize the infected persons. On the other hand, medical imaging has the ability to provide more details about COVID-19 infection, including its severity and spread, which makes it possible to evaluate the infection and follow-up the patient's state. CT scans are the most informative tool for COVID-19 infection, where the evaluation of COVID-19 infection is usually performed through infection segmentation. However, segmentation is a tedious task that requires much effort and time from expert radiologists. To deal with this limitation, an efficient framework for estimating COVID-19 infection as a regression task is proposed. The goal of the Per-COVID-19 challenge is to test the efficiency of modern deep learning methods on COVID-19 infection percentage estimation (CIPE) from CT scans. Participants had to develop an efficient deep learning approach that can learn from noisy data. In addition, participants had to cope with many challenges, including those related to COVID-19 infection complexity and crossdataset scenarios. This paper provides an overview of the COVID-19 infection percentage estimation challenge (Per-COVID-19) held at MIA-COVID-2022. Details of the competition data, challenges, and evaluation metrics are presented. The best performing approaches and their results are described and discussed. [ABSTRACT FROM AUTHOR]

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for coronavirus disease-19 (COVID-19). This virus has caused a global pandemic, marked by several mutations leading to multiple waves of infection. This paper proposes a comprehensive and integrative mathematical approach to the third wave of COVID-19 (Omicron) in the Kingdom of Saudi Arabia (KSA) for the period between 16 December 2022 and 8 February 2023. It may help to implement a better response in the next waves. For this purpose, in this article, we generate a new mathematical transmission model for coronavirus, particularly during the third wave in the KSA caused by the Omicron variant, factoring in the impact of vaccination. We developed this model using a fractal-fractional derivative approach. It categorizes the total population into six segments: susceptible, vaccinated, exposed, asymptomatic infected, symptomatic infected, and recovered individuals. The conventional least-squares method is used for estimating the model parameters. The Perov fixed point theorem is utilized to demonstrate the solution's uniqueness and existence. Moreover, we investigate the Ulam–Hyers stability of this fractal–fractional model. Our numerical approach involves a two-step Newton polynomial approximation. We present simulation results that vary according to the fractional orders (γ) and fractal dimensions (θ), providing detailed analysis and discussion. Our graphical analysis shows that the fractal-fractional derivative model offers more biologically realistic results than traditional integer-order and other fractional models. [ABSTRACT FROM AUTHOR]

Coronavirus disease 2019 (COVID-19) was a global pandemic with high mortality and morbidity that led to an increased health burden all over the world. Although the virus mostly affects the pulmonary tract, cardiovascular implications are often observed among COVID-19 patients and are predictive of poor outcomes. Increased values of myocardial biomarkers such as troponin I or NT-proBNP were proven to be risk factors for respiratory failure. Although the risk of acute coronary syndromes (ACSs) was greater in the acute phase of COVID-19, there were lower rates of hospitalization for ACSs, due to patients' hesitation in presenting at the hospital. Hospitalized ACSs patients with COVID-19 infection had a prolonged symptom-to-first-medical-contact time, and longer door-to-balloon time. The mechanisms of myocardial injury in COVID-19 patients are still not entirely clear; however, the most frequently implicated factors include the downregulation of ACE2 receptors, endothelial dysfunction, pro-coagulant status, and increased levels of pro-inflammatory cytokines. The aim of this paper is to evaluate the long-term outcomes and prognosis of COVID-19 survivors that presented an acute myocardial infarction, by reviewing existing data. The importance of the association between this infectious disease and myocardial infarction arises from the increased mortality of patients with SARS-CoV-2 infection and AMI (10–76%, compared with 4.6% for NSTEMI patients and 7% for STEMI patients without COVID-19). The literature review showed an increased risk of cardiovascular events in COVID-19 survivors compared with the general population, even after the acute phase of the disease, with poorer long-term outcomes. [ABSTRACT FROM AUTHOR]

Given the pronounced impact COVID-19 continues to have on society—infecting 700 million reported individuals and causing 6.96 million deaths—many deep learning works have recently focused on the virus's diagnosis. However, assessing severity has remained an open and challenging problem due to a lack of large datasets, the large dimensionality of images for which to find weights, and the compute limitations of modern graphics processing units (GPUs). In this paper, a new, iterative application of transfer learning is demonstrated on the understudied field of 3D CT scans for COVID-19 severity analysis. This methodology allows for enhanced performance on the MosMed Dataset, which is a small and challenging dataset containing 1130 images of patients for five levels of COVID-19 severity (Zero, Mild, Moderate, Severe, and Critical). Specifically, given the large dimensionality of the input images, we create several custom shallow convolutional neural network (CNN) architectures and iteratively refine and optimize them, paying attention to learning rates, layer types, normalization types, filter sizes, dropout values, and more. After a preliminary architecture design, the models are systematically trained on a simplified version of the dataset-building models for two-class, then three-class, then four-class, and finally five-class classification. The simplified problem structure allows the model to start learning preliminary features, which can then be further modified for more difficult classification tasks. Our final model CoSev boosts classification accuracies from below 60% at first to 81.57% with the optimizations, reaching similar performance to the state-of-the-art on the dataset, with much simpler setup procedures. In addition to COVID-19 severity diagnosis, the explored methodology can be applied to general image-based disease detection. Overall, this work highlights innovative methodologies that advance current computer vision practices for high-dimension, low-sample data as well as the practicality of data-driven machine learning and the importance of feature design for training, which can then be implemented for improvements in clinical practices. [ABSTRACT FROM AUTHOR]

The coronavirus disease 2019 (COVID-19) global pandemic, caused by severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2), has been marked by severe cases demonstrating a "cytokine storm", an upsurge of pro-inflammatory cytokines in the bloodstream. NLRP3 inflammasomes, integral to the innate immune system, are speculated to be activated by SARS-CoV-2 within host cells. This review investigates the potential correlation between NLRP3 inflammasomes and COVID-19, exploring the cellular and molecular mechanisms through which SARS-CoV-2 triggers their activation. Furthermore, promising strategies targeting NLRP3 inflammasomes are proposed to mitigate the excessive inflammatory response provoked by SARS-CoV-2 infection. By synthesizing existing studies, this paper offers insights into NLRP3 as a therapeutic target, elucidating the interplay between COVID-19 and its pathophysiology. It serves as a valuable reference for future clinical approaches in addressing COVID-19 by targeting NLRP3, thus providing potential avenues for therapeutic intervention. [ABSTRACT FROM AUTHOR]

The COVID-19 lockdown has had serious consequences, including rethinking higher education. The study aims to enhance the knowledge base of online education and academic integrity through a case study of the Ludovika University of Public Service (LUPS), Budapest, Hungary. The research aimed to assess the teachers' experience with distance learning and examinations, including the change in workload, digital competencies, Moodle, Turnitin, and other software used during and after the lockdown. This paper summarizes the university-level policy changes induced during the lockdown, covering the introduction of emergency distance teaching and online examinations in academic integrity at the university. Two years after the first lockdown, the researchers made a survey (n = 145) about the continuation of the introduced solutions. The results show that a remarkable reordering started while the technical and technological backgrounds were available for the changes. The teachers could feel a significant increase in workload with distance education and have low trust in maintaining the standards of academic integrity. However, the research shows moderate and low levels of digital competencies in the majority of teachers, which clearly defines the most crucial task leading to success. Maintaining the monitoring system with objective indicators of the development and the opinions of the interested parties is essential for successful strategies in the field. [ABSTRACT FROM AUTHOR]

In this paper, we tackle the problem of forecasting future pandemics by training models with a COVID-19 time series. We tested this approach by producing one model and using it to forecast a non-trained time series; however, we limited this paper to the eight states with the highest population density in Mexico. We propose a generalized pandemic forecasting framework that transforms the time series into a dataset via three different transformations using random forest and backward transformations. Additionally, we tested the impact of the horizon and dataset window sizes for the training phase. A Wilcoxon test showed that the best transformation technique statistically outperformed the other two transformations with 100% certainty. The best transformation included the accumulated efforts of the other two plus a normalization that helped rescale the non-trained time series, improving the sMAPE from the value of 25.48 attained for the second-best transformation to 13.53. The figures in the experimentation section show promising results regarding the possibility of forecasting the early stages of future pandemics with trained data from the COVID-19 time series. [ABSTRACT FROM AUTHOR]

Polypharmacy, the use of multiple and potentially inappropriate medications, is an increasing problem among older adults. The global polypharmacy prevalence is 34.6% in patients with COVID-19, and polypharmacy in COVID-19 increases with age. The present paper proposes that polypharmacy in older adults with COVID-19 and other comorbid conditions is linked to the medication outcome reporting bias of randomized controlled trials. Outcome reporting bias can occur when treatment efficacy is reported as relative risk reductions, which overestimates medication benefits and exaggerates disease/illness risk reductions compared to unreported absolute risk reductions. The comorbidities common in patients with COVID-19 include high blood pressure, cardiovascular disease, dementia or cerebrovascular disease, and diabetes. Accordingly, the present paper reassesses the relative and absolute risk reductions in clinical trials from a small convenience sample of antihypertension, statin, anticoagulant, and antihyperglycemic medications. Examples demonstrate a wide gap between reported relative risk reductions and unreported absolute risk reductions in medication clinical trials. This paper concludes that medication clinical trial outcome reporting bias is an important upstream factor that contributes to biased medication benefits and poor clinical decision making, leading to polypharmacy in older adults with COVID-19 and other comorbid conditions. Public health campaigns are urgently needed to educate the public about the link between polypharmacy and medication outcome reporting bias. [ABSTRACT FROM AUTHOR]