34 results on '"Kondo, Kenji"'
Search Results
2. Postoperative functional evaluation of obstructive sleep apnea syndrome by computational fluid dynamics
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Nomura, Tsutomu, Horikoshi, Tomomi, Kitano, Yuka, Yamada, Masato, Kondo, Kenji, and Kikuchi, Shigeru
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- 2022
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3. Effectiveness of Primary Total Hip Arthroplasty Combined with Intra-articular and Intravenous Tranexamic Acid: A Retrospective Analysis of Number of Doses and Dose Strength
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Nakamura, Masaru, Shimakawa, Tateaki, Nakano, Shunji, Sato, Ryosuke, Kondo, Kenji, Goto, Hitoshi, Sugimine, Yuto, Enishi, Tetsuya, and Sairyo, Koichi
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- 2022
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4. Prolonged and extended impacts of SARS-CoV-2 on the olfactory neurocircuit
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Kishimoto-Urata, Megumi, Urata, Shinji, Kagoya, Ryoji, Imamura, Fumiaki, Nagayama, Shin, Reyna, Rachel A., Maruyama, Junki, Yamasoba, Tatsuya, Kondo, Kenji, Hasegawa-Ishii, Sanae, and Paessler, Slobodan
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- 2022
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5. Lipocalin 15 in the olfactory mucus is a biomarker for Bowman’s gland activity
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Ijichi, Chiori, Kondo, Kenji, Kobayashi, Masayoshi, Shirasawa, Ayaka, Shimbo, Kazutaka, Nakata, Kunio, Maruyama, Yutaka, Ihara, Yusuke, Kawato, Yayoi, Mannen, Teruhisa, Takeshita, Rie, Kikuchi, Yoshimi, Saito, Yuki, and Yamasoba, Tatsuya
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- 2022
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6. Filtration-processed biomass nanofiber electrodes for flexible bioelectronics
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Ando, Daiki, Teshima, Tetsuhiko F., Zurita, Francisco, Peng, Hu, Ogura, Kota, Kondo, Kenji, Weiß, Lennart, Hirano-Iwata, Ayumi, Becherer, Markus, Alexander, Joe, and Wolfrum, Bernhard
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- 2022
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7. Immunological status of the olfactory bulb in a murine model of Toll-like receptor 3-mediated upper respiratory tract inflammation
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Kagoya, Ryoji, Toma-Hirano, Makiko, Yamagishi, Junya, Matsumoto, Naoyuki, Kondo, Kenji, and Ito, Ken
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- 2022
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8. Rapid fluorescent vital imaging of olfactory epithelium
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Nishijima, Hironobu, Zunitch, Matthew J., Yoshida, Masafumi, Kondo, Kenji, Yamasoba, Tatsuya, Schwob, James E., and Holbrook, Eric H.
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- 2022
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9. Vocal Fold Motion Impairment in Neurodegenerative Diseases.
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Ueha, Rumi, Miura, Cathrine, Matsumoto, Naoyuki, Sato, Taku, Goto, Takao, and Kondo, Kenji
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VOCAL cords ,NEURODEGENERATION ,AMYOTROPHIC lateral sclerosis ,MULTIPLE system atrophy ,CONTINUOUS positive airway pressure ,LARYNGEAL nerve injuries - Abstract
Vocal fold motion impairment (VFMI) is the inappropriate movement of the vocal folds during respiration, leading to vocal fold adduction and/or abduction problems and causing respiratory and vocal impairments. Neurodegenerative diseases (NDDs) are a wide range of disorders characterized by progressive loss of neurons and deposition of altered proteins in the brain and peripheral organs. VFMI may be unrecognized in patients with NDDs. VFMI in NDDs is caused by the following: laryngeal muscle weakness due to muscular atrophy, caused by brainstem and motor neuron degeneration in amyotrophic lateral sclerosis; hyperactivity of laryngeal adductors in Parkinson's disease; and varying degrees of laryngeal adductor hypertonia and abductor paralysis in multiple system atrophy. Management of VFMI depends on whether there is a presence of glottic insufficiency or insufficient glottic opening with/without severe dysphagia. VFMI treatment options for glottic insufficiency range from surgical interventions, including injection laryngoplasty and medialization thyroplasty, to behavioral therapies; for insufficient glottic opening, various options are available based on the severity and underlying cause of the condition, including continuous positive airway pressure therapy, botulinum toxin injection, tracheostomy, vocal fold surgery, or a combination of interventions. In this review, we outline the mechanisms, clinical features, and management of VFMI in NDDs and provide a guide for physicians who may encounter these clinical features in their patients. NDDs are always progressive; hence, timely evaluation, proper diagnosis, and appropriate management of the patient will greatly affect their vocal, respiratory, and swallowing functions as well as their quality of life. [ABSTRACT FROM AUTHOR]
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- 2024
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10. Management and Treatment for Dysphagia in Neurodegenerative Disorders.
- Author
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Ueha, Rumi, Cotaoco, Carmel, Kondo, Kenji, and Yamasoba, Tatsuya
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DEGLUTITION disorders ,NEURODEGENERATION ,ALIMENTARY canal ,AMYOTROPHIC lateral sclerosis ,MULTIPLE system atrophy - Abstract
Patients with neurodegenerative disorders (NDDs) often experience functional dysphagia, which may involve dysfunction in a specific phase of swallowing or in the entire process. This review outlines the approach to dysphagia in the setting of NDDs. Distinguishing the etiology of dysphagia can be difficult, and it is important to always look out for signs pointing to NDD as the cause. Thorough diagnostic work-up is essential, and it includes a comprehensive history and physical examination, alongside swallowing function tests, such as fiberoptic endoscopic evaluation of swallowing, videofluoroscopic swallowing study, and high-resolution manometry. Management requires a multidisciplinary approach with a treatment plan tailored to each patient. This involves dietary guidance, swallowing rehabilitation, and surgery in cases in which improvement with rehabilitation is inadequate. Surgery may involve altering certain pharyngolaryngeal structures to facilitate swallowing and reduce the risk of aspiration (swallowing improvement surgery) or separating the airway and digestive tract while sacrificing laryngeal function, with the main goal of preventing aspiration (aspiration prevention surgery). Proper management stems from recognizing the impact of these disorders on swallowing and consistently finding ways to improve the quality of life of patients. [ABSTRACT FROM AUTHOR]
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- 2024
- Full Text
- View/download PDF
11. Predicting synkinesis caused by Bell's palsy or Ramsay Hunt syndrome using machine learning‐based logistic regression.
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Kishimoto‐Urata, Megumi, Urata, Shinji, Nishijima, Hironobu, Baba, Shintaro, Fujimaki, Yoko, Kondo, Kenji, and Yamasoba, Tatsuya
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BELL'S palsy ,LOGISTIC regression analysis ,RECEIVER operating characteristic curves ,MACHINE learning ,FACIAL paralysis ,BOOSTING algorithms ,K-nearest neighbor classification - Abstract
Objective: To investigate whether machine learning (ML)‐based algorithms, namely logistic regression (LR), random forest (RF), k‐nearest neighbor (k‐NN), and gradient‐boosting decision tree (GBDT), utilizing early post‐onset parameters can predict facial synkinesis resulting from Bell's palsy or Ramsay Hunt syndrome more accurately than the conventional statistics‐based LR. Methods: This retrospective study included 362 patients who presented to a facial palsy outpatient clinic. Median follow‐up of synkinesis‐positive and ‐negative patients was 388 (range, 177–1922) and 198 (range, 190–3021) days, respectively. Electrophysiological examinations were performed, and the rate of synkinesis in Bell's palsy and Ramsay Hunt syndrome was evaluated. Sensitivity and specificity were assessed using statistics‐based LR; and electroneurography (ENoG) value, the difference in the nerve excitability test (NET), and scores of the subjective Yanagihara scaling system were evaluated using early post‐onset parameters with ML‐based LR, RF, k‐NN, and GBDT. Results: Synkinesis rate in Bell's palsy and Ramsay Hunt syndrome was 20.2% (53/262) and 40.0% (40/100), respectively. Sensitivity and specificity obtained with statistics‐based LR were 0.796 and 0.806, respectively, and the area under the receiver operating characteristic curve (AUC) was 0.87. AUCs measured using ML‐based LR of "ENoG," "difference in NET," "Yanagihara," and all three components ("all") were 0.910, 0.834, 0.711, and 0.901, respectively. Conclusion: ML‐based LR model shows potential in predicting facial synkinesis probability resulting from Bell's palsy or Ramsay Hunt syndrome and has comparable reliability to the conventional statistics‐based LR. Level of Evidence: 3. [ABSTRACT FROM AUTHOR]
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- 2023
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12. Long-Term Outcomes of Endoscopic Transnasal Surgery in Conjunction with Stereotactic Radiosurgery for Skull Base Chordoma.
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Hasegawa, Hirotaka, Shin, Masahiro, Shinya, Yuki, Yoshimoto, Shoko, Takami, Hirokazu, Umekawa, Motoyuki, Kikuta, Shu, Kondo, Kenji, and Saito, Nobuhito
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ENDOSCOPIC surgery ,STEREOTACTIC radiosurgery ,SKULL base ,CHORDOMA ,STEREOTAXIC techniques - Published
- 2023
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13. Oral Administration of TrkB Agonist, 7, 8–Dihydroxyflavone Regenerates Hair Cells and Restores Function after Gentamicin–Induced Vestibular Injury in Guinea Pig.
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Kinoshita, Makoto, Fujimoto, Chisato, Iwasaki, Shinichi, Kondo, Kenji, and Yamasoba, Tatsuya
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ORAL drug administration ,HAIR cells ,GUINEA pigs ,CELL physiology ,BRAIN-derived neurotrophic factor ,INNER ear ,GRAY matter (Nerve tissue) - Abstract
The causes of vestibular dysfunction include the loss of hair cells (HCs), synapses beneath the HCs, and nerve fibers. 7, 8–dihydroxyflavone (DHF) mimics the physiological functions of brain-derived neurotrophic factor. We investigated the effects of the orally-administered DHF in the guinea pig crista ampullaris after gentamicin (GM)-induced injury. Twenty animals treated with GM received daily administration of DHF or saline for 14 or 28 days (DHF (+) or DHF (−) group; N = 5, each). At 14 days after GM treatment, almost all of the HCs had disappeared in both groups. At 28 days, the HCs number in DHF (+) and DHF (−) groups was 74% and 49%, respectively, compared to GM-untreated control. In the ampullary nerves, neurofilament 200 positive rate in the DHF (+) group was 91% at 28 days, which was significantly higher than 42% in DHF (−). On day 28, the synaptic connections observed between C–terminal–binding protein 2-positive and postsynaptic density protein-95-positive puncta were restored, and caloric response was significantly improved in DHF (+) group (canal paresis: 57.4% in DHF (+) and 100% in DHF (−)). Taken together, the oral administration of DHF may be a novel therapeutic approach for treating vestibular dysfunction in humans. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
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14. The clinical features of intractable allergic rhinitis based on a questionnaire administered to clinicians
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Imoto, Yoshimasa, Sakashita, Masafumi, Hayama, Masaki, Nakamaru, Yuji, Suzuki, Masanobu, Miyabe, Yui, Yamada, Takechiyo, Saito, Hidekazu, Yonekura, Syuji, Kondo, Kenji, Higaki, Takaya, Kawashima, Kayoko, Urashima, Mitsuyoshi, and Fujieda, Shigeharu
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- 2021
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15. Health-related quality of life and drug treatment satisfaction were low and correlated negatively with symptoms in patients having severe refractory chronic rhinosinusitis with nasal polyps
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Okano, Mitsuhiro, Kondo, Kenji, Takeuchi, Makiko, Taguchi, Yurie, and Fujita, Hiroyuki
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- 2021
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16. Oral SARS-CoV-2 Inoculation Causes Nasal Viral Infection Leading to Olfactory Bulb Infection: An Experimental Study.
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Ueha, Rumi, Ito, Toshihiro, Furukawa, Ryutaro, Kitabatake, Masahiro, Ouji-Sageshima, Noriko, Ueha, Satoshi, Koyama, Misaki, Uranaka, Tsukasa, Kondo, Kenji, and Yamasoba, Tatsuya
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SARS-CoV-2 ,OLFACTORY bulb ,VIRUS diseases ,CENTRAL nervous system ,NASAL septum - Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections can cause long-lasting anosmia, but the impact of SARS-CoV-2 infection, which can spread to the nasal cavity via the oral route, on the olfactory receptor neuron (ORN) lineage and olfactory bulb (OB) remains undetermined. Using Syrian hamsters, we explored whether oral SARS-CoV-2 inoculation can lead to nasal viral infection, examined how SARS-CoV-2 affects the ORN lineage by site, and investigated whether SARS-CoV-2 infection can spread to the OB and induce inflammation. On post-inoculation day 7, SARS-CoV-2 presence was confirmed in the lateral area (OCAM-positive) but not the nasal septum of NQO1-positive and OCAM-positive areas. The virus was observed partially infiltrating the olfactory epithelium, and ORN progenitor cells, immature ORNs, and mature ORNs were fewer than in controls. The virus was found in the olfactory nerve bundles to the OB, suggesting the nasal cavity as a route for SARS-CoV-2 brain infection. We demonstrated that transoral SARS-CoV-2 infection can spread from the nasal cavity to the central nervous system and the possibility of central olfactory dysfunction due to SARS-CoV-2 infection. The virus was localized at the infection site and could damage all ORN-lineage cells. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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17. Gustatory rhinitis in multiple system atrophy.
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Yamakawa, Kaoru, Kondo, Kenji, Unaki, Akihiko, Saigusa, Hideto, Horikiri, Kyohei, and Yamasoba, Tatsuya
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MULTIPLE system atrophy ,RHINITIS ,PARKINSON'S disease ,RHINORRHEA - Abstract
Gustatory rhinitis is a type of nonallergic, noninflammatory rhinitis. A high incidence of rhinorrhea, including gustatory rhinitis, is reported in patients with Parkinson's disease (PD). Herein, we report a case of gustatory rhinitis in a patient with a parkinsonian variant of multiple system atrophy (MSA-P). A 56-year-old man presented with gustatory rhinorrhea and bilateral copious nasal discharge while eating. Three years before visiting the ear, nose, and throat clinic, he developed Parkinsonism and was suspected of having MSA-P. He underwent posterior nasal neurectomy under endoscopic guidance, but it did not significantly reduce the rhinorrhea during eating. Pathological examination of the mucosa of the inferior turbinate demonstrated minimal inflammatory cellular infiltration. Severe (gustatory) rhinitis may also be a useful biomarker for the diagnosis of synucleinopathies, including PD and MSA, akin to anosmia, which is a well-known biomarker for the early diagnosis of PD. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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18. Squamous and Respiratory Metaplasia After Olfactory Mucosal Resection.
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Mori, Eri, Ueha, Rumi, Kondo, Kenji, Funada, Shotaro, Shimmura, Hajime, Kanemoto, Kai, Tanaka, Hirotaka, Nishijima, Hironobu, Otori, Nobuyoshi, Yamasoba, Tatsuya, and Kojima, Hiromi
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OLFACTORY receptors ,METAPLASIA ,SPRAGUE Dawley rats ,NASAL mucosa ,NASAL septum - Abstract
Resection of the olfactory mucosa (OM) is sometimes unavoidable during surgery; however, it is not known whether the OM can completely recover thereafter. The aim of this study was to uncover whether the OM fully recovers after mucosal resection and describe the process of OM regeneration. 8-week-old male Sprague–Dawley rats (n = 18) were subjected to OM resection at the nasal septum; six rats were euthanized for histological examination 0, 30, and 90 days after surgery. Immunohistochemistry was performed to identify olfactory receptor neuron (ORN) lineage cells [mature and immature ORNs and ORN progenitors, and olfactory ensheathing cells (OECs)], as well as dividing and apoptotic cells. Squamous and respiratory metaplasia and inflammatory cell infiltration were also assessed. On day 30 after resection, the mucosa had regenerated, and mainly contained thin nerve bundles, basal cells, and immature ORNs, with a few mature ORNs and OECs. On day 90, the repaired nasal mucosa had degenerated into stratified squamous or ciliated pseudostratified columnar epithelia, with reducing ORNs. The lamina propria contained numerous macrophages. Partial regeneration was observed within 1 month after OM resection, whereas subsequent degeneration into squamous and respiratory epithelia occurred within 3 months. Given the poor persistence of ORNs and OECs, OM resection is likely to result in olfactory impairment. Overall, surgeons should be cautious not to injure the OM during surgery. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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19. Endoscopic Transnasal Resection of Trigeminal Schwannoma.
- Author
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Kiyofuji, Satoshi, Shin, Masahiro, Kondo, Kenji, Kin, Taichi, Uchida, Tatsuya, and Saito, Nobuhito
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ENDOSCOPIC surgery ,RHINORRHEA ,RADIOSURGERY ,STEREOTAXIC techniques ,OCULOMOTOR nerve ,STEREOTACTIC radiosurgery ,MAGNETIC resonance imaging - Abstract
Trigeminal schwannoma is a rare skull base tumor that can be managed in a variety of treatments including image observation, surgery, stereotactic radiosurgery, such as gamma knife radiosurgery (GKS), and combination of these. Endoscopic transnasal resection is very effective when the tumor is not invading far laterally, or the risk of cerebrospinal fluid (CSF) leak is estimated to be low. A 74-year-old man with a history of prostate cancer and diabetes presented with left oculomotor nerve palsy over a month. Magnetic resonance images (MRI) demonstrated a 25-mm mass in the left cavernous sinus protruding to the left orbit via the superior orbital fissure (Fig. 1). The patient underwent endoscopic transnasal surgery to decompress the mass. The surgery was uneventful, and postoperative MRI demonstrated satisfactory subtotal resection of the mass (Fig. 2). The final pathology returned as schwannoma. At 1-year follow-up, the tumor slowly enlarged, and the patient underwent GKS with a marginal dose of 14 Gy. At the last follow-up, 4 months after GKS, the tumor was stable. Unfortunately the patient deceased from the known prostate cancer. Endoscopic transnasal surgery was especially useful in this case, considering the preoperative known cancer state that management of this benign tumor did not ruin the quality of life of this patient while minimizing hospitalization, as achieving satisfactory tumor control with aid from postoperative GKS, minimizing complications. The link to the video can be found at: https://youtu.be/Q0Ugc2VFV4w. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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20. Possible Use of Phytochemicals for Recovery from COVID-19-Induced Anosmia and Ageusia.
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Koyama, Sachiko, Kondo, Kenji, Ueha, Rumi, Kashiwadani, Hideki, and Heinbockel, Thomas
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COVID-19 , *COVID-19 pandemic , *CHEMICAL senses , *ESSENTIAL oils , *PHYTOCHEMICALS , *SARS-CoV-2 , *SMELL - Abstract
The year 2020 became the year of the outbreak of coronavirus, SARS-CoV-2, which escalated into a worldwide pandemic and continued into 2021. One of the unique symptoms of the SARS-CoV-2 disease, COVID-19, is the loss of chemical senses, i.e., smell and taste. Smell training is one of the methods used in facilitating recovery of the olfactory sense, and it uses essential oils of lemon, rose, clove, and eucalyptus. These essential oils were not selected based on their chemical constituents. Although scientific studies have shown that they improve recovery, there may be better combinations for facilitating recovery. Many phytochemicals have bioactive properties with anti-inflammatory and anti-viral effects. In this review, we describe the chemical compounds with anti- inflammatory and anti-viral effects, and we list the plants that contain these chemical compounds. We expand the review from terpenes to the less volatile flavonoids in order to propose a combination of essential oils and diets that can be used to develop a new taste training method, as there has been no taste training so far. Finally, we discuss the possible use of these in clinical settings. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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21. Efficacy of preoperative autologous blood storage in one-stage bilateral total knee arthroplasty.
- Author
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Nakamura, Masaru, Nakano, Shunji, Sato, Ryosuke, Kondo, Kenji, Goto, Hitoshi, Yoshinari, Haruhiko, Shimakawa, Tateaki, Enishi, Tetsuya, Yoshioka, Shinji, and Sairyo, Koichi
- Subjects
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SURGICAL blood loss , *TOTAL knee replacement , *HEMOGLOBINS , *BLOOD transfusion , *BLOOD collection , *RETROSPECTIVE studies , *HEMATOPOIETIC stem cell transplantation - Abstract
Background: One-stage bilateral total knee arthroplasty (TKA) has the advantages of a single hospital stay, shorter rehabilitation, and reduced financial burden on patients. However, perioperative bleeding is greater with one-stage bilateral TKA than with unilateral TKA and is more likely to require allogeneic blood transfusion. At our hospital, we normally store autologous blood about 1 month before surgery to reduce the need for allogeneic blood transfusion and avoid its adverse reactions as much as possible. The purpose of this study was to determine the efficacy of preoperative autologous blood storage for patients undergoing one-stage bilateral TKA.Methods: We retrospectively examined the allogeneic blood transfusion avoidance rate and the perioperative decrease in hemoglobin (Hb) level in 166 patients according to whether or not they had preoperative autologous blood stored. The patients for whom blood was stored were then subdivided according to whether the amount of blood stored was 400 mL or 200 mL.Results: Excluding allogeneic transfusion cases, the mean perioperative decrease in Hb was significantly lower in the patients with stored blood than in those without stored blood (3.5 g/dL vs 4.4 g/dL, p < 0.001). The allogeneic blood transfusion avoidance rate was significantly higher in the group with stored blood (98.5% vs 86.7%, p < 0.01). In the group with stored blood, the transfusion avoidance rate was higher, but not significantly, in the subgroup with 400 mL of blood stored than in those with 200 mL of blood stored (100% vs 97.5%) and the mean perioperative decrease in Hb was 3.5 g/dL in both blood storage volume groups.Conclusions: Preoperative autologous blood storage can help increase the likelihood of avoiding allogeneic blood transfusion in patients undergoing one-stage bilateral TKA. [ABSTRACT FROM AUTHOR]- Published
- 2022
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22. Genotypes and transmission routes of noroviruses causing sporadic acute gastroenteritis among adults and children, Japan, 2015–2019.
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Honjo, Saho, Kuronuma, Koji, Fujiya, Yoshihiro, Nakae, Mami, Ukae, Susumu, Nihira, Hiroshi, Yamamoto, Masaki, Akane, Yusuke, Kondo, Kenji, Takahashi, Satoshi, Kimura, Hirokazu, Tsutsumi, Hiroyuki, Kawasaki, Yukihiko, and Tsugawa, Takeshi
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NOROVIRUS diseases , *GASTROENTERITIS , *VIRAL gastroenteritis , *NOROVIRUSES , *GENOTYPES , *MEDICAL personnel - Abstract
Noroviruses (NoVs) are major causes of acute viral gastroenteritis at all ages worldwide. The molecular epidemiology of sporadic cases remains poorly understood, especially in adults. Additionally, no studies have analyzed the transmission route in sporadic acute gastroenteritis. In this study, we investigated cases of very mild sporadic NoV acute gastroenteritis in adults (medical staff) who do not visit the outpatient clinic and child outpatients. We also evaluated genotype differences between adults and children and possible transmission routes in adults during 5 years. The number of NoV positives were 58 in adults and 124 in children. In adults, the NoV positivity rate in this study was higher (64.4%) than that in previous reports of outpatients (10%) and inpatients (5%) in the United State. This finding suggested that the NoV positivity rate might be high in adults with very mild acute gastroenteritis. In adults, human-to-human transmission rates from children and food-borne transmission (raw oysters) were 21.6% (11/51) and 19.6% (10/51), respectively. Among adults, GII.2, GII.4, and GII.17 were the predominant genotypes, with rates of 32.7%, 30.9%, and 21.8%, respectively. Among children, GII.4 and GII.2 were the predominant genotypes, with rates of 45.5% and 40.6%, respectively. GII.17 was only detected in 0.8% (1/123) of children. Trends in NoV genotypes are expected to differ depending on the patient's age. Investigating sporadic cases including the patient's background (age and transmission route) may be helpful to monitor the trend of NoV strains, forecast prevalent NoV GII genotypes, and develop NoV vaccines. • Norovirus positivity rate was high in adults with very mild acute gastroenteritis. • In adults, human-to-human transmission was the most common (30%). • In 2015–2019, GII.4, GII.2, and GII.17 were the prevalent strains in adults. • GII.17, which was detected in adults, was almost undetectable in children (0.8%). [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
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23. Activation of the PGE 2 -EP2 pathway as a potential drug target for treating eosinophilic rhinosinusitis.
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Horikiri K, Taketomi Y, Kondo K, Yamasoba T, and Murakami M
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- Animals, Humans, Mice, Disease Models, Animal, Male, Signal Transduction drug effects, Prostaglandin-E Synthases genetics, Prostaglandin-E Synthases metabolism, Eosinophils immunology, Eosinophils metabolism, Eosinophils drug effects, Female, Chronic Disease, Mice, Inbred C57BL, Rhinosinusitis, Sinusitis drug therapy, Sinusitis metabolism, Sinusitis immunology, Rhinitis drug therapy, Rhinitis metabolism, Rhinitis immunology, Dinoprostone metabolism, Nasal Mucosa metabolism, Nasal Mucosa immunology, Nasal Mucosa drug effects, Eosinophilia drug therapy, Eosinophilia metabolism, Mice, Knockout, Receptors, Prostaglandin E, EP2 Subtype metabolism
- Abstract
Current treatments of eosinophilic chronic rhinosinusitis (ECRS) involve corticosteroids with various adverse effects and costly therapies such as dupilumab, highlighting the need for improved treatments. However, because of the lack of a proper mouse ECRS model that recapitulates human ECRS, molecular mechanisms underlying this disease are incompletely understood. ECRS is often associated with aspirin-induced asthma, suggesting that dysregulation of lipid mediators in the nasal mucosa may underlie ECRS pathology. We herein found that the expression of microsomal PGE synthase-1 (encoded by PTGES ) was significantly lower in the nasal mucosa of ECRS patients than that of non-ECRS subjects. Histological, transcriptional, and lipidomics analyses of Ptges -deficient mice revealed that defective PGE
2 biosynthesis facilitated eosinophil recruitment into the nasal mucosa, elevated expression of type-2 cytokines and chemokines, and increased pro-allergic and decreased anti-allergic lipid mediators following challenges with Aspergillus protease and ovalbumin. A nasal spray containing agonists for the PGE2 receptor EP2 or EP4, including omidenepag isopropyl that has been clinically used for treatment of glaucoma, markedly reduced intranasal eosinophil infiltration in Ptges -deficient mice. These results suggest that the present model using Ptges -deficient mice is more relevant to human ECRS than are previously reported models and that eosinophilic inflammation in the nasal mucosa can be efficiently blocked by activation of the PGE2 -EP2 pathway. Furthermore, our findings suggest that drug repositioning of omidenepag isopropyl may be useful for treatment of patients with ECRS., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2024 Horikiri, Taketomi, Kondo, Yamasoba and Murakami.)- Published
- 2024
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24. Role of stereotactic radiosurgery for recurrent skull base acinic cell carcinoma: illustrative case.
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Yoshihira T, Umekawa M, Shinya Y, Hasegawa H, Shin M, Kikuchi Y, Saito Y, Kondo K, Katano A, Shinozaki-Ushiku A, and Saito N
- Abstract
Background: Acinic cell carcinomas (AcCCs), rare malignancies of the salivary glands, often recur and metastasize, particularly in the skull base. Conventional radical resection can be invasive for skull base AcCCs adjacent to cranial nerves and major vasculature, and the effectiveness of stereotactic radiosurgery (SRS) as an alternative is not well established., Observations: This case report details the application of SRS for recurrent skull base AcCCs. A 71-year-old male with a history of resection for a right mandibular AcCC 23 years earlier experienced tumor recurrence involving the right cavernous sinus and nasal cavity. He underwent endoscopic transnasal surgery followed by SRS targeting different tumor locations-the cavernous sinus to the pterygopalatine fossa, maxillary sinus, and clivus-each with a prescribed dose of 20 Gy to the 40% to 50% isodose line. After the first skull base metastasis, additional sessions of localized SRS after endoscopic surgery led to a 12-year survival without sequela., Lessons: This is a report indicating that SRS for skull base AcCCs can achieve favorable local control, functional preservation, and long-term survival. SRS may be suitable for skull base AcCC given the lesion's tendency toward multiple local recurrences. Further investigation is needed to validate the treatment's efficacy.
- Published
- 2024
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25. Management and Treatment for Dysphagia in Neurodegenerative Disorders.
- Author
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Ueha R, Cotaoco C, Kondo K, and Yamasoba T
- Abstract
Patients with neurodegenerative disorders (NDDs) often experience functional dysphagia, which may involve dysfunction in a specific phase of swallowing or in the entire process. This review outlines the approach to dysphagia in the setting of NDDs. Distinguishing the etiology of dysphagia can be difficult, and it is important to always look out for signs pointing to NDD as the cause. Thorough diagnostic work-up is essential, and it includes a comprehensive history and physical examination, alongside swallowing function tests, such as fiberoptic endoscopic evaluation of swallowing, videofluoroscopic swallowing study, and high-resolution manometry. Management requires a multidisciplinary approach with a treatment plan tailored to each patient. This involves dietary guidance, swallowing rehabilitation, and surgery in cases in which improvement with rehabilitation is inadequate. Surgery may involve altering certain pharyngolaryngeal structures to facilitate swallowing and reduce the risk of aspiration (swallowing improvement surgery) or separating the airway and digestive tract while sacrificing laryngeal function, with the main goal of preventing aspiration (aspiration prevention surgery). Proper management stems from recognizing the impact of these disorders on swallowing and consistently finding ways to improve the quality of life of patients.
- Published
- 2023
- Full Text
- View/download PDF
26. Stereotactic radiosurgery for recurrent skull base polymorphous adenocarcinoma invading the cavernous sinus: illustrative case.
- Author
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Rai Y, Umekawa M, Shinya Y, Hasegawa H, Katano A, Kondo K, Shinozaki-Ushiku A, and Saito N
- Abstract
Bakground: Polymorphous adenocarcinomas (PACs) are rare tumors arising from the salivary glands. Radical resection and postoperative radiotherapy are the mainstays of treatment. However, complete tumor resection is not always achievable when the tumor invades the skull base. Stereotactic radiosurgery (SRS) could be a less invasive alternative for treating skull base PACs., Observations: A 70-year-old male with a history of surgery for a right palatine PAC presented with right visual impairment, diplopia, and ptosis. Imaging studies revealed tumor recurrence invading the right cavernous sinus (CS). SRS using a gamma knife was performed for this recurrence, prescribing a marginal dose of 18 Gy at a 50% isodose line. Five months after SRS, his symptoms were relieved, and the tumor was well-controlled for 55 months without any adverse events., Lessons: To the best of the authors' knowledge, this is the world's first case of recurrent skull base PAC invading the CS that was successfully treated with salvage SRS. Thus, SRS may be an applicable treatment option for skull base PACs.
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- 2023
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27. Sleep deprivation induces delayed regeneration of olfactory sensory neurons following injury.
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Han B, Kikuta S, Kamogashira T, Kondo K, and Yamasoba T
- Abstract
The circadian system, which is essential for the alignment of sleep/wake cycles, modulates adult neurogenesis. The olfactory epithelium (OE) has the ability to generate new neurons throughout life. Loss of olfactory sensory neurons (OSNs) as a result of injury to the OE triggers the generation of new OSNs, which are incorporated into olfactory circuits to restore olfactory sensory perception. This regenerative potential means that it is likely that the OE is substantially affected by sleep deprivation (SD), although how this may occur remains unclear. The aim of this study is to address how SD affects the process of OSN regeneration following OE injury. Mice were subjected to SD for 2 weeks, which induced changes in circadian activity. This condition resulted in decreased activity during the night-time and increased activity during the daytime, and induced no histological changes in the OE. However, when subjected to SD during the regeneration process after OE injury, a significant decrease in the number of mature OSNs in the dorsomedial area of the OE, which is the only area containing neurons expressing NQO1 (quinone dehydrogenase 1), was observed compared to the NQO1-negative OE. Furthermore, a significant decrease in proliferating basal cells was observed in the NQO1-positive OE compared to the NQO1-negative OE, but no increase in apoptotic OSNs was observed. These results indicate that SD accompanied by disturbed circadian activity could induce structurally negative effects on OSN regeneration, preferentially in the dorsomedial area of the OE, and that this area-specific regeneration delay might involve the biological activity of NQO1., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Han, Kikuta, Kamogashira, Kondo and Yamasoba.)
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- 2022
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28. Stereotactic radiosurgery for skull base adenoid cystic carcinoma: A report of two cases.
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Nakamura Y, Umekawa M, Shinya Y, Hasegawa H, Shin M, Katano A, Shinozaki-Ushiku A, Kondo K, and Saito N
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Background: Adenoid cystic carcinoma (ACC) is an uncommon salivary gland tumor with a relatively favorable prognosis. However, treating ACC is potentially challenging because radical resection is usually difficult once the skull base is involved due to the adjacent critical structures. Stereotactic radiosurgery (SRS) is a less invasive alternative for surgically recalcitrant lesions., Case Description: We report two patients with three metastatic skull base ACCs who underwent SRS using the Gamma Knife with a marginal dose of 20 Gy to a 50% isodose line. All tumors were effectively controlled without any adverse events., Conclusion: This case report and our review of the literature suggest that SRS can be considered for local control of ACC invading the skull base when surgical resection is unsuitable or a postoperative residual lesion is suspected. Further, investigations on the accumulated subjects are warranted to confirm the role of SRS for the treatment of ACCs., Competing Interests: There are no conflicts of interest., (Copyright: © 2022 Surgical Neurology International.)
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- 2022
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29. Editorial: Physiology and pathophysiology of the olfactory system.
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Kashiwadani H, Heinbockel T, Imamura F, Yamaguchi M, Koyama S, and Kondo K
- Abstract
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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- 2022
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30. Evidence for the spread of SARS-CoV-2 and olfactory cell lineage impairment in close-contact infection Syrian hamster models.
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Ueha R, Ito T, Ueha S, Furukawa R, Kitabatake M, Ouji-Sageshima N, Uranaka T, Tanaka H, Nishijima H, Kondo K, and Yamasoba T
- Subjects
- Cricetinae, Animals, Humans, SARS-CoV-2, Mesocricetus, Cell Lineage, Disease Models, Animal, COVID-19, Olfaction Disorders
- Abstract
Objectives: Close contact with patients with COVID-19 is speculated to be the most common cause of viral transmission, but the pathogenesis of COVID-19 by close contact remains to be elucidated. In addition, despite olfactory impairment being a unique complication of COVID-19, the impact of SARS-CoV-2 on the olfactory cell lineage has not been fully validated. This study aimed to elucidate close-contact viral transmission to the nose and lungs and to investigate the temporal damage in the olfactory receptor neuron (ORN) lineage caused by SARS-CoV-2., Methods: Syrian hamsters were orally administered SARS-CoV-2 nonvariant nCoV-19/JPN/TY/WK521/2020 as direct-infection models. On day 3 after inoculation, infected and uninfected hamsters were housed in the same cage for 30 minutes. These uninfected hamsters were subsequently assigned to a close-contact group. First, viral presence in the nose and lungs was verified in the infection and close-contact groups at several time points. Next, the impacts on the olfactory epithelium, including olfactory progenitors, immature ORNs, and mature ORNs were examined histologically. Then, the viral transmission status and chronological changes in tissue damage were compared between the direct-infection and close-contact groups., Results: In the close-contact group, viral presence could not be detected in both the nose and lungs on day 3, and the virus was identified in both tissues on day 7. In the direct-infection group, the viral load was highest in the nose and lungs on day 3, decreased on day 7, and was no longer detectable on day 14. Histologically, in the direct-infection group, mature ORNs were most depleted on day 3 (p <0.001) and showed a recovery trend on day 14, with similar trends for olfactory progenitors and immature ORNs. In the close-contact group, there was no obvious tissue damage on day 3, but on day 7, the number of all ORN lineage cells significantly decreased (p <0.001)., Conclusion: SARS-CoV-2 was transmitted even after brief contact and subsequent olfactory epithelium and lung damage occurred more than 3 days after the trigger of infection. The present study also indicated that SARS-CoV-2 damages all ORN lineage cells, but this damage can begin to recover approximately 14 days post infection., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Ueha, Ito, Ueha, Furukawa, Kitabatake, Ouji-Sageshima, Uranaka, Tanaka, Nishijima, Kondo and Yamasoba.)
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- 2022
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31. Case report: Unilateral transnasal endoscopic marsupialization of nasopalatine duct cyst.
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Kagoya R, Iwanami T, Mochizuki M, Kondo K, and Ito K
- Abstract
Nasopalatine duct cyst (NPDC) is the most common type of non-odontogenic cysts of the jaw. It has been treated with complete surgical resection using a sublabial or palatine approach. However, complete removal of the cyst can be accompanied by postoperative complications including oronasal fistula. Recently, endoscopic marsupialization for the disease has been advocated, but there are still few reports regarding the surgery. Herein, we report a case of NPDC that was treated with unilateral transnasal endoscopic marsupialization. A 43-year-old man with no relevant previous medical history was referred to our hospital for the treatment of lesion occupying the right nasal cavity. A computerized tomography scan of the sinus revealed an egg-shaped lesion with a well-defined border centered on the lower half of the nasal cavity and hard palate. Based on the site of the lesion, it was considered to be NPDC. Transnasal endoscopic marsupialization was performed to diagnose and improve nasal obstruction. Histopathological examination revealed stratified squamous epithelium without atypia, which was consistent with NPDC. Although the patient noticed paresthesia of the right upper incisor area, symptoms improved 3 months after surgery. Written informed consent was obtained from the patient for the publication of any potentially identifiable images or data included in this article. Transnasal endoscopic marsupialization for NPDC is minimally invasive and useful; however, it is necessary to build evidence for an appropriate excision range based on the position and size of the lesion., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (© 2022 Kagoya, Iwanami, Mochizuki, Kondo and ITO.)
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- 2022
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32. High CT Attenuation Values Relative to the Brainstem Predict Fungal Hyphae Within the Sinus.
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Kikuta S, Han B, Yoshihara S, Nishijima H, Kondo K, and Yamasoba T
- Abstract
Objectives: There is currently no established objective diagnostic indicator for the differentiation of sinus fungal ball (SFB) from unilateral nonfungal chronic sinusitis (UCRS). This study evaluated whether computed tomography (CT) attenuation values relative to those of the brainstem (relative CT number) are useful for differentiating SFB from UCRS., Materials and Methods: Consecutive patients who were pathologically diagnosed with SFB or UCRS between 2013 and 2021 were retrospectively identified. The relative CT numbers of region of interest (ROIs) within the sinuses were compared between the two patient groups. Factors with predictive power for differentiating SFBs from UCRSs were identified by uni/multivariable logistic regression analyses., Results: One hundred and eighty-three patients with unilateral chronic sinusitis were finally analyzed (SFB, 86 cases; UCRS, 97 cases). Regardless of the presence or absence of calcified lesions, the relative CT numbers in SFB were significantly higher than those in UCRS. ROIs showing high relative CT numbers were those where fungal hyphae were present. In the uni/multivariable logistic regression analysis, age ( p < 0.001), relative CT number ( p < 0.001), and calcification ( p = 0.002) had predictive value for distinguishing SFB from UCRS. Within those cases not showing calcification, age ( p = 0.004) and relative CT number ( p < 0.001) were predictive factors for differentiating SFB from UCRS. A relative CT number >1.5 was significantly associated with SFB (sensitivity, 70%; specificity, 91%), with a significantly larger area under the receiver operating characteristics curve than age., Conclusions: High relative CT numbers within the sinus are strongly associated with the presence of fungal hyphae, and measurement of relative CT number is a powerful adjunctive diagnostic method for distinguishing between SFB and UCRS., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Kikuta, Han, Yoshihara, Nishijima, Kondo and Yamasoba.)
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- 2022
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33. Endoscopic endonasal transpetroclival approach for recurrent bilateral petroclival meningioma.
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Shinya Y, Shin M, Hasegawa H, Koizumi S, Kin T, Kondo K, and Saito N
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The authors performed an endoscopic endonasal transpetroclival approach for recurrent bilateral petroclival meningioma, with the aim of sufficient tumor resection with cranial nerve functional preservation. The tumor was sufficiently removed with excellent postoperative course. Petroclival meningioma, especially located in the medial region with dural attachment of the clivus, is considered a good indication for this approach. Recurrent tumors after radiotherapy often have strong adhesion to the brainstem and basilar artery; therefore, careful assessment of whether or not tumor detachment is possible is essential. The endoscopic endonasal transpetroclival approach is an acceptable, less-invasive treatment for petroclival tumors. The video can be found here: https://stream.cadmore.media/r10.3171/2022.1.FOCVID21229., Competing Interests: Disclosures The authors report no conflict of interest concerning the materials or methods used in this study or the findings specified in this publication.The authors report no conflict of interest concerning the materials or methods used in this study or the findings specified in this publication., (© 2022, The Authors.)
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- 2022
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34. Combined endoscopic endonasal transtubercular and transclival approaches for large neurenteric cyst in posterior cranial fossa: A case report and literature review.
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Sato D, Hasegawa H, Shin M, Kondo K, and Saito N
- Abstract
Background: Intracranial neurenteric cysts (NCs) are extremely rare tumors that more commonly involve the posterior fossa than any other cranial part. While transcranial skull base surgery has been the mainstay of treatment, the utility of endoscopic transnasal surgery (ETS) remains to be established., Case Description: We report a case of a large posterior fossa NC extensively involving the suprasellar region, cerebellopontine angle, and prepontine cistern, which we successfully resected with ETS through a combination of transtubercular and transclival routes. Before surgery, the patient presented with abducens nerve and pseudobulbar palsies, which resolved within 2 weeks postoperatively. The patient remained free from recurrence for 3 years postoperatively., Conclusion: Extended ETS may offer a minimally invasive option for the posterior fossa NC, extensively occupying the ventral space of the brainstem., Competing Interests: There are no conflicts of interest., (Copyright: © 2021 Surgical Neurology International.)
- Published
- 2021
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