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The paper proves a theorem about the structure of the distribution function on which the extremum of the fractionally linear functional is reached in the presence of an uncountable number of linear constraints. The problem of finding an extremal distribution function arises when determining the optimal control strategy in a class of Markov homogeneous randomized control strategies. The structure of extremal functions is described by a finite number of parameters; hence, the problem is greatly simplified since it is reduced to the search for an extremum of some function. [ABSTRACT FROM AUTHOR]

General problems on maximizing the products of several positive real, rational and integer numbers whose sum is given are investigated. [ABSTRACT FROM AUTHOR]

We have shown the possibility of mathematical analysis of complex biochemical reactions without simplifying assumptions regarding their parameters by investigating the mechanism of adenosine triphosphate (ATP) hydrolysis by the "basal" Mg2+-ATPase in which ATP (substrate), Mg2+ (essential activator) and MgATP (true substrate) compete for binding with the enzyme catalytic site. For this mechanism, we proved, using the quasi-steady state principle by Bodenstein, the existence and uniqueness of a quasi-steady state at any fixed parameters (initial reactant concentrations, positive reaction rate constants). On this basis, the definition of the initial reaction rate v as a function of the initial concentrations of ATP (x1), Mg2+ (x2), ATPase (x3) is given and the dependencies v vs. xi are investigated. We proved that at fixed initial concentrations of any two reactants, the kinetic curve v vs. xi has a unique maximum point. In different regions of the kinetic curve located before and after the maximum point, the initial rate may vary in different ways: in one region it can change more slowly than the reactant concentration, as in the case of hyperbolic dependencies, and in the other it can change much faster than the reactant concentration, as in the case of sigmoid dependencies, which is typical for regulatory enzymes. This initial rate behaviour causes the existence of four different types of bell-shaped kinetic curves. To quantify the degree of sigmoidity of kinetics, we used derivatives ∂ ln v ∂ ln x i which allowed us to estimate the maximal velocity of the initial rate change. [ABSTRACT FROM AUTHOR]

We study extrema of the Mityuk radius depending on the choice of the canonical domain. Turning to the doubly connected case allows us to use the explicit form of mapping functions onto canonical domains. We obtain the results on the localization of critical points of the Mityuk radius for two types of such domains. [ABSTRACT FROM AUTHOR]

The paper proves a theorem about the structure of the distribution function on which the extremum of the fractionally linear functional is reached in the presence of an uncountable number of linear constraints. The problem of finding an extremal distribution function arises when determining the optimal control strategy in a class of Markov homogeneous randomized control strategies. The structure of extremal functions is described by a finite number of parameters; hence, the problem is greatly simplified since it is reduced to the search for an extremum of some function.