1. Pumpless deterministic lateral displacement separation using a paper capillary wick.
- Author
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Aghajanloo, Behrouz, Ejeian, Fatemeh, Frascella, Francesca, Marasso, Simone L., Cocuzza, Matteo, Tehrani, Alireza Fadaei, Nasr Esfahani, Mohammad Hossein, and Inglis, David W.
- Subjects
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MICROFLUIDICS , *FLOW separation , *MICROFLUIDIC devices , *CELL separation , *CAPILLARIES , *INTEGRATED circuits - Abstract
Deterministic lateral displacement (DLD) is a passive separation method that separates particles by hydrodynamic size. This label-free method is a promising technique for cell separation because of its high size resolution and insensitivity to flow rate. Development of capillary-driven microfluidic technologies allows microfluidic devices to be operated without any external power for fluid pumping, lowering their total cost and complexity. Herein, we develop and test a DLD-based particle and cell sorting method that is driven entirely by capillary pressure. We show microchip self-filling, flow focusing, flow stability, and capture of separated particles. We achieve separation efficiency of 92% for particle–particle separation and more than 99% efficiency for cell–particle separation. The high performance of driven flow and separation along with simplicity of the operation and setup make it a valuable candidate for point-of-care devices. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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