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To address the increasing hydrogen demand and carbon emissions of industrial parks, this paper proposes an integrated energy system dispatch strategy considering multi-hydrogen supply and comprehensive demand response. This model adopts power-to-gas technology to produce green hydrogen, replacing a portion of gray hydrogen and incorporates a carbon capture system to effectively reduce the overall carbon emissions of the industrial park. Meanwhile, incentive-based and price-based demand response strategies are implemented to optimize the load curve. A scheduling model is established targeting the minimization of procurement, operation, carbon emission, and wind curtailment costs. The case study of a northern industrial park in China demonstrates that the joint supply of green and gray hydrogen reduces carbon emissions by 40.98% and costs by 17.93% compared to solely using gray hydrogen. The proposed approach successfully coordinates the economic and environmental performance of the integrated energy system. This study provides an effective scheduling strategy for industrial parks to accommodate high shares of renewables while meeting hydrogen needs and carbon reduction targets. [ABSTRACT FROM AUTHOR]

Analysis of Chinese real estate market shifted from eco nomic fundamentals to non-fundamentals, but consensus conclusions are still rarely reached. This is because institutional perspectives and national subjects are still lacking. Based on critical realistic approach, this paper integrates a state–society relationship and institution provision, constructing an analytical framework for the role of state capacity in the institutional construction of the real estate market. In terms of the intervention of the state on actors in the Chinese real estate market, the central government influences local governments, interest groups, and society at large through its administrative, extracting, and market service capacities, respectively, forming a chain of interests that serves the state–society relationship. [ABSTRACT FROM AUTHOR]

To understand the characteristics of Vibrio isolates in aquatic environments in China and their public health significance, this study investigated water samples in six cities in China in 2020. A total of 88 sampling locations were included and Vibrio isolates were identified in 81 of them. A total of 143 Vibrio isolates belonging to 16 species were selected for characterization. The population structure of Vibrio species showed great differences among the six cities, indicating regional specificity. The presence of virulence genes was examined for the isolates (n = 78) of five pathogenic Vibrio species. All isolates except one (n = 77) contained at least one virulence gene and isolates belonging to the same species showed very similar virulence gene profiles. Then, 26 isolates from 12 species were examined by multilocus sequence typing and were assigned to 25 STs, of which 24 STs were new. Also, the presence of antibiotic-resistant genes was investigated for all 143 isolates and only three isolates were found to contain genes from aminoglycosides, phenicols, beta-lactams or the tetracycline family. Our results provide valuable insights into the Vibrio community in Chinese aquatic environments and can be applied as guidance for the environmental surveillance of the risk of Vibrio isolates. [ABSTRACT FROM AUTHOR]

Dengue fever virus (DENV) is a mosquito-borne flavivirus that poses a serious risk to human health. Aedes albopictus is a widely distributed vector of dengue fever in China. Based on the impact of physiological activity, the microbiome in A. albopictus will provide a novel environment-friendly approach to control DENV transmission. We performed metagenomic sequencing on A. albopictus before and after exposure to DENV blood meal to detect microbiome variation of A. albopictus with different susceptibilities to DENV. The dominant phyla in A. albopictus microbiome were Proteobacteria and Ascomycota , and the dominant genera were Aspergillus and Metarhizium. Gammaproteobacteria bacterium , Lactobacillus harbinensis , and Neurospora crassa differed significantly after DENV infection. There were 15 different microorganisms found to be involved in mosquito immunity and metabolism, such as Alphaproteobacteria bacterium , Methyloglobulus morosus , and Shigella sonnei , which might have an impact on the DENV susceptibility of A. albopictus. It was hypothesized that the lack of specific bacteria may lead to increased susceptibility of A. albopictus to DENV. Interventions in the microbiome composition or specific bacteria of A. albopictus may affect the susceptibility to DENV and control the mosquito-borne diseases efficiently. [ABSTRACT FROM AUTHOR]

Objective: To investigate parental knowledge, attitudes, and practices (KAP) toward adolescent depression., Methods: A cross-sectional survey was conducted between October 2022 and October 2023 at The First Affiliated Hospital of Ningbo University among parents of adolescents diagnosed with depression. A self-administered questionnaire was used to collect the parents' demographic characteristics and KAP toward adolescent depression., Results: A total of 522 questionnaires were collected from parents of depressed adolescents. Among the participants, 383 (73.37%) were female. In addition, 426 participants (81.61%) had children aged 14-18. The mean knowledge, attitude, and practice scores were 9.09 ± 2.37 (possible range: 0-12), 37.04 ± 4.11 (possible range: 11-55), and 31.53 ± 3.84 (possible range: 8-40), respectively. There were significant positive correlations between knowledge and attitude ( r  = 0.225, p  < 0.001), knowledge and practice ( r  = 0.240, p  < 0.001), and attitude and practice ( r  = 0.381, p  < 0.001). The path analysis showed significant direct effects of knowledge on attitude (β = 0.422, p  < 0.001) and practice (β = 0.283, p  < 0.001). There was an indirect effect of knowledge on practice through attitude (β = 0.131, p  = 0.004). Attitude directly impacted practice (β = 0.311, p  < 0.001)., Conclusion: Parents of adolescents diagnosed with depression exhibited moderate KAP regarding adolescent depression. The study underscored the importance of targeted interventions to improve parental KAP in supporting adolescents with depression. Moreover, future research should explore additional factors influencing parental attitudes and behaviors toward adolescent depression to develop more effective interventions., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2024 Gao, Dai, Lin, Ye, Yang, Zhang, Mao, Lou, Ji, Ruan and Hou.)

Aiming to understand the responses of soil seed bank to different water levels, we investigated vegetation and soil seed bank along a water level gradient (frequently flooded area, unflooded area) on the floodplain wetland of Juzhang River. We used the structural equation model to explore the direct and indirect effects of water level on soil seed bank, and used non-metric multidimensional scaling (NMDS) to assess the role of soil seed bank for vegetation regeneration. The results showed that the density of transient and persistent seed banks at unflooded area was 36.9% and 7.8% higher than that of frequently flooded area, respectively. Shannon index and Pielou index of seed bank and vegetation were significantly affected by water level and sampling location. Water level significantly affected the similarity between seed bank and aboveground vegetation, and the similarity of persistent seed bank with aboveground vegetation was significantly higher than that with transient seed bank. Structural equation model showed that water level had a direct effect on seed bank density, and indirect effects on density and richness of seed bank via affecting soil pH and NH 4 + -N content. NMDS results showed that there was no significant difference in the composition of the persistent seed bank and vegetation community in autumn under different water levels, but water level significantly changed the community composition of transient seed bank. Transient seed bank was affected by the vegetation and soil property, while persistent seed bank was determined by aboveground vegetation and water level. Although soil seed bank had low regeneration potential for the vegetation communities in floodplain wetlands, soil seed bank could not be neglected during the restoration of propagule diversity after disturbance in wetlands. Persistent seed bank would be an importance source of diversity of propagules for floodplain wetlands restoration following disturbance.

In recent years, a changing global climate and the continuous expansion of the intensity and scope of human activities have led to regional differentiation in the surface landscape. This has caused numerous ecological risks under multiple pressure sources, gradually becoming an important factor restricting the sustainable development of economic and social health. With the continuous development of the social economy, land use and associated ecological risks will inevitably change. According to the forest transformation theory and the environmental Kuznets curve, we put forward the theoretical framework of ecological risk transformation of land-use change and took Zhangjiachuan County (China) as an example to verify it. Therefore, on the basis of Landsat satellite data, this paper used landscape structures to calculate an ecological risk index, and evaluated the ecological risk of land-use changes through pattern index analyses. The results show that, from 2000 to 2020, the ecological risk index of land-use change in Zhangjiachuan County exhibited an increasing and then decreasing trend, showing an overall "inverted U-shaped" trend of change consistent with the transformation theoretical framework of ecological risks of land use change. Secondly, in terms of patterns, the ecological risk of land-use change in Zhangjiachuan County showed a distribution feature of high in the west and low in the east. In 2000, high-risk areas were mainly concentrated in the central and northern areas, while low-risk areas were mainly concentrated in the eastern areas. From 2000 to 2015, the medium-risk areas expanded to the west and midwest, and the geographic centers of the risk areas were slightly offset. From 2015 to 2020, the overall pattern of ecological risk areas was basically the same as that of the previous stage, but the medium-risk areas were slightly reduced. In terms of quantity, from 2000 to 2015, the areas of the lowest risk level and low risk level decreased, while the areas of medium risk level, high risk level, and the highest risk level increased; from 2015 to 2020, the areas of the lowest risk level and low risk level increased, and the areas of medium risk level, high risk level, and highest risk level decreased. Lastly, the spatial aggregation of ecological risks in Zhangjiachuan County weakened slightly from 2000 to 2005, gradually increased from 2005 to 2015, and then slightly weakened from 2015 to 2020.

Background: Tumor grade determined by the Ki67 index is the best prognostic factor for pancreatic neuroendocrine tumors (PanNETs). However, we often observe that the grade of metastases differs from that of their primary tumors. This study aimed to investigate the frequency of grade changes between primary tumors and metastases, explore its association with clinical characteristics, and correlate the findings with the prognosis., Methods: Six hundred forty-eight patients with pancreatic neuroendocrine neoplasms treated at Fudan University Shanghai Cancer Center were screened for inclusion, and 103 patients with PanNETs who had paired primary tumors and metastases with an available Ki67 index were included. Re-evaluation of Ki67 was performed on 98 available samples from 69 patients., Results: Fifty cases (48.5%) had a Ki67 index variation, and 18 cases (17.5%) displayed a grade increase. Metachronous metastases showed significantly higher Ki67 index variation than synchronous metastases ( P =0.028). Kaplan-Meier analyses showed that high-grade metastases compared to low-grade primary tumors were significantly associated with decreased progression-free survival (PFS, P =0.012) and overall survival (OS, P =0.027). Multivariable Cox regression analyses demonstrated that a low-grade increase to high-grade was an unfavorable and independent prognostic factor for PFS and OS ( P =0.010, and P =0.041, respectively)., Conclusions: A high-grade increase in metastases was an unfavorable predictor of PanNETs, which emphasized the importance of accurate pathological grading and could provide a reference for clinical decision-making., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Zhang, Gao, Liu, Qin, Ye, Lou, Wang, Zhang, Chen, Chen, Yu, Zhuo, Xu and Ji.)

Although coal is difficult to replace in the short term, the large-scale production and consumption of coal have significant impacts on the ecological environment. The severe disturbances, such as land excavation and occupation, that accompany the mining of mineral resources have caused dramatic changes in land cover and a significant pressure on the sensitive and fragile ecological environment. To analyze the temporal and spatial evolution trends and the differences in land use in different typical mining areas in Inner Mongolia, as well as the evaluation system and driving mechanisms of land use evolution, this study takes the typical open-pit coal mines in Inner Mongolia as the research objects and, based on the Google Earth Engine (GEE) platform, analyzes the dynamic evolution characteristics and driving factors of land use in typical open-pit coal mines in Inner Mongolia from 2001 to 2020. The change trend of land use in typical open-pit mining areas in Inner Mongolia for the past 20 years is obvious, with the highest fluctuations for grassland, mining land, cropland, and residential/industrial land. Land use in the open-pit coal mining area is greatly affected by mining factors. From the perspective of spatial variation, the most important driving factor is the distance from national roads and railways, followed by the annual average temperature and annual average precipitation and topographical conditions, such as elevation. In terms of policy, land reclamation and ecological restoration in mining areas have a positive impact on land use change. Improving the mechanism for environmental compensation in mining areas can promote the efficient and rational use of mining areas and the protection of ecosystems.

Background: Recent studies have found that there are significant associations between body iron status and the development of diabetes. In the present study, we aimed to analyze the association among iron overload (IO), insulin resistance (IR), and diabetes in Chinese adults, and to explore the sex difference., Methods: Men and women (age >19 years) who participated in the Chinese Health and Nutrition Survey and did not have diabetes at baseline were followed between 2009 and 2015 (n=5,779). Over a mean of 6 years, 75 participants were diagnosed with incident diabetes. Logistic regression was used to assess the risk factors associated with IO. Cox proportional hazard regression was used to estimate the risk of incident diabetes and to determine whether the risk differed among subgroups. Causal mediation analysis (CMA) was used to explore the mechanism linking IO and diabetes., Results: According to sex-stratified multivariable-adjusted Cox proportional hazards regression, IO increased the risk of incident diabetes. Women with IO had a higher risk of diabetes than men. Subgroup analysis with respect to age showed that the association between IO and diabetes was stronger in older women and younger men (P<0.001). CMA showed that liver injury (alanine transaminase) and lipid metabolism abnormalities (triglyceride, apolipoprotein B) contributed to the association between IO and diabetes., Conclusion: IO is associated with diabetes and this association is sex-specific. IO may indirectly induce IR via liver injury and lipid metabolism abnormalities, resulting in diabetes.