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With a single-switched DC-DC converter, a hybrid approach is proposed for a fast-charging (FC) dc to dc converter with the controller for an electric vehicle charging station (EVCS) that combines solar photovoltaic (PV), fuel cells (FC), and a battery energy storage system (BESS). The proposed hybrid technique integrates a radial-basis-function-neural-network (RBFNN) and a student-psychology-optimization-algorithm (SPOA); commonly known as the RBFNN-SPOA technique. The PV-FC hybrid electric vehicle systems, like controllers, electric vehicle, and the vehicle’s power source, are displayed. The proposed converter architectures have less voltage waveform changes, a low voltage stress on semiconductor power sources, and a high-voltage ratio of conversion. The proposed method is to use FC successfully at battery charge states and varied radiation levels. The FC in the controller of SPOA may change the inputs and outputs depending on the battery state of charge (SoC) and PV irradiation. Similarly, the needed input-torque for the motor is forecasted by the recalling recurrent neural network controller using several manually produced torque signals. The performance of the proposed technique is evaluated in MATLAB and is compared to ant colony optimization (ACO), crow optimization algorithm (COA), and fuzzy logic controller (FLC) approaches. According to the results, the efficiency of the proposed technique is 99.17%. [ABSTRACT FROM AUTHOR]

Summary: This article proposes a hybrid POA‐RBFNN approach for PV (photovoltaic) based grid tied intelligent controlled water pump system. The proposed method is the hybrid wrapper of Pelican Optimization Algorithm (POA) and Radial Basis Function Neural Network (RBFNN) and later it is termed as POA‐RBFNN method. On the basis of bidirectional power grids, this research presents bidirectional power flow control for PV systems. The water pump is driven through a three‐phase synchronous reluctance motor (RSM). A novel Cuk integrated Landsman converter can operate at low duty cycles to provide larger DC voltages with negligible switching losses is used. In addition, to enhance the pumping system reliability, solar panels and electric pumps can be used to their maximum potential. Despite fluctuating weather conditions, the system supplies nominal displacement all over the day and surplus energy to the grid. Furthermore, if one of the sources fails, the pump performance is unaffected. Switching losses are minimized since the Voltage Source Inverter (VSI) operates at a fundamental frequency. In all operational modes, this control delivers unique grid‐side power quality and unity power factor functioning. Here, the performance of the proposed hybrid system is implemented in the MATLAB and is compared with several existing methods. [ABSTRACT FROM AUTHOR]

Objective: Neonatal endotracheal intubation is a lifesaving but technically difficult procedure, particularly for inexperienced operators. This secondary analysis in a subgroup of inexperienced operators of the Stabilization with nasal High flow during Intubation of NEonates randomised trial aimed to identify the factors associated with successful intubation on the first attempt without physiological stability of the infant., Methods: In this secondary analysis, demographic factors were compared between infants intubated by inexperienced operators and those intubated by experienced operators. Following this, for inexperienced operators only, predictors of successful intubation without physiological instability were analysed., Results: A total of 251 intubations in 202 infants were included in the primary intention-to-treat analysis of the main trial. Inexperienced operators were more likely to perform intubations in larger and more mature infants in the neonatal intensive care unit where premedications were used. When intubations were performed by inexperienced operators, the use of nasal high flow therapy (nHF) and a higher starting fraction of inspired oxygen were associated with a higher rate of safe, successful intubation on the first attempt. There was a weaker association between premedication use and first attempt success., Conclusions: In inexperienced operators, this secondary, non-randomised analysis suggests that the use of nHF and premedications, and matching the operator to the infant and setting, may be important to optimise neonatal intubation success., Trial Registration Number: ACTRN12618001498280., Competing Interests: Competing interests: None declared., (© Author(s) (or their employer(s)) 2024. No commercial re-use. See rights and permissions. Published by BMJ.)

Residents of lower socioeconomic status (SES) areas are at a higher risk of overweight/obesity than those from higher SES areas. Built environment attributes may mitigate such inequalities. This systematic review synthesised findings of studies examining built environment attributes as potential moderators of the associations between area-level SES and overweight/obesity in adults. From five databases, nine eligible studies were identified. The SES-overweight/obesity relationship was stronger in inner areas and suburbs of large cities, while it was weaker in more rural areas. Two studies examined walkability and reported contrasting findings: no moderation in one and marginally significant moderation (less inequality in higher walkability areas) in the other. No evidence of moderation was found for street connectivity, population density, the food environment, access to physical activity facilities and several perceived environmental attributes. Further research is needed on other built environment attributes (e.g., access to, quantity and quality of green spaces, active transport features), and ideally using prospective study designs and objective makers of adiposity., Competing Interests: Declaration of competing interest None., (Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.)

Purpose: We examined the potential mediating roles of domain-specific physical activities and sedentary behaviors in the relationship between area-level socioeconomic status (SES) and cardiometabolic risk., Methods: Data were from the 2011/2012 Australian Diabetes, Obesity and Lifestyle study (n = 3431). The outcome was a clustered cardiometabolic risk (CCR) score, and the exposure was suburb-level SES. Potential mediators were domain-specific physical activities and sedentary behaviors. Multilevel linear regression models examined associations between SES and potential mediators (α) and between mediators and CCR (β). Mediation was assessed using the joint-significance test., Results: Higher SES was associated with a lower CCR score. Lower SES was associated with less frequent walking for transport, lower vigorous-intensity recreational physical activity, and higher TV time, which were associated with higher CCR scores. However, higher SES was associated with longer transport-related sitting time (all modes and in cars), which were associated with higher CCR scores., Conclusions: The SES-cardiometabolic risk relationship may be partially explained by walking for transport, vigorous-intensity recreational physical activity, and TV viewing. These findings, which require corroboration from prospective evidence and clarification of the roles of transport-related sitting and occupational physical activity, can inform initiatives addressing socioeconomic inequalities in cardiometabolic health., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 Elsevier Inc. All rights reserved.)

The antioxidant enzyme catalase represents an important therapeutic target due to its role in mitigating cellular reactive oxygen species that contribute to the pathogenesis of many disease states. Catalase-SKL (CAT-SKL), a genetically engineered, peroxisome-targeted, catalase derivative, was developed in order to increase the therapeutic potential of the enzyme, and has previously been shown to be effective in combating oxidative stress in a variety of in vitro and in vivo models, thereby mitigating cellular degeneration and death. In the present study we addressed important considerations for the development of an extracellular vesicle-packaged version of CAT-SKL (evCAT-SKL) as a therapeutic for neurodegenerative diseases by investigating its delivery potential to the brain when administered intranasally, and safety by assessing off-target toxicity in a mouse model. Mice received weekly intranasal administrations of evCAT-SKL or empty extracellular vesicles for 4 weeks. Fluorescent labeling for CAT-SKL was observed throughout all sections of the brain in evCAT-SKL-treated mice, but not in empty extracellular vesicle-treated mice. Furthermore, we found no evidence of gross or histological abnormalities following evCAT-SKL or empty extracellular vesicle treatment in a full-body toxicological analysis. Combined, the successful brain targeting and the lack of off-target toxicity demonstrates that intranasal delivery of extracellular vesicle-packaged CAT-SKL holds promise as a therapeutic for addressing neurological disorders., (© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)