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The manuscript presents an efficient method for the synthesis of various cis-azetidin-2-ones with high regio- and diastereoselectivity. This approach utilizes Kinugasa reaction involving diverse functionalized nitrones, including diaryl nitrones and α,β-unsaturated nitrones, in conjunction with acetylenic alcohols. Copper (I) serves as a catalyst to facilitate the transformation. [ABSTRACT FROM AUTHOR]

In this paper, behavioral modeling of a driver amplifier is implemented by using S2P and S2D model setup. By using the standard silicon-based driver amplifier for obtaining the measured results of Scattering (S)- parameters and large signal parameters for temperatures 25°C and 85°C. These parameters are imported into the S2P and S2D models to perform the small signal and large signal analysis at 3 GHz frequency for temperatures 25°C and 85°C. Then, the simulated results are compared with the measured results to verify the efficient utilization of behavioral models. The novelty of this work deals with the simulation study of the characteristics of a silicon-based driver amplifier, which are obtained directly from the measurements. This proposed method is essential for performing hetero-integration of transceiver design, which can be further utilized to improve the efficiency of transceiver for high-frequency band. At last, the study of relative error performance analysis between measured and simulated results of different parameters is carried out and calculated value of NMSE (in %) for S11, S12, S21, S22, gain, pout, 1 dB compression point, ACP, 3rd harmonics, 4th harmonics, and 5th harmonics are 0.0083, 0.0055, 0.0086, 0.011, 0.0844, 0.814, 0.926, 0.71, 0.22, 0.012 and 0.070 respectively. [ABSTRACT FROM AUTHOR]

The present methodology explored the effectiveness and versatility of deep eutectic solvent with ultrasonic energy as an eco-friendly protocol for the synthesis of bisthioglycolic acid derivatives. Bisthioglycolic moiety holds its role as a potent scaffold in sulfur-containing drugs. The presented strategy offers significant advantages such as green catalyst as well as solvent, excellent yield, short reaction time, and simple reaction workup. This methodology shows a wide range of substrate scope that contain both electron-donating as well as electron-withdrawing groups. [ABSTRACT FROM AUTHOR]

Here, we have reported a novel deep eutectic solvent (DES) with tremendous activity for the synthesis of dihydropyridines. DESs have played a trio role in the reaction. It acts as a green catalyst, solvent, and in-situ substrate in this chemical reaction. This method offers various advantages such as metal-free catalysis, green solvent, high yields of the products, and short reaction time. [ABSTRACT FROM AUTHOR]

An eco-friendly, easily achievable and efficient strategy has been explored to synthesize functionalized bisthioglycolic acids using a variety of aldehydes and thioglycolic acid. The employed protocol is solvent free and provides the desirable products in excellent yields (90–99%) with atom economy. Besides, cost effectiveness, short reaction times and milder reaction conditions are among other captivating benefits of the reported methodology. [ABSTRACT FROM AUTHOR]

Functionalized tricyclicpyrimidinones, a class of condensed heterocyclic systems, are found in numerouspotentially active molecules having both innate as well as synthetic origin. Different researchers across the world have explored different synthetic methods for the construction of appropriately functionalized tricyclicpyrimidinones. The present review article recapitulates various reports pertaining to substituted and functionalized tricyclic pyrimidinones reported since 2000. [ABSTRACT FROM AUTHOR]

The manuscript describes an efficient, atom economical synthesis of pyrimido[4,5-b][1,4]benzodiazepin-4-ones by relatively unexplored 7-endo-trig Pictet–Spengler type cyclisations. The synthetic methdodlogy involves the synthesis of different variants of 5-arylidene-amino-3H-pyrimidines and their p-toluene sulfonic acid mediated 7-endo-trig Pictet–Spengler type cyclisations to afford biologically relavent functionalized benzodiazepine condensed pyrimidinones such as pyrimido[4,5-b][1,4]benzodiazepines in good to excellent yields (82–94%). [ABSTRACT FROM AUTHOR]

3-Butadienyl-β-lactams are useful organic synthon which have efficiently been explored for the synthesis of a variety of heterocyclic systems. The present review compiles the various reports on the synthesis of 3-butadienyl-β-lactams and their explorations in the development of variety of monocyclic as well as condensed heterocyclic systems. [ABSTRACT FROM AUTHOR]

Rhodium-catalyzed intermolecular [3 + 2+2] cycloaddition reactions of bis(methylenecyclopropanes) with different alkynes are described. The rhodium-catalyzed [3 + 2+2] cycloadditions resulted in the formation of functionalized 5–7–3 spirocyclic carbocycles in moderate yields with excellent regio- and chemo-selectivity. [ABSTRACT FROM AUTHOR]

Polymeric membrane electrodes (PMEs) and coated graphite electrodes (CGEs) containing 1,3,4-trisubstituted-2-azetidinone derivatives as ion carriers are reported here for bismuth(III) ion selectivity. These electrodes exhibited Nernstian response for Bi3+ ions over a wide concentration range (5.0 × 10-7 M to 1.0 × 10-1 M for CGE) with a lower detection limit of 3.98 × 10-7 M (for CGE) and wide pH range (1.3-5.0). Compared to polymeric membrane electrode, the coated graphite electrode has shown better selectivity for Bi3+ ions with respect to common metal ions. Proposed electrodes have been used for the estimation of Bi3+ ions in pharmaceutical and glass samples. [ABSTRACT FROM AUTHOR]

Abstract InhA is an enoyl acyl carrier reductase that catalyzes the chemo-selective reduction of its 2-trans-enoyl-ACP substrate. The pharmacological effects of the frontline medications used in the treatment of tuberculosis are elicited by inhibiting the enzyme InhA, which disrupts the mycolic acid biosynthesis pathway. The present study involves development of ligand-based pharmacophore model, docking studies, generation of 3D-QSAR model, and molecular dynamic simulation studies of virtually screened putative InhA inhibitors. The best field-based 3D-QSAR model was validated using partial least-square regression (PLS) method with high regression coefficient for training set (R 2) = 0.9256 and test set (R 2) = 0.7542, cross-validated coefficient (r cv 2) = 0.72 and R 2 pred = 0.9764. Also, virtual screening yielded compounds 4, 25, 1, and 30 exhibiting appreciable interactions (docking scores −5.972, −3.819, −3.801, and −3.701, respectively with InhA synthetase; PDB ID: 1BVR). Further, ADMET studies supported drug-like potential of compounds 25, 1, and 30 whereas compound 4 showed negligible human oral absorption. The molecular dynamic simulation studies of the top scored molecule 25 suggested stability of 25-1BVR complex over the course of simulation run. Therefore, this work can be helpful for future discovery of novel InhA inhibitors against drug-resistant tuberculosis. [ABSTRACT FROM AUTHOR]

Abstract The reported work presents the diastereo, regio-, and π-facial selective synthesis of hetero-Diels-Alder (H-DA) cycloadducts with diazene derivatives viz. di-isopropyldiazocarboxylate and diethylazodicarboxylate with cis-/trans-3-butadienyl-β-lactams having stereocentres at its α and β-position. The H-DA reactions resulted in the formation of β-lactam tethered—3,6-dihydro-pyridazines in good yields. [ABSTRACT FROM AUTHOR]