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Objective: Despite numerous neural computational models proposed to explain physiological and pathological mechanisms of brain activity, a large gap remains between theory and application of the models. Building on the successful application of data-driven methods in epileptic seizure detection, we aim to build a bridge between data and models in this paper. Methods: We first propose a novel model-driven seizure detection method based on dynamic features in epileptic EEGs, where the rationale for dynamic features in epileptic EEGs can be clarified in theory by characterizing the variation of parameters of the model. Then we apply the proposed D&F-model-driven method to the problem of early epileptic seizure detection, where the evolution of model parameters selected and optimized by the proposed method is measured and used to detect the starting point of the seizure. Results: Numerical results on two open EEG databases demonstrate that our proposed method does a good job of early epileptic seizure detection. The average detection sensitivity, false positive rate and early detection period attain 100%, 0.1/h, and 7.1 s respectively. Conclusion: This paper provides a strategy to characterize EEG signals using a NMM-related method and the model parameters optimized by real EEG may then serve as features in their own right for early seizure detection. Significance: An useful attempt to early detect epileptic seizures by combining the neural mass model with data analysis. [ABSTRACT FROM AUTHOR]

The rapid development of information technologies provided unprecedented big data environments for condition monitoring and degradation analyses. However, the available big data sets are often sparse with a limited number of observations per recorded unit. For example, in many healthcare systems, data are collected from a large number of patients, but the available observations from each patient are quite limited. Unfortunately, most of the existing approaches for data-driven degradation modeling may not work well in this scenario as they either pool the information from the population or require rich historical observations in each unit. To address the challenges in “sparse data environments,” this paper proposes a structural degradation modeling framework (SDM). The SDM is inspired by the recommender system, which provides recommendations about specific items for the user. In addition, it is also tailored to the needs of degradation modeling. In particular, the framework takes into consideration: 1) the available data from the unit of interest; 2) the population characteristics; 3) the relationship between the available units; and 4) the precision of the available units. Simulation studies and a case study that involves the Alzheimer’s disease (AD) neuroimaging initiative data set are conducted, which shows satisfactory performance of the proposed method. Note to Practitioners—This paper proposes a framework for modeling and predicting the degradation level and/or condition of units with time. Our framework is particularly useful where many units have missing and/or limited degradation observations. Essentially, our proposed method integrates two important ideas: 1) leveraging the available data from the unit of interest to improve the modeling fitting of the individual unit over the observed time domain and 2) considering the relationship between the available units to extract proper and accurate population characteristics to address the challenge of limited observations. The proposed approach is validated via simulation studies as well as a healthcare case study based on AD. In the future research, we will further explore the extension of the proposed method such as considering more generic degradation models and optimal parameter tunings. [ABSTRACT FROM AUTHOR]

An optimum operating strategy is needed for early amortization of expensive hybrid electric vehicle powertrain parts. Especially in the operation of long-haul trucks, fuel costs have a large impact on the total cost of ownership, which is the key entrepreneurial figure in the transportation business. Combined with route information, a predictive powertrain control (PPC) system increases the fuel-saving. In a MATLAB/Simulink model-based generic approach, the operating strategy and the PPC are optimized using a genetic algorithm. The tradeoff between minimizing the fuel consumption and simultaneously maximizing the vehicle speed and gradeability to decrease time-related fixed costs has to be solved. This leads to a multi-optimization problem. The operating strategy is developed for a parallel hybrid topology that includes the fuel-saving functions of regenerative braking, boosting, shifting the load point, and electric drive only operation. The methodology developed answers the search for an optimum control parameter setup combining the operational strategy and the PPC system in long-haul operations. This paper describes the model building, simulation, and optimization of a rule-based control strategy. The route profile and fuel consumption of an internal combustion engine long haul truck were measured in a real-life test run. The recorded data are used for model building and to validate the simulation tool. With an optimized parameter setup, fuel-saving of up to 11% were achieved in theory with acceptable vehicle speed and gradeability. [ABSTRACT FROM AUTHOR]

The hospital system is a complex service system in which patients and hospitals interact and make their decisions based on bounded rationality and information. In this paper, we develop a generative agent-based model to simulate the behavior of a hospital service system. Our model combines agent-based simulation and queueing models to mimic the hospital service processes. Our goal is to simulate and understand the growth and size distribution of hospitals. This simulation model includes agents for supply elements (i.e., hospitals with different resources and expansion strategies) and demand elements (i.e., patients with different preferences for their hospital selections) in a hospital service system. Three important questions are investigated: 1) what is the emergent size distribution of hospitals? 2) what key factors influence the size distribution? and 3) how sensitive is the size distribution to these key factors? Simulation results show that the size distribution is neither power law nor lognormal. Rather, the distribution is leptokurtic, and more skewed than normal but less skewed than lognormal. This result contradicts those in extant literature on the size distributions of human and natural systems, including cities, firms, power-grids, and citation network. We conduct a set of experiments to identify the generative mechanisms for the hospital size distribution and to test the robustness of the results. The model was validated empirically by using a U.S. hospital size dataset. [ABSTRACT FROM AUTHOR]

This paper proposes a novel optimization scheme by hybridizing an artificial bee colony optimizer (HABC) with a bee life-cycle mechanism, for both stationary and dynamic optimization problems. The main innovation of the proposed HABC is to develop a cooperative and population-varying scheme, in which individuals can dynamically shift their states of birth, foraging, death, and reproduction throughout the artificial bee colony life cycle. That is, the bee colony size can be adjusted dynamically according to the local fitness landscape during algorithm execution. This new characteristic of HABC helps to avoid redundant search and maintain diversity of population in complex environments. A comprehensive experimental analysis is implemented that the proposed algorithm is benchmarked against several state-of-the-art bio-inspired algorithms on both stationary and dynamic benchmarks. Then the proposed HABC is applied to the real-world applications including data clustering and image segmentation problems. Statistical analysis of all these tests highlights the significant performance improvement due to the life-cycle mechanism and shows that the proposed HABC outperforms the reference algorithms. [ABSTRACT FROM PUBLISHER]

Storing biometric templates and/or encryption keys, as adopted in traditional biometrics-based authentication methods, has raised a matter of serious concern. To address such a concern, biometric key generation, which derives encryption keys directly from statistical features of biometric data, has emerged to be a promising approach. Existing methods of this approach, however, are generally unable to appropriately model user variations, making them difficult to produce consistent and discriminative keys of high entropy for authentication purposes. This paper develops a semisupervised clustering scheme, which is optimized through a niching memetic algorithm, to effectively and simultaneously model both intra- and interuser variations. The developed scheme is employed to model the user variations on both single features and feature subsets with the purpose of recovering a large number of consistent and discriminative feature elements for key generation. Moreover, the scheme is designed to output a large number of clusters, thus further assisting in producing long while consistent and discriminative keys. Based on this scheme, a biometric key generation method is finally proposed. The performance of the proposed method has been evaluated on the biometric modality of handwritten signatures and compared with existing methods. The results show that our method can deliver consistent and discriminative keys of high entropy, outperforming-related methods. [ABSTRACT FROM AUTHOR]

To respond to volatility and congestion in the power grid, demand response (DR) mechanisms allow for shaping the load compared to a base load profile. When tapping on a large population of heterogeneous appliances as a DR resource, the challenge is in modeling the dimensions available for control. Such models need to strike the right balance between accuracy of the model and tractability. The goal of this paper is to provide a medium-grained stochastic hybrid model to represent a population of appliances that belong to two classes: deferrable or thermostatically controlled loads. We preserve quantized information regarding individual load constraints, while discarding information about the identity of appliance owners. The advantages of our proposed population model are 1) it allows us to model and control load in a scalable fashion, useful for ex-ante planning by an aggregator or for real-time load control; 2) it allows for the preservation of the privacy of end-use customers that own submetered or directly controlled appliances. [ABSTRACT FROM PUBLISHER]

The most effective cancer treatments are the ones that prolong patients’ lives while offering a reasonable quality of life during and after treatment. The treatments must also carry out their actions rapidly and with high efficiency such that a very large percentage of tumor cells die or shift into a state where they stop proliferating. Due to biological and microenvironmental variabilities within tumor cells, the action period of an administered drug can vary among a population of patients. In this paper, based on a recently proposed model for tumor growth inhibition, we first probabilistically characterize the variability of the length of drug action. Then, we present a methodology to devise optimal intervention strategies for any Markovian genetic regulatory network governing the tumor when the antitumor drug has a random-length duration of action. [ABSTRACT FROM PUBLISHER]