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Your search keyword '"Guo, Chang"' showing total 2,664 results
Start Over Author "Guo, Chang" Publication Year Range Last 50 years Publication Type Academic Journals
2,664 results on '"Guo, Chang"'

10. AOD Smelting of Austenitic Stainless 1Mn18Cr18N Protective Ring Steel

Author

Zhang Donghai, Xu Rongchuan, Guo Chang, Xu Yong, Zhang Xiaolei, Pan Mingxu

Subjects
aod；1mn18cr18n steel； thermodynamic； nitrogen alloying； austenitic stainless steel, Materials of engineering and construction. Mechanics of materials, TA401-492, Technology
Abstract

Through the thermodynamic calculation and analysis of nitrogen solubility in 1Mn18Cr18N protective ring steel， it is found that increasing the content of Cr and Mn elements in the steel can significantly improve the solubility of nitrogen. At the same time， the solubility of nitrogen increases as the molten steel temperature decreases . This paper describes the production process of 1Mn18Cr18N protective ring steel by non-vacuum induction furnace， electric furnace，AOD and LF refining， and alloying treatment with bottom blowing nitrogen， which is shorten the production time， and the composition control is quite stable. When AOD refining bottom blowing nitrogen is used for alloying， the nitrogen content in the molten steel can reach 0. 547% and the nitrogen solubility tends to be saturated. In the LF refining process， when using bottom blowing nitrogen and nitrogen-containing alloys， the nitrogen content in the steel can reach 0.68%.

Published
2024
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12. Stepped-up development of accelerator mass spectrometry method for the detection of 60Fe with the HI-13 tandem accelerator

Author

Zhang, Yang, Yan, Sheng-Quan, He, Ming, Zhao, Qing-Zhang, Zhang, Wen-Hui, Kan, Chao-Xin, Zhou, Jian-Ming, Li, Kang-Ning, Wang, Xiao-Fei, Liu, Jian-Cheng, Peng, Zhao-Hua, Liang, Zhuo, Li, Ai-Ling, Zheng, Jian, Fan, Qi-Wen, Li, Yun-Ju, Wang, You-Bao, Li, Zhi-Hong, Shen, Yang-Ping, Nan, Ding, Nan, Wei, Zhang, Yu-Qiang, Li, Jia-Ying-Hao, Tian, Jun-Wen, Hou, Jiang-Lin, Guo, Chang-Xin, Zhang, Zhi-Cheng, Zhu, Ming-Hao, Chen, Yu-Wen, Jiang, Yu-Chen, Tian, Tao, Ma, Jin-Long, Liu, Yi-Hui, Dong, Jing-Yu, Liu, Run-Long, Ma, Mei-Yue-Nan, Chen, Yong-Shou, Liu, Wei-Ping, and Guo, Bing

Published
2024
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15. Nicotinamide mononucleotide as a therapeutic agent to alleviate multi-organ failure in sepsis

Author

Ting Cao, Rui Ni, Weimin Ding, Xiaoyun Ji, Guo-Chang Fan, Zhuxu Zhang, and Tianqing Peng

Subjects
Medicine
Abstract

Abstract Background Sepsis-caused multi-organ failure remains the major cause of morbidity and mortality in intensive care units with limited therapeutics. Nicotinamide mononucleotide (NMN), a precursor of nicotinamide adenine dinucleotide (NAD+), has been recently reported to be protective in sepsis; however, its therapeutic effects remain to be determined. This study sought to investigate the therapeutic effects of NMN in septic organ failure and its underlying mechanisms. Methods Sepsis was induced by feces-injection-in-peritoneum in mice. NMN was given after an hour of sepsis onset. Cultured neutrophils, macrophages and endothelial cells were incubated with various agents. Results We demonstrate that administration of NMN elevated NAD+ levels and reduced serum lactate levels, oxidative stress, inflammation, and caspase-3 activity in multiple organs of septic mice, which correlated with the attenuation of heart dysfunction, pulmonary microvascular permeability, liver injury, and kidney dysfunction, leading to lower mortality. The therapeutic effects of NMN were associated with lower bacterial burden in blood, and less ROS production in septic mice. NMN improved bacterial phagocytosis and bactericidal activity of macrophages and neutrophils while reducing the lipopolysaccharides-induced inflammatory response of macrophages. In cultured endothelial cells, NMN mitigated mitochondrial dysfunction, inflammation, apoptosis, and barrier dysfunction induced by septic conditions, all of which were offset by SIRT3 inhibition. Conclusion NAD+ repletion with NMN prevents mitochondrial dysfunction and restrains bacterial dissemination while limiting inflammatory damage through SIRT3 signaling in sepsis. Thus, NMN may represent a therapeutic option for sepsis.

Published
2023
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35. An Insulin-Modified pH-Responsive Nanopipette Based on Ion Current Rectification

Author

Xu-Fan Wang, Yi-Fan Duan, Yue-Qian Zhu, Zi-Jing Liu, Yu-Chen Wu, Tian-Hao Liu, Ling Zhang, Jian-Feng Wei, and Guo-Chang Liu

Subjects
nanopipettes, bovine insulin, ion current rectification, silanization and amidation, pH response, Chemical technology, TP1-1185
Abstract

The properties of nanopipettes largely rely on the materials introduced onto their inner walls, which allow for a vast extension of their sensing capabilities. The challenge of simultaneously enhancing the sensitivity and selectivity of nanopipettes for pH sensing remains, hindering their practical applications. Herein, we report insulin-modified nanopipettes with excellent pH response performances, which were prepared by introducing insulin onto their inner walls via a two-step reaction involving silanization and amidation. The pH response intensity based on ion current rectification was significantly enhanced by approximately 4.29 times when utilizing insulin-modified nanopipettes compared with bare ones, demonstrating a linear response within the pH range of 2.50 to 7.80. In addition, insulin-modified nanopipettes featured good reversibility and selectivity. The modification processes were monitored using the I-V curves, and the relevant mechanisms were discussed. The effects of solution pH and insulin concentration on the modification results were investigated to achieve optimal insulin introduction. This study showed that the pH response behavior of nanopipettes can be greatly improved by introducing versatile molecules onto the inner walls, thereby contributing to the development and utilization of pH-responsive nanopipettes.

Published
2024
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