17 results on '"Wright, Lauren E."'
Search Results
2. Leveraging Electronic Health Records Data for Enhanced Colorectal Cancer Screening Efforts
- Author
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Baus, Adam, Wright, Lauren E., Kennedy-Rea, Stephenie, Conn, Mary E, Eason, Susan, Boatman, Dannell, Pollard, Cecil, Calkins, Andrea, and Gadde, Divya
- Published
- 2020
3. Socioeconomic Strain, Bullying Perpetration, and Negative Emotions: A Re-specification of GST.
- Author
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Strohacker, Emily, Watts, Stephen J., and Wright, Lauren E.
- Subjects
CYBERBULLYING ,BULLYING ,EMOTIONS ,AFFECT (Psychology) ,DATA modeling ,SOCIOECONOMICS - Abstract
Traditional bullying and cyberbullying are common problems faced by today's youth. Research seeking to explain bullying perpetration has often invoked Agnew's general strain theory (GST). However, research to date has often explored within a given study only a single emotion at a time that can result from strain. Further, prior research has tended to take the causal ordering arguments of GST at face value. The current study seeks to focus on the correlation of strains related to socioeconomics with traditional and cyberbullying perpetration and negative emotions. Utilizing the Add Health data and path modeling in Mplus, results suggest that socioeconomic strain positively correlates with bullying perpetration and recent negative emotions. However, results suggest a potential causal chain that is the opposite of an expectation of GST, with bullying perpetration potentially affecting negative emotions, and not the other way around. Implications of the results for theory and policy are discussed. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
4. Erratum to “Muscle insulin sensitivity and glucose metabolism are controlled by the intrinsic muscle clock” [Mol Metab 3 (2014) 29–41]
- Author
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Dyar, Kenneth A, Ciciliot, Stefano, Wright, Lauren E, Biensø, Rasmus S, Tagliazucchi, Guidantonio Malagoli, Patel, Vishal R, Forcato, Mattia, Peña-Paz, Marcia I, Gudiksen, Anders, Solagna, Francesca, Albiero, Mattia, Moretti, Irene, Eckel-Mahan, Kristin L, Baldi, Pierre, Sassone-Corsi, Paolo, Rizzuto, Rosario, Bicciato, Silvio, Pilegaard, Henriette, Blaauw, Bert, and Schiaffino, Stefano
- Subjects
Biochemistry and Cell Biology ,Biological Sciences ,Physiology ,Biochemistry and cell biology - Abstract
[This corrects the article DOI: 10.1016/j.molmet.2013.10.005.].
- Published
- 2014
5. Muscle insulin sensitivity and glucose metabolism are controlled by the intrinsic muscle clock.
- Author
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Dyar, Kenneth A, Ciciliot, Stefano, Wright, Lauren E, Biensø, Rasmus S, Tagliazucchi, Guidantonio M, Patel, Vishal R, Forcato, Mattia, Paz, Marcia IP, Gudiksen, Anders, Solagna, Francesca, Albiero, Mattia, Moretti, Irene, Eckel-Mahan, Kristin L, Baldi, Pierre, Sassone-Corsi, Paolo, Rizzuto, Rosario, Bicciato, Silvio, Pilegaard, Henriette, Blaauw, Bert, and Schiaffino, Stefano
- Subjects
2-DG ,2-Deoxyglucose ,BSA ,bovine serum albumin ,Bmal1 ,Circadian rhythms ,GSEA ,Gene Set Enrichment Analysis ,Glucose metabolism ,Glucose uptake ,HK2 ,hexokinase 2 ,KHB ,Krebs–Henseleit buffer ,Muscle insulin resistance ,PDH ,pyruvate dehydrogenase ,PDK ,PDH kinase ,PDP ,PDH phosphatase ,SCN ,suprachiasmatic nucleus ,Skeletal muscle ,ZT ,Zeitgeber time ,imKO ,inducible muscle-specific Bmal1 knockout ,mKO ,muscle-specific Bmal1 knockout ,2-DG ,2-Deoxyglucose ,BSA ,bovine serum albumin ,GSEA ,Gene Set Enrichment Analysis ,HK2 ,hexokinase 2 ,KHB ,Krebs–Henseleit buffer ,PDH ,pyruvate dehydrogenase ,PDK ,PDH kinase ,PDP ,PDH phosphatase ,SCN ,suprachiasmatic nucleus ,ZT ,Zeitgeber time ,imKO ,inducible muscle-specific Bmal1 knockout ,mKO ,muscle-specific Bmal1 knockout ,Biochemistry and Cell Biology ,Physiology - Abstract
Circadian rhythms control metabolism and energy homeostasis, but the role of the skeletal muscle clock has never been explored. We generated conditional and inducible mouse lines with muscle-specific ablation of the core clock gene Bmal1. Skeletal muscles from these mice showed impaired insulin-stimulated glucose uptake with reduced protein levels of GLUT4, the insulin-dependent glucose transporter, and TBC1D1, a Rab-GTPase involved in GLUT4 translocation. Pyruvate dehydrogenase (PDH) activity was also reduced due to altered expression of circadian genes Pdk4 and Pdp1, coding for PDH kinase and phosphatase, respectively. PDH inhibition leads to reduced glucose oxidation and diversion of glycolytic intermediates to alternative metabolic pathways, as revealed by metabolome analysis. The impaired glucose metabolism induced by muscle-specific Bmal1 knockout suggests that a major physiological role of the muscle clock is to prepare for the transition from the rest/fasting phase to the active/feeding phase, when glucose becomes the predominant fuel for skeletal muscle.
- Published
- 2014
6. SIRT3 overexpression in rat muscle does not ameliorate peripheral insulin resistance.
- Author
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Osborne, Brenna, Wright, Lauren E., Brandon, Amanda E., Stuart, Ella, Small, Lewin, Hoeks, Joris, Schrauwen, Patrick, Sinclair, David A., Montgomery, Magdalene K., Cooney, Gregory J., and Turner, Nigel
- Subjects
- *
INSULIN resistance , *GENETIC overexpression , *ISOCITRATE dehydrogenase , *SKELETAL muscle , *METABOLIC disorders , *NAD (Coenzyme) , *SOLEUS muscle , *PYRUVATES - Abstract
Reduced expression of the NAD+-dependent deacetylase, SIRT3, has been associated with insulin resistance and metabolic dysfunction in humans and rodents. In this study, we investigated whether specific overexpression of SIRT3 in vivo in skeletal muscle could prevent high-fat diet (HFD)-induced muscle insulin resistance. To address this, we used a muscle-specific adeno-associated virus (AAV) to overexpress SIRT3 in rat tibialis and extensor digitorum longus (EDL) muscles. Mitochondrial substrate oxidation, substrate switching and oxidative enzyme activity were assessed in skeletal muscles with and without SIRT3 overexpression. Muscle-specific insulin action was also assessed by hyperinsulinaemic–euglycaemic clamps in rats that underwent a 4-week HFD-feeding protocol. Ex vivo functional assays revealed elevated activity of selected SIRT3-target enzymes including hexokinase, isocitrate dehydrogenase and pyruvate dehydrogenase that was associated with an increase in the ability to switch between fatty acid- and glucose-derived substrates in muscles with SIRT3 overexpression. However, during the clamp, muscles from rats fed an HFD with increased SIRT3 expression displayed equally impaired glucose uptake and insulin-stimulated glycogen synthesis as the contralateral control muscle. Intramuscular triglyceride content was similarly increased in the muscle of high-fat-fed rats, regardless of SIRT3 status. Thus, despite SIRT3 knockout (KO) mouse models indicating many beneficial metabolic roles for SIRT3, our findings show that muscle-specific overexpression of SIRT3 has only minor effects on the acute development of skeletal muscle insulin resistance in high-fat-fed rats. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
7. Black, White, and Read all Over: Exploring Racial Bias in Print media Coverage of Serial Rape Cases.
- Author
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Wright, Lauren E. and Watts, Stephen J.
- Subjects
RACISM ,PRESS ,SERIAL rape investigation - Abstract
The discussion of race and crime has been a long-standing interest of researchers, with statistics consistently showing an overrepresentation of non-white offenders compared to their white counterparts – specifically in relation to violent crimes such as murder and rape. Prior research has found that about 46 percent of identified serial rapists are black, which correlates with other sensationalized violent crimes such as mass murder and serial murder (Wright, Vander Ven, & Fesmire; 2016). The news media are the primary sources of this kind of information for the general public, with previous studies acknowledging that the media primarily focus on discussing non-white offenders in their crime-based news stories. With the majority of Americans receiving their information about crime from the news media, it is important to increase our understanding of how they present crime information. The current study explores the print media representations of serial rapists, from 1940–2010, from five prominent newspapers: The Los Angeles Times, The New York Times, The Boston Globe, The Washington Post, and the Chicago Tribune. A content analysis was conducted on 524 articles covering 297 serial rape offenders from the data compiled by Wright and colleagues (2016) in which race of the offender was known. Results suggest that while newspapers dehumanize both white and non-white offenders, white offenders tend to have their behavior neutralized using techniques to garner more sympathy, while these same neutralization techniques are not generally applied to non-white offenders, thus potentially increasing racial and ethnic bias. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
8. Enhancement of Muscle Mitochondrial Oxidative Capacity and Alterations in Insulin Action Are Lipid Species Dependent: Potent Tissue-Specific Effects of Medium-Chain Fatty Acids
- Author
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Turner, Nigel, Hariharan, Krit, TidAng, Jennifer, Frangioudakis, Georgia, Beale, Susan M., Wright, Lauren E., Zeng, Xiao Yi, Leslie, Simon J., Li, Jing-Ya, Kraegen, Edward W., Cooney, Gregory J., and Ye, Ji-Ming
- Published
- 2009
9. Gender, Bullying Victimization, Depressive Symptoms, and Suicidality.
- Author
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Strohacker, Emily, Wright, Lauren E., and Watts, Stephen J.
- Subjects
- *
CYBERBULLYING , *MENTAL depression , *SUICIDAL ideation , *BULLYING , *SCHOOL bullying , *GENDER , *CRIME victims - Abstract
Bullying victimization can have serious consequences for adolescents. This article examines the association between traditional and cyberbullying victimization, depressive symptoms, and suicidality in a national school-based sample, utilizing general strain theory (GST) as a guide to how these variables might relate to each other. We additionally examine whether the associations between these variables differ by gender. Results suggest that traditional and cyberbullying victimization have significant, positive associations with both depressive symptoms and suicidality. Results are partly supportive of the full model suggested by GST, with the associations between bullying and suicidality being weakened in some models when accounting for depressive symptoms. Gender differences also emerge. These findings are discussed in relation to their relevance for policy and theory. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
10. Military combat, mental health, and crime: A preliminary test of a general strain theory model.
- Author
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Watts, Stephen J. and Wright, Lauren E.
- Subjects
MENTAL health ,MODEL theory ,DELINQUENT behavior ,MENTAL health policy ,CRIMINAL behavior ,POST-traumatic stress disorder ,CRIME - Abstract
Research has shown that military combat experience can shape later mental health in a negative fashion and increase subsequent antisocial behaviors. Limited research to date has attempted to explore if military combat experience is related to antisocial behaviors because it increases the likelihood of negative mental health states. Using general strain theory (GST) as a guide, the current study offers a preliminary test of how military combat experience, negative mental health, with a focus on depressive symptoms and posttraumatic stress disorder (PTSD), and antisocial behavior, with a focus on criminal behavior, might relate together in a single theoretically informed model. Results from the Add Health sample suggest that military combat experience correlates with depressive symptoms, PTSD, and crime. Further, results suggest that PTSD, but not depressive symptoms, could potentially act as a mediator between military combat experience and subsequent criminal behavior. Implications for theory and policy are discussed. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
11. Actions Speak Louder Than Words: Examining the Relationship Between Violent Behaviors and Bullying Victimization Among Adolescents.
- Author
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Priesman, Emily R. and Wright, Lauren E.
- Published
- 2018
- Full Text
- View/download PDF
12. Increased mitochondrial calcium uniporter in adipocytes underlies mitochondrial alterations associated with insulin resistance.
- Author
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Wright, Lauren E., Reane, Denis Vecellio, Milan, Gabriella, Terrin, Anna, Di Bello, Giorgia, Belligoli, Anna, Sanna, Marta, Foletto, Mirto, Favaretto, Francesca, Raffaello, Anna, Mammucari, Cristina, Nitti, Donato, Vettor, Roberto, and Rizzuto, Rosario
- Subjects
- *
FAT cells , *MITOCHONDRIA , *INSULIN resistance - Abstract
Intracellular calcium influences an array of pathways and affects cellular processes. With the rapidly progressing research investigating the molecular identity and the physiological roles of the mitochondrial calcium uniporter (MCU) complex, we now have the tools to understand the functions of mitochondrial Ca2 + in the regulation of pathophysiological processes. Herein, we describe the role of key MCU complex components in insulin resistance in mouse and human adipose tissue. Adipose tissue gene expression was analyzed from several models of obese and diabetic rodents and in 72 patients with obesity as well as in vitro insulin-resistant adipocytes. Genetic manipulation of MCU activity in 3T3-L1 adipocytes allowed the investigation of the role of mitochondrial calcium uptake. In insulin-resistant adipocytes, mitochondrial calcium uptake increased and several MCU components were upregulated. Similar results were observed in mouse and human visceral adipose tissue (VAT) during the progression of obesity and diabetes. Intriguingly, subcutaneous adipose tissue (SAT) was spared from overt MCU fluctuations. Furthermore, MCU expression returned to physiological levels in VAT of patients after weight loss by bariatric surgery. Genetic manipulation of mitochondrial calcium uptake in 3T3-L1 adipocytes demonstrated that changes in mitochondrial calcium concentration ([Ca2+]mt) can affect mitochondrial metabolism, including oxidative enzyme activity, mitochondrial respiration, membrane potential, and reactive oxygen species formation. Finally, our data suggest a strong relationship between [Ca2+]mt and the release of IL-6 and TNFa in adipocytes. Altered mitochondrial calcium flux in fat cells may play a role in obesity and diabetes and may be associated with the differential metabolic profiles of VAT and SAT. [ABSTRACT FROM AUTHOR]
- Published
- 2017
- Full Text
- View/download PDF
13. American Serial Rape, 1940–2010.
- Author
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Wright, Lauren E., Vander Ven, Thomas, and Fesmire, Clara
- Subjects
SERIAL rape investigation ,SEMISKILLED labor - Abstract
Little is known about the social correlates of serial rape or about trends in offending across time and space in the United States. Furthermore, the limited serial rape scholarship that exists was largely generalized from small, captive samples. The current study aims to amplify our understanding of serial rape by pursuing three fundamental objectives. First, guided by theory and research we propose a new, more precise, and comprehensive conceptualization of serial rape. Next, we draw from media representations of serial rape published in five major American newspapers from 1940 to 2010 to develop an offender social profile and to identify patterns in attack style. Our analysis of a broad and diverse sample of serial offenders described in media accounts (N = 1,037) produced the following profile estimates—age: 27 years; race/ethnicity: African American, 46%; Caucasian, 29%; Latino, 19%; Asian, 5%. Most offenders were employed in unskilled or semiskilled occupations and the most common attack strategy was the surprise approach (47%). Finally, our data allow us to estimate and interpret historical trends as depicted in media accounts. Our analysis revealed low levels of serial rape in newspaper accounts during the 1940s to 1950s, followed by a steady increase (with periodic decreases) leading to a peak in 1991. This peak is followed by a steady and dramatic decline from 1992 to 2010. [ABSTRACT FROM AUTHOR]
- Published
- 2016
- Full Text
- View/download PDF
14. Overexpression of SIRT1 in Rat Skeletal Muscle Does Not Alter Glucose Induced Insulin Resistance.
- Author
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Brandon, Amanda E., Tid-Ang, Jennifer, Wright, Lauren E., Stuart, Ella, Suryana, Eurwin, Bentley, Nicholas, Turner, Nigel, Cooney, Gregory J., Ruderman, Neil B., and Kraegen, Edward W.
- Subjects
GENETIC overexpression ,SIRTUINS ,SKELETAL muscle ,LABORATORY rats ,INSULIN resistance ,TIBIALIS anterior - Abstract
SIRT1 is a NAD
+ -dependent deacetylase thought to regulate cellular metabolic pathways in response to alterations in nutrient flux. In the current study we investigated whether acute changes in SIRT1 expression affect markers of muscle mitochondrial content and also determined whether SIRT1 influenced muscle insulin resistance induced by acute glucose oversupply. In male Wistar rats either SIRT1 or a deacetylase inactive mutant form (H363Y) was electroprated into the tibialis cranialis (TC) muscle. The other leg was electroporated with an empty control vector. One week later, glucose was infused and hyperglycaemia was maintained at ~11mM. After 5 hours, 11mM glucose induced significant insulin resistance in skeletal muscle. Interestingly, overexpression of either SIRT1 or SIRT1 (H363Y) for 1 week did not change markers of mitochondrial content or function. SIRT1 or SIRT1 (H363Y) overexpression had no effect on the reduction in glucose uptake and glycogen synthesis in muscle in response to hyperglycemia. Therefore we conclude that acute increases in SIRT1 protein have little impact on mitochondrial content and that overexpressing SIRT1 does not prevent the development of insulin resistance during hyperglycaemia. [ABSTRACT FROM AUTHOR]- Published
- 2015
- Full Text
- View/download PDF
15. Liver-specific overexpression of SIRT3 enhances oxidative metabolism, but does not impact metabolic defects induced by high fat feeding in mice.
- Author
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Osborne, Brenna, Reznick, Jane, Wright, Lauren E., Sinclair, David A., Cooney, Gregory J., and Turner, Nigel
- Subjects
- *
SIRTUINS , *BODY composition , *GENETIC overexpression , *METABOLISM , *TYPE 2 diabetes , *MICE - Abstract
The mitochondrial enzyme SIRT3 is an NAD+-dependent deacetylase important in cell metabolism, and a decline in its protein expression or activity has been linked with insulin resistance in obesity, ageing and type 2 diabetes. While studies in SIRT3 knockout mice have dramatically improved our understanding of the function of SIRT3, the impact of increasing SIRT3 levels remains under-examined. In this study we investigated the effects of liver-specific SIRT3 overexpression in mice on mitochondrial function and metabolic profile in both isolated hepatocytes and in vivo. Primary hepatocytes overexpressing SIRT3 displayed increased oxygen consumption and a reduction in triglyceride accumulation. In mice with hepatic SIRT3 overexpression, increased fasting β-hydroxybutyrate levels were observed, coupled with an increase in oxygen consumption in isolated mitochondria and increased substrate utilization in liver homogenates. However, metabolic profiling of mice exposed to either chow or high-fat diet revealed no effect of hepatic SIRT3 overexpression on glucose tolerance, body composition or tissue triglyceride accumulation. These findings suggest limited whole-body benefit of increasing hepatic SIRT3 during the development of diet-induced insulin resistance. • Increasing SIRT3 in isolated hepatocytes boosts respiration and lowers lipid levels. • Liver SIRT3 overexpression in mice has moderate impact on substrate metabolism. • Elevating hepatic SIRT3 does not prevent high fat diet-induced metabolic defects. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
16. The evolution of insulin resistance in muscle of the glucose infused rat
- Author
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Brandon, Amanda E., Hoy, Andrew J., Wright, Lauren E., Turner, Nigel, Hegarty, Bronwyn D., Iseli, Tristan J., Julia Xu, X., Cooney, Gregory J., Saha, Asish K., Ruderman, Neil B., and Kraegen, Edward W.
- Subjects
- *
INSULIN resistance , *GLUCOSE , *LABORATORY rats , *QUADRICEPS muscle , *DIGLYCERIDES , *INSULIN receptors , *RAPAMYCIN , *GLYCOGEN synthase kinase-3 - Abstract
Abstract: Glucose infusion into rats causes skeletal muscle insulin resistance that initially occurs without changes in insulin signaling. The aim of the current study was to prolong glucose infusion and evaluate other events associated with the transition to muscle insulin resistance. Hyperglycemia was produced in rats by glucose infusion for 3, 5 and 8h. The rate of infusion required to maintain hyperglycemia was reduced at 5 and 8h. Glucose uptake into red quadriceps (RQ) and its incorporation into glycogen decreased between 3 and 5h, further decreasing at 8h. The earliest observed change in RQ was decreased AMPKα2 activity associated with large increases in muscle glycogen content at 3h. Activation of the mTOR pathway occurred at 5h. Akt phosphorylation (Ser473) was decreased at 8h compared to 3 and 5, although no decrease in phosphorylation of downstream GSK-3β (Ser9) and AS160 (Thr642) was observed. White quadriceps showed a similar but delayed pattern, with insulin resistance developing by 8h and decreased AMPKα2 activity at 5h. These results indicate that, in the presence of a nutrient overload, alterations in muscle insulin signaling occur, but after insulin resistance develops and appropriate changes in energy/nutrient sensing pathways occur. [Copyright &y& Elsevier]
- Published
- 2011
- Full Text
- View/download PDF
17. Muscle insulin sensitivity and glucose metabolism are controlled by the intrinsic muscle clock.
- Author
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Dyar KA, Ciciliot S, Wright LE, Biensø RS, Tagliazucchi GM, Patel VR, Forcato M, Paz MI, Gudiksen A, Solagna F, Albiero M, Moretti I, Eckel-Mahan KL, Baldi P, Sassone-Corsi P, Rizzuto R, Bicciato S, Pilegaard H, Blaauw B, and Schiaffino S
- Abstract
Circadian rhythms control metabolism and energy homeostasis, but the role of the skeletal muscle clock has never been explored. We generated conditional and inducible mouse lines with muscle-specific ablation of the core clock gene Bmal1. Skeletal muscles from these mice showed impaired insulin-stimulated glucose uptake with reduced protein levels of GLUT4, the insulin-dependent glucose transporter, and TBC1D1, a Rab-GTPase involved in GLUT4 translocation. Pyruvate dehydrogenase (PDH) activity was also reduced due to altered expression of circadian genes Pdk4 and Pdp1, coding for PDH kinase and phosphatase, respectively. PDH inhibition leads to reduced glucose oxidation and diversion of glycolytic intermediates to alternative metabolic pathways, as revealed by metabolome analysis. The impaired glucose metabolism induced by muscle-specific Bmal1 knockout suggests that a major physiological role of the muscle clock is to prepare for the transition from the rest/fasting phase to the active/feeding phase, when glucose becomes the predominant fuel for skeletal muscle.
- Published
- 2013
- Full Text
- View/download PDF
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