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Metal sulfide nanoparticles are synthesized for their biomedical applications, including cancer drug targeting. This paper reports a novel nanocomposite made of praseodymium sulfide nanoparticles and poly-cyclodextrin. The praseodymium sulfide nanoparticles were synthesized hydrothermal, autoclaving the nitrate precursors at 150 °C for 18 hours. The material is characterized using XRD and shows an orthorhombic crystal system with high crystallinity. The size and morphology of the nanomaterial were optimized. The material shows a rod-shaped morphology, as seen in the TEM image, with 150 ± 3 nm length and 25 ± 5 nm width. Particle size analysis supports this size range. The colloidal particles were stable in the aqueous medium without precipitation at neutral pH. The elements in the material in the polymer-coated form and their electronic states are studied by X-ray photoelectron spectroscopy. Thermogravimetry confirms that the material contains about 18.5% of the weight of the polymer. The material has an observable magnetic property at room temperature due to the praseodymium element. The UV–vis–NIR absorption spectrum of the material shows a long absorption range that extends to 1200 nm. The drug 5-fluorouracil is encapsulated in the nanoparticles through host: guest association, and its release profile is analyzed. The release is modulated at a slightly acidic pH, indicating the pH-tunability. The nanoparticles and 5-fluorouracil were taken in the w/w ratio of 2:1 (2/1 mg in 1 mL of deionized water). Further, the in vitro anticancer activity of the drug-encapsulated material is screened on breast cancer and non-cancerous cell lines. The IC 50 values are reported, and the advantageous properties of the material as drug carriers are discussed. • Drug carrier nanorods are designed using praseodymium sulfide and poly-cyclodextrin. • The nanoparticles are weakly magnetic with low saturation. • It shows a long tail absorption band that extends up to the NIR-II wavelength range. • The encapsulated 5-fluorouracil is released continually for more than 10 days. • Drug-containing Pr2S3 nanoparticles are selectively active on MCF-7 cell lines. [ABSTRACT FROM AUTHOR]

This paper presents the fabrication of cobalt doped-cerium oxide nanocomposites (Co/CeO 2 NCs) by solid combustion method. Synthesized cobalt doped CeO 2 nanocomposites and pure CeO 2 were confirmed by UV–Visible spectrophotometer, Fourier transform infrared spectrometer (FTIR), X-ray diffraction study (XRD), BET analysis and transmission electron microscope coupled with energy dispersive spectroscopy (TEM-EDS). The bandgap energies of CeO 2 , 0.25, 0.50 and 0.75%Co/CeO 2 NCs were 3.02, 2.98, 2.81 and 2.80 eV, respectively. The 50 % inhibitory concentration (IC 50) values of CeO 2, 0.25, 0.50, and 0.75 % of Co-doped CeO 2 were 57.02, 38.65, 35.33 and 39.87 μg/mL, respectively. The oxidation state of Cobalt and Cerium was confirmed by X-ray photoelectron spectrum. The Co/CeO 2 NCs exhibited a zone of inhibition against bacteria and fungi. Thus, Co/CeO 2 NCs can be used as a biomaterial for controlling pathogenic bacteria, fungi and lung cancer cell lines. • Co/CeO 2 NCs were prepared by solid combustion method. • The Co/CeO 2 NCs exhibited excellent antimicrobial properties compared to pure CeO 2. • Cytotoxicity of these Co/CeO 2 NCs against A549 lung cancer cells was evaluated by MTT assay. • Co/CeO 2 NCs (0.50 %) showed potent MTT assay activity, IC50 < 35.33 μM. [ABSTRACT FROM AUTHOR]

• Soft ferromagnetic copper nanoparticles coated with β-cyclodextrin-citrate are synthesized. • Possess a size of 10 ± 3 nm and show a high drug loading capacity. • The encapsulation efficiency of the nanocarrier is 94.28% • In vitro anticancer activity on MDA-MB-231 breast cancer cell lines is examined. • The nanocarrier is a simple, low toxic, and sustained releasing drug delivery agent. Metal nanoparticles represent simple nanoscale structures that can be employed in drug delivery. The complication due to multiple elements in inorganic nanoparticles having more than one element, which leads to unprecedented toxicity, is avoided through metal nanoparticles as preferred nanocarriers. Although gold and silver nanoparticles have been explored widely for biomedical applications, copper metal nanoparticles are scarcely reported as drug delivery agents. We conducted this present study to explore the size, surface control, and magnetic and near-infrared absorption characteristics of copper nanoparticles which are particularly intriguing. In this paper, we report the hydrothermal synthesis of β-cyclodextrin citrate-coated copper nanoparticles. The nanoparticles are characterized using XRD, FT-IR, and TGA. The nanoparticles possess a size of around 10 nm and show a near-spherical morphology as shown by the TEM image. The composition and functional groups corresponding to β-cyclodextrin-citrate are shown by X-ray photoelectron and FT-IR spectroscopic techniques respectively. The chemotherapy molecule, 5-fluorouracil, is loaded in the nanoparticles with a high encapsulation of above 94% efficiency. The time-dependent expulsion of the drug is investigated, and it occurs for over 12 hours. The in vitro cytotoxic studies on the breast cancer cell lines (MDA-MB-231) are carried out for the empty nanocarrier and the drug-loaded one. The cytotoxicity is dose-dependent and the IC 50 values of the empty and the drug-loaded nanocarriers are reported. Flow cytometric analysis and cell-cycle interruption by the empty nanocarrier and the 5-fluorouracil-loaded nanocarrier show the intervention of each sample at different phases of the cell cycle. The results show the suitability of β-cyclodextrin-citrate coated copper nanoparticles as a nanocarrier of 5-fluorouracil. [Display omitted] [ABSTRACT FROM AUTHOR]