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Background: Spexin is a novel peptide hormone and has shown antinociceptive effects in experimental mice. This study is aimed at evaluating the association of serum spexin level with diabetic peripheral neuropathy (DPN) and related pain in a Chinese population. Methods: We enrolled 167 type 2 diabetes mellitus (T2DM) including 56 patients without DPN (non-DPN), 67 painless DPN, and 44 painful DPN. Serum spexin was measured using ELISA. Logistic regression models were performed to analyze the independent effects of spexin on prevalence of DPN and painful DPN. In streptozotocin (STZ)-induced diabetic mice, mechanical pain threshold was measured using electronic von Frey aesthesiometer. Human peripheral blood mononuclear cells (PBMCs) were isolated and further stimulated with lipopolysaccharide without or with spexin. The gene expression was assayed by qPCR. Results: Compared with non-DPN, serum spexin level decreased in painless DPN and further decreased in painful DPN. The odds of DPN was associated with low spexin level in T2DM, which was similar by age, sex, BMI, and diabetes duration, but attenuated in smokers. The odds of having pain was associated with decreased spexin level in DPN, which was similar by age, sex, smoking status, and diabetes duration, but attenuated in normal weight. Furthermore, we observed that mechanical pain threshold increased in spexin-treated diabetic mice. We also found that lipopolysaccharide treatment increased the mRNA level of TNF-α, IL-6, and MCP-1 in human PBMCs, while spexin treatment prevented this increase. Conclusions: These results suggested that spexin might serve as a protective factor for diabetes against neuropathology and pain-related pathogenesis. [ABSTRACT FROM AUTHOR]

Purpose. To examine the mediating role of positive psychological capital in the relationship between nursing students' perceived social support and bullying behavior in nursing education. Design and Methods. In May 2021, a sample of 1196 nursing students majoring in nursing at a medical college was conveniently selected as the study population. A set of questionnaires, including a General Information Questionnaire, Perceived Social Support Scale (PSSS), Positive Psychological Capital Questionnaire (PPQ), and Bullying Behaviors in Nursing Education Scale (BBNE), were utilized to examine and analyze the relationships among the variables. Findings. The scores of nursing students' PSSS, PPQ, and BBNE were 68.19 ± 11.90, 123.97 ± 18.74, and 13.31 ± 9.24, respectively. There was a negative correlation (r = −0.421, P < 0.01) between perceived social support and bullying behaviors in nursing education among nursing students. Positive psychological capital partially mediated the relationship between perceived social support and bullying behaviors in nursing education, accounting for 19.88% of the total effect. Further analysis revealed that self-efficacy, resilience, optimism, and hope in positive psychological capital each played a partial mediating role in the impact of nursing students' perceived social support on bullying behaviors in nursing education, with the ratio of indirect effect to total effect being 5.38%, 7.74%, 6.09%, and 5.34%, respectively. Practice Implications. The impact of perceived social support on bullying behaviors in nursing education is substantial among nursing students, and it can indirectly influence bullying behaviors through positive psychological capital. Nursing educators should pay attention to nursing students with lower levels of social support, and they can decrease the occurrence of bullying behaviors by enhancing social support and fostering higher levels of psychological capital. [ABSTRACT FROM AUTHOR]