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Past quantitative studies have shown that most media coverage is of men. Here we ask if the scarce coverage that women get is qualitatively different from that of men. We use computer-coded sentiment scores for 14 million person names covered in 1,323 newspapers to investigate the three-way relationship between gender, fame, and sentiment. Additional large-scale data on occupational categories allow us to compare women and men within the same profession and rank. We propose that as women's fame increases their media coverage becomes negative more quickly when compared to men (a "paper cut"), because their violation of gender hierarchies and social expectations about typical feminine behavior evokes disproportionate scrutiny. We find that while overall media coverage is much more positive for women than for men, this difference disappears and even reverses at higher levels of fame. In encyclopedic sentiment data we find no biographic basis for women's disproportionate decline in media coverage sentiment at high fame, consistent with the conjectured double standard in media discourse. [ABSTRACT FROM AUTHOR]

Throughout its serial run, Charles Dickens's Pickwick Papers (1836–7), was repurposed hundreds of times by the provincial press. From acting as innocuous filler material to making strategic political statements, provincial newspaper editors evoked, excerpted and adapted Pickwick as quickly as Dickens was penning the instalments, showing a keen responsiveness to political topicalities relevant to their reading communities. This article contends that these types of journalistic re-use benefit from being read collectively as a form of remediation, defined by Jay David Bolter and Richard Grusin as 'the formal logic by which new media refashion prior media forms'. It argues that these remediations are vital to understanding the politics of the provincial press because they became one method through which provincial newspapers articulated a localised response to the national political debates that raged following the 1832 Reform Act. As well as reflecting the political priorities of specific communities, these remediations nuance our understanding of Pickwick 's popularity by drawing attention to aspects of its construction that lent themselves to re-use. While explicit engagement with party politics is conspicuously absent from Pickwick , provincial editors capitalised upon this generality and imbued their re-workings of the serial with a partisanship that Dickens himself avoided, while using his name to substantiate and authorise their own pieces. In this respect, these remediations invite us to place Pickwick at the heart of political debate in the papers, by foregrounding the close relationship between newspaper politics, serial literature, and provincial identity in the 1830s. [ABSTRACT FROM AUTHOR]

We present the analysis of the stellar population and star formation history of 181 MIRI selected galaxies at z  = 0 − 3.5 in the massive galaxy cluster field SMACS J0723.3–7327, commonly referred to as SMACS0723, using the JWST Mid-Infrared Instrument (MIRI). We combine the data with the JWST Near Infrared Camera (NIRCam) catalogue, in conjunction with the Hubble Space Telescope (HST) WFC3/IR and ACS imaging. We find that the MIRI bands capture PAH features and dust emission, significantly enhancing the accuracy of photometric redshift and measurements of the physical properties of these galaxies. The median photo- z 's of galaxies with MIRI data are found to have a small 0.1 per cent difference from spectroscopic redshifts and reducing the error by 20 per cent. With MIRI data included in SED fits, we find that the measured stellar masses are unchanged, while the star formation rate is slightly lower by 0.1 dex. We also fit the median SED of active galactic nuclei (AGNs) and star-forming galaxies (SFG) separately. MIRI data provides tighter constraints on the AGN contribution, reducing the typical AGN contributions by ∼15 per cent. In addition, we also compare the median SED obtained with and without MIRI, and we find that including MIRI data yields steeper optical and UV slopes, indicating bluer colours, lower dust attenuation, and younger stellar populations. In the future, MIRI/MRS will enhance our understanding by providing more detailed spectral information and allowing for the study of specific emission features and diagnostics associated with AGN. [ABSTRACT FROM AUTHOR]

This article studies the contested legal–political dynamics around forced migration flows to and through an unrecognized state: the Turkish Republic of Northern Cyprus (TRNC). We adopt an analytical perspective drawn from the literature on performative politics and the legal anthropology of documents to explore how migration dynamics interact with the contested legal status of the TRNC. Our two main questions are: What practical shape do the human rights of refugees and asylum seekers take in an interstitial legal space, where the foundation of law is itself subject to ambiguity, suspension, and contestation? And what implications—opportunities and hazards—does this constellation have for refugees and asylum-seekers? Drawing on interviews, lived experience and fieldwork observations, we make two arguments. First, we contend that the interstitial status of the TRNC represents both an opportunity for refugees and a threat. Secondly, we argue that a purely legal or technical understanding of legal identity and concurrent rights is inadequate; we must subject these phenomena to a politically informed analysis of the everyday practices through which legal norms and spaces are continuously shaped and reshaped. [ABSTRACT FROM AUTHOR]

Purpose: The purpose of this white paper is to educate health care professionals about the evolution of telemedicine (TM) and to propose a hybrid model that leverages the strengths of traditional in-person medicine as well as virtual medicine while maximizing the safety and quality of men's sexual health care. Literature Search Strategy: A literature search focused on the use of TM in urology and men's health was performed through PubMed/MEDLINE, Embase, and Web of Science (January 1, 2012–April 26, 2022). Keywords included all known permutations of the terminology used to refer to virtual health, care as well as the terminology used to refer to urologic diseases, issues specific to men's health, and men's sexual health concerns. Publications that emerged after the literature search that met this criterion also were incorporated. Opinion pieces, letters to the editor, meeting abstracts, and conference proceedings were excluded. Additional resources were retrieved, such as governmental technical reports, legislative updates and reviews, and blogs. This search strategy yielded 1684 records across databases after removal of duplicates. Abstracts from the retrieved records were reviewed for relevance. Relevant publications were defined as those that reported data on any aspect of TM use specific to urology, men's health, and/or men's sexual health. If relevance was unclear from the abstract, then the full text of the article was retrieved for a more detailed review. In addition, the published evidence-based practice guidelines relevant to care for erectile dysfunction, Peyronie's disease, ejaculatory dysfunction, and hypogonadism were retrieved. The most common reasons for article exclusions were a focus on TM use in disciplines other than urology and the absence of data (ie, opinion pieces). After exclusions, a total of 91 publications remained and constituted the evidence base for this paper. [ABSTRACT FROM AUTHOR]

Introduction Roll-your-own (RYO) tobacco is a popular choice in Australia, with some people who smoke finding these products more attractive than factory-made cigarettes (FMC). Differences in visual and tactile properties and in the feel and taste of the smoke may contribute to this attractiveness. These differences may be driven by variation in tobacco constituents and wrapping paper permeability. However, to date, there has been no comparison of RYO and FMC products on the Australian market. Aims and Methods Chemical constituents, pH, flavorants, and paper permeability were compared in unburned RYO tobacco and tobacco from FMC. RYO and FMC products from matched brands were compared, as were products from the most popular FMC and RYO brands on the Australian market in 2018. Results RYO tobacco had higher moisture and humectant content (glycerol and propylene glycol) than FMC tobacco. RYO tobacco also had higher amounts of total and reducing sugars and lower nicotine when comparing the most popular brands. RYO papers were less permeable than FMC papers. Both RYO and FMC tobacco contained many chemicals identified as flavorants, including fourteen with known potential health risks. For most measured constituents and flavorants, RYO tobaccos had more in common with other RYO than FMC, with the commonalities remaining even when matched brands were compared. Conclusions Higher levels of moisture, humectants, and sugars in Australian RYO tobacco compared to FMC may be increasing attractiveness of RYO by reducing the harsh taste of the smoke and increasing the moist feel of the tobacco. Implications While price is the main factor driving the use of RYO tobacco, some people who smoke find these products more attractive. This study has shown that Australian RYO tobacco contains higher amounts of glycerol, propylene glycol, and sugars than FMC. These chemicals may be improving the taste of the tobacco, as well as creating a moist feel that is falsely perceived as indicating that the tobacco is "fresh" and "less chemically." Ironically, it may be that higher amounts of some added chemicals in RYO contribute to false perceptions of a more natural and less harmful product. [ABSTRACT FROM AUTHOR]

Previous research has evaluated the extent to which cocaine and other drugs were detectable on currency in the USA. The literature was in agreement that the majority of bills exhibited some degree of contamination. With the increase of fentanyl in the illicit drug supply, this study was designed to evaluate the extent that fentanyl, cocaine, methamphetamine and other substances were present on circulating currency in 2022. A quantitative assay using liquid chromatography–triple quadrupole mass spectrometry was developed and validated to detect six analytes: fentanyl, 4-anilino- N -phenethylpiperidine, acetylfentanyl, benzylfentanyl, cocaine and methamphetamine. One-dollar bills were collected from 13 cities across the country. Sample preparation consisted of soaking the bills in methanol followed by liquid–liquid extraction. Chromatographic separation was achieved using a C18 analytical column and gradient elution with ammonium formate in water (5 mM, pH 3) and 0.1% formic acid in acetonitrile. The quantitative working range for this assay was 0.1 μg to 1.0 μg per bill (equivalent to 1 ng/mL to 100 ng/mL of extract). Fentanyl was detected on the majority (63%) of samples, with 61% of samples having ≥0.1 μg of fentanyl and 4% of samples having ≥1.0 μg. Cocaine and methamphetamine were detected on 100% and 98% of bills, respectively, typically in amounts >1.0 μg. The remaining fentanyl-related substances were detected in 15% of samples in amounts no >0.69 μg per bill and exclusively in the presence of fentanyl. Unsurprisingly, areas of the country with higher incidence of fentanyl use yielded higher frequency of contaminated bills and higher concentrations. Human exposure to drugs on currency is unlikely to have any significant impacts toxicologically or pharmacologically; however, our research findings suggest that paper currency could serve as a useful substrate for surveillance of drug trends regionally, nationally and/or internationally. [ABSTRACT FROM AUTHOR]

The Centers for Medicare & Medicaid Services (CMS) introduced the Severe Sepsis/Septic Shock Management Bundle (SEP-1) as a pay-for-reporting measure in 2015 and is now planning to make it a pay-for-performance measure by incorporating it into the Hospital Value-Based Purchasing Program. This joint IDSA/ACEP/PIDS/SHEA/SHM/SIPD position paper highlights concerns with this change. Multiple studies indicate that SEP-1 implementation was associated with increased broad-spectrum antibiotic use, lactate measurements, and aggressive fluid resuscitation for patients with suspected sepsis but not with decreased mortality rates. Increased focus on SEP-1 risks further diverting attention and resources from more effective measures and comprehensive sepsis care. We recommend retiring SEP-1 rather than using it in a payment model and shifting instead to new sepsis metrics that focus on patient outcomes. CMS is developing a community-onset sepsis 30-day mortality electronic clinical quality measure (eCQM) that is an important step in this direction. The eCQM preliminarily identifies sepsis using systemic inflammatory response syndrome (SIRS) criteria, antibiotic administrations or diagnosis codes for infection or sepsis, and clinical indicators of acute organ dysfunction. We support the eCQM but recommend removing SIRS criteria and diagnosis codes to streamline implementation, decrease variability between hospitals, maintain vigilance for patients with sepsis but without SIRS, and avoid promoting antibiotic use in uninfected patients with SIRS. We further advocate for CMS to harmonize the eCQM with the Centers for Disease Control and Prevention's (CDC) Adult Sepsis Event surveillance metric to promote unity in federal measures, decrease reporting burden for hospitals, and facilitate shared prevention initiatives. These steps will result in a more robust measure that will encourage hospitals to pay more attention to the full breadth of sepsis care, stimulate new innovations in diagnosis and treatment, and ultimately bring us closer to our shared goal of improving outcomes for patients. [ABSTRACT FROM AUTHOR]

Objective The primary aim of this paper is to review evidence and clinical implications related to lifestyle activities associated with promoting brain and cognitive health. Our review targets four key lifestyle factors: physical activity and exercise, social engagement, cognitively stimulating activity, and consuming Mediterranean-style diets. Method We conducted a critical review of the lifestyle factor literature in the four domains listed earlier. We contextualize this literature review by translating findings, when possible, into evidence-based recommendations to consider when providing neuropsychological services. Results There is significant current evidence supporting the role of physical activity and exercise, social engagement, cognitively stimulating activity, and consuming Mediterranean-style diets on positive brain and cognitive health outcomes. While some null findings are present in all four areas reviewed, the weight of the evidence supports the notion that engaging in these activities may promote brain and cognitive functioning. Conclusions Clinical neuropsychologists can have confidence in recommending engagement in physical activity, social activity, and cognitively stimulating activity, and adhering to a Mediterranean-style diet to promote brain and cognitive health. We discuss limitations in existing lifestyle factor research and future directions to enhance the existing evidence base, including additional research with historically underrepresented groups and individuals with neurological conditions. [ABSTRACT FROM AUTHOR]

The ecological relationships among antimicrobial producing, resistant, and sensitive strains have been proposed to follow rock-paper-scissors dynamics, but evidence is mainly based on Gram-negative bacteriocins in vitro. The ecological relevance of antimicrobials in vivo or in situ has not been systematically studied. This study therefore aimed to analyze binary and ternary competitions among reutericyclin-producing strain Limosilactobacillus reuteri TMW1.656, its reutericyclin-resistant, nonproducing isogenic derivative L. reuteri TMW1.656 ∆rtcN , and the reutericyclin-sensitive, nonproducing L. reuteri TMW1.656 ∆rtcN∆rtcT in vitro (liquid culture and static plate), in situ (sourdough fermentation), and in vivo (gut of germ-free mice). In liquid culture, L. reuteri TMW1.656 had a higher fitness than TMW1.656 ∆rtcN and TMW1.656 ∆rtcN∆rtcT. Limosilactobacillus reuteri TMW1.656 ∆rtcN∆rtcT had a higher fitness than TMW1.656 ∆rtcN. On agar plates, L. reuteri TMW1.656 had a higher fitness than TMW1.656 ∆rtcN∆rtcT. In situ , reutericyclin production and resistance had no influence on the fitness of the strains. In vivo , TMW1.656 had an advantage over TMW1.656 ∆rtcN and TMW1.656 ∆rtcN∆rtcT. Ternary competitions showed reutericyclin production was ecologically beneficial in all ecosystems. The findings support the ecological importance of reutericyclin in a variety of environments/niches, providing an explanation for the acquisition of the reutericyclin gene cluster in L. reuteri and its contribution to the ecological fitness of Streptococcus mutans. [ABSTRACT FROM AUTHOR]

In this work, we update and develop algorithms for KMTNet tender-love care (TLC) photometry in order to create a new, mostly automated, TLC pipeline. We then start a project to systematically apply the new TLC pipeline to the historic KMTNet microlensing events, and search for buried planetary signals. We report the discovery of such a planet candidate in the microlensing event MOA-2019-BLG-421/KMT-2019-BLG-2991. The anomalous signal can be explained by either a planet around the lens star or the orbital motion of the source star. For the planetary interpretation, despite many degenerate solutions, the planet is most likely to be a Jovian planet orbiting an M or K dwarf, which is a typical microlensing planet. The discovery proves that the project can indeed increase the sensitivity of historic events and find previously undiscovered signals. [ABSTRACT FROM AUTHOR]

Background and Aims Cress seeds release allelochemicals that over-stimulate the elongation of hypocotyls of neighbouring (potentially competing) seedlings and inhibit their root growth. The hypocotyl promoter is potassium, but the root inhibitor was unidentified; its nature is investigated here. Methods Low-molecular-weight cress-seed exudate (LCSE) from imbibed Lepidium sativum seeds was fractionated by phase partitioning, paper chromatography, high-voltage electrophoresis and gel-permeation chromatography (on Bio-Gel P-2). Fractions, compared with pure potassium salts, were bioassayed for effects on Amaranthus caudatus seedling growth in the dark for 4 days. Key Results The LCSE robustly promoted amaranth hypocotyl elongation and inhibited root growth. The hypocotyl inhibitor was non-volatile, hot acid stable, hydrophilic and resistant to incineration, as expected for K+. The root inhibitor(s) had similar properties but were organic (activity lost on incineration). The root inhibitor(s) remained in the aqueous phase (at pH 2.0, 6.5 and 9.0) when partitioned against butan-1-ol or toluene, and were thus hydrophilic. Activity was diminished after electrophoresis, but the remaining root inhibitors were neutral. They became undetectable after paper chromatography; therefore, they probably comprised multiple compounds, which separated from each other, in part, during fractionation. On gel-permeation chromatography, the root inhibitor co-eluted with hexoses. Conclusions Cress-seed allelochemicals inhibiting root growth are different from the agent (K+) that over-stimulates hypocotyl elongation and the former probably comprise a mixture of small, non-volatile, hydrophilic, organic substances. Abundant components identified chromatographically and by electrophoresis in cress-seed exudate fitting this description include glucose, fructose, sucrose and galacturonic acid. However, none of these sugars co-chromatographed and co-electrophoresed with the root-inhibitory principle of LCSE, and none of them (in pure form at naturally occurring concentrations) inhibited root growth. We conclude that the root-inhibiting allelochemicals of cress-seed exudate remain unidentified. [ABSTRACT FROM AUTHOR]

A recent study published in the British Journal of Dermatology discusses the use of beremagene geperpavec (B-VEC) gene therapy for the treatment of cutaneous wounds in patients with dystrophic epidermolysis bullosa (DEB). DEB is a rare inherited skin disease characterized by blistering and slow-to-heal wounds. The study found that B-VEC treatment resulted in significantly higher rates of wound healing compared to a placebo. The therapy has received approval from the US Food and Drug Administration and is expected to provide a new treatment option for patients with DEB. [Extracted from the article]

The Society of Toxicology has awarded the Paper of the Year to a study titled "Increased renal expression of complement components in patients with liver diseases: nonalcoholic steatohepatitis, alcohol-associated, viral hepatitis, and alcohol-viral combination." The study examined the impact of liver dysfunction on renal physiology and identified overlapping renal expression changes across different liver disease etiologies. The findings provide insight into the mechanisms of renal dysfunction associated with chronic liver disease. Two other papers received Honorable Mention, one exploring the impact of particulate matter exposure on foam cell formation in atherosclerosis and the other investigating the effects of developmental exposure to environmental chemicals on CD8+ T cell function during influenza A virus infection. These studies contribute to our understanding of toxicological effects and offer potential strategies for intervention. [Extracted from the article]

There are a few results about the global nonlinear stability of nontrivial large solution to quasilinear wave equations. Time-like extremal surface in Minkowski space is an important model of quasilinear wave equation. There are two folds in this paper. Firstly, we get the existence of traveling wave solution to the time-like extremal hypersurface in |$\mathbb {R}^{1+(n+1)}$|⁠ , which can be considered as the generalized Bernstein theorem. For |$n=2$|⁠ , we are also concerned with global stability of traveling wave solutions with speed of light to time-like extremal hypersurface equation in |$1+(2+1)$| dimensional Minkowski space, which is corresponding with quasilinear wave equation in two space dimensions. [ABSTRACT FROM AUTHOR]

The Genetics Society of America is calling for submissions of papers on biobank-scale genomic data analyses. Biobanks, which are large collections of biological, medical, and genetic data on the same individuals, have revolutionized human genomics research. However, there is substantial heterogeneity between biobanks worldwide, creating both challenges and opportunities for data analysis. The series will focus on various topics, including population structures, selection bias, measurement errors, clinical observations, linkage with external data sources, meta-analysis, computational analysis methods, family-based analyses, ethical and privacy-related issues, and technological considerations. Manuscripts can be submitted until May 31, 2024, and the series will be an ongoing resource in this area. [Extracted from the article]

The article calls for papers on genomic data analyses in biobanks by highlighting the opportunities and challenges stemming from the heterogeneity between biobanks worldwide. Topics include population structures, selection bias effects, clinical observations, ethical considerations, and technological advancements in data generation for omics studies.

Background During the first epidemic wave, COVID-19 surveillance focused on quantifying the magnitude and the escalation of a growing global health crisis. The scientific community first assessed risk through basic indicators, such as the number of cases or rates of new cases and deaths, and later began using other direct impact indicators to conduct more detailed analyses. We aimed at synthesizing the scientific community's contribution to assessing the direct impact of the COVID-19 pandemic on population health through indicators reported in research papers. Methods We conducted a rapid scoping review to identify and describe health indicators included in articles published between January 2020 and June 2021, using one strategy to search PubMed, EMBASE and WHO COVID-19 databases. Sixteen experts from European public health institutions screened papers and retrieved indicator characteristics. We also asked in an online survey how the health indicators were added to and used in policy documents in Europe. Results After reviewing 3891 records, we selected a final sample of 67 articles and 233 indicators. We identified 52 (22.3%) morbidity indicators from 33 articles, 105 severity indicators (45.1%, 27 articles) and 68 mortality indicators (29.2%, 51). Respondents from 22 countries completed 31 questionnaires, and the majority reported morbidity indicators (29, 93.5%), followed by mortality indicators (26, 83.9%). Conclusions The indicators collated here might be useful to assess the impact of future pandemics. Therefore, their measurement should be standardized to allow for comparisons between settings, countries and different populations. [ABSTRACT FROM AUTHOR]

Conceptualizing tobacco dependence as a chronic relapsing condition suggests the need to use analytic strategies that reflect that premise. However, clinical trials for smoking cessation typically define the primary endpoint as a measure of abstinence at a single timepoint distal to the intervention, typically 3–12 months. This reinforces the concept of tobacco outcomes as a dichotomous state—one is, or is not, abstinent. Fortunately, there are several approaches available to handle longitudinal data that reflect the relapsing and remitting nature of tobacco use during treatment studies. In this paper, sponsored by the Society for Research on Nicotine and Tobacco's Treatment Research Network, we present an introductory overview of these techniques and their application in smoking cessation clinical trials. Topics discussed include models to examine abstinence outcomes (eg, trajectory models of abstinence, models for transitions in smoking behavior, models for time to event), models that examine reductions in tobacco use, and models to examine joint outcomes (eg, examining changes in the use of more than one tobacco product). Finally, we discuss three additional relevant topics (ie, heterogeneity of effects, handling missing data, and power and sample size) and provide summary information about the type of model that can be used based on the type of data collected and the focus of the study. We encourage investigators to familiarize themselves with these techniques and use them in the analysis of data from clinical trials of smoking cessation treatment. Implications Clinical trials of tobacco dependence treatment typically measure abstinence 3–12 months after participant enrollment. However, because smoking is a chronic relapsing condition, these measures of intervention success may not accurately reflect the common trajectories of tobacco abstinence and relapse. Several analytical techniques facilitate this type of outcome modeling. This paper is meant to be an introduction to these concepts and techniques to the global nicotine and tobacco research community including which techniques can be used for different research questions with visual summaries of which types of models can be used for different types of data and research questions. [ABSTRACT FROM AUTHOR]

The estimation of the slope (b -value) of the frequency–magnitude distribution of earthquakes is based on a formula derived by Aki decades ago, assuming a continuous exponential distribution. However, as the magnitude is usually provided with a limited resolution, its distribution is not continuous but discrete. In the literature, this problem was initially solved by an empirical correction (due to Utsu) to the minimum magnitude, and later by providing an exact formula such as that by Tinti and Mulargia, based on the geometric distribution theory. A recent paper by van der Elst showed that the b -value can be estimated also by considering the magnitude differences (which are proven to follow an exponential discrete Laplace distribution) and that in this case the estimator is more resilient to the incompleteness of the magnitude data set. In this work, we provide the complete theoretical formulation including (i) the derivation of the means and standard deviations of the discrete exponential and Laplace distributions; (ii) the estimators of the decay parameter of the discrete exponential and trimmed Laplace distributions and (iii) the corresponding formulas for the parameter b. We deduce (iv) the standard 1 σ intervals for the estimated b. Moreover, we are able (v) to quantify the error associated with the Utsu minimum-magnitude correction. Furthermore, we have discussed the formulas to produce statistically independent magnitude differences. We tested extensively the b -value estimators on simulated synthetic data sets including complete catalogues as well as catalogues affected by a strong incompleteness degree such as aftershock sequences where the incompleteness is made to vary from one event to the next. We have also analysed the real aftershock sequence of the 30/10/2016 Norcia (central Italy) to integrate the finding of the simulations. To judge the performance of the various estimators we have introduced an index p that can be seen as a non-parametric extension of the Student's t index. The main outcomes of this paper are that (1) the b -value estimators devised for continuous magnitude data are not adequate for binned magnitudes, (2) for complete data sets, estimators based on magnitudes and on magnitude differences provide substantially equivalent results, (3) for incomplete magnitude data sets, estimators based on magnitude differences provide better results and (4) for incomplete aftershock sequences there is no evidence that methods based on positive magnitude differences are superior than other methods using differences. This conclusion is further confirmed by our analysis of the above-mentioned Norcia seismic sequence. This last finding contrasts with the van der Elst's claim that the so called |${{b}_ + }$| method is the most adequate to treat real aftershock sequences. [ABSTRACT FROM AUTHOR]

Full-waveform inversion (FWI) is an effective method for imaging subsurface properties using sparsely recorded data. It involves solving a wave propagation problem to estimate model parameters that accurately reproduce the data. Recent trends in FWI have seen a renewed interest in extended methodologies, among which source extension methods leveraging reconstructed wavefields to solve penalty or augmented Lagrangian (AL) formulations have emerged as robust algorithms, even for inaccurate initial models. Despite their demonstrated robustness on synthetic data, challenges remain, such as the lack of a clear physical interpretation and reliance on difficult-to-compute least-squares (LS) wavefields. Moreover, the literature lacks a general and through comparison of these source extension methods with each other and with the standard FWI. This paper is divided into three critical parts. In the first, a novel formulation of these methods is explored within a unified Lagrangian framework. This novel perspective permits the introduction of alternative algorithms that use LS multipliers instead of wavefields. These multiplier-oriented variants appear as regularizations of the standard FWI, are suitable to the time domain, offer tangible physical interpretations, and foster enhanced convergence efficiency. The second part of the paper delves into understanding the underlying mechanisms of these techniques. This is achieved by solving the associated non-linear equations using iterative linearization and inverse scattering methods. The paper provides insight into the role and significance of Lagrange multipliers in enhancing the linearization of the equations. It explains how different methods estimate multipliers or make approximations to increase computing efficiency. Additionally, it presents a new physical understanding of the Lagrange multiplier used in the AL method, highlighting how important it is for improving algorithm performance when compared to penalty methods. In the final section, the paper presents numerical examples that compare different methods within a unified iterative algorithm, utilizing benchmark Marmousi and 2004 BP salt models. [ABSTRACT FROM AUTHOR]

This paper responds to Friend's (2023) critique of the Powers-BSA , a view according to which laws of nature are efficient descriptions of how modally laden properties (powers) are possibly distributed in spacetime. In the course of this response, the paper discusses the nature of scientific and metaphysical explanation, the aim of science, and the structure of modal space. [ABSTRACT FROM AUTHOR]

Is relativism a coherent thesis? The paper argues for a new view of relativism that opposes both classic and contemporary views. On this view, the thesis of relativism is coherent even if the key notions in the standard apparatus of relativism—of alternative conceptual schemes, relative truth, perspectival content—are all incoherent. The view defended here highlights issues about attitude attribution and explanation in formulating the thesis of relativism and it proposes a surprising connection between relativism and nonsense. The paper argues further that the thesis of relativism, so understood, is coherent, by considering different accounts of the semantics of attitude attributions in their application to the attribution of nonsensical thinking. [ABSTRACT FROM AUTHOR]

Using the concept of methodological congruence—where the different elements of a study 'fit' together—we explore both problematic and good practice in (reflexive) thematic analysis (TA) as reported in Health Promotion International (HPI). Aligning with the importance we place on 'owning your perspectives' we situate this exploration in relation to our understanding of the variation in approaches to TA and qualitative research more broadly. This contextualization is necessary for highlighting why we judge practices to be in/congruent, and to facilitate more knowing congruence in future research. We critically reviewed a 'sample' of 31 papers published in HPI between 2010 and 2023 citing Braun and Clarke as reference for TA. We overview a range of problematic and good features of the use of TA in HPI , before focusing on two domains that seemed to present key challenges: theory and themes. Methodological incongruence can occur when postpositivist values and practices unwittingly creep into ostensibly non-positivist TA; we encourage thoughtfully and what we term 'knowing' consideration of theory, and quality practices and criteria. Methodological incongruence can also occur through mismatched conceptualizations of themes—notably, the use of 'topic summaries' as themes for reflexive TA (and fragmented thematic structures with 'thin' themes). We provide examples from the reviewed papers to demonstrate good practice in researcher reflexivity, articulation of theoretical and methodological frameworks and congruent themes. However, mindful of power dynamics, we only discuss problematic practice in general terms, to protect author anonymity. To facilitate thoughtful, quality TA—of all kinds—we provide eight pointers for researchers (and reviewers) to guide quality practice, and facilitate the use of concepts, procedures and criteria that promote knowing methodological congruence. [ABSTRACT FROM AUTHOR]

Introduction Incontinence is a common, distressing condition, most prevalent in older people. There is an unmet need for effective interventions to support continence. This review focuses on non-pharmacological interventions to reduce incontinence among homebound older people. Aim: to identify interventions with potential to be delivered by care workers, nurses or family members in a person's home. Methods Multiple databases were searched until 15 September 2023 for randomised controlled trials reporting home-based interventions for incontinence for older people (≥65 years) living at home. Two reviewers independently screened titles, abstracts and papers against inclusion criteria, then assessed for the Risk of Bias (RoB2). A third reviewer resolved the discrepancies. Primary data were extracted and synthesised. Results A full-text review of 81 papers identified seven eligible papers (1996–2022, all USA), including n  = 636 participants (561 women and 75 men). Two studies focusing on multicomponent behavioural interventions showed benefit, as did one study of transcutaneous tibial nerve stimulation self-administered through electrode-embedded socks. Three, which included cognitively impaired people, reported improvement with toileting assistance programmes, but the effects were not all significant. Results were inconclusive from a study examining the effects of fluid intake adjustments. Interventions were delivered by nurses, three in collaboration with family caregivers. No faecal incontinence interventions met the criteria. Conclusion There is scant evidence for continence supporting interventions delivered in older people's own homes. With an ageing population often reliant on family or social care workers well-placed to support continence promotion and policy drives for services to support older people remaining at home, this evidence gap needs addressing. [ABSTRACT FROM AUTHOR]

The Fornax galaxy cluster is the richest nearby (D ∼ 20 Mpc) galaxy association in the southern sky. As such, it provides a wealth of opportunities to elucidate on the processes where environment holds a key role in transforming galaxies. Although it has been the focus of many studies, Fornax has never been explored with contiguous homogeneous wide-field imaging in 12 photometric narrow and broad bands like those provided by the Southern Photometric Local Universe Survey (S-PLUS). In this paper, we present the S-PLUS Fornax Project (S+FP) that aims to comprehensively analyse the galaxy content of the Fornax cluster using S-PLUS. Our data set consists of 106 S-PLUS wide-field frames (FoV∼1.4 × 1.4 deg2) observed in five Sloan Digital Sky Survey-like ugriz broad bands and seven narrow bands covering specific spectroscopic features like [O  ii ], Ca  ii  H+K, Hδ, G band, Mg b triplet, Hα, and the Ca  ii triplet. Based on S-PLUS specific automated photometry, aimed at correctly detecting Fornax galaxies and globular clusters in S-PLUS images, our data set provides the community with catalogues containing homogeneous 12-band photometry for ∼3 × 106 resolved and unresolved objects within a region extending over ∼208 deg2 (∼5  R vir in RA) around Fornax' central galaxy, NGC 1399. We further explore the eagle and IllustrisTNG cosmological simulations to identify 45 Fornax-like clusters and generate mock images on all 12 S-PLUS bands of these structures down to galaxies with M ⋆ ≥ 108 M⊙. The S+FP data set we put forward in this first paper of a series will enable a variety of studies some of which are briefly presented. [ABSTRACT FROM AUTHOR]

Quality control charts aim at raising an alarm as soon as sequentially obtained observations of an underlying random process no longer seem to be within stochastic fluctuations prescribed by an in-control scenario. Such random processes can often be modelled using the concept of stationarity, or even independence as in most classical works. An important out-of-control scenario is the changepoint alternative, for which the distribution of the process changes at an unknown point in time. In his seminal 1954 Biometrika paper, E. S. Page introduced the famous cumulative sum control charts for changepoint monitoring. Innovatively, decision rules based on cumulative sum procedures took the full history of the process into account, whereas previous procedures were based only on a fixed and typically small number of the most recent observations. The extreme case of using only the most recent observation, often referred to as the Shewhart chart, is more akin to serial outlier than changepoint detection. Page's cumulative sum approach, introduced seven decades ago, is ubiquitous in modern changepoint analysis, and his original paper has led to a multitude of follow-up papers in different research communities. This review is focused on a particular subfield of this research, namely nonparametric sequential, or online, changepoint tests that are constructed to maintain a desired Type-1 error as opposed to the more traditional approach seeking to minimize the average run length of the procedures. Such tests have originated at the intersection of econometrics and statistics. We trace the development of these tests and highlight their properties, mostly using a simple location model for clarity of exposition, but we also review more complex situations such as regression and time series models. [ABSTRACT FROM AUTHOR]

In this article, we review the ways in which replication has been and could be featured in consumer behavior, using Journal of Consumer Research as a specific setting. We present a framework for thinking about the generalizability of research findings and differentiate various potential benefits that replication can have for understanding variability in consumer research findings. We then define four different types of replications, describe how researchers can use these approaches to produce distinct benefits, and give guidance regarding conducting, interpreting, and the potential contributions of these different types of replications. We conclude with a discussion of various ways in which replication could be more fully integrated into different phases of the scientific research process, taking into account the contribution necessary for publication. In particular, we identify opportunities to incorporate independent replication into original papers, to increase the replication-based contribution in papers that build on prior work, and to use systematic replication in conjunction with meta-analysis to synthesize and confirm conclusions from a mature research literature. More fully integrating replication into scientific practice can yield a new equilibrium, in which replication is routine, typically consistent with previous results, and recognized as necessary for establishing an empirical generalization. [ABSTRACT FROM AUTHOR]

Rebel groups often develop governance during war by establishing administrative structures, engaging in taxation, and providing social services to the local population. Rebel governance structures, however, vary depending on the extent to which they include participatory arrangements. Some rebel groups allow civilian participation in their governance during the war, while others have highly hierarchical structures strictly limiting civilian participation. This paper examines whether and how the governance activities of rebel groups and participatory arrangements and institutions that they adopt during the war affect the durability of peace. I argue that participatory rebel governance can be particularly effective in establishing durable peace after the war. Civilian participation under rebel governance facilitates civilian political participation after conflict ends, which, in turn, discourages the use of political violence in response to grievances. Using rebel governance data between 1945 and 2012, I find strong empirical support for my argument. I then demonstrate the plausibility of the causal mechanism in the case of Indonesian and the Philippine civil wars. By establishing a strong positive empirical relationship between rebel wartime governance and the durability of peace, this paper identifies another important effect of rebel governance on conflict processes and outcomes in addition to its demonstrated effect on negotiations between warring parties and post-war democratization. [ABSTRACT FROM AUTHOR]

In this paper, regime complexes are conceptualized as dynamic networks constituted by relations between international organizations (IOs). We introduce "IO positioning" as a conceptual lens for studying patterns and shifts in IO networks resulting from negotiations between IOs over their distinctiveness and social membership in complex organizational fields. We suggest that IO positioning has two constitutive effects. First, on the level of individual IOs, positioning affects IO identities within the field as these are (re)negotiated in relations with other organizations. Secondly, the positioning practices of IOs have constitutive effects on the contours of entire policy fields too; they form and shift the boundaries of regime complexes. Empirically, the paper examines the utility of our approach by analyzing the history, dynamics, and positioning effects of interorganizational relations between eight IOs in global health governance—an area of international cooperation that is commonly portrayed as exceptionally fragmented, complex, and densely populated. Examining relations between our eight IOs, we provide network analytical longitudinal data of in- and out-reporting by IOs derived from IOs' annual reports between 1970 and 2017. We triangulate our network analysis with data derived from semi-structured interviews with health IO professionals. [ABSTRACT FROM AUTHOR]

What happens after border externalization? States and regional organizations of the Global North increasingly engage in transnational migration management that seeks to prevent potential irregular migration beyond their territory. Despite the impressive financial and political resources the involved actors mobilize to reach this goal, little is known about the effects of this strategy on their target states and populations. This paper conceptualizes border externalization as a spatial intervention that absorbs contingent migrant flows into an interplay of capital and race. It argues that the immobilization and differential integration produced through externalization can serve as a spatial fix for labor shortages in transit "migration" states. This differential integration disempowers the targeted migrant population and aggravates racial antagonisms. Hence, border externalization is not just a (by-)product of racist ideology and policy, but also intensifies racial hierarchies in the space it intervenes into. The paper studies this through the case of the "EU-Turkey Deal" and Turkey's Syrian refugee population, building on document analysis and primary interview data with industry representatives, farmers, NGO workers, and government officials. On a theoretical level, the paper thereby contributes to the recent trend that reinserts the border into global processes of racialized capital accumulation. [ABSTRACT FROM AUTHOR]

In this paper, we presented a detailed analysis of the Sloan Digital Sky Survey optical spectrum of a new sub-kpc scale dual AGN candidate SDSS J222428.53+261423.2 (=SDSS J2224). The target is one of the few AGNs with all the optical narrow emission lines characterized by double-peaked profiles and with peak separations in velocity units of about 930 km s−1. If the double-peaked narrow emission lines (DPNELs) are due to a dual AGN in SDSS J2224, the estimated physical separation between the two cores is about 500 pc. Meanwhile, three alternative explanations are also discussed in this paper, however, we can not find solid evidence to completely rule them out. Our results support the presence of a sub-kpc dual AGN with DPNELs in all lines, indicating a key episode of galaxy merging evolution at sub-kpc scale. [ABSTRACT FROM AUTHOR]

Background Caregiving for the adult benign brain tumor (aBBT) population is unique, as patients' extended period of survivorship poses significant challenges related to the long-term sequelae of the disease and the foreboding possibility of recurrence. In this integrative review, we examined the caregiving experience across the spectrum of the aBBT population. Methods We searched OVID, CINAHL, and PubMed databases from 2000 to 2022. We included studies primarily focused on caregivers of aBBT and written in English. Results Among 594 papers identified in the initial review, we included a final list of 7 papers. Among these 7 papers, 5 central themes emerged. First, we identified a theme surrounding psychosocial and emotional needs, which included the social isolation of caregiving. The second theme related to informational care needs, including what is considered to be the normal course of recovery after surgery. The third theme focused on access to services, including specialist neurosurgical care, and the fourth theme related to financial strain and the economic burdens associated with long-term follow-up. Lastly, we found a theme surrounding family role changes, which included the shift from spouse to caregiver. Conclusions In this review, we identified themes highlighting similarities to the high-grade glioma population. However, we uncovered distinct differences in terms of caregiver characteristics, length of survivorship, and the burden of caregiving over time. Collectively, our findings underscore the incomplete understanding of the caregiving experience across the spectrum of the aBBT population. [ABSTRACT FROM AUTHOR]

China's specific developmental context defines the need to understand its state logic of knowledge transfer, particularly from the agency perspective of universities. This paper proposes the new term 'university engagement with industry' (UEI) to highlight the active role of universities in university–industry linkages. A structural method is adopted to collect relevant literature and to provide a systematic and critical review of China's UEI. This paper makes four key contributions: (1) it illustrates a structural approach to collect literature via precise and transparent identification for a targeted topic from an interdisciplinary research field; (2) it systematically presents the China-specific external institutional environment and internal governance of universities for knowledge transfer and captures influential factors for university's embeddedness in multiscalar innovation systems; (3) it identifies China-specific UEI in comparison to Western findings; and (4) it suggests a research agenda on China's UEI for future studies. [ABSTRACT FROM AUTHOR]

The controversies surrounding the regulation of technology depend, among other factors, on the diversity of the regulatory objectives prioritized by the distinct social actors. These differences may also lead to controversies in the realm of regulatory science: controversies between distinct epistemic policies. As controversies are partly the result of prioritizing different objectives, comparing alternative regulatory options is a seemingly impossible endeavour. In this paper, we offer a partial solution to this problem by proposing a means of comparing different regulatory options. This proposal makes it possible to analyse and assess the different options and facilitates the adoption of compromises between the various parties to the controversy, even if it is unable to eliminate the differences in the prioritization of objectives. The case study we have used to illustrate the main ideas of this paper is the controversy surrounding the regulation of health claims in the European Union. [ABSTRACT FROM AUTHOR]

In various conflict contexts where the state is unable to maintain security and public order, non-state armed groups (NSAGs) and the United Nations (UN) conduct their activities alongside one another. While previous research has focused on hostile relations between the UN and NSAGs, less attention has been given to collaborative interactions. This paper aims to address this research gap by formulating a novel conceptual typology of NSAG–UN interactions in the context of a peace operation. The typological framework comprises two-dimensions: firstly, the thematic field of interaction including human rights, humanitarian needs and governance, security, and political processes and, secondly, the nature of interaction ranging from confrontation to cooperation. Based on the typology, interaction activities between the UN and NSAGs in two peacekeeping operations—the UN Operation in Côte d'Ivoire (UNOCI) and the UN Multidimensional Integrated Stabilization Mission in Mali (MINUSMA)—are systematically documented and described. While both cases show confrontation in the security field, UNOCI also commonly cooperated with NSAGs on security-related issues; MINUSMA instead cooperated with NSAGs primarily regarding the political process. The analysis further proposes factors that may explain such variation, including institutional arrangements and NSAG characteristics. The conceptual framework presented in this paper is crucial in advancing knowledge about an empirical phenomenon that we know little about and that has important implications for different forms of "local" engagement in peace operations and the effectiveness of UN policies and practices. [ABSTRACT FROM AUTHOR]

This document is an erratum to a paper titled "Components in Meandric Systems and the Infinite Noodle." The erratum acknowledges a missing argument in the proof of Proposition 5 in the original paper. It also refers to Proposition 1 and Proposition 2 from the original paper, which discuss the convergence of random meandric systems and well-parenthesized words, respectively. The document provides equations and a lemma related to these propositions. The erratum concludes by stating that the difference between two equations is the use of the same root in both well-parenthesized words. The document also introduces notation and provides a proof for a swapping lemma. The given text is a proof of Proposition 1, provided by Valentin Féray and Paul Thévenin. The authors use equations and arguments to demonstrate the convergence in expectation and convergence in probability for multiplicative functions. They acknowledge Svante Janson for pointing out an incomplete proof in their original paper. [Extracted from the article]

This paper defines a parabolic frequency for solutions of the heat equation along homothetically shrinking mean curvature flows (MCFs) and proves its monotonicity along such flows. As a corollary, frequency monotonicity provides a proof of backwards uniqueness. Additionally, for solutions of more general parabolic equations on MCF shrinkers, this paper provides bounds on the derivative of the frequency, which similarly imply backwards uniqueness. [ABSTRACT FROM AUTHOR]

We consider two finite and disjoint sets of homogeneous robots deployed at the nodes of an infinite grid graph. The grid graph also comprises two finite and disjoint sets of prefixed meeting nodes located over the nodes of the grid. The objective of our study is to design a distributed algorithm that gathers all the robots belonging to the first team at one of the meeting nodes belonging to the first type, and all the robots in the second team must gather at one of the meeting nodes belonging to the second type. The robots can distinguish between the two types of meeting nodes. However, a robot cannot identify its team members. This paper assumes the strongest adversarial model, namely the asynchronous scheduler. We have characterized all the initial configurations for which the gathering problem is unsolvable. For the remaining initial configurations, the paper proposes a distributed gathering algorithm. Assuming the robots are capable of global-weak multiplicity detection , the proposed algorithm solves the problem within a finite time period. The algorithm runs in |$\Theta (dn)$| moves and |$O(dn)$| epochs, where |$d$| is the diameter of the minimum enclosing rectangle of all the robots and meeting nodes in the initial configuration, and |$n$| is the total number of robots in the system. [ABSTRACT FROM AUTHOR]

Ridesharing is an effective approach to alleviate traffic congestion. In most existing works, drivers and passengers are assigned prices without considering the constraints of desired benefits. This paper investigates ridesharing by formulating a matching and pricing problem to maximize the total payoff of drivers, with the constraints of desired benefit and quality of experience. An efficient algorithm is proposed to solve the formulated problem based on coalitional double auction. Secondary pricing based strategy and sacrificed minimum bid based strategy are proposed to support the algorithm. This paper also proves that the proposed algorithm can achieve a Nash-stable coalition partition in finite steps, and the proposed two strategies guarantee truthfulness, individually rational and budget balance. Extensive simulation results on the real-world dataset of taxi trajectory in Beijing city show that the proposed algorithm outperforms the existing ones, in terms of average total payoff of drivers while meeting the benefits of passengers. [ABSTRACT FROM AUTHOR]

Multiconjugate adaptive optics (MCAO) stands as an essential technology for the development of future large-aperture solar telescopes. Its primary objective is to empower telescopes to achieve nearly diffraction-limited performance while substantially extending the correction field of view (FoV). Conventional solar MCAO relies on the combination of adaptive optics and high-altitude correction (AO + HAC) modules for multiconjugate correction. However, this architectural approach excels in correction performance primarily at the central position, with performance deteriorating as one moves farther from the centre. Consequently, it results in poor consistency of FoV correction performance. To address these limitations, a new architectural approach was introduced, which combines ground layer AO with HAC (GLAO + HAC). Preliminary results have shown that, compared to AO + HAC, this approach significantly enhances FoV correction uniformity. Building upon these initial findings, this paper undertakes a more extensive research of the GLAO + HAC system. Its objective is to compare various solar MCAO system architectures, including AO + HAC, GLAO + HAC, and general MCAO, to finally propose optimization tailored to GLAO + HAC. Through this analysis, the paper conducts the performance comparison between GLAO + HAC and general MCAO. It underscores that, under equivalent configuration parameters, the differences between these two systems are marginal. However, due to the advantage of the independent control of dual correction modules in GLAO + HAC, it can introduce an optimization strategy by increasing the number of subapertures at the cost of reducing the GLAO guide star sensing FoV. Finally, the results of this strategy demonstrate an obvious enhancement in performance and FoV correction consistency within the GLAO + HAC system. [ABSTRACT FROM AUTHOR]

Introduction Heated tobacco products (HTPs) have been advertised as "reduced-harm" tobacco products compared to conventional cigarettes (CC); however, no direct evidence supporting HTPs being desirable for human health exists. A previous systematic review reported that evidence on HTPs published in 2017 or earlier was primarily drawn from industry-related papers. We aimed to investigate whether tobacco industry-affiliated studies are more likely to conclude that HTPs are more desirable than CC. Methods PubMed and Ichushi -Web were searched up to March 15, 2022, for studies on HTPs published in 2017 or after. We selected studies that assessed any measures of HTPs and CC, including secondary analyses using gray literature in English or Japanese. We excluded review articles except for a meta-analysis that met the aforementioned criteria. Data on the authors' affiliations, grant, conflict of interest, category of research subjects, and interpretation were extracted. Research members in two groups independently assessed the papers; discrepancies were solved by discussion between the groups. Results Overall, 134 studies met the criteria. Eighty-seven (64.9%) of them were affiliated with the tobacco industry. Of the 134 studies, 56.3% (49/87) of the industry-affiliated studies versus 19.1% (9/47) of nonindustry-affiliated studies concluded that HTPs were more desirable than CC (p  < .01). No study investigated clinically relevant outcomes, such as disease occurrence. Conclusions Publications on HTPs in the biomedical literature from January 2017 to March 2022 were dominated by tobacco industry-affiliated studies. More than half of them concluded that HTPs were more desirable than CC compared to independent studies. Implications Tobacco industry advertises HTPs as "reduced-harm" tobacco products compared to CC. HTP users tend to consider HTPs as alternative tobacco products less harmful than CC (ie, products for "harm reduction"). Our results demonstrated that papers written by tobacco industry-affiliated authors concluded that HTPs were more desirable than CC compared to papers by independent authors. However, all their judgments were based on surrogate outcomes. Surrogate outcomes are not necessarily linked to clinically relevant outcomes such as disease occurrence. Further studies on HTPs using clinically relevant outcomes are warranted by independent authors from tobacco industry. [ABSTRACT FROM AUTHOR]

This paper identifies an absence in currently constituted criminological discourse on the Global North and Global South. This absence is the Global East. The Global East is not a defined region but a relation of betweenness, geographically and geo-politically, within and between the South and North, representing peoples from countries and societies which fit imperfectly into a North/South binary. We focus on the Eastern European and Eurasian regions to demonstrate this point, concentrating specifically on its omission in punishment and society studies. Our paper makes a positive argument for the Global East concept, disrupting the assumed categories of North and South and producing a strategic essentialism to help better represent peoples thus far overlooked in southern criminology. [ABSTRACT FROM AUTHOR]

This paper provides insights into the predominant styles of political reasoning in England and Wales that inform penal policy reform. It does so in relation to a particular development that constitutes a dramatic, perhaps even unique, wholesale reversal of a previously introduced market-based criminal justice delivery model. This is the 'unification' of probation services in England and Wales, which unwound the consequential privatization reforms introduced less than a decade earlier. This paper draws on in-depth interviews with senior policy makers to present a narrative reconstruction of the unification of probation services in England and Wales. Analogies with desistance literature are drawn upon in order to encapsulate the tensions posed for policy makers as they sought to enact this penal policy reform. [ABSTRACT FROM AUTHOR]

This paper draws on interview data and published court judgment reports to reveal first-hand accounts of illegal transactions involving protected wildlife and how criminals collaborate with one another. This research finds that wildlife supply is controlled by a small number of key suppliers. Further, trust is embedded in the criminals' relationship based on kinship and friendship ties, while individuals' ethnicity and reputation also facilitate collaboration. These arrangements shape the criminal networks that exploit protected wildlife. This paper suggests further research into online trading of protected wildlife products, the presence of women in the illegal wildlife trade and the impact of COVID-19 on the criminal networks supplying wildlife. [ABSTRACT FROM AUTHOR]

Introduction Nerve agents have emerged as a global threat since their discovery in the 1930s, posing severe risks due to their inhibition of acetylcholinesterase and the subsequent accumulation of acetylcholine in nerve synapses. Despite the enforcement of the Chemical Weapon Convention to control chemical weapons, including nerve agents, recent events, such as the Novichok attacks on Sergei Skripal and Alexei Navalny, have highlighted the persistent threat. Novichok, a distinct class of nerve agents, raises specific concerns regarding its management due to limited understanding. This article aims to comprehensively analyze existing literature. Materials and Methods A scoping review was employed to comprehensively assess the current state of knowledge on managing patients poisoned with Novichok. Following the PRISMA-ScR guidelines, relevant literature was identified in peer-reviewed journals covering symptoms, diagnosis, treatment, decontamination, and long-term effects. Searches were conducted on February 1, 2023, across four electronic databases (PubMed, EMBASE, MEDLINE, and Web of Science) using "Novichok" as a keyword. No restrictions were applied, and additional studies were sought from the references of identified papers. Eligible papers included discussions on Novichok or its specific properties impacting management, regardless of study type, language, or publication date, while those unrelated to the study's conceptual framework were excluded. Results A total of 170 records were identified from the initial database search, with 86 studies screened after removing duplicates. Among these, 28 publications met the eligibility criteria and were included in the analysis. An additional relevant study was identified from the citation lists of included studies, bringing the total to 29. The review encompasses studies published from 2018 onwards, indicating the growing interest in this topic. While most studies are reviews on Novichok or nerve agents in general, several theoretical and experimental investigations were also found. Conclusion This review highlights the significant uncertainties and knowledge gaps surrounding the management of patients poisoned with Novichok. While some aspects align with other nerve agents, limited research likely due to safety and ethical challenges leads to assumptions and uncertainties in patient care. The review identifies areas with ongoing research, such as decontamination and biomarker recognition, while other aspects remain understudied. The possible inefficacy of current treatment options and the need for further research on oximes, bioscavengers, and long-term effects emphasize the necessity for increased research to optimize patient outcomes. More studies are essential to clarify the actual threat and toxicity of Novichok. Moreover, raising awareness among medical staff is crucial for early diagnosis, prompt treatment, and safety. This review offers valuable insights into managing Novichok-poisoned patients and calls for increased research and awareness in this critical area. [ABSTRACT FROM AUTHOR]

Natural language processing (NLP) has become an essential technique in various fields, offering a wide range of possibilities for analyzing data and developing diverse NLP tasks. In the biomedical domain, understanding the complex relationships between compounds and proteins is critical, especially in the context of signal transduction and biochemical pathways. Among these relationships, protein–protein interactions (PPIs) are of particular interest, given their potential to trigger a variety of biological reactions. To improve the ability to predict PPI events, we propose the protein event detection dataset (PEDD), which comprises 6823 abstracts, 39 488 sentences and 182 937 gene pairs. Our PEDD dataset has been utilized in the AI CUP Biomedical Paper Analysis competition, where systems are challenged to predict 12 different relation types. In this paper, we review the state-of-the-art relation extraction research and provide an overview of the PEDD's compilation process. Furthermore, we present the results of the PPI extraction competition and evaluate several language models' performances on the PEDD. This paper's outcomes will provide a valuable roadmap for future studies on protein event detection in NLP. By addressing this critical challenge, we hope to enable breakthroughs in drug discovery and enhance our understanding of the molecular mechanisms underlying various diseases. [ABSTRACT FROM AUTHOR]

Compared with other health disciplines, there is a stagnation in technological innovation in the field of clinical neuropsychology. Traditional paper-and-pencil tests have a number of shortcomings, such as low-frequency data collection and limitations in ecological validity. While computerized cognitive assessment may help overcome some of these issues, current computerized paradigms do not address the majority of these limitations. In this paper, we review recent literature on the applications of novel digital health approaches, including ecological momentary assessment, smartphone-based assessment and sensors, wearable devices, passive driving sensors, smart homes, voice biomarkers, and electronic health record mining, in neurological populations. We describe how each digital tool may be applied to neurologic care and overcome limitations of traditional neuropsychological assessment. Ethical considerations, limitations of current research, as well as our proposed future of neuropsychological practice are also discussed. [ABSTRACT FROM AUTHOR]