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This research letter discusses the emerging role of SAMSN1+ mast cells in chronic sinusitis and obesity. The authors conducted Mendelian randomization and transcriptomic analyses to explore the genetic and molecular mechanisms linking these two conditions. The results suggest that obesity may increase the risk of chronic sinusitis, but there is no evidence of chronic sinusitis contributing to obesity. Additionally, the study found that SAMSN1+ mast cells are associated with the activation of the TGF-β pathway in chronic sinusitis, highlighting a potential therapeutic target. [Extracted from the article]

In this study, a multi-functional layer was developed based on the commercially available cellulose triacetate (CTA) forward osmosis (FO) membrane to improve its antifouling property. Tannic acid/ferric ion (TA/Fe 3+ ) complexes were firstly coated as a precursor layer on the membrane surface via self-assembly. Afterwards, the tannic acid/diethylenetriamine (TA/DETA) hydrophilic functional layer was further coated, following Ag/polyvinylpyrrolidone (PVP) anti-bacterial layer was formed in situ through the reducibility of TA to obtain TA/Fe 3+ -TA/DETA-Ag/PVP-modified membrane. The optimized precursor layer was acquired by adjusting the buffer solution pH to 8, TA/Fe 3+ ratio to 4 and the number of self-assembled layers to 5. The permeability testing results illustrated that the functional layer had an insignificant effect on the membrane transport parameters. The TA/Fe 3+ -TA/DETA-Ag/PVP-modified membrane simultaneously exhibited excellent physical and chemical stability. The coated membrane also demonstrated enhanced anti-bacterial properties, achieving 98.63 and 97.30% inhibition against Staphylococcus aureus and Escherichia coli , respectively. Furthermore, the dynamic fouling experiment showed a 12% higher water flux decrease for the TA/Fe 3+ -TA/DETA-Ag/PVP CTA membrane compared to the nascent CTA membrane, which proved its excellent antifouling performance. This work provides a feasible strategy to heighten the antifouling property of the CTA FO membrane., Competing Interests: The authors declare there is no conflict., (© 2024 The Authors This is an Open Access article distributed under the terms of the Creative Commons Attribution Licence (CC BY 4.0), which permits copying, adaptation and redistribution, provided the original work is properly cited (http://creativecommons.org/licenses/by/4.0/).)