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Background: Radiofrequency catheter ablation (RFCA) may lead to decreased quality of life (QOL) and increased anxiety and depression in patients with paroxysmal supraventricular tachycardia (PSVT), possibly due to the lack of selectivity of the ablation tissue and the long ablation time. In recent years, pulsed field ablation (PFA) has been used for the first time in China to treat PSVT patients because of its ability to ablate abnormal tissue sites in a precise and transient manner. This study was conducted to compare the effects of PFA and RFCA on QOL and psychological symptoms of PSVT patients. Methods: We have designed a single-center, randomized, single-blind, standard-controlled trial. A total of 50 participants who met the eligibility criteria would be randomly allocated into the PFA group or RFCA group in a 1:1 ratio. All participants were assessed using the 36-Item Short-Form Health Survey (SF-36) and the Hospital Anxiety and Depression Scale (HADS) at pre-procedure (T0), post-procedure (T1), and 3 months post-procedure (T2). The SPSS 21.0 software was used to analyze the data through Wilcoxon and Fisher's exact tests and repeated measures ANOVA. Results: Twenty-five in the PFA group and 24 in the RFCA group completed the trial. SF-36: (1) Between-group comparison: At T1, PFA group had significantly higher SF-36 scores on physiological function (PF) and general health (GH) than RFCA group, with a treatment difference of 5.61 points and 18.51 points(P < 0.05). (2) Within-group comparison: We found that in the PFA and RFCA groups, T2 showed significant improvement in the remaining 6 subscales of the SF-36 scale compared to T1 and T0 (P < 0.05), except for body pain (BP) and social function (SF) scores. HADS: (1) Between-group comparison: no significant difference (P > 0.05). (2) Within-group comparison: The HADS scores of the PFA and RFCA groups were statistically significant at T2 compared to T0 and T1 (P < 0.05). Conclusions: Our study provided new and meaningful evidence that PFA was effective in significantly improving QOL and decreasing anxiety and depression in PFA patients. Trial registration: Chinese Clinical Trial Registry, ChiCTR2200060272. [ABSTRACT FROM AUTHOR]

Background: Atractylodes chinensis (DC) Koidz., a dicotyledonous and hypogeal germination species, is an important medicinal plant because its rhizome is enriched in sesquiterpenes. The development and production of A. chinensis are negatively affected by drought stress, especially at the seedling stage. Understanding the molecular mechanism of A. chinensis drought stress response plays an important role in ensuring medicinal plant production and quality. In this study, A. chinensis seedlings were subjected to drought stress treatment for 0 (control), 3 (D3), and 9 days (D9). For the control, the sample was watered every two days and collected on the second morning after watering. The integration of physiological and transcriptomic analyses was carried out to investigate the effects of drought stress on A. chinensis seedlings and to reveal the molecular mechanism of its drought stress response. Results: The malondialdehyde, proline, soluble sugar, and crude protein contents and antioxidative enzyme (superoxide dismutase, peroxidase, and catalase) activity were significantly increased under drought stress compared with the control. Transcriptomic analysis indicated a total of 215,665 unigenes with an average length of 759.09 bp and an N50 of 1140 bp. A total of 29,449 differentially expressed genes (DEGs) were detected between the control and D3, and 14,538 DEGs were detected between the control and D9. Under drought stress, terpenoid backbone biosynthesis had the highest number of unigenes in the metabolism of terpenoids and polyketides. To identify candidate genes involved in the sesquiterpenoid and triterpenoid biosynthetic pathways, we observed 22 unigene-encoding enzymes in the terpenoid backbone biosynthetic pathway and 15 unigene-encoding enzymes in the sesquiterpenoid and triterpenoid biosynthetic pathways under drought stress. Conclusion: Our study provides transcriptome profiles and candidate genes involved in sesquiterpenoid and triterpenoid biosynthesis in A. chinensis in response to drought stress. Our results improve our understanding of how drought stress might affect sesquiterpenoid and triterpenoid biosynthetic pathways in A. chinensis. [ABSTRACT FROM AUTHOR]

We consider the growth of the convex viscosity solution of the Monge–Ampère equation $\det D^2u=1$ outside a bounded domain of the upper half space. We show that if u is a convex quadratic polynomial on the boundary $\{x_n=0\}$ and there exists some $\varepsilon>0$ such that $u=O(|x|^{3-\varepsilon })$ at infinity, then $u=O(|x|^2)$ at infinity. As an application, we improve the asymptotic result at infinity for viscosity solutions of Monge–Ampère equations in half spaces of Jia, Li and Li ['Asymptotic behavior at infinity of solutions of Monge–Ampère equations in half spaces', J. Differential Equations 269 (1) (2020), 326–348]. [ABSTRACT FROM AUTHOR]

[Display omitted] The development of interfacial engineering was crucial for achieving the industrialization of high-performance carbon fiber/phenolic composites. In this study, establishing scalable interpenetrating networks (cellulose nanofiber-zeolitic imidazolate frameworks-8/aramid nanofiber-boron nitride) on the fiber/matrix interphase, was in favor of realizing precise repairation of interfacial defects, further regulating thermal conductivity, mechanical and tribological properties of the composites. Based on the physical and chemical bridging-effects arising from above spider-web networks, the flexural strength and modulus of modified sample were 74.69 MPa and 6.22 GPa, showing an increase of 135.99% and 56.68%, respectively. Meanwhile, this trans-scale spider-web structure acted as a micron skeleton-nano unit continuous thermal conductive network, significantly reduced phonon scattering and displayed a 258.33% enhancement in the thermal management capability of modified sample. This study reveals key design principles of trans-scale interfacial structure to dynamicly regulate performances and meet service requirements of next-generation carbon fiber/phenolic composites. [ABSTRACT FROM AUTHOR]

Matrix deposition plays a critical role in image quality of matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI). To improve the ionization efficiency and overcome the limitation of traditional matrix deposition methods in the face of difficult-to-sublimate or difficult-to-dissolve matrix, covalent organic frameworks (COFs) named COF-DhaTab was successfully synthesized and firstly used as matrix film. It was fabricated by imprinting of sieved COF-DhaTab powder on the surface of a double-sided adhesive tape. Outstanding reproducibility and uniformity of COF-DhaTab film were demonstrated by relative standard deviation (RSD) within 8.37% and 7.71% from dot-to-dot and plate-to-plate, respectively. With the introduction of double-sided adhesive tape, water contact angle (WCA) of COF-DhaTab film increased from 55° to 141°, resulting in significant suppression of analyte diffusion. Moreover, the intensity of potassium perfluorooctanic sulfonate (PFOS, C 8 F 17 SO 3 −, m/z 498.93) was 9.3 × 105, more than six hundred times higher than that using DHB matrix. This enhancement was attributed to the rough surface and multiple branches of the synthesized COF-DhaTab. To verify the ability of COF-DhaTab film as substrate, the spatial distribution of PFOS in zebrafish, rat liver and kidney tissues was explored. Superior imaging capability was displayed with high-spatial resolution and reliable location distribution. These results not only demonstrate the outstanding ability of COF-DhaTab as matrix for MALDI-MS and MALDI-MSI, but also provide a facile approach for fabrication of novel matrix films for MALDI-MSI. [Display omitted] • A novel strategy was developed to fabricate matrix film for difficult-to-sublimate or difficult-to-dissolve matrix. • MALDI-MS signal of PFOS with COF-DhaTab matrix was increased by 600 times than DHB matrix. • Matrix film of sieved COF-DhaTab was used to study spatial distribution of PFOS by MALDI-MSI. • Excellent MALDI image quality was demonstrated by COF-DhaTab matrix film. [ABSTRACT FROM AUTHOR]

[Display omitted] • Industrialization of ultra-robust hybrid aerogels with micro-nano structure. • Recycling waste resources was a green and sustainable development strategy. • The multiscale interpenetrating networks acted as effective thermal isolation barriers. • Decoration of ZIF-8 crystals on the cross-linking points of nanofibers induced constructing rigid-flexible frameworks. • The hybrid aerogel exhibited remarkable mechanical, thermal isolation, gas and dye adsorption capacities. Ultra-low density nanoaerogels as the lightest solid material have aroused extensive attention. However, lacking crack extension resistance limited their further development and application. Here, aramid and cellulose wastes were recycled to prepare high value-added nanofibers, which were further self-assembled to construct multilfunctional hybrid aerogels. In-situ growth of zeolitic imidazolate frameworks-8 (ZIF-8) on the cellulose nanofiber (CNF) created a robust skeleton. Flexible aramid nanofibers (ANF), as burgeoning building blocks were employed to inlay into the microscopic skeleton structure for establishing micro-nano double networks. Benefiting from the existence of multiscale networks, the maximum value in the compressive stress of S 0 , S 1 , S 2 and S 3 increased from 2.74 to 4.63, 5.19 and 6.61 MPa, respectively. Meanwhile, ANF-ZIF-8-CNF hybrid aerogels exhibited low thermal conductivity of 3.58–3.97 × 10-2 W/(m⋅K). The significant increase in the specific surface area (481.46 m2/g) endowed hybrid aerogels with high adsorption abilities for nitrogen (280.83 cm3/g), prussian blue (34.12 mg⋅g−1), rhodamine B (37.30 mg⋅g−1), DMF (25.13 g⋅g−1) and DMSO (15.48 g⋅g−1), respectively. This multiscale structural engineering strategy opens an avenue toward to upcycle waste resources into the next-generation high-performance nanoaerogels, showing huge application potential in thermal management, air purification and sewage treatment. [ABSTRACT FROM AUTHOR]

The purpose of this study was to investigate the collaborative dialogue patterns of pair programming and their impact on programming self‐efficacy and coding performance for both slow‐ and fast‐paced students. Forty‐six postgraduate students participated in the study. The students were asked to solve programming problems in pairs; those pairs' conversations were recorded when they worked on their tasks. Data analysis methods, including lag sequential analysis, cluster analysis and paired t‐test, were employed, and the results showed that (1) four collaborative dialogue patterns emerged: Lecture, Guide, Question and Answer (Q&A), and Inquiry patterns; (2) Guide and Inquiry patterns significantly increased programming self‐efficacy for both fast‐ and slow‐paced students while Lecture and Q&A patterns significantly increased programming self‐efficacy for slow‐paced students but not for fast‐paced students; (3) Guide and Inquiry patterns played a significant role in improving coding performance for slow‐paced students. The study reveals a complex relationship between collaborative dialogue patterns with programming self‐efficacy and coding performance, critically affecting students' pair programming quality. Further details of the findings are also discussed. Practitioner notesWhat is already known about this topic Pair programming is promising in promoting problem solving and knowledge transfer and is widely used in programming education.There are different patterns observed in the pair programming process.Collaborative dialogue patterns found in "expert‐novice" pair programming were derived from a single programming task.What this paper adds Four collaborative dialogue patterns of pair programming emerged by increasing the different tasks and experiment duration and expanding the sample size, which further verified the stability of the similar patterns in previous studies.Four collaborative dialogue patterns showed different significant impacts on different students' programming self‐efficacy and coding performance.This study presents the finer‐grained characteristics of collaborative interaction in programmer pairs and contributes to the explanation regarding the different effects of pair programming reported in previous studies.Implications for practice and/or policy Four collaborative dialogue patterns can help the teachers understand the collaborative process of pair programming between fast‐ and slow‐paced students.The collaborative dialogue patterns can be used to formulate effective intervention strategies to stimulate the process of collaboration in pairs and applied in future programming education to provide a new path for cultivating and promoting students' programming abilities.It is worth further investigating the impact of collaborative dialogue patterns on students' computational thinking. [ABSTRACT FROM AUTHOR]

Background: The existence of aggressive behavior in autism spectrum disorders (ASD) raises questions about whether cognitive and emotional factors in social information processing play a role between autistic traits (ATs) and aggressive behavior in the general population, especially in the context of Chinese culture. Moreover, given a possible gender difference in these variables, the study aimed to examine the effect of ATs on aggressive behavior, and the potential mediating role of hostile attribution bias and alexithymia on this association, as well as gender difference. Methods: 850 Chinese college students participated in the assessment, including their ATs, hostile attribution bias, alexithymia, and aggressive behavior. Pearson correlation, mediation effects analyses, and multiple-group comparison were conducted. Results: The results indicated that ATs indirectly predicted increased aggressive behavior through attribution bias and alexithymia. Gender difference in mediating effects was revealed: ATs indirectly predicted increased aggressive behavior through the serial mediating effect only in males. Conclusion: Hostile attribution bias and alexithymia completely mediated the association between ATs and aggressive behavior, which contained the separate mediating effects of (a) hostile attribution bias and (b) alexithymia and the serial mediating effect of (c) hostile attribution bias and alexithymia. Gender differences in mediating effects were found only in the serial mediating effect, which was significant in males but not in females. The findings revealed the internal mechanism of ATs affecting aggressive behavior and gender difference, which have implications for the intervention of aggressive behavior of individuals with autism and those with high levels of ATs. [ABSTRACT FROM AUTHOR]

The modeling of blind people's behavior is an important topic in pedestrian evacuation dynamics. In order to study movement characteristics of blind people in evacuation process and the effect of indoor obstacles on the evacuation efficiency of blind people, an extended cellular automata model is proposed to simulate blind people evacuation by considering the influence of obstacles. The control variable method is adopted to study the effect of indoor obstacles on the blind evacuation efficiency rule. The numerical simulation is applied to analyze the evacuation process of blind people under different setting (e.g. the location, size and other factors) of obstacles and different evacuation scenarios. The shunt effect of obstacles is discussed and the layout strategy of obstacles is optimized. The results show that the longitudinal obstacles in front of the exit can effectively play the diversion role of obstacles when the obstacle is at a certain distance from the exit, which will improve the evacuation efficiency of the blind. Furthermore, a horizontal obstacle of appropriate length can constrain the trajectory of the blind people and improve the efficiency of evacuation, but when the horizontal obstacle is too long, it will induce extra jam on both sides of the obstacle and hinder the evacuation of the blind. The finding can provide the theoretical basis for the blind people's organization, management and the optimization of evacuation strategies during an emergency. [ABSTRACT FROM AUTHOR]

Carbon fabric/resin laminated composites (CFRC) are extensively used in aerospace, transportation, and other fields owing to their superiorities of lightweight, high strength, and convenient integral molding. Therefore, strong interlaminar binding and prominent wear resistance are urgent requirements for avoiding premature failure of laminated materials in harsh working environments. To elevate the superficial wear resistance and interlaminar bonding strength of composites simultaneously, the modified composites were obtained by introducing carbon fiber powder (CFP) with different densities on the surface of the composites and between layers. The experimental results indicate that CFP can be evenly distributed in the interlaminar resin enrichment zone of the sample (CFRC‐40) when the deposition density is 40 g/m2. Consequently, CFRC‐40 presents optimal thermal conductivity owing to better heat transfer bridges between layers of the composite established by CFP. At the same time, the mechanical properties such as the tensile, impact, and interlaminar shear strengths of CFRC‐40 are improved by 42.8%, 10.2%, and 8.5%, respectively, compared with the original CFRC, which are attributed to the absorption of crack propagation energy and the inhibition of crack propagation by CFP. Furthermore, the dynamic friction coefficient maintains at a high level after introducing CFP with a density of 40 g/m2, while the wear rate significantly decreases by 61.2% from 12.99 × 10−14 m3(N m)−1 to 5.04 × 10−14 m3(N m)−1. This study proposes an innovative strategy to improve the interlaminar bonding of carbon fabric/resin laminated composite, which is conducive to obtaining composite with excellent mechanical and tribological properties. Highlights: A facile and effectual method was adopted to introduce carbon fiber powder (CFP) into the interlamination and surface of the composites simultaneously.The mechanical properties and abrasive resistance of the composites were obviously strengthened by regulating the content and distribution of CFP.CFP at a certain scale, could not only hinder the propagation of cracks but also alleviate the surface wear and extend the service life of composites. [ABSTRACT FROM AUTHOR]

[Display omitted] • Biomimetic fabrication bioprinting strategies based on decellularized extracellular matrix are reviewed. • Fabrication of decellularized extracellular matrix and common 3D Bioprinting Techniques are summarized. • Decellularized extracellular matrix-based bioprinting for musculoskeletal tissue regeneration is overviewed. • The challenge and future perspectives of bioprinting strategies based on decellularized extracellular matrix are prospected. Musculoskeletal disorders, as one of the prevalent categories of ailments, exert significant impacts on individuals' lives, occupations, and physical activities. Degenerative changes, injuries, infections, and tumor resections causing defects in musculoskeletal tissues such as cartilage, bones, skeletal muscles, menisci, ligaments, and rotator cuffs can detrimentally affect patients' quality of life and mental well-being. Traditional autologous and allogeneic transplantations have been clinically employed. However, autologous transplantation suffers from the limitation of a finite number of transplantable tissues, while allogeneic transplantation faces challenges such as immune rejection. The extracellular matrix (ECM) serves as a natural scaffold for cells to fulfill physiological functions such as adhesion, proliferation, and differentiation. Decellularized extracellular matrix (dECM) emerges as a promising biomaterial generated through specific tissue or organ decellularization. Leveraging 3D bioprinting technology, dECM-based biomaterials enable customized printing and construction. This study reviews various decellularization techniques, post-decellularization strategies, and commonly used 3D bioprinting technologies. It summarizes the integration of dECM-based biomaterials with 3D bioprinting technology applied in musculoskeletal system research. These investigations showcase the exciting potential of dECM-based biomaterials in the musculoskeletal system, offering prospects for clinical translation in orthopedics. [ABSTRACT FROM AUTHOR]

• The energy bands of Fe and Mn co-adsorbed monolayers of SnSe 2 exhibit semi-metallicity. • As tensile strain increases, the adsorption system transitions from semi-metallic to metallic, accompanied. • The co-adsorption system's curie temperature is calculated to be 205.2 K. • The application of Fe and Mn double transition metal atoms to monolayer SnSe 2 may have potential. Pure 2D SnSe 2 is not magnetic, which limits its application in spintronics. However, magnetic properties can be induced in pure 2D SnSe 2 by introducing transition metal elements. In this study, we used first-principles calculations based on density-functional theory to predict the electronic structure and magnetic properties of monolayer SnSe 2 under adsorption of Fe and Mn double transition metal atoms. Our findings show that the energy bands of Fe and Mn co-adsorbed monolayers of SnSe 2 exhibit semi-metallicity. As tensile strain increases, the adsorption system transitions from semi-metallic to metallic, accompanied by an increase in total magnetic moment. Based on the Heisenberg model, the co-adsorption system's Curie temperature is calculated to be 205.2 K. Our studies suggest that the application of Fe and Mn double transition metal atoms to monolayer SnSe 2 may have potential in spintronics. [ABSTRACT FROM AUTHOR]

Accurate determination of the electrostatic force exerted on multipole moments is essential in comprehending the interaction between charged bodies and dielectric layers. A comprehensive solution is presented in this study for the calculation of the electric potential, field, and force generated by n th-order electric multipole above a semi-infinite dielectric body covered by a dielectric layer using the image multipole method. The present study investigates the impact of dielectric thickness, permittivity, and separation distance on the electrostatic interaction between an electric multipole moment and a semi-infinite dielectric body. The calculation results indicate that as the thickness of the dielectric layer increases and the dielectric constant of the surrounding medium surpasses that of the dielectric layer, the electrostatic attractive force undergoes a transition to a repulsive force. The magnitude of the electrostatic force acting on a n th-order electric multipole moment is directly proportional to the square of the value of the electric multipole moment and inversely proportional to the 2 (n +1) power of the distance. [ABSTRACT FROM AUTHOR]

Nowadays, two-dimensional materials are ideal for fabricating optoelectronic and spintronic devices. We have investigated the optical and magnetic properties of −6 % to 6 % strain on Mn-adsorbed monolayer SnSe 2 films using a first-principles approach. The Mn-adsorbed monolayer SnSe 2 is a magnetic semiconductor in the absence of strain effects. As the tensile strain increases, the band gap of the Mn-adsorbed monolayer SnSe 2 decreases and the structure becomes unstable, and Mn adsorption changes to exothermic adsorption at −6 % strain. The magnetic moment of the system increases slightly with increasing tensile strain and decreases rapidly when the strain reaches 4%. As the compressive strain increases, the magnetic moment first decreases slightly and then decreases rapidly when the strain reaches −4 %. Calculations of the optical properties show that the static dielectric constants at −6 %, −4 %, −2 %, 0 %, 2 %, 4 % and 6 % strains are 15.23, 10.19, 8.67, 7.78, 6.38, 5.99 and 5.92, respectively, which increase with increasing compressive strain. It decreases with increase in tensile strain. The static dielectric function increases as the compressive strain increases and decreases as the tensile strain increases. In the visible light region, the reflectivity, refractive index, extinction coefficient and photoconductivity in the XX and ZZ directions increase with increasing tensile strain. Our study shows that the optoelectronic and magnetic properties of the SnSe 2 adsorbed Mn system can be improved to some extent by applying strain, and this study is expected to provide theoretical guidance for the fabrication of SnSe 2 -based magnetic optoelectronic devices. [ABSTRACT FROM AUTHOR]

Alzheimer's disease (AD) is a chronic neurodegenerative disease with high prevalence, long duration and poor prognosis. The blood-brain barrier (BBB) is a physiologic barrier in the central nervous system, which hinders the entry of most drugs into the brain from the blood, thus affecting the efficacy of drugs for AD. Natural products are recognized as one of the promising and unique therapeutic approaches to treat AD. To improve the efficiency and therapeutic effect of the drug across the BBB, a natural polyphenolic compound, procyanidin C-1 (C1) was encapsulated in glucose-functionalized bovine serum albumin (BSA) nanoparticles to construct Glu-BSA/C1 NPs in our study. Glu-BSA/C1 NPs exhibited good stability, slow release, biocompatibility and antioxidant properties. In addition, Glu-BSA/C1 NPs penetrated the BBB, accumulated in the brain by targeting Glut1, and maintained the BBB integrity both in vitro and in vivo. Moreover, Glu-BSA/C1 NPs alleviated memory impairment of 5 × FAD mice by reducing Aβ deposition and Tau phosphorylation and promoting neurogenesis. Mechanistically, Glu-BSA/C1 NPs significantly activated the PI3K/AKT pathway and inhibited the NLRP3/Caspase-1/IL-1β pathway thereby suppressing neuroinflammation. Taken together, Glu-BSA/C1 NPs could penetrate the BBB and mitigate neuroinflammation in AD, which provides a new therapeutic approach targeting AD. Schematic illustration of the synthesis and application of Glu-BSA/C1 NPs in a mouse model of Alzheimer's disease. [Display omitted] [ABSTRACT FROM AUTHOR]

The adverse microenvironment, including neuroinflammation, hinders the recovery of spinal cord injury (SCI). Regulating microglial polarization to alleviate neuroinflammation at the injury site is an effective strategy for SCI recovery. MG53 protein exerts obvious repair ability on multiple tissues damage, but with short half-life. In this study, we composited an innovative MG53/GMs/HA-Dex neural scaffold using gelatin microspheres (GMs), hyaluronic acid (HA), and dextran (Dex) loaded with MG53 protein. This novel neural scaffold could respond to MMP-2/9 protein and stably release MG53 protein with good physicochemical properties and biocompatibility. In addition, it significantly improved the motor function of SCI mice, suppressed M1 polarization of microglia and neuroinflammation, and promoted neurogenesis and axon regeneration. Further mechanistic experiments demonstrated that MG53/GMs/HA-Dex hydrogel inhibited the JAK2/STAT3 signaling pathway. Thus, this MG53/GMs/HA-Dex neural scaffold promotes the functional recovery of SCI mice by alleviating neuroinflammation, which provides a new intervention strategy for the neural regeneration and functional repair of SCI. Schematic illustration of the preparation and application of MG53/GMs/HA-Dex neural scaffolds in a mouse model of spinal cord injury. [Display omitted] • MGHD responded to MMP-2/9 and stably released MG53 protein with good physicochemical properties and biocompatibility. • MGHD improved the motor function of SCI mice, suppressed neuroinflammation, and promoted neurogenesis and axon regeneration. • MGHD inhibited the JAK2/STAT3 signaling pathway. [ABSTRACT FROM AUTHOR]

[Display omitted] • Bomidin is a new recombinant antimicrobial peptide AMP derived from BMAP-27. • Bomidin mediates Keap1 protein degradation, enhancing Nrf2 nuclear translocation. • Bomidin can suppress ferroptosis, further relieving periodontitis. • Bomidin is a promising medicine for periodontitis. Periodontitis is a prevalent oral immunoinflammatory condition that is distinguished by the compromised functionality of periodontal ligament stem cells (PDLSCs). Bomidin, a new recombinant antimicrobial peptide (AMP), exhibits antibacterial properties and modulates immune responses. Nevertheless, the precise anti-inflammatory impact of bomidin in periodontitis has yet to be fully elucidated. Thus, the study aimed to clarified the role of bomidin in modulating inflammation and its underlying mechanisms. TNF-α was applied to treating PDLSCs for establishing a cell model of periodontitis. Bomidin, RSL3, ML385 and cycloheximide were also used to treat PDLSCs. Transcriptome sequencing, RT-qPCR, western blot, immunofluorescence, immunohistochemistry, Fe2+ detection probe, molecular docking, Co-IP assay, ubiquitination assay and murine models of periodontitis were used. Our study demonstrated that bomidin effectively suppressed inflammation in PDLSCs stimulated by TNF-α, through down-regulating the MAPK and NF-κB signaling pathways. Furthermore, bomidin exerted inhibitory effects on ferroptosis and activated the Keap1/Nrf2 pathway in the TNF-α group. There is a strong likelihood of bonding bomidin with Keap1 protein, which facilitated the degradation of Keap1 protein via the ubiquitin–proteasome pathway, leading to an enhanced translocation of Nrf2 protein to the nucleus. Bomidin can directly bond to Keap1 protein, resulting in the degradation of Keap1 through the ubiquitin–proteasome pathway, thereby further activating the Keap1/Nrf2 pathway. The upregulation of the Keap1/Nrf2 signaling pathway was found to contribute to the suppression of ferroptosis, ultimately alleviating inflammation in treatment of periodontitis. [ABSTRACT FROM AUTHOR]