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304 stainless steel demonstrates a low thermal conductivity and work hardening characteristics, resulting in its processing, and will adhere to the tip of the tool; as well as the phenomenon of chipping, shortening the life of the tool. AlTiN coatings are representative of coatings applied to carbide tools. In this paper, AlTiN coatings with different arc current processes were deposited on carbide milling inserts using arc ion plating. The microstructure, mechanical properties, and milling properties of the coatings were investigated by using the SEM, EDS, XRD, scratch meter, friction and wear meter, and vertical machining center. The findings revealed that all coatings displayed columnar crystal growth, free from cracks and voids. With an increasing arc current, there was a notable increase in surface droplets, pits, and coating thickness. The coating deposited at a 140 A arc current showed a pronounced (200) orientation preference. The adhesion force peaked at 56.0 N with a subsequent decline, and the friction coefficient hit its lowest point of 0.429 at 140 A, contrasting with its highest value of 0.55 at 160 A. After 39 min of dry milling, the tool with a 140 A AlTiN coating exhibited minimal wear of 0.196 mm, just below the 0.2 mm failure threshold, indicating superior performance at this arc current setting. [ABSTRACT FROM AUTHOR]

With global warming intensifying, weather patterns become more volatile and extremes more common. Tornadoes are the most destructive natural disasters causing significant damage to infrastructure. Meanwhile, high-speed railways now face greater risks from tornado events as the national railway network and mass transit trains expand. Thus, studying the tornado flow characteristics and associated effects on high-speed trains is necessary. A study is presented regarding the wind-loading characteristics of a high-speed train running over a railway bridge induced by a tornado belonging to the future railway network. The wind-loading characteristics analyses are performed using the improved delayed detached eddy simulation method. After verifying the numerical approach and mesh strategy, computational studies are conducted to produce a tornado-like vortex and investigate the tornado-induced wind-loading characteristics of a high-speed train running on the bridge by combining a tornado simulation with a moving mesh technique. For the wind-loading parameters studied herein, the selected train's velocity range is between 50 and 350 km/h, the typical operation speed of either regular or high-speed trains. The numerical results show that the time histories of aerodynamic forces on the train revealed a pattern in tornadic flow variability, the time evolutions of the wind loads on the train were affected by train speeds, and the fluctuation was the greatest when the train ran at 50 km/h. Moreover, the train is subjected to larger aerodynamic forces and moments when it operates along with the rotating vortex flow, especially in the core region, and the train is more dangerous when it runs at a lower speed. The results in this study provide references for assessing operation safety, while a train running on the bridge encounters tornadoes. [ABSTRACT FROM AUTHOR]

Objective: Cardiac autonomic function predicts cardiovascular disease risk. The aim of this study was to investigate the relationship between sensitization to dust allergens and cardiac autonomic dysfunction in patients with chronic obstructive pulmonary disease (COPD), and to provide new ideas for the prevention of cardiovascular complications in these patients., Methods: Immunoassays for sensitization to cats/dogs, cockroaches and dust mites were performed in 840 patients with COPD. Indicators of heart rate variability in these patients were used to assess cardiac autonomic function, including standard deviation of normal-to-normal intervals (SDNN), root-mean square of successive differences between normal-to-normal intervals (RMSSD), low-frequency power (LF), high-frequency power (HF), and LF/HF ratios, which were obtained based on ambulatory electrocardiographic monitoring data. The relationship between sensitization to these dust allergens and heart rate variability was explored using multivariate logistic regression., Findings: The multivariate analyses showed that sensitization to total allergens was associated with reduced levels of SDNN, RMSSD, LF and HF and with increased levels of the LF/HF ratio in the patients with COPD ( p < .05)., Conclusion: Dust allergen sensitization may be associated with cardiac autonomic dysfunction in patients with COPD. Whether desensitization can prevent cardiovascular complications in these patients should be further explored., Competing Interests: Declaration of conflicting interestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.