Search

[Display omitted] Therapeutic modalities and drug formulations play a crucial and prominent role in actualizing effective treatment and radical cures of tumors. However, the therapeutic efficiency was severely limited by tumor recurrence and complex multi-step preparation of formulation. Therefore, the exploration of novel nanoparticles via a simple and green synthesis process for conquering traditional obstacles and improving therapeutic efficiency is an appealing, yet remarkably challenging task. Herein, a universal nanoplatform allows all cancerous cell-targeting, acid-responsive, cell imaging, synergistic chemotherapy, and nucleolar targeted phototherapy function was tactfully designed and constructed by using chemotherapeutic agents ursolic acid (UA), sorafenib (SF), and carbon dots (CDs) photosensitizers (PSs). The designed US NPs were formed by self-assembly of UA and SF associated with electrostatic, π-π stacking, and hydrophobic interactions. After hydrogen bonding reaction with CDs, the obtained (denoted as USC NPs) have a relatively uniform size of an average 125.6 nm, which facilitated the favorable accumulation of drugs at the tumor region through a potential enhanced permeability and retention (EPR) effect as compared to their counterpart of free CDs solution. Both in vitro and in vivo studies revealed that the advanced platform commenced synergistic anticancer therapeutic potency, imperceptible systematical toxicity, and remarkable reticence towards drug-resistant cancer cells. Moreover, the CDs PSs possess intrinsic nucleolus-targeting ability. Taken together, this theranostics system can fully play the role of "killing three birds with one stone" in a safe manner, implying a promising direction for exploring treatment strategies for cancer and endowing them with great potential for future translational research and providing a new vision for the advancing of an exceptionally forceful protocol for practical cancer therapy. [ABSTRACT FROM AUTHOR]

In this paper, we investigate the asymptotic behavior of solutions for the non-autonomous fractional stochastic reaction-diffusion equations driven by multiplicative noise with s ∈ (0 , 1). We prove the existence and uniqueness of tempered pullback random attractors for the equations in a bounded domain U by the compactness of Sobolev embedding H s (U) ↪ L 2 (U) , which is different from the previous work [46]. [ABSTRACT FROM AUTHOR]

Hollandite ceramics are considered as a promising host matrix for cesium immobilization. In the paper, [Cs x Ba y [Fe3+ 2 y + x Ti4+ 8-2 y - x O 16 (0.3 ​≤ ​ x , y ​≤ ​0.75) ceramics were synthesized by solid-state reaction method using 133Cs and 133Ba as the substitutes for radioactive Cs and its daughter product Ba. It was found that the as-prepared (Cs,Ba)-hollandite solid solution shows a tetragonal structure (I 4/m) with >90% crystallinity and good Cs retention at 1250 ​°C. Moreover, the normalized release rates of Cs and Ba are in the order of 10−3 ​g ​m−2 ​d−1 for 28 days, exhibiting excellent aqueous durability. The Fe-substituted hollandite provides a large enough space to accommodate Cs+ and Ba2+ cations and forms a solid solution with excellent structural stability and aqueous durability. Image 1 • The high purity (Cs,Ba)(Fe,Ti) 8 O 16 hollandite ceramics with above 90% crystallinity were fabricated at 1250 ​°C for 4 ​h. • The effects of substitutions of Ba2+ for Cs+ and Fe3+ for Ti4+ on the phase structure, chemical compositions and microstructure were investigated. • The (Cs,Ba)(Fe,Ti) 8 O 16 hollandite exhibits an excellent capacity to accommodate Cs and its daughter Ba in its crystal structure. • The normalized release rates of Cs and Ba are in the order of 10−3 ​g ​m−2 ​d−1 for 28 days, exhibiting excellent aqueous durability. [ABSTRACT FROM AUTHOR]