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Dockless bicycle sharing is one of the low-carbon transportation modes towards sustainable mobilities. Electric fences, as an effective solution for parking management, may have a high potential in guiding the usage of dockless bicycles at a low operation cost. However, new issues arise with the implementation of electric fences. The location of electric fences in hotspots fails to match the parking demand, leading the parking congestion in urban central areas. In this paper, a novel methodology of bicycle hotspots identification and classification is proposed to support parking management. An evaluation framework for bicycle hotspots is also proposed covering three aspects: demand and supply, unbalance, and land use. The methodology is applied to the case of Xiamen Island by using the trip data covering 53,629 bicycles during morning peak hours. Applying the methodology proposed, 47 pick-up hotspots and 53 return hotspots are identified, respectively. The total parking overload of return hotspots during the morning peak is 12,587 bicycles in Xiamen Island. The 53 return hotspots are classified into three clusters, including (1) hotspots where bicycle sharing is in overload status, (2) hotspots where bicycle sharing service quality needs to be improved, and (3) hotspots where bicycle sharing is in stable status. Based on the demand and land use characteristics, parking management schemes and policy implications are proposed. The result of this paper provides guidance for the layout of dockless bicycle sharing electric fences in different areas., Author(s): Ying Hui [1]; Yingkun Xie [1]; Qing Yu (corresponding author) [1]; Xiaolei Liu [1]; Xinyuan Wang [1] 1. Introduction Bicycle sharing (BS) is a popular short-distance travel mode all [...]

The Yellow River is very important for human health and social development in China to require good water quality. This study selected the Ningxia section of the Yellow River as the study area to investigate the water quality variation in 2016–2020. A total of 9 water quality parameters were monitored, and 8 parameters including pH, dissolved oxygen, biological oxygen demand, chemical oxygen demand, total phosphate, fluoride, ammonia-nitrogen, and permanganate index were in the range of Class II standard requirement. Dissolved oxygen concentrations ranged from 7.5 to 9.4 mg/L. However, total nitrogen concentrations in 2018–2020 ranged from 1.87 to 2.8 mg/L to cause the pollution. Both the Nemerow index method and the contamination degree method showed that total nitrogen with high concentration exerted the water pollution. Principal component analysis also proved this. Stricter environmental management strategies for controlling total nitrogen should be taken in the future. The findings provided some useful information for water pollution of the Ningxia section of the Yellow River. [ABSTRACT FROM AUTHOR]

Rare germline variations contribute to the missing heritability of human complex diseases including cancers. Given their very low frequency, discovering and testing disease‐causing rare germline variations remains challenging. The tag‐single nucleotide polymorphism rs17728461 in 22q12.2 is highly associated with lung cancer risk. Here, we identified a functional rare germline variation rs548071605 (A>G) in a p65‐responsive enhancer located within 22q12.2. The enhancer significantly promoted lung cancer cell proliferation in vitro and in a xenograft mouse model by upregulating the leukemia inhibitory factor (LIF) gene via the formation of a chromatin loop. Differential expression of LIF and its significant correlation with first progression survival time of patients further supported the lung cancer‐driving effects of the 22q‐Enh enhancer. Importantly, the rare variation was harbored in the p65 binding sequence and dramatically increased the enhancer activity by increasing responsiveness of the enhancer to p65 and B‐cell lymphoma 3 protein, an oncoprotein that assisted the p65 binding. Our study revealed a regulatory rare germline variation with a potential lung cancer‐driving role in the 22q12.2 risk region, providing intriguing clues for investigating the "missing heritability" of cancers, and also offered a useful experimental model for identifying causal rare variations. [ABSTRACT FROM AUTHOR]

Hydraulic fracturing is an effective mean to prevent coal bumps in deep coal mining. The calculation of stress redistribution of coal sidewall after hydraulic fracturing can evaluate the fracturing effect and provide a reference for the hydraulic fracturing scheme design. In this paper, a theoretical model of stress redistribution of roadway sidewall after hydraulic fracturing is established with considering the effect of crushing zone. And the influences of the water injection length and the fracturing radius on the stress redistribution of roadway sidewall are investigated. The results show that the water injection section should be set at a deeper position with considering the existence of the crushing zone. The coal roadway sidewall after hydraulic fracturing is divided into five zones: the crushing zone, the shallow plastic zone, the pressure relief zone, the deep plastic zone, and the elastic zone. The stress redistribution law is obviously affected by the water injection section length and fracturing radius. With the increase of water injection length or fracturing radius, the pressure relief effect is more evident, but the axial force of rockbolt increases gradually. In order to acquire a better pressure relief effect, the matching of the water injection length and the fracturing radius should be considered crucially in the hydraulic fracturing design for preventing coal bumps. [ABSTRACT FROM AUTHOR]