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Your search keyword '"Karagianni, Paraskevi"' showing total 3 results
Start Over Author "Karagianni, Paraskevi" Search Limiters Peer Reviewed Publication Type Academic Journals Publisher mdpi
3 results on '"Karagianni, Paraskevi"'

1. The Intertemporal Role of Respiratory Support in Improving Neonatal Outcomes: A Narrative Review.

Author

Sarafidis, Kosmas, Chotas, William, Agakidou, Eleni, Karagianni, Paraskevi, and Drossou, Vasiliki

Subjects
HEALTH outcome assessment, MEDICAL care, BRONCHOPULMONARY dysplasia, ARTIFICIAL respiration, NEWBORN infants
Abstract

Defining improvements in healthcare can be challenging due to the need to assess multiple outcomes and measures. In neonates, although progress in respiratory support has been a key factor in improving survival, the same degree of improvement has not been documented in certain outcomes, such as bronchopulmonary dysplasia. By exploring the evolution of neonatal respiratory care over the last 60 years, this review highlights not only the scientific advances that occurred with the application of invasive mechanical ventilation but also the weakness of the existing knowledge. The contributing role of non-invasive ventilation and less-invasive surfactant administration methods as well as of certain pharmacological therapies is also discussed. Moreover, we analyze the cost– benefit of neonatal care-respiratory support and present future challenges and perspectives. [ABSTRACT FROM AUTHOR]

Published
2021
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2. Neonatal Sepsis and Hemostasis.

Author

Gialamprinou, Dimitra, Mitsiakos, Georgios, Katsaras, Georgios N., Kontovazainitis, Christos-Georgios, Karagianni, Paraskevi, Roilides, Emmanuel, and Kenet, Gili

Subjects
NEONATAL sepsis, HEMOSTASIS, VASCULAR endothelium, NEONATAL mortality, CARDIOVASCULAR system, FLOW cytometry
Abstract

Neonatal sepsis is considered critical for a significant increase in neonatal morbidity and mortality among hospitalized neonates. Neonatal sepsis, in most cases, coexists with coagulopathy, which can prove to be life-threatening. Complex molecular and cellular systems are involved in the cross-talk between inflammation and hemostasis during sepsis. Disturbances in the regulating systems of the vascular endothelium, and platelet–endothelial and platelet–neutrophil interactions play a pivotal role in both inflammation and coagulation. This complex process is poorly understood in neonates. In addition to the developmental maturation of hemostasis and the immune response in neonatal sepsis, a cellular model of hemostasis during sepsis should be taken into account. This review focused on the molecular and cellular mechanisms underlying inflammation and hemostasis during neonatal sepsis, taking the developmental immune response and developmental hemostasis into account in order to provide future diagnostic approaches to be applied in everyday clinical settings. Regarding the diagnostic modalities, we briefly provide the limitations of the currently used conventional coagulation assays, focusing on viscoelastic tests and platelet flow cytometry. [ABSTRACT FROM AUTHOR]

Published
2022
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3. A New ABCA3 Gene Mutation c.3445G>A (p.Asp1149Asn) as a Causative Agent of Newborn Lethal Respiratory Distress Syndrome.

Author

Mitsiakos G, Tsakalidis C, Karagianni P, Gialamprinou D, Chatziioannidis I, Papoulidis I, Tsanakas I, and Soubasi V

Subjects
ATP-Binding Cassette Transporters genetics, Adrenal Cortex Hormones therapeutic use, Azithromycin therapeutic use, Humans, Hydroxychloroquine therapeutic use, Infant, Newborn, Lung Diseases, Interstitial genetics, Male, Mutation genetics, Pulmonary Surfactants antagonists & inhibitors, Respiratory Distress Syndrome, Newborn diagnostic imaging, Tomography, X-Ray Computed methods, ATP-Binding Cassette Transporters adverse effects, Respiratory Distress Syndrome, Newborn etiology, Respiratory Distress Syndrome, Newborn genetics
Abstract

Mutations in adenosine triphosphate-binding cassette transporter A3 (ABCA3) (OMIM: 601615) gene constitute the most frequent genetic cause of severe neonatal respiratory distress syndrome (RDS) and interstitial lung disease (ILD) in children. Interstitial lung disease in children and especially in infants, in contrast to adults, is more likely to appear as a result of developmental deficits or is characterized by genetic aberrations of pulmonary surfactant homeostasis not responding to exogenous surfactant administration. The underlying ABCA3 gene mutations are commonly thought, regarding null mutations, to determine the clinical course of the disease while there exist mutation types, especially missense variants, whose effects on surfactant proteins are difficult to predict. In addition, clinical and radiological signs overlap with those of surfactant proteins B and C mutations making diagnosis challenging. We demonstrate a case of a one-term newborn male with lethal respiratory failure caused by homozygous missense ABCA3 gene mutation c.3445G>A (p.Asp1149Asn), which, to our knowledge, was not previously reported as a causative agent of newborn lethal RDS. Therapeutic strategies for patients with ABCA3 gene mutations are not sufficiently evidence-based. Therefore, the description of the clinical course and treatment of the disease in terms of a likely correlation between genotype and phenotype is crucial for the development of the optimal clinical approach for affected individuals., Competing Interests: The authors declare no conflict of interest.

Published
2019
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