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The Tarim Basin is a large inland arid basin in the arid region of northwest China and has been experiencing significant "warming and wetting" since 1987. As a result, the purpose of this paper is to determine whether the climate transition phenomenon occurred in the Tarim Basin as well as the role of atmospheric circulation in this process. We use meteorological data and atmospheric circulation indexes to study the seasonal trends of climate change in this region from 1987 to 2020 to understand how they are affected by atmospheric circulation. The findings show that, from 1987 to 2020, the Tarim Basin experienced significant warming and wetting; with the exception of the winter scale, all other seasonal scales exhibited a clear warming and wetting trend. From the perspective of spatial distribution, most of the areas showed a significant warming trend, and the warming amplitude around the basin is greater than that in the central area of the basin. However, there are significant regional differences in precipitation change rates. Meanwhile, wavelet analysis shows that there is a significant oscillation period of 17–20 years between climate change and the atmospheric circulation index during 1987–2020. The correlation analysis shows that the Pacific decadal oscillation (PDO) and El Niño-Southern Oscillation (ENSO) are the main influencing factors of climate change in the Tarim Basin at different seasonal scales, while the teleconnection of the Arctic Oscillation (AO) and North Atlantic Oscillation (NAO) is low and the PDO dominates the summer and autumn temperature changes in the Tarim Basin. The research results of this paper show that, despite the warming and wetting trends since 1987 in the Tarim Basin, the climate type did not change. From 1987 to 2020, the main teleconnection factors of climate change in the Tarim Basin were PDO and ENSO. [ABSTRACT FROM AUTHOR]