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Climate variability and change greatly affect agricultural and water resource management over West Africa. This paper presents the current characteristics and projected change in regional crop water demand (CWD), irrigation requirement (IR), and water availability (WA) over West Africa. Observed and simulated daily rainfall, minimum temperature, maximum temperature, and evapotranspiration are used to derive the above agro-meteorological and hydrological variables. For future periods, high-resolution climate data from three regional climate models under two different scenarios, i.e., representative concentration pathway (RCP) 4.5 and 8.5, are considered. Evaluation of the characteristics of present-day CWD, IR, and WA indicated that the ensemble mean of the model-derived outputs reproduced the prevailing spatial patterns of CWD and IR. Moreover, the wetter part of the domain, especially along the southern coast, was correctly delineated from the drier northern regions, despite having biases. The ensemble model also simulated the annual cycle of water supply and the bimodal pattern of the water demand curves correctly. In terms of future projections, the outcomes from the study suggest an average increase in the CWD by up to 0.808 mm/day and IR by 1.244 mm/day towards the end of the twenty-first century, compared to the baseline period. The hot-spot areas, where there is higher projected increment in CWD and IR, are over Senegal, Southern Mali, and Western Burkina Faso. In most cases, WA is projected to decrease towards the end of the twenty-first century by −0.418 mm/day. The largest decline in WA is found to be over Guinea and most of the eastern parts of West Africa. Despite the current under-utilization of the existing groundwater resources, the threat of global warming in reducing future WA and increasing CWD suggested caution on the scale of irrigation schemes and management strategies. The outcomes from the study could be a crucial input for the agricultural and water managers for introducing effective measures to ensure sustainability of irrigated farm lands. [ABSTRACT FROM AUTHOR]