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Background: Management of cleft lip and palate is interdisciplinary. An evidence-mapping approach was envisaged to highlight the existing gaps in this field, using only the highest level of evidence. Objectives: To conduct evidence mapping and quality analysis of systematic reviews and meta-analyses related to any aspect of cleft lip and palate. Search Methods: The cleft lip and palate field was divided into 9 domains and 50 subdomains and a method of categorization of systematic reviews was established. A comprehensive search strategy was carried out in seven databases along with the search of gray literature and references of included articles. Selection criteria: Systematic reviews related to any aspect of cleft lip and palate, conducted by a minimum of two reviewers, with a comprehensive search strategy and adequate quality analysis were included. Data collection and analysis: A self-designed, pre-piloted data-extraction sheet was used to collect information that was analyzed through an expert group discussion. Quality analysis was performed using ROBIS-I, AMSTAR 2, and the PRISMA checklist. Results: A total of 144 systematic reviews published between 2008 and 2022 were included. The largest number of these could be categorized in the therapeutic domain (n = 58). A total of 27% of the studies were categorized as inconclusive, 40% as partially conclusive, and 33% as conclusive. As per ROBIS-I, 77% of reviews had high risk of bias while 58% were graded as critically low in quality as per AMSTAR 2. The majority of systematic reviews showed low reporting errors. Conclusions: The majority of systematic reviews related to cleft lip and palate relate to therapeutic and prognostic domains and show high risk of bias and critically low quality regardless of the source journal. The results of this paper might serve as a starting point encouraging authors to carry out high-quality research where evidence is lacking. Registration: A multidisciplinary expert-group formulated an a priori protocol, registered in Open Science Framework (DOI 10.17605/OSF.IO/NQDV2). [ABSTRACT FROM AUTHOR]

Traumatic dental injuries (TDI) are frequent among individuals of all ages, with a prevalence ranging from 12–22%, with crown and crown–root fractures being the most common. Fragment reattachment using light-cured nanocomposites is the recommended method for the management of these fractures. Though there are several clinical studies that have assessed the efficacy of such materials, an in-silico characterization of the effects of traumatic forces on the re-attached fragments has never been performed. Hence, this study aimed to evaluate the efficacy of various adhesive materials in crown and crown–root reattachments through computational modelling. A full-scale permanent maxillary anterior tooth model was developed by segmenting 3D scanned cone beam computed tomography (CBCT) images of the pulp, root, and enamel precisely. The full-scale 3D tooth model was then subjected to a novel numerical cutting operation to describe the crown and crown–root fractures. The fractured tooth models were then filled computationally with three commonly used filler (or adhesive) materials, namely flowable composite, resin cement, and resin adhesive, and subjected to masticatory and traumatic loading conditions. The flowable composite demonstrated a statistically significant difference and the lowest produced stresses when subjected to masticatory loading. Resin cement demonstrated reduced stress values for crown–root fractures that were masticatory loaded after being reattached using adhesive materials. During traumatic loading, resin cement demonstrated lower displacements and stress values across both fractures. The novel findings reported in this study are anticipated to assist dentists in selecting the most appropriate adhesive materials that induce the least stress on the reattached tooth when subjected to second trauma, for both crown and crown–root fractures. [ABSTRACT FROM AUTHOR]

Sodium fluoride (NaF) is widely used in clinical dentistry. However, the administration of high or low concentrations of NaF has various functions in different tissues. Understanding the mechanisms of the different effects of NaF will help to optimize its use in clinical applications. Studies of NaF and epithelial cells, osteoblasts, osteoclasts, and periodontal cells have suggested the significant roles of fluoride treatment. In this review, we summarize recent studies on the biphasic functions of NaF that are related to both soft and hard periodontal tissues, multiple diseases, and clinical dentistry. [ABSTRACT FROM AUTHOR]