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Previous studies have indicated that nuclear factor-κB (NF-κB) has an important role in the pathogenesis of epilepsy. The aim of the present study was to evaluate the expression of microRNA (miRNA)‑146a, phosphorylated (p)‑P65/P65, B‑cell lymphoma‑2(Bcl‑2)/Bcl‑2‑associated X protein (Bax) and pro‑inflammatory cytokines, such as interleukin (IL)‑6, IL‑1β and tumor necrosis factor (TNF‑α) in the brain tissue of rats with epilepsy. Sprague‑Dawley rats were used to establish the epilepsy model using the lithium‑pilocarpine method. The expression of miR‑146a, pro‑inflammatory cytokines, P‑glycoprotein (P‑gp), Bcl‑2/Bax and p‑P65/P65 were assessed by reverse transcription‑semi‑quantitative polymerase chain reaction, enzyme‑linked immunosorbent assay and western blotting, respectively. Hematoxylin and eosin staining was used to determine the pathology of epilepsy. The current findings revealed that the expression of miR‑146a was greater in the model group compared with the control group, and that the expression of miR‑146a reached a maximum at 7 days post‑treatment. The expression levels of IL‑1β, IL‑6 and TNF‑α were significantly reduced in the miR‑146a antagonist group when compared with the model group. Additionally, the expression levels of P‑gp and p‑P65/P65 were significantly reduced following the addition of the miR‑146a antagonist, whereas the expression levels of Bcl‑2/Bax significantly increased under the same conditions. Therefore, the NF‑κB pathway and miR‑146a may be potential therapeutic targets in the treatment of epilepsy. [ABSTRACT FROM AUTHOR]

Late spontaneous recanalization (SR) of an occluded internal carotid artery (ICA) has been rarely reported and the prognosis of affected patients remains elusive. In the present study, the incidence of late SR of atherosclerotic occlusion of the ICA and associated outcomes were assessed in a single center. A total of 36 patients with ICA occlusion, who underwent carotid artery stenting or vertebral artery stenting in arteries other than the occluded ICA, were prospectively included and followed up for ≥18 months. SR was diagnosed by color Doppler ultrasound imaging. The incidence of late SR, the functional outcome and the incidence of adverse cardiovascular events in these patients were evaluated. During the follow-up, three patients had late SR of the occluded ICA (8.3%). All patients had vascular events prior to the confirmation of late SR of the ICA. Subsequent to SR, the patients were clinically stable with preserved functional ability, based on the Modified Rankin Scale. Of these patients, one suffered from re-occlusion of the recanalized ICA without presenting with any novel significant symptoms. In conclusion, patients with late SR of the ICA appear to have preserved functional ability and favorable clinical outcomes. Large-scale cohorts are required to determine the clinical characteristics that contribute to the incidence of late SR of the ICA. [ABSTRACT FROM AUTHOR]