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Immune dysregulation has been widely observed in patients with psychiatric disorders. This study aims to examine the association between HLA alleles and depression and anxiety. Using data from the UK Biobank, we performed regression analyses to assess the association of 359 HLA alleles with depression and anxiety, as determined by Patient Health Questionnaire (PHQ) score (n = 120,033), self‐reported depression (n = 121,685), general anxiety disorder (GAD‐7) score (n = 120,590), and self‐reported anxiety (n = 108,310). Subsequently, we conducted gene environmental interaction study (GEIS) to evaluate the potential effects of interactions between HLA alleles and environmental factors on the risk of depression and anxiety. Sex stratification was implemented in all analysis. Our study identified two significant HLA alleles associated with self‐reported depression, including HLA‐C*07:01 (β = −0.015, p = 5.54 × 10−5) and HLA‐B*08:01 (β = −0.015, p = 7.78 × 10−5). Additionally, we identified four significant HLA alleles associated with anxiety score, such as HLA‐DRB1*07:01 (β = 0.084, p = 9.28 × 10−5) and HLA‐B*57:01 (β = 0.139, p = 1.22 × 10−4). GEIS revealed that certain HLA alleles interacted with environmental factors to influence mental health outcomes. For instance, HLA‐A*02:07 × cigarette smoking was associated with depression score (β = 0.976, p = 1.88 × 10−6). Moreover, sex stratification analysis revealed significant sex‐based differences in the interaction effects of certain HLA alleles with environmental factors. Our findings indicate the considerable impact of HLA alleles on the risks of depression and anxiety, providing valuable insights into the functional relevance of immune dysfunction in these conditions. [ABSTRACT FROM AUTHOR]

Grain size control is an important aspect to manipulate the microstructure and high temperature stability of ceramic fibers. In the present work, phase competition mechanism was proposed to regulate the grain size of ZrO2/CaZrO3 composite fibers. Calcium precursor with different molar ratio of Ca/Zr was introduced to the zirconia system not only for phase stabilization of ZrO2 but also for phase competition between solid‐solution CaxZr1‐xO2‐x and new phase CaZrO3. Effects of Ca/Zr molar ratio on the thermal pyrolysis, crystallization, solid reaction of precursor fibers were fully explored. The change of grain size of fibers with various Ca/Zr molar ratio was characterized and discussed. Furthermore, the near‐infrared reflectivity and high‐temperature stability of fibrous membranes were also presented. The results indicated that ZrO2/CaZrO3 fibrous membrane has promising applications in high‐temperature for the excellent thermal stability and high near infrared (NIR) reflectivity. [ABSTRACT FROM AUTHOR]

Disrupted brain structures and several life environmental factors have been shown to influence depression and anxiety, but their interactions with anxiety and depression remain elusive. Genome‐wide association study datasets of 15 brain structure longitudinal changes (N = 15,640) were obtained from the published study. Genotype and phenotype‐related data of depression, anxiety, and life environmental factors (including smoking, alcohol drinking, coffee intake, maternal smoking, physical activity, vitamin D, insomnia, sleep duration, and family satisfaction) were collected from UK Biobank. We calculated the polygenic risk scores (PRS) of 15 brain structure changes and then conducted linear regression analyses to explore the interactions of brain structure changes and life environmental factors on depression and anxiety using 15 brain structure change‐related PRS, life environmental factors and interactions of them as instrumental variables, and depression score or anxiety score as outcomes. Sex stratification in all analyses was performed to reveal sex‐specific differences in the interactions. We found 14 shared interactions related to both depression and anxiety in total sample, such as alcohol drinking × cerebellum white matter 3 (WM; beta = −.003, p =.018 for depression; beta = −003, p =.008 for anxiety) and maternal smoking × nucleus accumbens 2 (beta =.088, p =.002 for depression; beta =.070, p =.008 for anxiety). We also observed sex‐specific differences in the interactions, for instance, alcohol drinking × cerebellum WM 3 was negatively associated with depression and anxiety in males (beta = −.004, p =.020 for depression; beta = −.005, p =.002 for anxiety). Our study results reveal the important interactions between brain structure changes and several life environmental factors on depression and anxiety, which may help to explore the pathogenesis of depression and anxiety. [ABSTRACT FROM AUTHOR]

We aim to systematically explore the potential genetic correlations between five major psychiatric disorders and gestational ages. Genome‐wide association study (GWAS) summary datasets of attention deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), bipolar disorder (BD), schizophrenia (SCZ) and major depressive disorder (MDD) in discovery were downloaded from the Psychiatric GWAS Consortium (PGC) website. Suggestive (Raw p < 0.05) genetic associations in the discovery phrase were further replicated in independent GWASs which downloaded from PGC, the FinnGen study or Integrative Psychiatric Research (iPSYCH) website. GWASs of gestational duration, preterm and post‐term birth were derived from previous studies of infants from the Early Growth Genetics (EGG) Consortium, the iPSYCH study, and the Genomic and Proteomic Network for Preterm Birth Research (GPN). We calculated genetic correlations using linkage disequilibrium score (LDSC) regression. Mendelian randomization (MR) analyses were performed to investigate the causal effects. We identified four suggestive genetic correlations between psychiatric disorders and gestational age factors in discovery LDSC and two replicated in a confirmation LDSC: gestational duration and ADHD (rg = −0.1405, FDR p = 0.0406), post‐term birth and SCZ (rg = −0.2003, FDR p = 0.0042). We also observed causal effect of post‐term birth on SCZ by MR (PWeighted median = 0.037, PInverse variance weighted = 0.007). Our analysis suggested no significant evidence of horizontal pleiotropy and heterogeneity. This study showed the genetic correlation evidences between gestational age phenotypes and psychiatric disorders, providing novel clues for understanding the pathogenic factors of common psychiatric disorders. Lay Summary: Whereas gestational age factors were reported to be associated with psychiatric disorders, the genetic relationship and causality remain to be revealed. The present study reported the first large‐scale genetic correlations investigation of the associations between gestational age phenotypes and psychiatric disorders. Results indicate causal relationships between post‐term birth and schizophrenia (SCZ), as well as suggestive genetic correlations between gestational duration and attention deficit/hyperactivity disorder (ADHD). This study provided novel clues for understanding the pathogenic factors of common psychiatric disorders. [ABSTRACT FROM AUTHOR]

Kashin–Beck disease (KBD) is a complex endemic osteoarthropathy, which mainly occurs in the northeast to southwest China. Iodothyronine deiodinases 3 (DIO3) is one of the selenoproteins, which is closely related to bone metabolism and unclear to KBD. This study aims to investigate the role and associated mechanisms of methylation and expression of DIO3 with disease severity in patients with KBD. We performed a bioinformatics analysis first to identify the biological mechanisms involved in selenoproteins. The methylation status of the DIO3 gene and DIO3 gene expression, as well as DIO3‐related regulatory genes in patients with KBD, were analyzed. We found that 15 CpG sites of six selenoproteins were hypomethylated with 5‐azacytidine treatment. DIO3 hypermethylation was associated with an increased risk of KBD and may lead to downregulation of DIO3 gene expression as well as be an indicator of the severity of KBD, which may provide a new insight for gene–environment correlations and interactions in etiology and pathogenesis of KBD. [ABSTRACT FROM AUTHOR]

Ferrimagnetic nano‐crystal glass‐ceramics and glass fibers were prepared based on the ferrosilicate glass system of SiO2–Fe2O3–B2O3–Al2O3 using large amount of pyrite slag (PS) and small quantities of pure chemicals. Two different fabrication methods were employed, eg, annealing and fiber‐drawing method, without performing any nucleation and crystallization heat treatments. The influence of PS content on the magnetite spontaneous crystallization is investigated by the X‐ray diffraction, FTIR, SEM, and TEM. The X‐ray diffraction patterns show the presence of nanometric magnetite crystals in glass matrix. The ferrimagnetic glass fibers with a diameter of about 20 μm were one‐step drawn. The magnetic hysteresis loops of the glass‐ceramic and glass fiber samples were analyzed using a vibrating sample magnetometer (VSM). Electromagnetic parameters of samples were also examined. [ABSTRACT FROM AUTHOR]

Herein we report a highly efficient and enantiospecific borylation method to synthesize a wide range of enantiopure (>99 % ee) α‐amino tertiary boronic esters. The configurationally stable α‐N‐Boc substituted tertiary organolithium species and pinacolborane (HBpin) underwent enantiospecific borylation at −78 °C with the formation of a new stereogenic C−B bond. This reaction has a broad scope, enabling the synthesis of various α‐amino tertiary boronic esters in excellent yields and, importantly, with universally excellent enantiospecificity (>99 % es) and complete retention of configuration. Enantiospecific borylation: A highly enantiospecific borylation of configurationally stable α‐N‐Boc substituted tertiary organolithium species and HBpin has been developed to synthesize various α‐amino tertiary boronic esters through the formation of a new C−B bond with excellet enantiopurity and complete retention of configuration. [ABSTRACT FROM AUTHOR]

The Ce3+-, Ho3+-, and Sm3+- single and co-doped oxyfluoride silicate glasses for light emitting diodes are studied. These glasses were prepared by melt quenching method and their optical and structural properties were investigated by absorption spectra, photoluminescence spectra, Commission International de I'Eclairage chromaticity coordinates, X-ray diffraction, and Fourier transform infrared spectra. It is found that the introduction of Al2O3 in glass composition can improve the emissions of Ho3+ and Sm3+. While the presence of B2O3 has the adverse effect and can suppress the emissions of Ho3+ and Sm3+. With substituting Na2O for CaO in the glass compositions, CaF2 crystals can be formed during the melt quenching process. We find the formation of CaF2 crystals can change the emission behavior of Ho3+ and Sm3+ ions. White light emissions can be achieved in the glasses and the luminescence colors can be tuned by varying the concentrations of the doped rare-earth ions and the composition of glass matrix. The Ce3+-, Ho3+-, and Sm3+-doped oxyfluoride silicate glasses presented here demonstrate promising applications in the fields of light emitting diodes. [ABSTRACT FROM AUTHOR]

A short and highly stereoselective asymmetric synthesis of 3,4- trans-disubstituted chromans employing nitrovinylphenols and acrolein as precursors via a domino oxa-Michael/Michael reaction is described. This cascade was efficiently catalyzed by diphenylprolinol TMS ether furnishing the products in good to excellent yields (62-91%) and excellent stereoselectivities ( dr: 94:6-97:3, 93-98% ee). The domino products can be converted into the corresponding N-alkylated trans-benzopyrano[3,4- c]pyrrolidines through a reductive amination/ N-alkylation sequence. This was demonstrated for the case of a descyano derivative of S33138. [ABSTRACT FROM AUTHOR]

An asymmetric synthesis of 3,4-trans-disubstituted chromans (III) employing nitrovinylphenols (I) and acrolein (II) as precursors is described. [ABSTRACT FROM AUTHOR]

A new and efficient method to prepare biologically important 3-sulfenylated oxindoles is reported. [ABSTRACT FROM AUTHOR]

The reaction proceeds through a Broenstedt base activation mode with DPS as the optimal catalyst. [ABSTRACT FROM AUTHOR]

Among 14 prolinol ethers tested in the reaction of oxindole (Ig) with nitrostyrene, didodecylprolinol Tms-ether PRO affords the best result with respect to both yield and diastereo- and enantioselectivity of the addition product. [ABSTRACT FROM AUTHOR]

A novel synthesis of title tetrazoles (VI) and their conversion to a variety of derivatives is described. [ABSTRACT FROM AUTHOR]