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The COVID-19 pandemic has affected many aspects of human life around the world, due to its tremendous outcomes on public health and socio-economic activities. Policy makers have tried to develop efficient responses based on technologies and advanced pandemic control methodologies, to limit the wide spreading of the virus in urban areas. However, techniques such as social isolation and lockdown are short-term solutions that minimize the spread of the pandemic in cities and do not invert long-term issues that derive from climate change, air pollution and urban planning challenges that enhance the spreading ability. Thus, it seems crucial to understand what kind of factors assist or prevent the wide spreading of the virus. Although AI frameworks have a very efficient predictive ability as data-driven procedures, they often struggle to identify strong correlations among multidimensional data and provide robust explanations. In this paper, we propose the fusion of a heterogeneous, spatio-temporal dataset that combine data from eight European cities spanning from 1 January 2020 to 31 December 2021 and describe atmospheric, socio-economic, health, mobility and environmental factors all related to potential links with COVID-19. Remote sensing data are the key solution to monitor the availability on public green spaces between cities in the study period. So, we evaluate the benefits of NIR and RED bands of satellite images to calculate the NDVI and locate the percentage in vegetation cover on each city for each week of our 2-year study. This novel dataset is evaluated by a tree-based machine learning algorithm that utilizes ensemble learning and is trained to make robust predictions on daily cases and deaths. Comparisons with other machine learning techniques justify its robustness on the regression metrics RMSE and MAE. Furthermore, the explainable frameworks SHAP and LIME are utilized to locate potential positive or negative influence of the factors on global and local level, with respect to our model's predictive ability. A variation of SHAP, namely treeSHAP, is utilized for our tree-based algorithm to make fast and accurate explanations. [ABSTRACT FROM AUTHOR]

COVID-19 evolution imposes significant challenges for the European healthcare system. The heterogeneous spread of the pandemic within EU regions elicited a wide range of policies, such as school closure, transport restrictions, etc. However, the implementation of these interventions is not accompanied by the implementation of quantitative methods, which would indicate their effectiveness. As a result, the efficacy of such policies on reducing the spread of the virus varies significantly. This paper investigates the effectiveness of using deep learning paradigms to accurately model the spread of COVID-19. The deep learning approaches proposed in this paper are able to effectively map the temporal evolution of a COVID-19 outbreak, while simultaneously taking into account policy interventions directly into the modelling process. Thus, our approach facilitates data-driven decision making by utilizing previous knowledge to train models that predict not only the spread of COVID-19, but also the effect of specific policy measures on minimizing this spread. Global models at the EU level are proposed, which can be successfully applied at the national level. These models use various inputs in order to successfully model the spatio-temporal variability of the phenomenon and obtain generalization abilities. The proposed models are compared against the traditional epidemiological and Autoregressive Integrated Moving Average (ARIMA) models. [ABSTRACT FROM AUTHOR]