26 results on '"Håkansson, Karl"'
Search Results
2. Printable carbon-based supercapacitors reinforced with cellulose and conductive polymers
- Author
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Belaineh, Dagmawi, Brooke, Robert, Sani, Negar, Say, Mehmet Girayhan, Håkansson, Karl M.O., Engquist, Isak, Berggren, Magnus, and Edberg, Jesper
- Published
- 2022
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3. Effect of carboxymethylated cellulose nanofibril concentration regime upon material forming on mechanical properties in films and filaments
- Author
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Håkansson, Karl M. O.
- Published
- 2021
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4. Nanocellulose and PEDOT:PSS composites and their applications.
- Author
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Brooke, Robert, Lay, Makara, Jain, Karishma, Francon, Hugo, Say, Mehmet Girayhan, Belaineh, Dagmawi, Wang, Xin, Håkansson, Karl M. O., Wågberg, Lars, Engquist, Isak, Edberg, Jesper, and Berggren, Magnus
- Subjects
ELECTROACTIVE substances ,BIODEGRADABLE materials ,CONDUCTIVE ink ,MOLECULAR interactions ,ENERGY harvesting ,CONDUCTING polymers - Abstract
The need for achieving sustainable technologies has encouraged research on renewable and biodegradable materials for novel products that are clean, green, and environmentally friendly. Nanocellulose (NC) has many attractive properties such as high mechanical strength and flexibility, large specific surface area, in addition to possessing good wet stability and resistance to tough chemical environments. NC has also been shown to easily integrate with other materials to form composites. By combining it with conductive and electroactive materials, many of the advantageous properties of NC can be transferred to the resulting composites. Conductive polymers, in particular poly(3,4-ethylenedioxythiophene:poly(styrene sulfonate) (PEDOT:PSS), have been successfully combined with cellulose derivatives where suspensions of NC particles and colloids of PEDOT:PSS are made to interact at a molecular level. Alternatively, different polymerization techniques have been used to coat the cellulose fibrils. When processed in liquid form, the resulting mixture can be used as a conductive ink. This review outlines the preparation of NC/PEDOT:PSS composites and their fabrication in the form of electronic nanopapers, filaments, and conductive aerogels. We also discuss the molecular interaction between NC and PEDOT:PSS and the factors that affect the bonding properties. Finally, we address their potential applications in energy storage and harvesting, sensors, actuators, and bioelectronics. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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5. Bio‐Graphene Sensors for Monitoring Moisture Levels in Wood and Ambient Environment.
- Author
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Mulla, Mohammad Yusuf, Isacsson, Patrik, Dobryden, Illia, Beni, Valerio, Östmark, Emma, Håkansson, Karl, and Edberg, Jesper
- Abstract
Wood is an inherently hygroscopic material which tends to absorb moisture from its surrounding. Moisture in wood is a determining factor for the quality of wood being employed in construction, since it causes weakening, deformation, rotting, and ultimately leading to failure of the structures resulting in costs to the economy, the environment, and to the safety of residents. Therefore, monitoring moisture in wood during the construction phase and after construction is vital for the future of smart and sustainable buildings. Employing bio‐based materials for the construction of electronics is one way to mitigate the environmental impact of such electronics. Herein, a bio‐graphene sensor for monitoring the moisture inside and around wooden surfaces is fabricated using laser‐induced graphitization of a lignin‐based ink precursor. The bio‐graphene sensors are used to measure humidity in the range of 10% up to 90% at 25 °C. Using laser induced graphitization, conductor resistivity of 18.6 Ω sq−1 is obtained for spruce wood and 57.1 Ω sq−1 for pine wood. The sensitivity of sensors fabricated on spruce and pine wood is 2.6 and 0.74 MΩ per % RH. Surface morphology and degree of graphitization are investigated using scanning electron microscopy, Raman spectroscopy, and thermogravimetric analysis methods. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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6. Accelerator mass spectrometry of ultra-small samples with applications in the biosciences
- Author
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Salehpour, Mehran, Håkansson, Karl, and Possnert, Göran
- Published
- 2013
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7. Production of energy-storage paper electrodes using a pilot-scale paper machine.
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Isacsson, Patrik, Jain, Karishma, Fall, Andreas, Chauve, Valerie, Hajian, Alireza, Granberg, Hjalmar, Boiron, Lucie, Berggren, Magnus, Håkansson, Karl, Edberg, Jesper, Engquist, Isak, and Wågberg, Lars
- Abstract
The global efforts in electrifying our society drive the demand for low-cost and sustainable energy storage solutions. In the present work, a novel material concept was investigated to enable fabrication of several 10 meter-long rolls of supercapacitor paper electrodes on a pilot-scale paper machine. The material concept was based on cationized, cellulose-rich wood-derived fibres, conducting polymer PEDOT:PSS, and activated carbon filler particles. Cationic fibres saturated with anionic PEDOT:PSS provide a conducting scaffold hosting the activated carbon, which functions as the active charge-storage material. The response from further additives was systematically investigated for several critical paper properties. Cellulose nanofibrils were found to improve mechanical properties, while carbon black enhanced both the conductivity and the storage capacity of the activated carbon, reaching a specific capacitance of 67 F g
−1 . This pilot trial shows that "classical" papermaking methods are fit for the purpose and provides valuable insights on how to further advance bio-based energy storage solutions for large-scale applications. [ABSTRACT FROM AUTHOR]- Published
- 2022
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8. Spinning of Stiff and Conductive Filaments from Cellulose Nanofibrils and PEDOT:PSS Nanocomplexes.
- Author
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Fall, Andreas B., Hagel, Farnaz, Edberg, Jesper, Malti, Abdellah, Larsson, Per A., Wågberg, Lars, Granberg, Hjalmar, and Håkansson, Karl M. O.
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- 2022
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9. Measurement of width and intensity of particle streaks in turbulent flows
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Håkansson, Karl M. O., Kvick, Mathias, Lundell, Fredrik, Prahl Wittberg, Lisa, and Söderberg, L. Daniel
- Published
- 2013
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10. Evaluation of steerable filter for detection of fibers in flowing suspensions
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Carlsson, Allan, Håkansson, Karl, Kvick, Mathias, Lundell, Fredrik, and Söderberg, L. Daniel
- Published
- 2011
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11. Manufacturing Poly(3,4‐Ethylenedioxythiophene) Electrocatalytic Sheets for Large‐Scale H2O2 Production.
- Author
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Ahmed, Fareed, Ding, Penghui, Ail, Ujwala, Warczak, Magdalena, Grimoldi, Andrea, Ederth, Thomas, Håkansson, Karl M.O., Vagin, Mikhail, Gueskine, Viktor, Berggren, Magnus, and Crispin, Xavier
- Subjects
CONDUCTING polymer films ,THICK films ,CONDUCTING polymers ,HYDROGEN peroxide ,ATMOSPHERIC pressure ,WIRE netting ,PAPER pulp - Abstract
Producing thick films of conducting polymers by a low‐cost manufacturing technique would enable new applications. However, removing huge solvent volume from diluted suspension or dispersion (1–3 wt%) in which conducting polymers are typically obtained is a true manufacturing challenge. In this work, a procedure is proposed to quickly remove water from the conducting polymer poly(3,4‐ethylenedioxythiophene:poly(4‐styrene sulfonate) (PEDOT:PSS) suspension. The PEDOT:PSS suspension is first flocculated with 1 m H2SO4 transforming PEDOT nanoparticles (≈50–500 nm) into soft microparticles. A filtration process inspired by pulp dewatering in a paper machine on a wire mesh with apertures dimension between 60 µm and 0.5 mm leads to thick free‐standing films (≈0.5 mm). Wire mesh clogging that hinders dewatering (known as dead‐end filtration) is overcome by adding to the flocculated PEDOT:PSS dispersion carbon fibers that aggregate and form efficient water channels. Moreover, this enables fast formation of thick layers under simple atmospheric pressure filtration, thus making the process truly scalable. Thick freestanding PEDOT films thus obtained are used as electrocatalysts for efficient reduction of oxygen to hydrogen peroxide, a promising green chemical and fuel. The inhomogeneity of the films does not affect their electrochemical function. [ABSTRACT FROM AUTHOR]
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- 2022
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12. Materials from trees assembled by 3D printing – Wood tissue beyond nature limits
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Markstedt, Kajsa, Håkansson, Karl, Toriz, Guillermo, and Gatenholm, Paul
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- 2019
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13. Controlling the Organization of PEDOT:PSS on Cellulose Structures.
- Author
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Belaineh, Dagmawi, Andreasen, Jens W., Palisaitis, Justinas, Malti, Abdellah, Håkansson, Karl, Wågberg, Lars, Crispin, Xavier, Engquist, Isak, and Berggren, Magnus
- Published
- 2019
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14. Controlled molecular reorientation enables strong cellulose fibers regenerated from ionic liquid solutions
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Sundberg, Johan, Guccini, Valentina, Håkansson, Karl M.O., Salazar-Alvarez, German, Toriz, Guillermo, and Gatenholm, Paul
- Published
- 2015
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15. Nanofibril Alignment in Flow Focusing: Measurements and Calculations.
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Håkansson, Karl M. O., Lundell, Fredrik, Prahl-Wittberg, Lisa, and Söderberg, L. Daniel
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ANISOTROPY , *CELLULOSE , *X-ray scattering , *ISOTROPY subgroups , *BROWNIAN motion - Abstract
Alignment of anisotropic supermolecular building blocks is crucial to control the properties of many novel materials. In this study, the alignment process of cellulose nanofibrils (CNFs) in a flow-focusing channel has been investigated using small-angle X-ray scattering (SAXS) and modeled using the Smoluchowski equation, which requires a known flow field as input. This flow field was investigated experimentally using microparticle-tracking velocimetry and by numerically applying the two-fluid level set method. A semidilute dispersion of CNFs was modeled as a continuous phase, with a higher viscosity as compared to that of water. Furthermore, implementation of the Smoluchowski equation also needed the rotational Brownian diffusion coefficient, which was experimentally determined in a shear viscosity measurement. The order of the nanofibrils was found to increase during extension in the flow-focusing channel, after which rotational diffusion acted on the orientation distribution, driving the orientation of the fibrils toward isotropy. The main features of the alignment and dealignment processes were well predicted by the numerical model, but the model overpredicted the alignment at higher rates of extension. The apparent rotational diffusion coefficient was seen to increase steeply as the degree of alignment increased. Thus, the combination of SAXS measurements and modeling provides the necessary framework for quantified studies of hydrodynamic alignment, followed by relaxation toward isotropy. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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16. Online determination of anisotropy during cellulose nanofibril assembly in a flow focusing device.
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Håkansson, Karl M. O.
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- 2015
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17. Accelerator mass spectrometry offers new opportunities for microdosing of peptide and protein pharmaceuticals.
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Salehpour, Mehran, Ekblom, Jonas, Sabetsky, Vladimir, Håkansson, Karl, and Possnert, Göran
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- 2010
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18. Paper machine manufactured photocatalysts - Lateral variations.
- Author
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Sandberg, Mats, Håkansson, Karl, and Granberg, Hjalmar
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PAPERMAKING ,LAMINATED materials ,PHOTOCATALYSTS ,SULFATE pulping process ,CATALYSTS ,CATALYTIC activity ,REFLECTANCE measurement - Abstract
• Paper machine manufactured photocatalyst papers were investigated. • The photocatalyst papers were soaked by indicator solutions in a laminate structure. • Lateral variations of the photoconversion were followed by reflectance measurements. • Lateral variations show maximum values during the conversion. • The catalyst loading does not influence the overall conversion rate significantly. Paper machine manufacturing of photocatalysts can enable low cost devices for removal of low concentrated pollutants. Lateral variations originating from the paper making process leads to variations of the catalytic activity over the paper area. Paper machine manufactured papers made from tetrapodal ZnO whiskers and kraft pulp were investigated in this test geometry using simulated solar light. Photocatalytic ZnO papers were laminated between polyethylene sheets and an indicator solution seeped into the laminated photocatalytic paper, to create a test geometry where the indicator ink is confined to a small volume between the polyethylene sheets. The photocatalyst papers exhibited surprisingly similar photocatalytic behavior although having different catalyst loading 15, 30 and 45 wt percent. All papers exhibited lateral variations that peaked during the conversion. The results show that production of effective photocatalytic composite papers can be scaled. Further, the results show that variations must be considered for photocatalytic papers. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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19. PEDOT‐Cellulose Gas Diffusion Electrodes for Disposable Fuel Cells.
- Author
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Mitraka, Evangelia, Vagin, Mikhail, Sjöstedt, Anna, Berggren, Magnus, Håkansson, Karl M. O., Jonsson, Magnus P., and Crispin, Xavier
- Subjects
FUEL cell electrodes ,DIFFUSION ,RENEWABLE energy sources ,CELL membrane formation ,PROTON exchange membrane fuel cells - Abstract
The mass implementation of renewable energy sources is limited by the lack of energy storage solutions operating on various timescales. Electrochemical technologies such as supercapacitors and batteries cannot handle long storage time because of self‐discharge issues. The combination of fuel storage technology and fuel cells is an attractive solution for long storage times. In that context, large‐scale fuel cell solutions are required for massive energy storage in cities, which leads to possible concepts such as low‐cost disposable fully organic membrane assemblies in fuel cells to avoid regeneration of expensive poisoned electrodes. Here, the formation of an organic gas diffusion electrode (GDE) fabricated by paper‐making production, combined with in situ polymerization is demonstrated for the first time. Cellulose is used as a 3D scaffold functionalized with poly(3,4‐ethylenedioxythiophene) (PEDOT) serving as both an electrical conductor and an electrocatalyst of high efficiency for the oxygen reduction reaction. The PEDOT‐cellulose porous GDE is implemented in a membrane assembly and demonstrated in a H2‐O2 fuel cell. The demonstration of low‐cost material/manufacturing that is environmentally friendly is a paradigm shift in the development of fuel cells for a sustainable society. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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20. Continuous Assembly of Cellulose Nanofibrils and Nanocrystals into Strong Macrofibers through Microfluidic Spinning.
- Author
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Nechyporchuk, Oleksandr, Håkansson, Karl M. O., Gowda.V, Krishne, Lundell, Fredrik, Hagström, Bengt, and Köhnke, Tobias
- Subjects
- *
CELLULOSE nanocrystals , *YOUNG'S modulus , *X-ray scattering , *CELLULOSE fibers , *GROUNDWATER flow - Abstract
Microfluidic fiber spinning is a promising technique for assembling cellulose nanomaterials into macroscopic fibers. However, its implementation requires upscalabe fabrication processes while maintaining high strength of the fibers, which could not be previously achieved. Herein, a continuous wet spinning process based on microfluidic flow focusing is developed to produce strong fibers from cellulose nanofibrils (CNFs) and nanocrystals (CNCs). Fibers with an average breaking tenacity as high as 29.5 cN tex−1 and Young's modulus of 1146 cN tex−1 are reported for the first time, produced from nonhighly purified CNF grades. Using the same developed method, wet spinning of fibers from CNCs is achieved for the first time, reaching an average Young's modulus of 1263 cN tex−1 and a breaking tenacity of 10.6 cN tex−1, thus exhibiting strength twice as high as that of common CNC films. A rather similar stiffness of CNC and CNF spun fibers may originate from similar degrees of alignment, as confirmed by wide‐angle X‐ray scattering (WAXS) and birefringence measurements, whereas lower strength may primarily arise from the shorter length of CNCs compared to that of CNFs. The benefit of CNCs is their higher solids content in the dopes. By combining both CNCs and CNFs, the fiber properties can be tuned. A method for continuous bioinspired microfluidic fiber spinning from nanocellulose is developed. This allows continuous fabrication of macrofibers from nonhighly purified grades of cellulose nanofibrils with a breaking tenacity of 29.5 cN tex−1. Using the same developed method, an assembly of fibers from cellulose nanocrystals is demonstrated that exhibit strength twice as high as that of their common film counterparts. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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21. Anisotropic conductivity of Cellulose-PEDOT:PSS composite materials studied with a generic 3D four-point probe tool.
- Author
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Wang, Xin, Grimoldi, Andrea, Håkansson, Karl, Fall, Andreas, Granberg, Hjalmar, Mengistie, Desalegn, Edberg, Jesper, Engquist, Isak, Nilsson, David, Berggren, Magnus, and Gustafsson, Göran
- Subjects
- *
CELLULOSE , *ANISOTROPY , *CONDUCTING polymers , *IONIC conductivity , *SULFONATES , *POLYMERIC composites - Abstract
Abstract The conductive polymer poly(3,4-ethylenedioxythiphene):poly(styrenesulfonate) (PEDOT:PSS) is widely used in organic electronics and printed electronics due to its excellent electronic and ionic conductivity. PEDOT:PSS films exhibit anisotropic conductivities originating from the interplay of film deposition processes and chemical structure. The previous studies found that high boiling point solvent treated PEDOT:PSS exhibits an anisotropy of 3–4 orders magnitude. Even though both the in-plane and out-of-plane conductivities are important for the device performance, the out-of-plane conductivity is rarely studied due to the complexity with the experiment procedure. Cellulose-based paper or films can also exhibit anisotropic behavior due to the combination of their intrinsic fibric structure and film formation process. We have previously developed a conductive paper based on PEDOT:PSS and cellulose which could be used as the electrodes in energy storage devices. In this work we developed a novel measurement set-up for studying the anisotropy of the charge transport in such composite materials. A tool with two parallel plates mounted with spring loaded probes was constructed enabling probing both lateral and vertical directions and resistances from in-plane and out-of-plane directions to be obtained. The measurement results were then input and analyzed with a model based on a transformation method developed by Montgomery, and thus the in-plane and out-of-plane conductivities could be detangled and derived. We also investigated how the conductivity anisotropy depends on the microstructure of the cellulose template onto which the conductive polymer self-organizes. We show that there is a relatively small difference between the in-plane and out-of-plane conductivities which is attributed to the unique 3D-structure of the composites. This new knowledge gives a better understanding of the possibilities and limitations for using the material in electronic and electrochemical devices. Graphical abstract Image 1 Highlights • Developed a simple to use generic tool for measuring 3-D resistances of thick conducting self-standing films. • The in-plane and out-of-plane conductivities were deduced by a method developed by Montgomery. • Both CNF-PEDOT:PSS and pulp-PEDOT:PSS films exhibit anisotropic conductivity. • CNF-PEDOT:PSS films show thickness independent anisotropic conductivity. • Pulp-PEDOT:PSS became less anisotropic with increasing thicknesses. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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22. Hydrodynamic alignment and assembly of nanofibrils resulting in strong cellulose filaments.
- Author
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Håkansson, Karl M. O., Fall, Andreas B., Lundell, Fredrik, Yu, Shun, Krywka, Christina, Roth, Stephan V., Santoro, Gonzalo, Kvick, Mathias, Prahl Wittberg, Lisa, Wågberg, Lars, and Söderberg, L. Daniel
- Published
- 2014
- Full Text
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23. Simulations of 3D bioprinting: predicting bioprintability of nanofibrillar inks.
- Author
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Göhl J, Markstedt K, Mark A, Håkansson K, Gatenholm P, and Edelvik F
- Subjects
- Cellulose chemistry, Computer Simulation, Rheology, Bioprinting methods, Ink, Nanofibers chemistry, Printing, Three-Dimensional
- Abstract
3D bioprinting with cell containing bioinks show great promise in the biofabrication of patient specific tissue constructs. To fulfil the multiple requirements of a bioink, a wide range of materials and bioink composition are being developed and evaluated with regard to cell viability, mechanical performance and printability. It is essential that the printability and printing fidelity is not neglected since failure in printing the targeted architecture may be catastrophic for the survival of the cells and consequently the function of the printed tissue. However, experimental evaluation of bioinks printability is time-consuming and must be kept at a minimum, especially when 3D bioprinting with cells that are valuable and costly. This paper demonstrates how experimental evaluation could be complemented with computer based simulations to evaluate newly developed bioinks. Here, a computational fluid dynamics simulation tool was used to study the influence of different printing parameters and evaluate the predictability of the printing process. Based on data from oscillation frequency measurements of the evaluated bioinks, a full stress rheology model was used, where the viscoelastic behaviour of the material was captured. Simulation of the 3D bioprinting process is a powerful tool and will help in reducing the time and cost in the development and evaluation of bioinks. Moreover, it gives the opportunity to isolate parameters such as printing speed, nozzle height, flow rate and printing path to study their influence on the printing fidelity and the viscoelastic stresses within the bioink. The ability to study these features more extensively by simulating the printing process will result in a better understanding of what influences the viability of cells in 3D bioprinted tissue constructs.
- Published
- 2018
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24. Ultrastrong and Bioactive Nanostructured Bio-Based Composites.
- Author
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Mittal N, Jansson R, Widhe M, Benselfelt T, Håkansson KMO, Lundell F, Hedhammar M, and Söderberg LD
- Subjects
- Animals, Nanostructures chemistry, Recombinant Proteins, Spiders, Tensile Strength physiology, Cellulose chemistry, Protein Engineering methods, Silk chemistry
- Abstract
Nature's design of functional materials relies on smart combinations of simple components to achieve desired properties. Silk and cellulose are two clever examples from nature-spider silk being tough due to high extensibility, whereas cellulose possesses unparalleled strength and stiffness among natural materials. Unfortunately, silk proteins cannot be obtained in large quantities from spiders, and recombinant production processes are so far rather expensive. We have therefore combined small amounts of functionalized recombinant spider silk proteins with the most abundant structural component on Earth (cellulose nanofibrils (CNFs)) to fabricate isotropic as well as anisotropic hierarchical structures. Our approach for the fabrication of bio-based anisotropic fibers results in previously unreached but highly desirable mechanical performance with a stiffness of ∼55 GPa, strength at break of ∼1015 MPa, and toughness of ∼55 MJ m
-3 . We also show that addition of small amounts of silk fusion proteins to CNF results in materials with advanced biofunctionalities, which cannot be anticipated for the wood-based CNF alone. These findings suggest that bio-based materials provide abundant opportunities to design composites with high strength and functionalities and bring down our dependence on fossil-based resources.- Published
- 2017
- Full Text
- View/download PDF
25. Highly conducting, strong nanocomposites based on nanocellulose-assisted aqueous dispersions of single-wall carbon nanotubes.
- Author
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Hamedi MM, Hajian A, Fall AB, Håkansson K, Salajkova M, Lundell F, Wågberg L, and Berglund LA
- Subjects
- Mechanical Phenomena, Cellulose chemistry, Electric Conductivity, Nanocomposites chemistry, Nanofibers chemistry, Nanotubes, Carbon chemistry, Water chemistry
- Abstract
It is challenging to obtain high-quality dispersions of single-wall nanotubes (SWNTs) in composite matrix materials, in order to reach the full potential of mechanical and electronic properties. The most widely used matrix materials are polymers, and the route to achieving high quality dispersions of SWNT is mainly chemical functionalization of the SWNT. This leads to increased cost, a loss of strength and lower conductivity. In addition full potential of colloidal self-assembly cannot be fully exploited in a polymer matrix. This may limit the possibilities for assembly of highly ordered structural nanocomposites. Here we show that nanofibrillated cellulose (NFC) can act as an excellent aqueous dispersion agent for as-prepared SWNTs, making possible low-cost exfoliation and purification of SWNTs with dispersion limits exceeding 40 wt %. The NFC:SWNT dispersion may also offer a cheap and sustainable alternative for molecular self-assembly of advanced composites. We demonstrate semitransparent conductive films, aerogels and anisotropic microscale fibers with nanoscale composite structure. The NFC:SWNT nanopaper shows increased strength at 3 wt % SWNT, reaching a modulus of 13.3 GPa, and a strength of 307 MPa. The anisotropic microfiber composites have maximum conductivities above 200 S cm(-1) and current densities reaching 1400 A cm(-2).
- Published
- 2014
- Full Text
- View/download PDF
26. Application of accelerator mass spectrometry to macromolecules: preclinical pharmacokinetic studies on a polybisphosphonate.
- Author
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Salehpour M, Håkansson K, Höglund U, Grahn-Westin A, Nilsson S, Márquez M, Possnert G, and Holmberg AR
- Subjects
- Alendronate chemistry, Animals, Carbon Isotopes chemistry, Diphosphonates administration & dosage, Diphosphonates chemistry, Guanidines chemistry, Macromolecular Substances administration & dosage, Macromolecular Substances chemistry, Male, Polymers administration & dosage, Polymers chemistry, Rats, Rats, Sprague-Dawley, Tissue Distribution, Diphosphonates pharmacokinetics, Drug Evaluation, Preclinical methods, Macromolecular Substances pharmacokinetics, Mass Spectrometry methods, Polymers pharmacokinetics
- Abstract
Data on the use of accelerator mass spectrometry (AMS) in conjunction with in vivo studies of macromolecular drugs are scarce. The present study shows the versatility of this technique when investigating the pharmacokinetics (PK) of a macromolecular drug candidate, a polybisphosphonate conjugate (ODX). The aforementioned is a polymer (molecular weight ~30 kDa) constituting a carbohydrate backbone with covalently linked ligands (aldendronate and aminoguanidine) and is intended for treatment of osteoporosis and the therapy of bone metastasis from prostate cancer. The conjugate is prepared through partial oxidation of the carbohydrate and sequential coupling of the ligands by reductive amination. (14)C was incorporated in the conjugate by means of coupling a commercially available (14)C-lysine in the conjugation sequence. Fifteen rats were injected intravenously with (14)C-labelled ODX (150 µg, 14 Bq/rat) and blood samples were collected at 1, 2, 4, 6, and 24 h post-injection (3 rats/time point). Liver, spleen and kidney samples were collected at 4 and 24 h post-injection. Blood from each time point (triplicate) were collected for AMS measurement determining the isotopic ratio ((14)C/(12)C) and consequently the drug concentration in blood. ODX showed a transient presence in blood circulation; 93% of the total dose was cleared from the circulation within 1 h. The half-life after 1 h was estimated to be about 3 h; 0.7% of the administered (14)C dose of ODX remained in circulation after 24 h. The major (14)C accumulation was in the liver, the spleen and the kidneys indicating the probable route of metabolism and excretion. This study demonstrates the versatility of AMS for pharmacological in vivo studies of macromolecules. Labelling with (14)C is relatively simple, inexpensive and the method requires minimal radioactivity, eliminating the need for radioprotection precautions in contrast to methods using scintillation counting., (Copyright © 2011 John Wiley & Sons, Ltd.)
- Published
- 2011
- Full Text
- View/download PDF
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